메뉴 건너뛰기




Volumn 23, Issue 1, 2017, Pages 135-143

Chronic early-life stress in rat pups alters basal corticosterone, intestinal permeability, and fecal microbiota at weaning: Influence of sex

Author keywords

Corticosterone; Microbiota; Permeability; Psychological; Stress; Weaning

Indexed keywords

CORTICOSTERONE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; RNA 16S;

EID: 85010461784     PISSN: 20930879     EISSN: 20930887     Source Type: Journal    
DOI: 10.5056/jnm16105     Document Type: Article
Times cited : (96)

References (52)
  • 1
    • 55549116353 scopus 로고    scopus 로고
    • Childhood trauma and psychosis: evidence, pathways, and implications
    • Larkin W, Read J. Childhood trauma and psychosis: evidence, pathways, and implications. J Postgrad Med 2008;54:287-293.
    • (2008) J Postgrad Med , vol.54 , pp. 287-293
    • Larkin, W.1    Read, J.2
  • 2
    • 84858706883 scopus 로고    scopus 로고
    • Association between early adverse life events and irritable bowel syndrome
    • Bradford K, Shih W, Videlock EJ, et al. Association between early adverse life events and irritable bowel syndrome. Clin Gastroenterol Hepatol 2012;10:385-390.e3.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 385.e3-390.e3
    • Bradford, K.1    Shih, W.2    Videlock, E.J.3
  • 3
    • 84878766587 scopus 로고    scopus 로고
    • Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
    • Li M, Xue X, Shao S, Shao F, Wang W. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Res 2013;1518:82-90.
    • (2013) Brain Res , vol.1518 , pp. 82-90
    • Li, M.1    Xue, X.2    Shao, S.3    Shao, F.4    Wang, W.5
  • 4
    • 84885581328 scopus 로고    scopus 로고
    • Towards translational rodent models of depression
    • O'Leary OF, Cryan JF. Towards translational rodent models of depression. Cell Tissue Res 2013;354:141-153.
    • (2013) Cell Tissue Res , vol.354 , pp. 141-153
    • O'Leary, O.F.1    Cryan, J.F.2
  • 5
    • 34548142214 scopus 로고    scopus 로고
    • New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models
    • Barreau F, Ferrier L, Fioramonti J, Bueno L. New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models. Pediatr Res 2007;62:240-245.
    • (2007) Pediatr Res , vol.62 , pp. 240-245
    • Barreau, F.1    Ferrier, L.2    Fioramonti, J.3    Bueno, L.4
  • 6
    • 47249141324 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of stress-induced intestinal damage
    • Gareau MG, Silva MA, Perdue MH. Pathophysiological mechanisms of stress-induced intestinal damage. Curr Mol Med 2008;8:274-281.
    • (2008) Curr Mol Med , vol.8 , pp. 274-281
    • Gareau, M.G.1    Silva, M.A.2    Perdue, M.H.3
  • 7
    • 0030249912 scopus 로고    scopus 로고
    • Abnormal corticosterone regulation in an immature rat model of continuous chronic stress
    • Gilles EE, Schultz L, Baram TZ. Abnormal corticosterone regulation in an immature rat model of continuous chronic stress. Pediatr Neurol 1996;15:114-119.
    • (1996) Pediatr Neurol , vol.15 , pp. 114-119
    • Gilles, E.E.1    Schultz, L.2    Baram, T.Z.3
  • 9
    • 46549086320 scopus 로고    scopus 로고
    • Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress
    • Ivy AS, Brunson KL, Sandman C, Baram TZ. Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress. Neuroscience 2008;154:1132-1142.
    • (2008) Neuroscience , vol.154 , pp. 1132-1142
    • Ivy, A.S.1    Brunson, K.L.2    Sandman, C.3    Baram, T.Z.4
  • 10
    • 84978734526 scopus 로고    scopus 로고
    • Early-life stress paradigm transiently alters maternal behavior, dam-pup interactions, and offspring vocalizations in mice
    • Heun-Johnson H, Levitt P. Early-life stress paradigm transiently alters maternal behavior, dam-pup interactions, and offspring vocalizations in mice. Front Behav Neurosci 2016;10:142.
    • (2016) Front Behav Neurosci , vol.10 , pp. 142
    • Heun-Johnson, H.1    Levitt, P.2
  • 11
    • 84901800832 scopus 로고    scopus 로고
    • Olfactory exposure to males, including men, causes stress and related analgesia in rodents
    • Sorge RE, Martin LJ, Isbester KA, et al. Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nat Methods 2014;11:629-632.
    • (2014) Nat Methods , vol.11 , pp. 629-632
    • Sorge, R.E.1    Martin, L.J.2    Isbester, K.A.3
  • 12
    • 84955672194 scopus 로고    scopus 로고
    • Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions
    • McLaughlin RJ, Verlezza S, Gray JM, Hill MN, Walker CD. Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions. Stress 2016;19:114-124.
