A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Bianchi, Laura ^a   Díez Sampedro, Ana ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; GLUTAMIC ACID; GLUTAMINE; SODIUM GLUCOSE COTRANSPORTER; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 3; UNCLASSIFIED DRUG; MUTANT PROTEIN; SLC5A1 PROTEIN, HUMAN; SLC5A4 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CARBOHYDRATE TRANSPORT; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSORY NERVE CELL; STOICHIOMETRY; ANIMAL; ENZYME SPECIFICITY; GENETICS; HUMAN; MISSENSE MUTATION; PHYSIOLOGY; SENSORY RECEPTOR; TRANSGENIC ANIMAL;

ANIMALIA; CAENORHABDITIS ELEGANS; VIBRIO;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; HUMANS; MONOSACCHARIDE TRANSPORT PROTEINS; MUTANT PROTEINS; MUTATION, MISSENSE; SENSORY RECEPTOR CELLS; SODIUM-GLUCOSE TRANSPORT PROTEINS; SODIUM-GLUCOSE TRANSPORTER 1; SUBSTRATE SPECIFICITY;

EID: 77956316182     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010241     Document Type: Article

References (32)

1. Mackenzie B, Loo DD, Wright EM (1998) Relationships between Na+/glucose cotransporter (SGLT1) currents and fluxes. J Membr Biol 162(2): 101-106.
2. Wright EM, Turk E, Martin MG (2002) Molecular basis for glucose-galactose malabsorption. Cell Biochem Biophys 36(2-3): 115-121.
3. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, et al. (2003) A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 100(20): 11753-11758.
4. Voss AA, Diez-Sampedro A, Hirayama BA, Loo DD, Wright EM (2007) Imino sugars are potent agonists of the human glucose sensor SGLT3. Mol Pharmacol 71(2): 628-634.
5. Freeman SL, Bohan D, Darcel N, Raybould HE (2006) Luminal glucose sensing in the rat intestine has characteristics of a sodium-glucose cotransporter. Am J Physiol Gastrointest Liver Physiol 291(3): G439-45.
6. O'Malley D, Reimann F, Simpson AK, Gribble FM (2006) Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes 55(12): 3381-3386.
7. Lam JT, Martin MG, Turk E, Hirayama BA, Bosshard NU, et al. (1999) Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. Biochim Biophys Acta 1453(2): 297-303.
8. Diez-Sampedro A, Wright EM, Hirayama BA (2001) Residue 457 controls sugar binding and transport in the Na(+)/glucose cotransporter. J Biol Chem 276(52): 49188-49194.
9. Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, et al. (2008) The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science 321(5890): 810-814.
10. Parent L, Supplisson S, Loo DD, Wright EM (1992) Electrogenic properties of the cloned Na+/glucose cotransporter: I. voltage-clamp studies. J Membr Biol 125(1): 49-62.
11. Birnir B, Loo DD, Wright EM (1991) Voltage-clamp studies of the Na+/glucose cotransporter cloned from rabbit small intestine. Pflugers Arch 418(1-2): 79-85.
12. Hirayama BA, Diez-Sampedro A, Wright EM (2001) Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl2/GABA (hGAT1) cotransporters. Br J Pharmacol 134(3): 484-495.
13. Bargmann CI, Horvitz HR (1991) Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7(5): 729-742.
14. Sambongi Y, Takeda K, Wakabayashi T, Ueda I, Wada Y, et al. (2000) Caenorhabditis elegans senses protons through amphid chemosensory neurons: Proton signals elicit avoidance behavior. Neuroreport 11(10): 2229-2232.
15. Wang Y, Apicella A, Jr., Lee SK, Ezcurra M, Slone RD, et al. (2008) A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. EMBO J 27(18): 2388-2399.
16. Troemel ER, Chou JH, Dwyer ND, Colbert HA, Bargmann CI (1995) Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell 83(2): 207-218.
17. Accardi A, Miller C (2004) Secondary active transport mediated by a prokaryotic homologue of ClC cl- channels. Nature 427(6977): 803-807.
18. Graves AR, Curran PK, Smith CL, Mindell JA (2008) The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes. Nature 453(7196): 788-792.
19. Picollo A, Pusch M (2005) Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436(7049): 420-423.
20. Scheel O, Zdebik AA, Lourdel S, Jentsch TJ (2005) Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436(7049): 424-427.
21. Wadiche JI, Amara SG, Kavanaugh MP (1995) Ion fluxes associated with excitatory amino acid transport. Neuron 15(3): 721-728.
22. Ashcroft F, Gadsby D, Miller C (2009) Introduction. The blurred boundary between channels and transporters. Philos Trans R Soc Lond B Biol Sci 364(1514): 145-147.
23. Lisal J, Maduke M (2009) Review. proton-coupled gating in chloride channels. Philos Trans R Soc Lond B Biol Sci 364(1514): 181-187.
24. Dean PM, Matthews EK (1968) Electrical activity in pancreatic islet cells. Nature 219(5152): 389-390.
25. Hevener AL, Bergman RN, Donovan CM (1997) Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes 46(9): 1521-1525.
26. Levin BE, Routh VH, Kang L, Sanders NM, Dunn-Meynell AA (2004) Neuronal glucosensing: What do we know after 50 years? Diabetes 53(10): 2521-2528.
27. Oomura Y, Kimura K, Ooyama H, Maeno T, Iki M, et al. (1964) Reciprocal activities of the ventromedial and lateral hypothalamic areas of cats. Science 143: 484-485.
28. Pardal R, Lopez-Barneo J (2002) Low glucose-sensing cells in the carotid body. Nat Neurosci 5(3): 197-198.
29. Ikeda TS, Hwang ES, Coady MJ, Hirayama BA, Hediger MA, et al. (1989) Characterization of a Na+/glucose cotransporter cloned from rabbit small intestine. J Membr Biol 110(1): 87-95.
30. Diez-Sampedro A, Eskandari S, Wright EM, Hirayama BA (2001) Na+-to-sugar stoichiometry of SGLT3. Am J Physiol Renal Physiol 280(2): F278-82.
31. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77(1): 71-94.
32. Chalfie M, Sulston J (1981) Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol 82(2): 358-370.