Lead exposure induces weight gain in adult rats, accompanied by DNA hypermethylation

PLoS ONE

Volumn 12, Issue 1, 2017, Pages

  Sun, Honglin ^a   Wang, Ningjian ^a   Nie, Xiaomin ^a   Zhao, Li ^a   Li, Qin ^a   Cang, Zhen ^a   Chen, Chi ^a   Lu, Meng ^a   Cheng, Jing ^a   Zhai, Hualing ^a   Xia, Fangzhen ^a   Ye, Lin ^a   Lu, Yingli ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LEAD; GLUCOSE BLOOD LEVEL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HOMEOSTASIS ASSESSMENT OF INSULIN RESISTANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; LIPID STORAGE; LIVER FUNCTION; MALE; METABOLIC PARAMETERS; NONHUMAN; OBESITY; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; DNA METHYLATION; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LEAD; LIPID METABOLISM; MALE; RATS; RATS, WISTAR; WEIGHT GAIN;

EID: 85010376032     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0169958     Document Type: Article

References (36)

1. Scinicariello F, Buser MC, Mevissen M, Portier CJ. Blood lead level association with lower body weight in NHANES 1999-2006. Toxicology and applied pharmacology. 2013; 273(3):516-23. doi: 10.1016/j.taap.2013.09.022 PMID: 24099784
2. Wang N, Chen C, Nie X, Han B, Li Q, Chen Y, et al. Blood lead level and its association with body mass index and obesity in China-Results from SPECT-China study. Scientific reports. 2015; 5.
3. Grun F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology. 2006; 147(6 Suppl):S50-5.
4. Faulk C, Barks A, Liu K, Goodrich JM, Dolinoy DC. Early-life lead exposure results in dose- and sex-specific effects on weight and epigenetic gene regulation in weanling mice. Epigenomics. 2013; 5(5):487-500. doi: 10.2217/epi.13.49 PMID: 24059796
5. Leasure JL, Giddabasappa A, Chaney S, Johnson JE Jr., Pothakos K, Lau YS, et al. Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice. Environmental health perspectives. 2008; 116(3):355-61. doi: 10.1289/ehp.10862 PMID: 18335103
6. Hauser R, Sergeyev O, Korrick S, Lee MM, Revich B, Gitin E, et al. Association of blood lead levels with onset of puberty in Russian boys. Environmental health perspectives. 2008; 116(7):976-80. doi: 10.1289/ehp.10516 PMID: 18629324
7. Iavicoli I, Carelli G, Stanek EJ 3rd, Castellino N, Calabrese EJ. Effects of low doses of dietary lead on puberty onset in female mice. Reproductive toxicology (Elmsford, NY). 2004; 19(1):35-41.
8. Rossi-George A, Virgolini MB, Weston D, Cory-Slechta DA. Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles. Toxicology and applied pharmacology. 2009; 234(1):117-27. doi: 10.1016/j.taap.2008.10.003 PMID: 18977374
9. Gump BB, Stewart P, Reihman J, Lonky E, Darvill T, Parsons PJ, et al. Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children. Environmental health perspectives. 2008; 116(2):249-55. doi: 10.1289/ehp.10391 PMID: 18288326
10. Cory-Slechta DA, Virgolini MB, Thiruchelvam M, Weston DD, Bauter MR. Maternal stress modulates the effects of developmental lead exposure. Environmental health perspectives. 2004; 112(6):717-30. PMID: 15121516
11. Beier EE, Inzana JA, Sheu TJ, Shu L, Puzas JE, Mooney RA. Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice. Environmental health perspectives. 2015; 123(10):935-43. doi: 10.1289/ehp.1408581 PMID: 25861094
12. Faulk C, Barks A, Sanchez BN, Zhang Z, Anderson OS, Peterson KE, et al. Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course. PloS one. 2014; 9(8):e104273. doi: 10.1371/journal.pone.0104273 PMID: 25105421
13. Kim R, Hu H, Rotnitzky A, Bellinger D, Needleman H. A longitudinal study of chronic lead exposure and physical growth in Boston children. Environmental health perspectives. 1995; 103(10):952-7. PMID: 8529592
14. Afeiche M, Peterson KE, Sanchez BN, Cantonwine D, Lamadrid-Figueroa H, Schnaas L, et al. Prenatal Lead Exposure and Weight of 0-to 5-Year-Old Children in Mexico City. Environmental health perspectives. 2011; 119(10):1436-41. doi: 10.1289/ehp.1003184 PMID: 21715242
15. Gonzalez-Cossio T, Peterson KE, Sanin LH, Fishbein E, Palazuelos E, Aro A, et al. Decrease in birth weight in relation to maternal bone-lead burden. Pediatrics. 1997; 100(5):856-62. PMID: 9346987
16. Holliday R. Epigenetics: a historical overview. Epigenetics. 2006; 1(2):76-80. PMID: 17998809
