Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis

Annals of the Rheumatic Diseases

Volumn 76, Issue 6, 2017, Pages 1123-1132

  Ciccia, Francesco ^a   Guggino, Giuliana ^a   Rizzo, Aroldo ^b   Alessandro, Riccardo ^a   Luchetti, Michele Maria ^c   Milling, Simon ^d   Saieva, Laura ^a   Cypers, Heleen ^e,f   Stampone, Tommaso ^b   Di Benedetto, Paola ^g   Gabrielli, Armando ^a   Fasano, Alessio ^h   Elewaut, Dirk ^e,f   Triolo, Giovanni ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Ospedali Riuniti Villa Sofia Cervello   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e GHENT UNIVERSITY   (Belgium)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

^g UNIVERSITY OF L'AQUILA   (Italy)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Ankylosing Spondylitis; Infections; Inflammation

Indexed keywords

CD14 ANTIGEN; FATTY ACID BINDING PROTEIN 2; HLA B27 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ZONULIN; ACUTE PHASE PROTEIN; ANTIINFECTIVE AGENT; CADHERIN; CARRIER PROTEIN; CHOLERA TOXIN; FATTY ACID BINDING PROTEIN; JUNCTIONAL ADHESION MOLECULE A; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MESSENGER RNA; PLVAP PROTEIN, HUMAN; VASCULAR ENDOTHELIAL CADHERIN;

ANKYLOSING SPONDYLITIS; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; BIOPSY TECHNIQUE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DYSBIOSIS; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ILEITIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINE EPITHELIUM; INTESTINE FLORA; MONOCYTE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STAINING; TIGHT JUNCTION; UPREGULATION; ACUTE DISEASE; ADHERENS JUNCTION; ANIMAL; BACTERIUM; BLOOD; CACO-2 CELL LINE; CASE CONTROL STUDY; CHRONIC DISEASE; DRUG EFFECTS; ENDOTHELIUM; GENE EXPRESSION; GENETICS; ILEUM; IMMUNOLOGY; INTESTINE MUCOSA; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PERMEABILITY; TRANSGENIC RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; ADHERENS JUNCTIONS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGENS, CD; BACTERIA; CACO-2 CELLS; CADHERINS; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHOLERA TOXIN; CHRONIC DISEASE; DYSBIOSIS; ENDOTHELIUM; FATTY ACID-BINDING PROTEINS; GENE EXPRESSION; HLA-B27 ANTIGEN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ILEITIS; ILEUM; INTERLEUKIN-8; INTESTINAL MUCOSA; JUNCTIONAL ADHESION MOLECULE A; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MONOCYTES; PERMEABILITY; RATS; RATS, TRANSGENIC; RNA, MESSENGER; SPONDYLITIS, ANKYLOSING; TIGHT JUNCTIONS; UP-REGULATION;

EID: 85010460288     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2016-210000     Document Type: Article

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