An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque

Anatolian Journal of Cardiology

Volumn 17, Issue 1, 2017, Pages 56-63

  Kocaman, Sinan Altan ^a   Baysan, Oben ^a   Çetin, Mustafa ^b   Altuner, Tuğba Kayhan ^a   Ocaklı, Ezgi Polat ^a   Durakoğlugil, Murtaza Emre ^b   Erdoğan, Turan ^b   Karaoğuz, Mustafa Remzi ^a  

^a GÜVEN HOSPITAL   (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

Atherosclerotic plaque; Carotid intima media thickness; Epicardial adipose tissue; LDL cholesterol; Subclinical atherosclerosis

Indexed keywords

LOW DENSITY LIPOPROTEIN; BIOLOGICAL MARKER; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOSE TISSUE; ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; TWO DIMENSIONAL ECHOCARDIOGRAPHY; BLOOD; CORONARY ARTERY DISEASE; ECHOCARDIOGRAPHY; MIDDLE AGED; PATHOPHYSIOLOGY; PERICARDIUM; RISK FACTOR;

ADIPOSE TISSUE; BIOMARKERS; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; PERICARDIUM; PLAQUE, ATHEROSCLEROTIC; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 85010661888     PISSN: 21492263     EISSN: 21492271     Source Type: Journal    
DOI: 10.14744/AnatolJCardiol.2016.6885     Document Type: Article

References (29)

1. Bauer M, Caviezel S, Teynor A, Erbel R, Mahabadi AA, Schmidt-Trucksass A. Carotid intima-media thickness as a biomarker of subclinical atherosclerosis. Swiss Med Wkly 2012; 142: w13705.
2. Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C. Carotid atherosclerosis measured by B-mode ultrasound in populations: Associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 1991; 134: 250-6.
3. Rosvall M, Persson M, Ostling G, Nilsson PM, Melander O, Hedblad B, et al. Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: The Malmo Diet and Cancer Study. Atherosclerosis 2015; 239: 615-21.
4. Fitzgibbons TP, Czech MP. Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations. J Am Heart Assoc 2014;3:e000582.
5. Iacobellis G, Bianco AC. Epicardial adipose tissue: Emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab 2011; 22: 450-7.
6. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009; 119: 1661-70.
7. Cheng VY, Dey D, Tamarappoo B, Nakazato R, Gransar H, Miranda-Peats R, et al. Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events. JACC Cardiovasc Imaging 2010; 3: 352-60.
8. Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, et al. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: The Framingham heart study. Eur Heart J 2009; 30: 850-6.
9. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
10. Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004; 17: 1086-119.
11. Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, et al. Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction. Obes Res 2003; 11: 304-10.
12. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: A new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003; 88: 5163-8.
13. th european stroke conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis 2012; 34: 290-6.
14. European Society of Hypertension-European society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011-53.
15. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34: 2159-219.
16. Weber LA, Cheezum MK, Reese JM, Lane AB, Haley RD, Lutz MW, et al. Cardiovascular imaging for the primary prevention of atherosclerotic cardiovascular disease events. Curr Cardiovasc Imaging Rep 2015; 8: 36.
17. Herder M, Johnsen SH, Arntzen KA, Mathiesen EB. Risk factors for progression of carotid intima-media thickness and total plaque area: A 13-year follow-up study: The Tromso study. Stroke 2012; 43: 1818-23.
18. Chambless LE, Folsom AR, Davis V, Sharrett R, Heiss G, Sorlie P, et al. Risk factors for progression of common carotid atherosclerosis: The atherosclerosis risk in communities study, 1987-1998. Am J Epidemiol 2002; 155: 38-47.
19. Cabrera-Rego JO, Iacobellis G, Castillo-Herrera JA, Valiente-Mustelier J, Gandarilla-Sarmientos JC, Marin-Julia SM, et al. Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents. Pediatr Cardiol 2014; 35: 450-6.
20. Nelson MR, Mookadam F, Thota V, Emani U, Al Harthi M, Lester SJ, et al. Epicardial fat: An additional measurement for subclinical atherosclerosis and cardiovascular risk stratification? J Am Soc Echocardiogr 2011; 24: 339-45.
21. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DT. Epicardial adipose tissue: Far more than a fat depot. Cardiovasc Diagn Ther 2014; 4: 416-29.
22. Wu FZ, Chou KJ, Huang YL, Wu MT. The relation of location-specific epicardial adipose tissue thickness and obstructive coronary artery disease: Systemic review and meta-analysis of observational studies. BMC Cardiovasc Disord 2014; 14: 62.
23. Katsiki N, Mikhailidis DP, Wierzbicki AS. Epicardial fat and vascular risk: A narrative review. Curr Opin Cardiol 2013; 28: 458-63.
24. Iacobellis G. Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol 2015; 11: 363-71.
25. Gaborit B, Abdesselam I, Dutour A. Epicardial fat: More than just an "epi" phenomenon? Horm Metab Res 2013; 45: 991-1001.
26. Boyraz M, Pirgon O, Akyol B, Dundar B, Çekmez F, Eren N. Importance of epicardial adipose tissue thickness measurement in obese adolescents, its relationship with carotid intima-media thickness, and echocardiographic findings. Eur Rev Med Pharmacol Sci 2013; 17: 3309-17.
27. Kocaman SA, Durakoğlugil ME, Cetin M, Erdoğan T, Ergül E, Canga A. The independent relationship of epicardial adipose tissue with carotid intima-media thickness and endothelial functions: The association of pulse wave velocity with the active facilitated arterial conduction concept. Blood Press Monit 2013; 18: 85-93.
28. Bertaso AG, Bertol D, Duncan BB, Foppa M. Epicardial fat: Definition, measurements and systematic review of main outcomes. Arq Bras Cardiol 2013; 101: e18-28.
29. Virnig BA, Shippee ND, O'Donnell B, Zeglin J, Parashuram S. Trends in the use of echocardiography, 2007 to 2011: Data points #20. Data points publication series. Rockville (MD); 2011.