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Volumn 7, Issue , 2017, Pages

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ASTROCYTE; CELL DIFFERENTIATION; DISEASE MODEL; EPENDYMA; MOUSE; NEURAL STEM CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SCAR; SPINAL CORD INJURY; TRANSGENIC MOUSE;

EID: 85010875151     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep41122     Document Type: Article
Times cited : (108)

References (54)
  • 2
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • Burda, J. E., & Sofroniew, M. V. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81, 229-248 (2014
    • (2014) Neuron , vol.81 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 3
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple, S. The development of neural stem cells. Nature 414, 112-117 (2001
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 4
    • 84866392805 scopus 로고    scopus 로고
    • Long-distance growth and connectivity of neural stem cells after severe spinal cord injury
    • Lu, P., et al. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell 150, 1264-1273 (2012
    • (2012) Cell , vol.150 , pp. 1264-1273
    • Lu, P.1
  • 5
    • 85010851267 scopus 로고    scopus 로고
    • Smart materials for central nervous system cell delivery and tissue engineering
    • ed. Wang, Q.) Royal Society of Chemistry
    • O'Shea, T. M., et al. Smart materials for central nervous system cell delivery and tissue engineering. In Applications of Smart Materials in Tissue Engineering (ed. Wang, Q.) (Royal Society of Chemistry, 2016
    • (2016) Applications of Smart Materials in Tissue Engineering
    • O'Shea, T.M.1
  • 6
  • 7
    • 84880851472 scopus 로고    scopus 로고
    • Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury
    • Wanner, I. B., et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci 33, 12870-12886 (2013
    • (2013) J Neurosci , vol.33 , pp. 12870-12886
    • Wanner, I.B.1
  • 8
    • 84928122606 scopus 로고    scopus 로고
    • Astrocyte barriers to neurotoxic inflammation
    • Sofroniew, M. V. Astrocyte barriers to neurotoxic inflammation. Nat Rev Neurosci 16, 249-263 (2015
    • (2015) Nat Rev Neurosci , vol.16 , pp. 249-263
    • Sofroniew, M.V.1
  • 9
    • 0032540266 scopus 로고    scopus 로고
    • Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
    • Bush, T. G., et al. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93, 189-201 (1998
    • (1998) Cell , vol.93 , pp. 189-201
    • Bush, T.G.1
  • 10
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • Bush, T. G., et al. Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23, 297-308 (1999
    • (1999) Neuron , vol.23 , pp. 297-308
    • Bush, T.G.1
  • 11
    • 33749508895 scopus 로고    scopus 로고
    • Essential protective roles of reactive astrocytes in traumatic brain injury
    • Myer, D. J., Gurkoff, G. G., Lee, S. M., Hovda, D. A., & Sofroniew, M. V. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 129, 2761-2772 (2006
    • (2006) Brain , vol.129 , pp. 2761-2772
    • Myer, D.J.1    Gurkoff, G.G.2    Lee, S.M.3    Hovda, D.A.4    Sofroniew, M.V.5
  • 12
    • 1542317072 scopus 로고    scopus 로고
    • Reactive astrocytes protect tissue and preserve function after spinal cord injury
    • Faulkner, J. R., et al. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J. Neurosci. 24, 2143-2155 (2004
    • (2004) J. Neurosci , vol.24 , pp. 2143-2155
    • Faulkner, J.R.1
  • 13
    • 49049091210 scopus 로고    scopus 로고
    • STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    • Herrmann, J. E., et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 28, 7231-7243 (2008
    • (2008) J. Neurosci , vol.28 , pp. 7231-7243
    • Herrmann, J.E.1
  • 14
    • 70349103383 scopus 로고    scopus 로고
    • Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    • Voskuhl, R. R., et al. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J. Neurosci. 29, 11511-11522 (2009
    • (2009) J. Neurosci , vol.29 , pp. 11511-11522
    • Voskuhl, R.R.1
  • 15
    • 79958042327 scopus 로고    scopus 로고
    • Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation
    • Haroon, F., et al. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J Immunol 186, 6521-6531 (2011
    • (2011) J Immunol , vol.186 , pp. 6521-6531
    • Haroon, F.1
  • 16
    • 39749132193 scopus 로고    scopus 로고
    • Protective role of reactive astrocytes in brain ischemia
    • Li, L., et al. Protective role of reactive astrocytes in brain ischemia. J. Cereb. Blood Flow Metab. 28, 468-481 (2008
    • (2008) J. Cereb. Blood Flow Metab , vol.28 , pp. 468-481
    • Li, L.1
  • 17
    • 52949085996 scopus 로고    scopus 로고
    • Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis
    • Drogemuller, K., et al. Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis. J. Immunol. 181, 2683-2693 (2008
    • (2008) J. Immunol , vol.181 , pp. 2683-2693
    • Drogemuller, K.1