    • (2016) Stress , vol.19 , pp. 114-124
    • McLaughlin, R.J.1    Verlezza, S.2    Gray, J.M.3    Hill, M.N.4    Walker, C.D.5
  • 13
    • 0034825948 scopus 로고    scopus 로고
    • Altered regulation of gene and protein expression of hypothalamicpituitary-adrenal axis components in an immature rat model of chronic stress
    • Avishai-Eliner S, Gilles EE, Eghbal-Ahmadi M, Bar-El Y, Baram TZ. Altered regulation of gene and protein expression of hypothalamicpituitary-adrenal axis components in an immature rat model of chronic stress. J Neuroendocrinol 2001;13:799-807.
    • (2001) J Neuroendocrinol , vol.13 , pp. 799-807
    • Avishai-Eliner, S.1    Gilles, E.E.2    Eghbal-Ahmadi, M.3    Bar-El, Y.4    Baram, T.Z.5
  • 14
    • 85010448762 scopus 로고    scopus 로고
    • Limited nesting stress alters maternal behavior and in vivo intestinal permeability in male Wistar pup rats
    • Moussaoui N, Larauche M, Biraud M, et al. Limited nesting stress alters maternal behavior and in vivo intestinal permeability in male Wistar pup rats. PLoS one 2016;11:e0155037.
    • (2016) PLoS one , vol.11
    • Moussaoui, N.1    Larauche, M.2    Biraud, M.3
  • 16
    • 4644230928 scopus 로고    scopus 로고
    • Stress and the developing limbic-hypothalamic-pituitaryadrenal axis
    • Vázquez DM. Stress and the developing limbic-hypothalamic-pituitaryadrenal axis. Psychoneuroendocrinology 1998;23:663-700.
    • (1998) Psychoneuroendocrinology , vol.23 , pp. 663-700
    • Vázquez, D.M.1
  • 17
    • 84896788911 scopus 로고    scopus 로고
    • Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats
    • Moussaoui N, Braniste V, Ait-Belgnaoui A, et al. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS one 2014;9:e88382.
    • (2014) PLoS one , vol.9
    • Moussaoui, N.1    Braniste, V.2    Ait-Belgnaoui, A.3
  • 18
    • 10544222835 scopus 로고    scopus 로고
    • Developmental changes in distribution of the mucous gel layer and intestinal permeability in rat small intestine
    • Iiboshi Y, Nezu R, Khan J, et al. Developmental changes in distribution of the mucous gel layer and intestinal permeability in rat small intestine. JPEN J Parenter Enteral Nutr 1996;20:406-411.
    • (1996) JPEN J Parenter Enteral Nutr , vol.20 , pp. 406-411
    • Iiboshi, Y.1    Nezu, R.2    Khan, J.3
  • 19
    • 0023583098 scopus 로고
    • Intestinal macromolecular transmission in the young rat: influence of protease inhibitors during development
    • Telemo E, Weström BR, Ekström G, Karlsson BW. Intestinal macromolecular transmission in the young rat: influence of protease inhibitors during development. Biol Neonate 1987;52:141-148.
    • (1987) Biol Neonate , vol.52 , pp. 141-148
    • Telemo, E.1    Weström, B.R.2    Ekström, G.3    Karlsson, B.W.4
  • 20
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9:799-809.
    • (2009) Nat Rev Immunol , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 21
    • 84938073613 scopus 로고    scopus 로고
    • Microbiota and host determinants of behavioural phenotype in maternally separated mice
    • De Palma G, Blennerhassett P, Lu J, et al. Microbiota and host determinants of behavioural phenotype in maternally separated mice. Nat Commun 2015;6:7735.
    • (2015) Nat Commun , vol.6 , pp. 7735
    • De Palma, G.1    Blennerhassett, P.2    Lu, J.3
  • 22
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    • O'Mahony SM, Marchesi JR, Scully P, et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 2009;65:263-267.
    • (2009) Biol Psychiatry , vol.65 , pp. 263-267
    • O'Mahony, S.M.1    Marchesi, J.R.2    Scully, P.3
  • 23
    • 34547111846 scopus 로고    scopus 로고
    • Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
    • Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut 2007;56:1522-1528.
    • (2007) Gut , vol.56 , pp. 1522-1528
    • Gareau, M.G.1    Jury, J.2    MacQueen, G.3    Sherman, P.M.4    Perdue, M.H.5
  • 24
    • 77958545436 scopus 로고    scopus 로고
    • Animal models of early life stress: implications for understanding resilience
    • Lyons DM, Parker KJ, Schatzberg AF. Animal models of early life stress: implications for understanding resilience. Dev Psychobiol 2010;52:616-624.
    • (2010) Dev Psychobiol , vol.52 , pp. 616-624
    • Lyons, D.M.1    Parker, K.J.2    Schatzberg, A.F.3
  • 25
    • 0033548406 scopus 로고    scopus 로고
    • Short-and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects
    • McIntosh J, Anisman H, Merali Z. Short-and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Brain Res Dev Brain Res 1999;113:97-106.
    • (1999) Brain Res Dev Brain Res , vol.113 , pp. 97-106
    • McIntosh, J.1    Anisman, H.2    Merali, Z.3
  • 26
    • 84916238696 scopus 로고    scopus 로고
    • Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats
    • Guo Y, Wang Z, Mayer EA, Holschneider DP. Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats. Neuroreport 2015;1:13-16.
    • (2015) Neuroreport , vol.1 , pp. 13-16
    • Guo, Y.1    Wang, Z.2    Mayer, E.A.3    Holschneider, D.P.4
  • 27
    • 84920064888 scopus 로고    scopus 로고
    • Gender specific effects of neonatal limited nesting on viscerosomatic sensitivity and anxiety-like behavior in adult rats
    • Prusator DK, Greenwood-Van Meerveld B. Gender specific effects of neonatal limited nesting on viscerosomatic sensitivity and anxiety-like behavior in adult rats. Neurogastroenterol Motil 2015;1:72-81
    • (2015) Neurogastroenterol Motil , vol.1 , pp. 72-81
    • Prusator, D.K.1    Greenwood-Van Meerveld, B.2
  • 28
    • 84943324410 scopus 로고    scopus 로고
    • Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis
    • Tong M, Jacobs JP, McHardy IH, Braun J. Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis. Curr Protoc Immunol 2014;107:7.41.1-11.
    • (2014) Curr Protoc Immunol , vol.107 , pp. 7.41.1-11
    • Tong, M.1    Jacobs, J.P.2    McHardy, I.H.3    Braun, J.4
  • 29
    • 77952243141 scopus 로고    scopus 로고
    • QIIME allows analysis of high-throughput community sequencing data
    • Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010;7:335-336.
    • (2010) Nat Methods , vol.7 , pp. 335-336
    • Caporaso, J.G.1    Kuczynski, J.2    Stombaugh, J.3
  • 30
    • 0002154022 scopus 로고    scopus 로고
    • A new method for non-parametric multivariate analysis of variance
    • Anderson MJ. A new method for non-parametric multivariate analysis of variance. Austral Ecology 2001;26:32-46.
    • (2001) Austral Ecology , vol.26 , pp. 32-46
    • Anderson, M.J.1
  • 31
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 2014;15:550.
    • (2014) Genome Biol , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 32
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci 2003;100:9440-9445.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 33
  • 34
    • 84911444327 scopus 로고    scopus 로고
    • Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
    • Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues Clin Neurosci 2014;16:321-333.
    • (2014) Dialogues Clin Neurosci , vol.16 , pp. 321-333
    • Anacker, C.1    O'Donnell, K.J.2    Meaney, M.J.3
  • 35
    • 66449137661 scopus 로고    scopus 로고
    • Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats
    • Walker DM, Juenger TE, Gore AC. Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats. Endocrinology 2009;150:2308-2316.
    • (2009) Endocrinology , vol.150 , pp. 2308-2316
    • Walker, D.M.1    Juenger, T.E.2    Gore, A.C.3
  • 36
    • 4143081461 scopus 로고    scopus 로고
    • Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats
    • Barreau F, Cartier C, Ferrier L, Fioramonti J, Bueno L. Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats. Gastroenterology 2004;127:524-534.
    • (2004) Gastroenterology , vol.127 , pp. 524-534
    • Barreau, F.1    Cartier, C.2    Ferrier, L.3    Fioramonti, J.4    Bueno, L.5
  • 38
    • 0033665517 scopus 로고    scopus 로고
    • Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
    • Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804-811.
    • (2000) Gut , vol.47 , pp. 804-811
    • Spiller, R.C.1    Jenkins, D.2    Thornley, J.P.3
  • 39
    • 11144330063 scopus 로고    scopus 로고
    • Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
    • Marshall JK, Thabane M, Garg AX, Clark W, Meddings J, Collins SM. Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario. Aliment Pharmacol Ther 2004;20:1317-1322.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 1317-1322
    • Marshall, J.K.1    Thabane, M.2    Garg, A.X.3    Clark, W.4    Meddings, J.5    Collins, S.M.6
  • 40
    • 58849136276 scopus 로고    scopus 로고
    • Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators
    • Piche T, Barbara G, Aubert P, et al. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 2009;58:196-201.
    • (2009) Gut , vol.58 , pp. 196-201
