Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo

International Journal of Nanomedicine

Volumn 11, Issue , 2016, Pages 1879-1887

  He, Yan ^a   Du, Zhiyun ^a   Ma, Shijing ^a   Liu, Yue ^b   Li, Dongli ^a   Huang, Huarong ^a   Jiang, Sen ^a   Cheng, Shupeng ^a   Wu, Wenjing ^a   Zhang, Kun ^a   Zheng, Xi ^a,b  

^a GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Antitumor; Cytotoxicity; H1299; Lung cancer; Silver nanoparticles

Indexed keywords

BACULOVIRAL IAP REPEAT CONTAINING PROTEIN 5; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; SILVER NANOPARTICLE; STAT3 PROTEIN; METAL NANOPARTICLE; SILVER; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; LUNG CANCER; MOUSE; MTT ASSAY; NCI-H1299 CELL LINE; NONHUMAN; PROTEIN EXPRESSION; TRYPAN BLUE ASSAY; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GENETIC TRANSCRIPTION; GREEN CHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG NEOPLASMS; METABOLISM; PARTICLE SIZE; PATHOLOGY; PROCEDURES; SCID MOUSE; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; GREEN CHEMISTRY TECHNOLOGY; HUMANS; INJECTIONS, INTRAPERITONEAL; LUNG NEOPLASMS; METAL NANOPARTICLES; MICE, SCID; NEOPLASM PROTEINS; NF-KAPPA B; PARTICLE SIZE; SILVER; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85010347085     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S103695     Document Type: Article

References (41)