17. Kirchner H, Sinha I, Gao H, Ruby MA, Schonke M, Lindvall JM, et al. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Molecular metabolism. 2016; 5(3):171-83. doi: 10.1016/j.molmet.2015.12.004 PMID: 26977391
18. Nilsson E, Matte A, Perfilyev A, de Mello VD, Kakela P, Pihlajamaki J, et al. Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels. The Journal of clinical endocrinology and metabolism. 2015; 100(11):E1491-501. doi: 10.1210/jc.2015-3204 PMID: 26418287
19. Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schonfels W, Ahrens M, et al. Obesity accelerates epigenetic aging of human liver. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43):15538-43. doi: 10.1073/pnas.1412759111 PMID: 25313081
20. Myers JP, Zoeller RT, vom Saal FS. A clash of old and new scientific concepts in toxicity, with important implications for public health. Environmental health perspectives. 2009; 117(11):1652-5. doi: 10.1289/ehp.0900887 PMID: 20049113
21. Padilla MA, Elobeid M, Ruden DM, Allison DB. An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02. International journal of environmental research and public health. 2010; 7(9):3332-47. doi: 10.3390/ijerph7093332 PMID: 20948927
22. Ronco AM, Gutierrez Y, Gras N, Munoz L, Salazar G, Llanos MN. Lead and arsenic levels in women with different body mass composition. Biological trace element research. 2010; 136(3):269-78. doi: 10.1007/s12011-009-8546-z PMID: 19851721
23. Mostafalou S, Baeeri M, Bahadar H, Soltany-Rezaee-Rad M, Gholami M, Abdollahi M. Molecular mechanisms involved in lead induced disruption of hepatic and pancreatic glucose metabolism. Environmental toxicology and pharmacology. 2015; 39(1):16-26. doi: 10.1016/j.etap.2014.11.001 PMID: 25434758
24. Hou L, Zhang X, Wang D, Baccarelli A. Environmental chemical exposures and human epigenetics. International journal of epidemiology. 2012; 41(1):79-105. doi: 10.1093/ije/dyr154 PMID: 22253299
25. Masoud AM, Bihaqi SW, Machan JT, Zawia NH, Renehan WE. Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease. Journal of Alzheimer's disease: JAD. 2016; 51(4):1257-64. doi: 10.3233/JAD-151018 PMID: 26923026
26. Alashwal H, Dosunmu R, Zawia NH. Integration of genome-wide expression and methylation data: relevance to aging and Alzheimer's disease. Neurotoxicology. 2012; 33(6):1450-3. doi: 10.1016/j.neuro.2012.06.008 PMID: 22743688
27. Dosunmu R, Alashwal H, Zawia NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging Mechanisms of ageing and development. 2012; 133(6):435-43.
28. Bihaqi SW, Huang H, Wu J, Zawia NH. Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease. Journal of Alzheimer's disease: JAD. 2011; 27(4):819-33. doi: 10.3233/JAD-2011-111013 PMID: 21891863
29. Schneider JS, Kidd SK, Anderson DW. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Toxicology letters. 2013; 217(1):75-81. doi: 10.1016/j.toxlet.2012.12.004 PMID: 23246732
30. Nye MD, Hoyo C, Murphy SK. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicology in vitro: an international journal published in association with BIBRA. 2015; 29(3):544-50.
31. Faulk C, Liu K, Barks A, Goodrich JM, Dolinoy DC. Longitudinal epigenetic drift in mice perinatally exposed to lead. Epigenetics. 2014; 9(7):934-41. doi: 10.4161/epi.29024 PMID: 24786859
32. Li C, Yang X, Xu M, Zhang J, Sun N. Epigenetic marker (LINE-1 promoter) methylation level was associated with occupational lead exposure. Clinical toxicology (Philadelphia, Pa). 2013; 51(4):225-9.
33. Wright RO, Schwartz J, Wright RJ, Bollati V, Tarantini L, Park SK, et al. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environmental health perspectives. 2010; 118(6):790-5. doi: 10.1289/ehp.0901429 PMID: 20064768
34. Sen A, Heredia N, Senut MC, Land S, Hollocher K, Lu X, et al. Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Scientific reports. 2015; 5:14466. doi: 10.1038/srep14466 PMID: 26417717
35. Lee JH, Friso S, Choi SW. Epigenetic Mechanisms Underlying the Link between Non-Alcoholic Fatty Liver Diseases and Nutrition. Nutrients. 2014; 6(8):3303-25. doi: 10.3390/nu6083303 PMID: 25195642
36. Chang X, Yan H, Fei J, Jiang M, Zhu H, Lu D, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of lipid research. 2010; 51(9):2504-15. doi: 10.1194/jlr.M001958 PMID: 20567026