  • 18
    • 80054910077 scopus 로고    scopus 로고
    • The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis
    • Macauley, S. L., Pekny, M., & Sands, M. S. The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. J Neurosci 31, 15575-15585 (2011
    • (2011) J Neurosci , vol.31 , pp. 15575-15585
    • Macauley, S.L.1    Pekny, M.2    Sands, M.S.3
  • 19
    • 84871905759 scopus 로고    scopus 로고
    • Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
    • Kraft, A. W., et al. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. FASEB J 27, 187-198 (2013
    • (2013) FASEB J , vol.27 , pp. 187-198
    • Kraft, A.W.1
  • 20
    • 84964324589 scopus 로고    scopus 로고
    • Astrocyte scar formation AIDS central nervous system axon regeneration
    • Anderson, M. A., et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature 532, 195-200 (2016
    • (2016) Nature , vol.532 , pp. 195-200
    • Anderson, M.A.1
  • 21
    • 84856090845 scopus 로고    scopus 로고
    • Lineage tracing
    • Kretzschmar, K., & Watt, F. M. Lineage tracing. Cell 148, 33-45 (2012
    • (2012) Cell , vol.148 , pp. 33-45
    • Kretzschmar, K.1    Watt, F.M.2
  • 22
    • 48349122033 scopus 로고    scopus 로고
    • Spinal cord injury reveals multilineage differentiation of ependymal cells
    • Meletis, K., et al. Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol 6, e182 (2008
    • (2008) PLoS Biol , vol.6 , pp. e182
    • Meletis, K.1
  • 23
    • 77957331909 scopus 로고    scopus 로고
    • Origin of new glial cells in intact and injured adult spinal cord
    • Barnabe-Heider, F., et al. Origin of new glial cells in intact and injured adult spinal cord. Cell Stem Cell 7, 470-482 (2010
    • (2010) Cell Stem Cell , vol.7 , pp. 470-482
    • Barnabe-Heider, F.1
  • 24
    • 84887293716 scopus 로고    scopus 로고
    • Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice
    • Sabelstrom, H., et al. Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science 342, 637-640 (2013
    • (2013) Science , vol.342 , pp. 637-640
    • Sabelstrom, H.1
  • 25
    • 84908378496 scopus 로고    scopus 로고
    • Neural stem cells in the adult spinal cord
    • Sabelstrom, H., Stenudd, M., & Frisen, J. Neural stem cells in the adult spinal cord. Exp Neurol 260, 44-49 (2014
    • (2014) Exp Neurol , vol.260 , pp. 44-49
    • Sabelstrom, H.1    Stenudd, M.2    Frisen, J.3
  • 26
    • 84884545941 scopus 로고    scopus 로고
    • Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
    • Zukor, K., et al. Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J Neurosci 33, 15350-15361 (2013
    • (2013) J Neurosci , vol.33 , pp. 15350-15361
    • Zukor, K.1
  • 28
    • 84969257207 scopus 로고    scopus 로고
    • Thermoresponsive copolypeptide hydrogel vehicles for central nervous system cell delivery
    • Zhang, S., et al. Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery. ACS Biomater Sci Eng 1, 705-717 (2015
    • (2015) ACS Biomater Sci Eng , vol.1 , pp. 705-717
    • Zhang, S.1
  • 29
    • 84898783446 scopus 로고    scopus 로고
    • A knock-in Foxj1 (CreERT2: GFP) mouse for recombination in epithelial cells with motile cilia
    • Muthusamy, N., Vijayakumar, A., Cheng, G. Jr., & Ghashghaei, H. T. A knock-in Foxj1 (CreERT2: GFP) mouse for recombination in epithelial cells with motile cilia. Genesis 52, 350-358 (2014
    • (2014) Genesis , vol.52 , pp. 350-358
    • Muthusamy, N.1    Vijayakumar, A.2    Cheng, G.3    Ghashghaei, H.T.4
  • 30
    • 73949140059 scopus 로고    scopus 로고
    • A robust and high-Throughput Cre reporting and characterization system for the whole mouse brain
    • Madisen, L., et al. A robust and high-Throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133-140 (2010
    • (2010) Nat. Neurosci , vol.13 , pp. 133-140
    • Madisen, L.1
  • 31
    • 78349285121 scopus 로고    scopus 로고
    • Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-Term in vitro self-renewal and in vivo gene expression
    • Pfenninger, C. V., Steinhoff, C., Hertwig, F., & Nuber, U. A. Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-Term in vitro self-renewal and in vivo gene expression. Glia 59, 68-81 (2011
    • (2011) Glia , vol.59 , pp. 68-81
    • Pfenninger, C.V.1    Steinhoff, C.2    Hertwig, F.3    Nuber, U.A.4
  • 34
    • 20044362061 scopus 로고    scopus 로고
    • Cell proliferation and replacement following contusive spinal cord injury
    • Zai, L. J., & Wrathall, J. R. Cell proliferation and replacement following contusive spinal cord injury. Glia 50, 247-257 (2005
    • (2005) Glia , vol.50 , pp. 247-257
    • Zai, L.J.1    Wrathall, J.R.2
  • 36
    • 0035816356 scopus 로고    scopus 로고
    • Localisation of the SRY-related HMG box protein, SOX9, in rodent brain
    • Pompolo, S., & Harley, V. R. Localisation of the SRY-related HMG box protein, SOX9, in rodent brain. Brain Res 906, 143-148 (2001
    • (2001) Brain Res , vol.906 , pp. 143-148