1. Austin LA, Mackey MA, Dreaden EC, El-Sayed MA. The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery. Arch Toxicol. 2014;88(7):1391–1417.
2. Vaidyanathan R, Kalishwaralal K, Gopalram S, Gurunathan S. Nano-silver – the burgeoning therapeutic molecule and its green synthesis. Biotechnol Adv. 2009;27(6):924–937.
3. Dar MA, Ingle A, Rai M. Enhanced antimicrobial activity of silver nanoparticles synthesized by Cryphonectria sp. evaluated singly and in combination with antibiotics. Nanomedicine. 2013;9(1):105–110.
4. Tolaymat TM, El Badawy AM, Genaidy A, Scheckel KG, Luxton TP, Suidan M. An evidence-based environmental perspective of manufac-tured silver nanoparticle in syntheses and applications: a systematic review and critical appraisal of peer-reviewed scientific papers. Sci Total Environ. 2010;408(5):999–1006.
5. Schluesener JK, Schluesener HJ. Nanosilver: application and novel aspects of toxicology. Arch Toxicol. 2013;87(4):569–576.
6. Poulose S, Panda T, Nair PP, Théodore T. Biosynthesis of silver nano-particles. J Nanosci Nanotechnol. 2014;14(2):2038–2049.
7. He Y, Du Z, Lv H, et al. Green synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat. extract and their application in clinical ultrasound gel. Int J Nanomed. 2013;8:1809–1815.
8. Harshiny M, Matheswaran M, Arthanareeswaran G, Kumaran S, Rajasree S. Enhancement of antibacterial properties of silver nanopar-ticles-ceftriaxone conjugate through Mukia maderaspatana leaf extract mediated synthesis. Ecotoxicol Environ Saf. 2015;121:135–141.
9. Stensberg MC, Wei Q, McLamore ES, Porterfield DM, Wei A, Sepúlveda MS. Toxicological studies on silver nanoparticles: chal-lenges and opportunities in assessment, monitoring and imaging. Nanomedicine. 2011;6(5):879–898.
10. Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010; 28(11):580–588.
11. Kohl Y, Kaiser C, Bost W, et al. Preparation and biological evaluation of multifunctional PLGA nanoparticles designed for photoacoustic imaging. Nanomedicine. 2011;7(2):228–237.
12. Tian J, Wong KK, Ho CM, et al. Topical delivery of silver nanoparticles promotes wound healing. Chem Med Chem. 2007;2(1):129–136.
13. dos Santos CA, Seckler MM, Ingle AP, et al. Silver nanoparticles: therapeutical uses, toxicity, and safety issues. J Pharm Sci. 2014;103(7): 1931–1944.
14. Ong C, Lim JZ, Ng CT, Li JJ, Yung LY, Bay BH. Silver nanoparticles in cancer: therapeutic efficacy and toxicity. Curr Med Chem. 2013; 20(6):772–781.
15. Locatelli E, Naddaka M, Uboldi C, et al. Targeted delivery of silver nanoparticles and alisertib: in vitro and in vivo synergistic effect against glioblastoma. Nanomedicine. 2014;9(6):839–849.
16. Wei X, Li H, Li Z, et al. Metal-enhanced fluorescent probes based on silver nanoparticles and its application in IgE detection. Anal Bioanal Chem. 2012;402(3):1057–1063.
17. Gengan RM, Anand K, Phulukdaree A, Chuturgoon A. A549 lung cell line activity of biosynthesized silver nanoparticles using Albizia adianthifolia leaf. Colloids and Surfaces B Biointerfaces. 2013;105(4):87–91.
18. Jeyaraj M, Sathishkumar G, Sivanandhan G, et al. Biogenic silver nanoparticles for cancer treatment: an experimental report. Colloids Surf B Biointerfaces. 2013;106(2):86–92.
19. Sanpui P, Chattopadhyay A, Ghosh SS. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocar-rier. ACS Appl Mater Interfaces. 2011;3(2):218–228.
20. Jeyaraj M, Rajesh M, Arun R, et al. An investigation on the cytotoxicity and caspase-3-mediated apoptotic effect of biologically synthesized silver nanoparticles using Podophyllum hexandrum on human cervical carcinoma cells. Colloids Surf B Biointerfaces. 2013;102(1):708–717.
21. Sriram MI, Kanth SB, Kalishwaralal K, Gurunathan S. Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model. Int J Nanomed. 2010;5(1):753–762.
22. Hsin YH, Chen CF, Huang S, Shih TS, Lai PS, Chueh PJ. The apop-totic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett. 2008;179(3):130–139.
23. Gurunat han S, Lee KJ, Kal i shwaral al K, Shei kpranbabu S, Vaidyanathan R, Eom SH. Antiangiogenic properties of silver nano-particles. Biomaterials. 2009;30(31):6341–6350.
24. De Lima R, Seabra AB, Durán N. Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles. J Appl Toxicol. 2012;32(11):867–879.
25. Greulich C, Braun D, Peetsch A, et al. The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range. RSC Advances. 2012;2(17):6981–6987.
26. Sun C, Yin N, Wen R, et al. Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions. Neurotoxicology. 2016;52:210–221.
27. AshaRani PV, Mun GLK, Hande MP, Valiyaveettil S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. Acs Nano. 2009; 3(2):279–290.
28. José HL, Ricardo GF, Patricia TG, Enriqueta MC, Reyes TG, Cristina RP. In vivo antitumor activity of metal silver and silver nano-particles in the L5178Y-R murine lymphoma model. Br J Med Med Res. 2013;3(4):1308–1316.
29. Zheng X, Chang RL, Cui XX, et al. Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. Clin Cancer Res. 2006;12(11 Pt 1):3444–3451.
30. Zhou DY, Ding N, Van Doren J, et al. Effects of curcumin analogues for inhibiting human prostate cancer cells and the growth of human PC-3 prostate xenografts in immunodeficient mice. Biol Pharm Bull. 2014;37(6):1029–1034.
31. De Matteis V, Malvindi MA, Galeone A, et al. Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol. Nanomedicine. 2015;11(3):731–739.
32. Li L, Sun J, Li X, et al. Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxic-ity. Biomaterials. 2012;33(6):1714–1721.
33. Park MV, Neigh AM, Vermeulen JP, et al. The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles. Biomaterials. 2011;32(36):9810–9817.
34. Singh S, Nalwa HS. Nanotechnology and health safety-toxicity and risk assessments of nanostructured materials on human health. J Nanosci Nanotechnol. 2007;7(9):3048–3070.
35. Saintigny P, Burger JA. Recent advances in non-small cell lung cancer biology and clinical management. Discov Med. 2012;13(71):287–297.
36. Kiruba Daniel SCG, Abirami J, Kumaran S, Sivakumar M. Microbicidal tissue paper using green synthesized silver nanoparticles. Curr Nanosci. 2015;11(1):64–68.
37. Kiruba Daniel SCG, Nazeema Banu B, Harshiny M, et al. Ipomea carnea-based silver nanoparticle synthesis for antibacterial activity against selected human pathogens. J Exp Nanosci. 2014;9(2):197–209.
38. Söderstjerna E, Bauer P, Cedervall T, Abdshill H, Johansson F, Johansson UE. Silver and gold nanoparticles exposure to in vitro cultured retina – studies on nanoparticle internalization, apoptosis, oxidative stress, glial-and microglial activity. PLoS One. 2014;9(8):e105359.
39. Stȩpkowski TM, Brzóska K, Kruszewski M. Silver nanoparticles induced changes in the expression of NF-κB related genes are cell type specific and related to the basal activity of NF-κB. Toxicol In Vitro. 2014; 28(4):473–478.
40. Matsushita H, Morishita R, Nata T, et al. Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation. Circ Res. 2000;86(9):974–981.
41. Jin HO, Seo SK, Woo SH, et al. A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation. Lung Cancer. 2008;61(1):317–327.