Enhanced ethanol fermentation by engineered Saccharomyces cerevisiae strains with high spermidine contents

Bioprocess and Biosystems Engineering

Volumn 40, Issue 5, 2017, Pages 683-691

  Kim, Sun Ki ^a   Jo, Jung Hyun ^a   Jin, Yong Su ^b   Seo, Jin Ho ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Biofuels; Inhibitor tolerance; Repeated batch fermentation; Spermidine; Xylose

Indexed keywords

BIOFUELS; ETHANOL; GLUCOSE; PRODUCTIVITY; XYLOSE; YEAST;

ETHANOL FERMENTATION; ETHANOL PRODUCTIVITY; FERMENTATION INHIBITORS; GLUCOSE FERMENTATION; INHIBITOR TOLERANCES; REPEATED BATCH; SACCHAROMYCES CEREVISIAE STRAINS; SPERMIDINE;

FERMENTATION;

ACETIC ACID; ALCOHOL; ANTIZYME; CARRIER PROTEIN; FURAN DERIVATIVE; FURFURAL; GLUCOSE; HISTIDINE; LEUCINE; POLYAMINE TRANSPORT PROTEIN; SPERMIDINE; TRYPTOPHAN; UNCLASSIFIED DRUG; URACIL; XYLOSE;

ARTICLE; BIOFUEL PRODUCTION; CELL VIABILITY; CONTROLLED STUDY; ESCHERICHIA COLI; FUNGAL STRAIN; GENE; GENETIC CODE; GENETIC MANIPULATION; NONHUMAN; OAZ1 GENE; OPTICAL DENSITY; PRIORITY JOURNAL; REPEATED BATCH FERMENTATION; SACCHAROMYCES CEREVISIAE; TPO1 GENE; FERMENTATION; GENETICS; METABOLIC ENGINEERING; METABOLISM;

ETHANOL; FERMENTATION; GLUCOSE; METABOLIC ENGINEERING; SACCHAROMYCES CEREVISIAE; SPERMIDINE; XYLOSE;

EID: 85010796686     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-016-1733-3     Document Type: Article

References (26)

1. Farrell AE, Plevin RJ, Turner BT, Jones AD, O’Hare M, Kammen DM (2006) Ethanol can contribute to energy and environmental goals. Science 311:506–508
2. Yangcheng HY, Jiang HX, Blanco M, Jane JL (2013) Characterization of normal and waxy corn starch for bioethanol production. J Agric Food Chem 61:379–386
3. Bai FW, Anderson WA, Moo-Young M (2008) Ethanol fermentation technologies from sugar and starch feedstocks. Biotechnol Adv 26:89–105
4. Verbelen PJ, Saerens SMG, Van Mulders SE, Delvaux F, Delvaux FR (2009) The role of oxygen in yeast metabolism during high cell density brewery fermentations. Appl Microbiol Biotechnol 82:1143–1156
5. Pereira FB, Gomes DG, Guimares PMR, Teixeira JA, Domingues L (2012) Cell recycling during repeated very high gravity bio-ethanol fermentations using the industrial Saccharomyces cerevisiae strain PE-2. Biotechnol Lett 34:45–53
6. Argueso JL, Carazzolle MF, Mieczkowski PA, Duarte FM, Netto OVC, Missawa SK, Galzerani F, Costa GGL, Vidal RO, Noronha MF, Dominska M, Andrietta MGS, Andrietta SR, Cunha AF, Gomes LH, Tavares FCA, Alcarde AR, Dietrich FS, McCusker JH, Petes TD, Pereira GAG (2009) Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Res 19:2258–2270
7. Maristela Freitas SP, Laluce C (1998) Ethanol tolerance of thermotolerant yeasts cultivated on mixtures of sucrose and ethanol. J Ferment Bioeng 85:388–397
8. Kim SK, Jin YS, Choi IG, Park YC, Seo JH (2015) Enhanced tolerance of Saccharomyces cerevisiae to multiple lignocellulose-derived inhibitors through modulation of spermidine contents. Metab Eng 29:46–55
9. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frohlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11:1305–1314
10. Almeida JRM, Modig T, Petersson A, Hähn-Hägerdal B, Lidén G, Gorwa-Grauslund MF (2007) Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. J Chem Technol Biotechnol 82:340–349
11. Hahn-Hagerdal B, Galbe M, Gorwa-Grauslund MF, Liden G, Zacchi G (2006) Bio-ethanol - the fuel of tomorrow from the residues of today. Trends Biotechnol 24:549–556
12. Demeke MM, Dumortier F, Li YY, Broeckx T, Foulquie-Moreno MR, Thevelein JM (2013) Combining inhibitor tolerance and D-xylose fermentation in industrial Saccharomyces cerevisiae for efficient lignocellulose-based bioethanol production. Biotechnol Biofuels 6:120
13. Smith J, van Rensburg E, Gorgens JF (2014) Simultaneously improving xylose fermentation and tolerance to lignocellulosic inhibitors through evolutionary engineering of recombinant Saccharomyces cerevisiae harbouring xylose isomerase. BMC Biotechnol 14:41
14. Kim SR, Ha SJ, Kong II, Jin YS (2012) High expression of XYL2 coding for xylitol dehydrogenase is necessary for efficient xylose fermentation by engineered Saccharomyces cerevisiae. Metab Eng 14:336–343
15. Hosaka K, Nikawa J, Kodaki T, Yamashita S (1992) A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae. J Biochem 111:352–358
16. Kim SR, Skerker JM, Kang W, Lesmana A, Wei N, Arkin AP, Jin YS (2013) Rational and evolutionary engineering approaches uncover a small set of genetic changes efficient for rapid xylose fermentation in Saccharomyces cerevisiae. Plos One 8:2
17. Fabrizio P, Longo VD (2003) The chronological life span of Saccharomyces cerevisiae. Aging Cell 2:73–81
18. Park SE, Koo HM, Park YK, Park SM, Park JC, Lee OK, Park YC, Seo JH (2011) Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae. Bioresour Technol 102:6033–6038
19. Gorsich SW, Dien BS, Nichols NN, Slininger PJ, Liu ZL, Skory CD (2006) Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 71:339–349
20. Almeida JRM, Roder A, Modig T, Laadan B, Liden G, Gorwa-Grauslund MF (2008) NADH- vs NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 78:939–945
21. Nogae I, Johnston M (1990) Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase. Gene 96:161–169
22. Verduyn C, Vankleef R, Frank J, Schreuder H, Vandijken JP, Scheffers WA (1985) Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis. Biochem J 226:669–677
23. Palmqvist E, Grage H, Meinander NQ, Hahn-Hagerdal B (1999) Main and interaction effects of acetic acid, furfural, and p-hydroxybenzoic acid on growth and ethanol productivity of yeasts. Biotechnol Bioeng 63:46–55
24. Aguilar R, Ramirez JA, Garrote G, Vazquez M (2002) Kinetic study of the acid hydrolysis of sugar cane bagasse. J Food Eng 55:309–318
25. Eliasson A, Christensson C, Wahlbom CF, Hahn-Hagerdal B (2000) Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures. Appl Environ Microbiol 66:3381–3386
26. Almeida JRM, Bertilsson M, Hahn-Hagerdal B, Liden G, Gorwa-Grauslund MF (2009) Carbon fluxes of xylose-consuming Saccharomyces cerevisiae strains are affected differently by NADH and NADPH usage in HMF reduction. Appl Microbiol Biotechnol 84:751–761