Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

Neuroscience

Volumn 277, Issue , 2014, Pages 885-901

  O'Mahony, S M ^a,b   Felice, V D ^a,b   Nally, K ^a,b   Savignac, H M ^b   Claesson, M J ^a,b   Scully, P ^b   Woznicki, J ^b   Hyland, N P ^a,b   Shanahan, F ^a,b   Quigley, E M ^b,d   Marchesi, J R ^b,c   O'Toole, P W ^a,b   Dinan, T G ^a,b   Cryan, J F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Antibiotic; Behavior; Brain gut axis; Microbiota; Neonatal; Visceral pain

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BACITRACIN; CHOLECYSTOKININ B RECEPTOR; CORTICOSTERONE; NATAMYCIN; NEOMYCIN; VANCOMYCIN; VANILLOID RECEPTOR 1; ALPHA 2A ADRENERGIC RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; STRESS HORMONE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT;

ADULT; ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ANXIETY; ARTICLE; BACTERIAL COLONIZATION; CELL COUNT; COGNITIVE DEVELOPMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSBIOSIS; EARLY LIFE STRESS; ELEVATED PLUS MAZE TEST; FECES MICROFLORA; FEMALE; IMMUNOCOMPETENT CELL; INTESTINE FLORA; MALE; MORRIS WATER MAZE TEST; NERVE CELL DIFFERENTIATION; NEWBORN; NOCICEPTION; NONHUMAN; OPEN FIELD TEST; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TASK PERFORMANCE; TIME TO TREATMENT; VISCERAL PAIN; ACTINOBACTERIA; ADRENAL GLAND; ADRENAL GLAND WEIGHT; BACTEROIDETES; COGNITION; CORTICOSTERONE BLOOD LEVEL; CYTOKINE RESPONSE; DRUG EXPOSURE; DRUG HYPERSENSITIVITY; EXPLORATORY BEHAVIOR; FIRMICUTES; HEART WEIGHT; HORMONE BLOOD LEVEL; LOCOMOTION; MAST CELL; ORGAN WEIGHT; PROTEIN DETERMINATION; SPLEEN WEIGHT; THYMUS; THYMUS WEIGHT; WEIGHT GAIN; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; GASTROINTESTINAL TRACT; HYPERALGESIA; MICROBIOLOGY; MICROFLORA; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; ANXIETY; BACITRACIN; BEHAVIOR, ANIMAL; COGNITION; FEMALE; GASTROINTESTINAL TRACT; HYPERALGESIA; MALE; MICROBIOTA; NATAMYCIN; NEOMYCIN; RATS, SPRAGUE-DAWLEY; VANCOMYCIN; VISCERAL PAIN;

EID: 84907059504     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.07.054     Document Type: Article

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