    • Pompolo, S.1    Harley, V.R.2
  • 38
    • 84873621145 scopus 로고    scopus 로고
    • Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke
    • Young, C. C., et al. Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke. Cereb Cortex 23, 647-659 (2013
    • (2013) Cereb Cortex , vol.23 , pp. 647-659
    • Young, C.C.1
  • 39
    • 84938723222 scopus 로고    scopus 로고
    • The ependymal region of the adult human spinal cord differs from other species and shows ependymomalike features
    • Garcia-Ovejero, D., et al. The ependymal region of the adult human spinal cord differs from other species and shows ependymomalike features. Brain 138, 1583-1597 (2015
    • (2015) Brain , vol.138 , pp. 1583-1597
    • Garcia-Ovejero, D.1
  • 41
  • 42
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • Sofroniew, M. V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638-647 (2009
    • (2009) Trends Neurosci , vol.32 , pp. 638-647
    • Sofroniew, M.V.1
  • 43
    • 38149129457 scopus 로고    scopus 로고
    • A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function
    • Cahoy, J. D., et al. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 28, 264-278 (2008
    • (2008) J. Neurosci , vol.28 , pp. 264-278
    • Cahoy, J.D.1
  • 44
    • 78650248298 scopus 로고    scopus 로고
    • Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice
    • Yang, Y., et al. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59, 200-207 (2011
    • (2011) Glia , vol.59 , pp. 200-207
    • Yang, Y.1
  • 45
    • 84880811955 scopus 로고    scopus 로고
    • Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions
    • Molofsky, A. V., et al. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia 61, 1518-1532 (2013
    • (2013) Glia , vol.61 , pp. 1518-1532
    • Molofsky, A.V.1
  • 46
    • 37549049804 scopus 로고    scopus 로고
    • Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-Type stem cells have a limited capacity for self-renewal
    • Balordi, F., & Fishell, G. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-Type stem cells have a limited capacity for self-renewal. J Neurosci 27, 14248-14259 (2007
    • (2007) J Neurosci , vol.27 , pp. 14248-14259
    • Balordi, F.1    Fishell, G.2
  • 47
    • 79959646008 scopus 로고    scopus 로고
    • Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-To-postnatal transition of neurogenesis in the olfactory bulb
    • Jacquet, B. V., et al. Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-To-postnatal transition of neurogenesis in the olfactory bulb. J Neurosci 31, 9368-9382 (2011
    • (2011) J Neurosci , vol.31 , pp. 9368-9382
    • Jacquet, B.V.1
  • 48
    • 70450159775 scopus 로고    scopus 로고
    • FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain
    • Jacquet, B. V., et al. FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development 136, 4021-4031 (2009
    • (2009) Development , vol.136 , pp. 4021-4031
    • Jacquet, B.V.1
  • 49
    • 80051769464 scopus 로고    scopus 로고
    • Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis
    • Guo, F., et al. Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci 31, 11914-11928 (2011
    • (2011) J Neurosci , vol.31 , pp. 11914-11928
    • Guo, F.1
  • 50
    • 1942425481 scopus 로고    scopus 로고
    • The pathology of human spinal cord injury: Defining the problems
    • Norenberg, M. D., Smith, J., & Marcillo, A. The pathology of human spinal cord injury: defining the problems. J Neurotrauma 21, 429-440 (2004
    • (2004) J Neurotrauma , vol.21 , pp. 429-440
    • Norenberg, M.D.1    Smith, J.2    Marcillo, A.3
  • 51
    • 0037194887 scopus 로고    scopus 로고
    • LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    • Capela, A., & Temple, S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 35, 865-875 (2002
    • (2002) Neuron , vol.35 , pp. 865-875
    • Capela, A.1    Temple, S.2
  • 52
    • 84902299428 scopus 로고    scopus 로고
    • Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells
    • Sachewsky, N., et al. Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells. Stem Cell Reports 2, 810-824 (2014
    • (2014) Stem Cell Reports , vol.2 , pp. 810-824
    • Sachewsky, N.1
  • 53
    • 84859046711 scopus 로고    scopus 로고
    • Tamoxifen-induced cre-loxp recombination is prolonged in pancreatic islets of adult mice
    • Reinert, R. B., et al. Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One 7, e33529 (2012
    • (2012) PLoS One , vol.7 , pp. e33529
    • Reinert, R.B.1
  • 54
    • 34547145165 scopus 로고    scopus 로고
    • G Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
    • Faul, F., Erdfelder, E., Lang, A. G., & Buchner, A. G Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior research methods 39, 175-191 (2007
    • (2007) Behavior Research Methods , vol.39 , pp. 175-191
    • Faul, F.1    Erdfelder, E.2    Lang, A.G.3    Buchner, A.4


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