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Volumn 114, Issue , 2016, Pages 89-100

Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes

(4) Pan, Xuan a Huan, Yi a Shen, Zhufang a Liu, Zhanzhu a

a INSTITUTE OF MATERIA MEDICA (China)

Author keywords

SGLT2 inhibitors; Tetrahydroisoquinoline; Tetrahydroisoquinoline C aryl glucosides; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DIABETES MELLITUS, TYPE 2; DOSE RESPONSE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETULUS; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSIDES; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR STRUCTURE; SODIUM-GLUCOSE TRANSPORTER 2; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 84964284445 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2016.02.053 Document Type: Article

Times cited : (22)

References (25)

1
- 84964307023
- S.H. Lee, M.J. Kim, S.H. Lee, J. Kim, H.J. Park, J. Lee, Eur. J. Med. Chem. 46 (2011) 2622-2675.
- (2011) Eur. J. Med. Chem. , vol.46 , pp. 2622-2675
- Lee, S.H.¹ Kim, M.J.² Lee, S.H.³ Kim, J.⁴ Park, H.J.⁵ Lee, J.⁶

2
- 77953139287
- B.H. Xu, Y. Feng, B.H. Lv, G. Xu, L.L. Zhang, J.Y. Du, K. Peng, M. Xu, J.J. Dong, W.B. Zhang, T. Zhang, L.C. Zhu, H.F. Ding, Z.L. Sheng, A. Welihinda, B. Seed, Y.W. Chen, Bioorg. Med. Chem. 18 (2010) 4422-4432.
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 4422-4432
- Xu, B.H.¹ Feng, Y.² Lv, B.H.³ Xu, G.⁴ Zhang, L.L.⁵ Du, J.Y.⁶ Peng, K.⁷ Xu, M.⁸ Dong, J.J.⁹ Zhang, W.B.¹⁰ Zhang, T.¹¹ Zhu, L.C.¹² Ding, H.F.¹³ Sheng, Z.L.¹⁴ Welihinda, A.¹⁵ Seed, B.¹⁶ Chen, Y.W.¹⁷

3
- 79951810378
- W.B. Zhang, A. Welihinda, J. Mechanic, H.F. Ding, L.C. Zhu, Y. Lu, Z.P. Deng, Z.L. Sheng, B.H. Lv, Y.W. Chen, J.Y. Roberge, B. Seed, Y.X. Wang, Pharmacol. Res. 63 (2011) 284-293.
- (2011) Pharmacol. Res. , vol.63 , pp. 284-293
- Zhang, W.B.¹ Welihinda, A.² Mechanic, J.³ Ding, H.F.⁴ Zhu, L.C.⁵ Lu, Y.⁶ Deng, Z.P.⁷ Sheng, Z.L.⁸ Lv, B.H.⁹ Chen, Y.W.¹⁰ Roberge, J.Y.¹¹ Seed, B.¹² Wang, Y.X.¹³

4
- 84862156420
- Y. Ohtake, T. Sato, H. Matsuoka, T. Kobayashi, M. Nishimoto, N. Taka, K. Takano, K. Yamamoto, M. Ohmori, T. Higuchi, M. Murakata, K. Morikawa, N. Shimma, M. Suzuki, H. Hagita, K. Ozawa, K. Yamaguchi, M. Kato, S. Ikeda, Bioorg. Med. Chem. 20 (2012) 4117-4127.
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 4117-4127
- Ohtake, Y.¹ Sato, T.² Matsuoka, H.³ Kobayashi, T.⁴ Nishimoto, M.⁵ Taka, N.⁶ Takano, K.⁷ Yamamoto, K.⁸ Ohmori, M.⁹ Higuchi, T.¹⁰ Murakata, M.¹¹ Morikawa, K.¹² Shimma, N.¹³ Suzuki, M.¹⁴ Hagita, H.¹⁵ Ozawa, K.¹⁶ Yamaguchi, K.¹⁷ Kato, M.¹⁸ Ikeda, S.¹⁹

5
- 34248191309
- F. Castaneda, A. Burse, W. Boland, R.K.-H. Kinne, Int. J. Med. Sci. 4 (2007) 131-139.
- (2007) Int. J. Med. Sci. , vol.4 , pp. 131-139
- Castaneda, F.¹ Burse, A.² Boland, W.³ Kinne, R.K.-H.⁴

6
- 4544233390
- J. Dudash Jr., X.Y. Zhang, R.E. Zeck, S.G. Johnson, G.G. Cox, B.R. Conway, P.J. Rybczynski, K.T. Demarest, Bioorg. Med. Chem. Lett. 14 (2004) 5121-5125.
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5121-5125
- Dudash, J.¹ Zhang, X.Y.² Zeck, R.E.³ Johnson, S.G.⁴ Cox, G.G.⁵ Conway, B.R.⁶ Rybczynski, P.J.⁷ Demarest, K.T.⁸

7
- 74049131929
- H. Morita, J. Deguchi, Y. Motegi, S. Sato, C. Aoyama, J. Takeo, M. Shiro, Y. Hirasawa, Bioorg. Med. Chem. Lett. 20 (2010) 1070-1074.
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1070-1074
- Morita, H.¹ Deguchi, J.² Motegi, Y.³ Sato, S.⁴ Aoyama, C.⁵ Takeo, J.⁶ Shiro, M.⁷ Hirasawa, Y.⁸

8
- 41649087328
- W. Meng, B.A. Ellsworth, A.A. Nirschl, P.J. McCann, M. Patel, R.N. Girotra, G. Wu, P.M. Sher, E.P. Morrison, S.A. Biller, R. Zahler, P.P. Despande, A. Pullockaran, D.L. Hagan, N. Morgan, J.R. Taylor, M.T. Obermeier, W.G. Humphreys, A. Khanna, L. Discenza, J.G. Robertson, A. Wang, S. Han, J.R. Wetterau, E.B. Janovitz, O.P. Flint, J.M. Whaley, W.N. Washburn, J. Med. Chem. 51 (2008) 1145-1149.
- (2008) J. Med. Chem. , vol.51 , pp. 1145-1149
- Meng, W.¹ Ellsworth, B.A.² Nirschl, A.A.³ McCann, P.J.⁴ Patel, M.⁵ Girotra, R.N.⁶ Wu, G.⁷ Sher, P.M.⁸ Morrison, E.P.⁹ Biller, S.A.¹⁰ Zahler, R.¹¹ Despande, P.P.¹² Pullockaran, A.¹³ Hagan, D.L.¹⁴ Morgan, N.¹⁵ Taylor, J.R.¹⁶ Obermeier, M.T.¹⁷ Humphreys, W.G.¹⁸ Khanna, A.¹⁹ Discenza, L.²⁰ more..

9
- 77956319973
- S. Nomura, S. Sakamaki, M. Hongu, E. Kawanishi, Y. Koga, T. Sakamoto, Y. Yamamoto, K. Ueta, H. Kimata, K. Nakayama, T.T. Minoru, J. Med. Chem. 53 (2010) 6355-6360.
- (2010) J. Med. Chem. , vol.53 , pp. 6355-6360
- Nomura, S.¹ Sakamaki, S.² Hongu, M.³ Kawanishi, E.⁴ Koga, Y.⁵ Sakamoto, T.⁶ Yamamoto, Y.⁷ Ueta, K.⁸ Kimata, H.⁹ Nakayama, K.¹⁰ Minoru, T.T.¹¹

10
- 77955672603
- H.Q. Zhou, D.P. Danger, S.T. Dock, L. Hawley, S.G. Roller, C.D. Smith, A.L. Handlon, ACS Med. Chem. Lett. 1 (2010) 19-23.
- (2010) ACS Med. Chem. Lett. , vol.1 , pp. 19-23
- Zhou, H.Q.¹ Danger, D.P.² Dock, S.T.³ Hawley, L.⁴ Roller, S.G.⁵ Smith, C.D.⁶ Handlon, A.L.⁷

11
- 76649110175
- R.P. Robinson, V. Mascitti, C.M. Boustany-Kari, C.L. Carr, P.M. Foley, E. Kimoto, M.T. Leininger, A. Lowe, M.K. Klenotic, J.I. Macdonald, R.J. Maguire, V.M. Masterson, T.S. Maurer, Z. Miao, J.D. Patel, C. Preville, M.R. Reese, L. She, C.M. Steppan, B.A. Thuma, T. Zhu, Bioorg. Med. Chem. Lett. 20 (2010) 1569-1572.
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1569-1572
- Robinson, R.P.¹ Mascitti, V.² Boustany-Kari, C.M.³ Carr, C.L.⁴ Foley, P.M.⁵ Kimoto, E.⁶ Leininger, M.T.⁷ Lowe, A.⁸ Klenotic, M.K.⁹ Macdonald, J.I.¹⁰ Maguire, R.J.¹¹ Masterson, V.M.¹² Maurer, T.S.¹³ Miao, Z.¹⁴ Patel, J.D.¹⁵ Preville, C.¹⁶ Reese, M.R.¹⁷ She, L.¹⁸ Steppan, C.M.¹⁹ Thuma, B.A.²⁰ Zhu, T.²¹ more..

12
- 79955380414
- D.J. Leaver, A.B. Hughes, A. Polyzos, J.M. White, J. Carbohydr. Chem. 29 (2010) 379-385.
- (2010) J. Carbohydr. Chem. , vol.29 , pp. 379-385
- Leaver, D.J.¹ Hughes, A.B.² Polyzos, A.³ White, J.M.⁴

13
- 84860492610
- M. Imamura, K. Nakanishi, T. Suzuki, K. Ikegal, R. Shiraki, T. Ogiyama, T. Murakami, E. Kurosaki, A. Noda, Y. Kobayashi, M. Yokota, T. Koide, K. Kosakai, Y. Ohkura, M. Takeuchi, H. Tomiyama, M. Ohta, Bioorg. Med. Chem. 20 (2012) 3263-3279.
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 3263-3279
- Imamura, M.¹ Nakanishi, K.² Suzuki, T.³ Ikegal, K.⁴ Shiraki, R.⁵ Ogiyama, T.⁶ Murakami, T.⁷ Kurosaki, E.⁸ Noda, A.⁹ Kobayashi, Y.¹⁰ Yokota, M.¹¹ Koide, T.¹² Kosakai, K.¹³ Ohkura, Y.¹⁴ Takeuchi, M.¹⁵ Tomiyama, H.¹⁶ Ohta, M.¹⁷

14
- 84964196379
- E. Matthias, E. Peter, H. Frank, S. Achim, T. Leo, WO2007093610 (A1), 2007-08-23
- E. Matthias, E. Peter, H. Frank, S. Achim, T. Leo, WO2007093610 (A1), 2007-08-23.

15
- 77951143723
- H. Kakinuma, T. Oi, Y.H. Tsuchiya, M. Arai, Y. Kawakita, Y. Fukasawa, I. Iida, N. Hagima, H. Takeuchi, Y. Chino, J. Asami, L.O. Kitajima, F. Io, D. Yamamoto, N. Miyata, T. Takahashi, S. Uchida, K. Yamamoto, J. Med. Chem. 53 (2010) 3247-3261.
- (2010) J. Med. Chem. , vol.53 , pp. 3247-3261
- Kakinuma, H.¹ Oi, T.² Tsuchiya, Y.H.³ Arai, M.⁴ Kawakita, Y.⁵ Fukasawa, Y.⁶ Iida, I.⁷ Hagima, N.⁸ Takeuchi, H.⁹ Chino, Y.¹⁰ Asami, J.¹¹ Kitajima, L.O.¹² Io, F.¹³ Yamamoto, D.¹⁴ Miyata, N.¹⁵ Takahashi, T.¹⁶ Uchida, S.¹⁷ Yamamoto, K.¹⁸

16
- 69949089767
- B.H. Xu, B.H. Lv, Y. Feng, G. Xu, J.Y. Du, A. Welihinda, Z. Sheng, B. Seed, Y.W. Chen, Bioorg. Med. Chem. 19 (2009) 5632-5635.
- (2009) Bioorg. Med. Chem. , vol.19 , pp. 5632-5635
- Xu, B.H.¹ Lv, B.H.² Feng, Y.³ Xu, G.⁴ Du, J.Y.⁵ Welihinda, A.⁶ Sheng, Z.⁷ Seed, B.⁸ Chen, Y.W.⁹

17
- 84964241748
- T. Christos, B. Norbert, US2011028414 (A1), 2011-02-03
- T. Christos, B. Norbert, US2011028414 (A1), 2011-02-03.

18
- 84964215151
- B. G. Raymond, B. S. Bhausaheb, B. Debnath, H. A. Kashinath, M. Tanaji, M. Parthap, P. Pvenkata, R. D. Srinivas, WO2010128152 (A1), 2010-11-11
- B. G. Raymond, B. S. Bhausaheb, B. Debnath, H. A. Kashinath, M. Tanaji, M. Parthap, P. Pvenkata, R. D. Srinivas, WO2010128152 (A1), 2010-11-11.

19
- 77957840828
- M.A. Fernandez-Herrera, S. Mohan, H. Lopez-Munoz, J.M.V. Hernandez-Vazquez, E. Perez-Cervantes, M.L. Escobar-Sanchez, L. Sanchez-Sanchez, I. Regla, B.M. Pinto, J. Sandoval-Ramirez, Eur. J. Med. Chem. 45 (2010) 4827-4837.
- (2010) Eur. J. Med. Chem. , vol.45 , pp. 4827-4837
- Fernandez-Herrera, M.A.¹ Mohan, S.² Lopez-Munoz, H.³ Hernandez-Vazquez, J.M.V.⁴ Perez-Cervantes, E.⁵ Escobar-Sanchez, M.L.⁶ Sanchez-Sanchez, L.⁷ Regla, I.⁸ Pinto, B.M.⁹ Sandoval-Ramirez, J.¹⁰

20
- 35548955986
- F. Zhang, A. Vasella, Carbohydr. Res. 342 (2007) 2546-2556.
- (2007) Carbohydr. Res. , vol.342 , pp. 2546-2556
- Zhang, F.¹ Vasella, A.²

21
- 49849094737
- B.A. Ellsworth, W. Meng, M. Patel, R.N. Girota, G. Wu, P.M. Sher, D.L. Hagan, M.T. Obermeier, W.G. Humphreys, J.G. Robertson, A. Wang, S. Han, T.L. Waldron, N.N. Morgan, J.M. Whaley, W.N. Washburn, Bioorg. Med. Chem. Lett. 18 (2008) 4770-4773.
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4770-4773
- Ellsworth, B.A.¹ Meng, W.² Patel, M.³ Girota, R.N.⁴ Wu, G.⁵ Sher, P.M.⁶ Hagan, D.L.⁷ Obermeier, M.T.⁸ Humphreys, W.G.⁹ Robertson, J.G.¹⁰ Wang, A.¹¹ Han, S.¹² Waldron, T.L.¹³ Morgan, N.N.¹⁴ Whaley, J.M.¹⁵ Washburn, W.N.¹⁶

22
- 84964220757
- C. Romualdo, C. Giuseppe, G. Annalisa, P. Giovanni, P. Silvana, Eur. J. Org. Chem. 17 (2001) 3050-3054.
- (2001) Eur. J. Org. Chem. , vol.17 , pp. 3050-3054
- Romualdo, C.¹ Giuseppe, C.² Annalisa, G.³ Giovanni, P.⁴ Silvana, P.⁵

23
- 54049092884
- M. Movassaghi, M.D. Hill, Org. Lett. 10 (2008) 3485-3488.
- (2008) Org. Lett. , vol.10 , pp. 3485-3488
- Movassaghi, M.¹ Hill, M.D.²

24
- 0029933891
- N. Uematsu, A. Fujii, S. Hashiguchi, T. Ikariya, R. Noyori, J. Am. Chem. Soc. 118 (1996) 4916-4917.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 4916-4917
- Uematsu, N.¹ Fujii, A.² Hashiguchi, S.³ Ikariya, T.⁴ Noyori, R.⁵

25
- 0004104385
- Thieme, France
- K.B. Henri, Stereochemistry: Fundamentals and Methods, Thieme, France, 1977, pp. 60-63.
- (1977) Stereochemistry: Fundamentals and Methods , pp. 60-63
- Henri, K.B.¹

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