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Volumn 6, Issue 7, 2016, Pages

Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BORTEZOMIB; CYSTEINE; GLUTATHIONE; PROTEASOME; TRANSCRIPTION FACTOR NRF2;

EID: 85010514097     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/BCJ.2016.56     Document Type: Article
Times cited : (49)

References (32)
  • 4
    • 0345447210 scopus 로고    scopus 로고
    • Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy
    • Kane RC, Bross PF, Farrell AT, Pazdur R. Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy. Oncologist 2003; 8: 508–513.
    • (2003) Oncologist , vol.8 , pp. 508-513
    • Kane, R.C.1    Bross, P.F.2    Farrell, A.T.3    Pazdur, R.4
  • 5
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001; 61: 3071–3076.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6
  • 7
    • 33847714599 scopus 로고    scopus 로고
    • Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
    • Meister S, Schubert U, Neubert K, Herrmann K, Burger R, Gramatzki M et al. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res 2007; 67: 1783–1792.
    • (2007) Cancer Res , vol.67 , pp. 1783-1792
    • Meister, S.1    Schubert, U.2    Neubert, K.3    Herrmann, K.4    Burger, R.5    Gramatzki, M.6
  • 9
    • 79954599366 scopus 로고    scopus 로고
    • S-glutathionylation: From molecular mechanisms to health outcomes
    • Xiong Y, Uys JD, Tew KD, Townsend DM. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal 2011; 15: 233–270.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 233-270
    • Xiong, Y.1    Uys, J.D.2    Tew, K.D.3    Townsend, D.M.4
  • 10
    • 84922783167 scopus 로고    scopus 로고
    • Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
    • Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 2015; 27: 1–12.
    • (2015) Cancer Cell , vol.27 , pp. 1-12
    • Harris, I.S.1    Treloar, A.E.2    Inoue, S.3    Sasaki, M.4    Gorrini, C.5    Lee, K.C.6
  • 11
    • 84875744148 scopus 로고    scopus 로고
    • Glutathione synthesis
    • Lu SC. Glutathione synthesis. Biochim Biophys Acta 2013; 1830: 3143–3153.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3143-3153
    • Lu, S.C.1
  • 12
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011; 19: 387–400.
    • (2011) Cancer Cell , vol.19 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3    Tamada, M.4    Motohara, T.5    Oshima, H.6
  • 13
    • 59149104276 scopus 로고    scopus 로고
    • Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway
    • Chen R-S, Song Y-M, Zhou Z-Y, Tong T, Li Y, Fu M et al. Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Oncogene 2009; 28: 599–609.
    • (2009) Oncogene , vol.28 , pp. 599-609
    • Chen, R.-S.1    Song, Y.-M.2    Zhou, Z.-Y.3    Tong, T.4    Li, Y.5    Fu, M.6
  • 14
    • 42949126711 scopus 로고    scopus 로고
    • The x(c)-cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases
    • Lo M, Wang Y-Z, Gout PW. The x(c)-cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases. J Cell Physiol 2008; 215: 593–602.
    • (2008) J Cell Physiol , vol.215 , pp. 593-602
    • Lo, M.1    Wang, Y.-Z.2    Gout, P.W.3
  • 15
    • 84872800192 scopus 로고    scopus 로고
    • Cystine/ glutamic acid transporter is a novel marker for predicting poor survival in patients with hepatocellular carcinoma
    • Kinoshita H, Okabe H, Beppu T, Chikamoto A, Hayashi H, Imai K et al. Cystine/ glutamic acid transporter is a novel marker for predicting poor survival in patients with hepatocellular carcinoma. Oncol Rep 2013; 29: 685–689.
    • (2013) Oncol Rep , vol.29 , pp. 685-689
    • Kinoshita, H.1    Okabe, H.2    Beppu, T.3    Chikamoto, A.4    Hayashi, H.5    Imai, K.6
  • 16
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
    • Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011; 16: 123–140.
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 17
    • 84908460595 scopus 로고    scopus 로고
    • Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
    • Hoadley Ka, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 2014; 158: 929–944.
    • (2014) Cell , vol.158 , pp. 929-944
    • Hoadley Ka, Y.C.1    Wolf, D.M.2    Cherniack, A.D.3    Tamborero, D.4    Ng, S.5
  • 18
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011; 475: 106–109.
    • (2011) Nature , vol.475 , pp. 106-109
    • Denicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3    Gopinathan, A.4    Wei, C.5    Frese, K.6
  • 19
    • 0037160092 scopus 로고    scopus 로고
    • Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