    • Piche, T.1    Barbara, G.2    Aubert, P.3
  • 41
    • 84894057244 scopus 로고    scopus 로고
    • Tight junctions and IBS-the link between epithelial permeability, low-grade inflammation, and symptom generation?
    • Piche T. Tight junctions and IBS-the link between epithelial permeability, low-grade inflammation, and symptom generation? Neurogastroenterol Motil 2014;26:296-302.
    • (2014) Neurogastroenterol Motil , vol.26 , pp. 296-302
    • Piche, T.1
  • 42
    • 70349799526 scopus 로고    scopus 로고
    • Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
    • Zhou Q, Zhang B, Verne GN. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain 2009;146:41-46.
    • (2009) Pain , vol.146 , pp. 41-46
    • Zhou, Q.1    Zhang, B.2    Verne, G.N.3
  • 43
    • 25444522615 scopus 로고    scopus 로고
    • Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats
    • Schwetz I, McRoberts JA, Coutinho SV, et al. Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats. Am J Physiol Gastrointest Liver Physiol 2005;289:G704-G712.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289 , pp. G704-G712
    • Schwetz, I.1    McRoberts, J.A.2    Coutinho, S.V.3
  • 44
    • 84942739564 scopus 로고    scopus 로고
    • Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain
    • Jašarevic E, Howerton CL, Howard CD, Bale TL. Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain. Endocrinology 2015;156:3265-3276.
    • (2015) Endocrinology , vol.156 , pp. 3265-3276
    • Jašarevic, E.1    Howerton, C.L.2    Howard, C.D.3    Bale, T.L.4
  • 45
    • 59849113547 scopus 로고    scopus 로고
    • Microbes in gastrointestinal health and disease
    • Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology 2009;136:65-80.
    • (2009) Gastroenterology , vol.136 , pp. 65-80
    • Neish, A.S.1
  • 46
    • 0035212123 scopus 로고    scopus 로고
    • Bacterial translocation in neonatal rats: the relation between intestinal flora, translocated bacteria, and influence of milk
    • Yajima M, Nakayama M, Hatano S, et al. Bacterial translocation in neonatal rats: the relation between intestinal flora, translocated bacteria, and influence of milk. J Pediatr Gastroenterol Nutr 2001;33:592-601.
    • (2001) J Pediatr Gastroenterol Nutr , vol.33 , pp. 592-601
    • Yajima, M.1    Nakayama, M.2    Hatano, S.3
  • 47
    • 84871120114 scopus 로고    scopus 로고
    • Intestinal microbiota in functional bowel disorders: a Rome foundation report
    • Simrén M, Barbara G, Flint HJ, et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut 2013;62:159-176.
    • (2013) Gut , vol.62 , pp. 159-176
    • Simrén, M.1    Barbara, G.2    Flint, H.J.3
  • 48
    • 84964779646 scopus 로고    scopus 로고
    • The intestinal microenvironment and functional gastrointestinal disorders
    • Barbara G, Feinle-Bisset C, Ghoshal UC, et al. The intestinal microenvironment and functional gastrointestinal disorders. Gastroenterology 2016;150:1305-1318.e8.
    • (2016) Gastroenterology , vol.150 , pp. 1305.e8-1318.e8
    • Barbara, G.1    Feinle-Bisset, C.2    Ghoshal, U.C.3
  • 49
    • 84907059504 scopus 로고    scopus 로고
    • Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
    • O'Mahony SM, Felice VD, Nally K, et al. Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats. Neuroscience 2014;277:885-901.
    • (2014) Neuroscience , vol.277 , pp. 885-901
    • O'Mahony, S.M.1    Felice, V.D.2    Nally, K.3
  • 50
    • 84877769093 scopus 로고    scopus 로고
    • Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome
    • Distrutti E, Cipriani S, Mencarelli A, Renga B, Fiorucci S. Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome. PLoS One 2013;8:e63893.
    • (2013) PLoS One , vol.8
    • Distrutti, E.1    Cipriani, S.2    Mencarelli, A.3    Renga, B.4    Fiorucci, S.5
  • 51
    • 85006739295 scopus 로고    scopus 로고
    • Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome
    • Chumpitazi BP, Shulman RJ. Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome. Mol Cell Pediatr 2016;3:11.
    • (2016) Mol Cell Pediatr , vol.3 , pp. 11
    • Chumpitazi, B.P.1    Shulman, R.J.2
  • 52
    • 84896822809 scopus 로고    scopus 로고
    • Sex hormones in the modulation of irritable bowel syndrome
    • Mulak A, Taché Y, Larauche M. Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol 2014;20:2433-2448.
    • (2014) World J Gastroenterol , vol.20 , pp. 2433-2448
    • Mulak, A.1    Taché, Y.2    Larauche, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.