Ascorbate inhibits platelet-endothelial adhesion in an in-vitro model of sepsis via reduced endothelial surface P-selectin expression

Blood Coagulation and Fibrinolysis

Volumn 28, Issue 1, 2017, Pages 28-33

  Secor, Dan ^a,b   Swarbreck, Scott ^a,b   Ellis, Christopher G ^a,b   Sharpe, Michael D ^c   Feng, Qingping ^b   Tyml, Karel ^a,b  

^a Lawson Health Research Institute   (United Kingdom)

^b Department of Physiology and Pharmacology ^*  (United Kingdom)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Ascorbic acid; Capillaries; Endothelial cells; Platelet adhesiveness; Sepsis

Indexed keywords

ASCORBIC ACID; BLOCKING ANTIBODY; LIPOPOLYSACCHARIDE; PADGEM PROTEIN; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CAPILLARY FLOW; CAPILLARY WALL; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; IMMUNOFLUORESCENCE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PLATELET ENDOTHELIAL CELL ADHESION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; SKELETAL MUSCLE; SURFACE PROPERTY; THROMBOCYTE ADHESION; ANIMAL; C57BL MOUSE; HUMAN; METABOLISM;

ANIMALS; ASCORBIC ACID; ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED C57BL; P-SELECTIN; PLATELET ADHESIVENESS; SEPSIS;

EID: 85010189117     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000528     Document Type: Article

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