    • Sasaki H, Sato H, Kuriyama-Matsumura K, Sato K, Maebara K, Wang H et al. Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem 2002; 277: 44765–44771.
    • (2002) J Biol Chem , vol.277 , pp. 44765-44771
    • Sasaki, H.1    Sato, H.2    Kuriyama-Matsumura, K.3    Sato, K.4    Maebara, K.5    Wang, H.6
  • 20
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171: 603–614.
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5
  • 21
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun J-A, Outzen H et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282: 24131–24145.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.-A.5    Outzen, H.6
  • 22
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010; 12: 213–223.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5    Ichimura, Y.6
  • 23
    • 84883830467 scopus 로고    scopus 로고
    • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
    • Ichimura Y, Waguri S, Sou Y-S, Kageyama S, Hasegawa J, Ishimura R et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 2013; 51: 618–631.
    • (2013) Mol Cell , vol.51 , pp. 618-631
    • Ichimura, Y.1    Waguri, S.2    Sou, Y.-S.3    Kageyama, S.4    Hasegawa, J.5    Ishimura, R.6
  • 24
    • 77953366801 scopus 로고    scopus 로고
    • A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
    • Lau A, Wang X-J, Zhao F, Villeneuve NF, Wu T, Jiang T et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 2010; 30: 3275–3285.
    • (2010) Mol Cell Biol , vol.30 , pp. 3275-3285
    • Lau, A.1    Wang, X.-J.2    Zhao, F.3    Villeneuve, N.F.4    Wu, T.5    Jiang, T.6
  • 25
    • 0035068530 scopus 로고    scopus 로고
    • Gp130 and ras mediated signaling in human plasma cell line INA-6: A cytokine-regulated tumor model for plasmacytoma
    • Burger R, Guenther A, Bakker F, Schmalzing M, Bernand S, Baum W et al. Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. Hematol J 2001; 2: 42–53.
    • (2001) Hematol J , vol.2 , pp. 42-53
    • Burger, R.1    Guenther, A.2    Bakker, F.3    Schmalzing, M.4    Bernand, S.5    Baum, W.6
  • 26
    • 0035863916 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells
    • Hjertner O. Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. Blood 2001; 97: 516–522.
    • (2001) Blood , vol.97 , pp. 516-522
    • Hjertner, O.1
  • 27
    • 70349177837 scopus 로고    scopus 로고
    • OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus
    • Våtsveen TK, Tian E, Kresse SH, Meza-Zepeda LA, Gabrea A, Glebov O et al. OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. Leuk Res 2009; 33: 1670–1677.
    • (2009) Leuk Res , vol.33 , pp. 1670-1677
    • Våtsveen, T.K.1    Tian, E.2    Kresse, S.H.3    Meza-Zepeda, L.A.4    Gabrea, A.5    Glebov, O.6
  • 28
    • 84879474695 scopus 로고    scopus 로고
    • A method for measurement of drug sensitivity of myeloma cells co-cultured with bone marrow stromal cells
    • Misund K, Baranowska KA, Holien T, Rampa C, Klein DCG, Borset M et al. A method for measurement of drug sensitivity of myeloma cells co-cultured with bone marrow stromal cells. J Biomol Screen 2013; 18: 637–646.
    • (2013) J Biomol Screen , vol.18 , pp. 637-646
    • Misund, K.1    Baranowska, K.A.2    Holien, T.3    Rampa, C.4    Klein, D.C.G.5    Borset, M.6
  • 29
    • 84868148725 scopus 로고    scopus 로고
    • Failure of amino acid homeostasis causes cell death following proteasome inhibition
    • Suraweera A, Münch C, Hanssum A, Bertolotti A. Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell 2012; 6: 242–253.
    • (2012) Mol Cell , vol.6 , pp. 242-253
    • Suraweera, A.1    Münch, C.2    Hanssum, A.3    Bertolotti, A.4
  • 30
    • 84924927986 scopus 로고    scopus 로고
    • Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies
    • Nagel D, Vincendeau M, Eitelhuber AC, Krappmann D. Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies. Oncogene 2014; 33: 5655–5665.
    • (2014) Oncogene , vol.33 , pp. 5655-5665
    • Nagel, D.1    Vincendeau, M.2    Eitelhuber, A.C.3    Krappmann, D.4
  • 31
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • Apr
    • Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 2014 Apr; 39: 199–218.
    • (2014) Trends Biochem Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 32
    • 24344457766 scopus 로고    scopus 로고
    • A review of its use in the management of rheumatoid arthritis
    • Plosker GL, Croom KF. A review of its use in the management of rheumatoid arthritis. Drugs 2005; 65: 1825–1849.
    • (2005) Drugs , vol.65 , pp. 1825-1849
    • Plosker, G.L.1    Croom, K.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.