Rebamipide inhibits neutrophil adhesion to hypoxia/reoxygenation-stimulated endothelial cells via nuclear factor-κB-dependent pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 3, 2000, Pages 864-869

  Chi Dae Kim, ^a   Yong Ki Kim, ^a   So Hyun Lee, ^a   Ki Whan Hong, ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PADGEM PROTEIN; REBAMIPIDE;

ARTICLE; CELL HYPOXIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ALANINE; ANTIBODIES, MONOCLONAL; ANTIOXIDANTS; CELL ADHESION; CELL HYPOXIA; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; NEUTROPHILS; NF-KAPPA B; P-SELECTIN; QUINOLONES; UMBILICAL VEINS;

EID: 0033843149     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Adhesion molecules and inflammatory injury
2. Function and activation of NF-κB in the immune system
3. The effect of anti-intercellular adhesion molecule-1 on phorbol ester-induced rabbit lung inflammation
4. Biology of disease: Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion
5. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers
6. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature (Lond)
7. Transcriptional regulation of intercellular adhesion molecule 1 by phorbol ester in human neuroblastoma cell line SK-N-SH involves jun- and fos-containing activator protein 1 site binding complex(es)
8. Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells
9. Suppressive effect of antioxidants on intercellular adhesion molecule 1 (ICAM-1) expression in human epidermal keratinocytes
10. Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat
11. Inhibitory effect of rebamipide on the neutrophil adherence stimulated by conditioned media from Helicobacter pylori-infected gastric epithelial cells
12. Endothelial cell monolayers as a tool for studying microvascular pathophysiology
13. Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: A juxtacrine system for adhesion and activation of neutrophils
14. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
15. Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats
16. Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats
17. Regulation of the human P-selectin promotor by Bcl-3 and specific homodimeric members of the NF-κB/Rel family
18. Novel leukocyte agonists are released by endothelial cells exposed to peroxide
19. 2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter
20. Antioxidant and redox regulation of gene transcription
21. N-and C-terminal sequences control degradation of MAD3/IκBa in response to inducers of NF-κB activity
22. Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats