메뉴 건너뛰기




Volumn 5, Issue 6, 2014, Pages 242-254

Dapagliflozin efficacy and safety: A perspective review

Author keywords

dapagliflozin; hypoglycemic agents; sodium glucose transporter 2; type 2 diabetes mellitus

Indexed keywords

DAPAGLIFLOZIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR;

EID: 84911020493     PISSN: 20420986     EISSN: 20420994     Source Type: Journal    
DOI: 10.1177/2042098614551938     Document Type: Review
Times cited : (46)

References (41)
  • 1
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes–2014
    • (Suppl. 1)
    • American Diabetes Association (2014) Standards of medical care in diabetes–2014. Diabetes Care 37(Suppl. 1): S14–S80.
    • (2014) Diabetes Care , vol.37 , pp. S14-S80
  • 2
    • 84993714443 scopus 로고    scopus 로고
    • FORXIGA™ (dapagliflozin) now approved in European Union for treatment of type 2 diabetes
    • Available at:, accessed 8 July 2014
    • AstraZeneca (2012) FORXIGA™ (dapagliflozin) now approved in European Union for treatment of type 2 diabetes. Available at: http://www.astrazeneca.com/Media/Press-releases/Article/20121114–forxiga-eu-approval-type-2-diabetes (accessed 8 July 2014).
    • (2012)
  • 3
    • 84993734051 scopus 로고    scopus 로고
    • Xigduo™ (dapagliflozin and metformin hydrochloride) approved in the European Union for type 2 diabetes
    • Available at:, accessed 8 July 2014
    • AstraZeneca (2014a) Xigduo™ (dapagliflozin and metformin hydrochloride) approved in the European Union for type 2 diabetes. Available at: http://www.astrazeneca.com/Media/Press-releases/Article/20142101–xigduo-dapagliflozin-and-metformin-hydrochloride (accessed 8 July 2014).
    • (2014)
  • 4
    • 84993761577 scopus 로고    scopus 로고
    • U.S. FDA approves FarxigaTM (dapagliflozin) tablets for the treatment of adult patients with type 2 diabetes
    • Available at:, accessed 8 July 2014
    • AstraZeneca (2014b) U.S. FDA approves FarxigaTM (dapagliflozin) tablets for the treatment of adult patients with type 2 diabetes. Available at: http://www.astrazeneca-us.com/media/press-releases/Article/20140113-us-fda-approves-farxiga-tablets (accessed 8 July 2014).
    • (2014)
  • 5
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
    • Bailey C. Gross J. Pieters A. Bastien A. List J. (2010) Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 375: 2223–2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.1    Gross, J.2    Pieters, A.3    Bastien, A.4    List, J.5
  • 6
    • 84861095547 scopus 로고    scopus 로고
    • Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy
    • (Suppl. 1)
    • Bailey C. Gross J. Yadav M. Iqbal N. Mansfield T. List J. (2011) Sustained efficacy of dapagliflozin when added to metformin in type 2 diabetes inadequately controlled by metformin monotherapy. Diabetalogia 54(Suppl. 1): A146.
    • (2011) Diabetalogia , vol.54 , pp. A146
    • Bailey, C.1    Gross, J.2    Yadav, M.3    Iqbal, N.4    Mansfield, T.5    List, J.6
  • 7
    • 84866003015 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in drug-naïve patients with diabetes: a randomized-controlled trial of low-dose range
    • Bailey C. Iqbal N. T–joen C. List J. (2012) Dapagliflozin monotherapy in drug-naïve patients with diabetes: a randomized-controlled trial of low-dose range. Diabetes Obes Metab 14: 951–959.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 951-959
    • Bailey, C.1    Iqbal, N.2    T–joen, C.3    List, J.4
  • 8
    • 84921762258 scopus 로고    scopus 로고
    • Farxiga [package insert]
    • Princeton, NJ: Bristol-Myers Squibb Company.
    • Bristol-Myers Squibb Company (2014) Farxiga [package insert]. Princeton, NJ: Bristol-Myers Squibb Company.
    • (2014)
  • 9
    • 79959936188 scopus 로고    scopus 로고
    • National, regional and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
    • Danaei G. Finucane M. Lu Y. Singh G. Cowan M. Paciorek C. (2011) National, regional and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378: 31–40.
    • (2011) Lancet , vol.378 , pp. 31-40
    • Danaei, G.1    Finucane, M.2    Lu, Y.3    Singh, G.4    Cowan, M.5    Paciorek, C.6
  • 10
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    • Defronzo R. Hompesch M. Kasichayanula S. (2013) Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care 36: 3169–3176.
    • (2013) Diabetes Care , vol.36 , pp. 3169-3176
    • Defronzo, R.1    Hompesch, M.2    Kasichayanula, S.3
  • 11
    • 84871165283 scopus 로고    scopus 로고
    • Long-term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2-year results
    • (Suppl. 1)
    • Del Prato S. Nauck M. Rohwedder K. Thuerkauf A. Langkilde A. Parikh S. (2011) Long-term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with type 2 diabetes mellitus inadequately controlled with metformin: 2-year results. Diabetalogia 54(Suppl. 1): A852.
    • (2011) Diabetalogia , vol.54 , pp. A852
    • Del Prato, S.1    Nauck, M.2    Rohwedder, K.3    Thuerkauf, A.4    Langkilde, A.5    Parikh, S.6
  • 12
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise
    • Ferrannini E. Ramos S. Salsali A. Tang W. List J. (2010) Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise. Diabetes Care 33: 2217–2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.2    Salsali, A.3    Tang, W.4    List, J.5
  • 13
    • 79958731052 scopus 로고    scopus 로고
    • Pitfalls in outpatient diabetes management and inpatient glycemic control
    • Fowler M. (2011) Pitfalls in outpatient diabetes management and inpatient glycemic control. Clinical Diabetes 29: 79–85.
    • (2011) Clinical Diabetes , vol.29 , pp. 79-85
    • Fowler, M.1
  • 14
    • 38349070535 scopus 로고    scopus 로고
    • Urinary tract infections in patients with diabetes mellitus: epidemiology, pathogenesis and treatment
    • (Suppl. 1)
    • Geerlings S. (2008) Urinary tract infections in patients with diabetes mellitus: epidemiology, pathogenesis and treatment. Int J Antimicrob Agents 31(Suppl. 1): S54–S57.
    • (2008) Int J Antimicrob Agents , vol.31 , pp. S54-S57
    • Geerlings, S.1
  • 15
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry R. Murray A. Marmolejo M. Hennicken D. Ptaszynska A. List J. (2012) Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract 66: 446–456.
    • (2012) Int J Clin Pract , vol.66 , pp. 446-456
    • Henry, R.1    Murray, A.2    Marmolejo, M.3    Hennicken, D.4    Ptaszynska, A.5    List, J.6
  • 16
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi S. Bergenstal R. Buse J. Diamant M. Ferrannini E. Nauck M. (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 55: 1577–1596.
    • (2012) Diabetologia , vol.55 , pp. 1577-1596
    • Inzucchi, S.1    Bergenstal, R.2    Buse, J.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 17
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week multicenter, randomized, double-blind placebo-controlled study
    • Jabbour S. Hardy E. Sugg J. Parikh S., Study 10 Group (2014) Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week multicenter, randomized, double-blind placebo-controlled study. Diabetes Care 37: 740–750.
    • (2014) Diabetes Care , vol.37 , pp. 740-750
    • Jabbour, S.1    Hardy, E.2    Sugg, J.3    Parikh, S.4
  • 20
    • 84876335563 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial
    • Kaku K. Inoue S. Matsuoka O. Kiyosue A. Azuma H. Hayashi N. (2013) Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab 15: 432–440.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 432-440
    • Kaku, K.1    Inoue, S.2    Matsuoka, O.3    Kiyosue, A.4    Azuma, H.5    Hayashi, N.6
  • 21
    • 79951897566 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus
    • Kasichayanula S. Chang M. Hasegawa M. Liu X. Yamahira N. LaCreta F. (2011a) Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus. Diabetes Obes Metab 13: 357–365.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 357-365
    • Kasichayanula, S.1    Chang, M.2    Hasegawa, M.3    Liu, X.4    Yamahira, N.5    LaCreta, F.6
  • 22
    • 84882591638 scopus 로고    scopus 로고
    • The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus
    • Kasichayanula S. Liu X. Pe Benito M. Yao M. Pfister M. LaCreta F. (2013) The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus. Br J Clin Pharmacol 76: 432–444.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 432-444
    • Kasichayanula, S.1    Liu, X.2    Pe Benito, M.3    Yao, M.4    Pfister, M.5    LaCreta, F.6
  • 23
    • 78649715079 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects
    • Kasichayanula S. Liu X. Shyu W. (2011b) Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects. Diabetes Obes Metab 13: 47–54.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 47-54
    • Kasichayanula, S.1    Liu, X.2    Shyu, W.3
  • 24
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan D. Fioretto P. Tan W. List J. (2014) Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 85: 962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.1    Fioretto, P.2    Tan, W.3    List, J.4
  • 26
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List J. Woo V. Morales E. Tang W. Fiedorek F. (2009) Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 32: 650–657.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.5
  • 27
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • Mathers C. Loncar D. (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3: e442.
    • (2006) PLoS Med , vol.3 , pp. e442
    • Mathers, C.1    Loncar, D.2
  • 28
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin
    • Nauck M. Del Prato S. Meier J. Duran-Garcia S. Rohwedder K. Elze M. (2011) Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin. Diabetes Care 34: 2015–2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.1    Del Prato, S.2    Meier, J.3    Duran-Garcia, S.4    Rohwedder, K.5    Elze, M.6
  • 29
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J. Vico M. Wei L. Salsali A. List J. (2012) Effects of dapagliflozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care 35: 1473–1478.
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.5
  • 30
    • 84882254968 scopus 로고    scopus 로고
    • The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988–2010
    • Stark Casagrande S. Fradkin J. Saydah S. Rust K. Cowie C. (2013) The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988–2010. Diabetes Care 36: 2271–2279.
    • (2013) Diabetes Care , vol.36 , pp. 2271-2279
    • Stark Casagrande, S.1    Fradkin, J.2    Saydah, S.3    Rust, K.4    Cowie, C.5
  • 31
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K. Yoon K. Hruba V. Elze M. Langkilde A. Parikh S. (2011) Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab 13: 928–938.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.2    Hruba, V.3    Elze, M.4    Langkilde, A.5    Parikh, S.6
  • 32
    • 0028963260 scopus 로고
    • Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years
    • UK Prospective Diabetes Study (1995) Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 310: 83–88.
    • (1995) BMJ , vol.310 , pp. 83-88
  • 33
    • 0028817815 scopus 로고
    • Overview of 6 years– therapy of type II diabetes: a progressive disease. UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (1995) Overview of 6 years– therapy of type II diabetes: a progressive disease. UK Prospective Diabetes Study (UKPDS) Group. Diabetes 44: 1249–1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 34
    • 0036937335 scopus 로고    scopus 로고
    • Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    • van den Heuvel L. Assink K. Willemsen M. Monnens L. (2002) Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). Hum Genet 111: 544–547.
    • (2002) Hum Genet , vol.111 , pp. 544-547
    • van den Heuvel, L.1    Assink, K.2    Willemsen, M.3    Monnens, L.4
  • 35
    • 84993755982 scopus 로고    scopus 로고
    • Effects of dapagliflozin on blood pressure in diabetic patients with hypertension inadequately controlled by a renin–angiotensin system blocker
    • Presented at the Annual Meeting of the American Heart Association (AHA);, 16–20 November 2013,;, Dallas, TX. Poster 2095
    • Weber M. Mansfield T. Alessi F. Ptaszynska A. (2013a) Effects of dapagliflozin on blood pressure in diabetic patients with hypertension inadequately controlled by a renin–angiotensin system blocker. Presented at the Annual Meeting of the American Heart Association (AHA); 16–20 November 2013; Dallas, TX. Poster 2095.
    • (2013)
    • Weber, M.1    Mansfield, T.2    Alessi, F.3    Ptaszynska, A.4
  • 36
    • 84993699265 scopus 로고    scopus 로고
    • Dapagliflozin for reduction of blood pressure in diabetic patients inadequately controlled with combination antihypertensive regimen
    • Presented at the Annual Meeting of the American Heart Association (AHA);, 16–20 November 2013,;, Dallas, TX. Poster 2097
    • Weber M. Mansfield T. T–joen C. (2013b) Dapagliflozin for reduction of blood pressure in diabetic patients inadequately controlled with combination antihypertensive regimen. Presented at the Annual Meeting of the American Heart Association (AHA); 16–20 November 2013; Dallas, TX. Poster 2097.
    • (2013)
    • Weber, M.1    Mansfield, T.2    T–joen, C.3
  • 37
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers
    • Wilding J. Norwood P. T–joen C. Bastien A. List J. Fiedorek F. (2009) A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Diabetes Care 32: 1656–1662.
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Wilding, J.1    Norwood, P.2    T–joen, C.3    Bastien, A.4    List, J.5    Fiedorek, F.6
  • 38
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years
    • Wilding J. Woo V. Rohwedder K. Sugg J. Parikh S. for the Dapagliflozin 006 Study Group (2014) Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab 16: 124–136.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 124-136
    • Wilding, J.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 39
    • 0034997336 scopus 로고    scopus 로고
    • Renal Na+-glucose cotransporters
    • Wright E. (2001) Renal Na+-glucose cotransporters. Am J Physiol Renal Physiol 280: F10–F18.
    • (2001) Am J Physiol Renal Physiol , vol.280 , pp. F10-F18
    • Wright, E.1
  • 40
    • 1242272759 scopus 로고    scopus 로고
    • The sodium/glucose cotransport family SLC5
    • Wright E. Turk E. (2004) The sodium/glucose cotransport family SLC5. Eur J Physiol 447: 510–518.
    • (2004) Eur J Physiol , vol.447 , pp. 510-518
    • Wright, E.1    Turk, E.2
  • 41
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight
    • Zhang L. Feng Y. List J. Kasichayanula S. Pfister M. (2010) Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab 12: 510–516.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.