메뉴 건너뛰기




Volumn 15, Issue 1, 2017, Pages

Genetic instability and increased mutational load: Which diagnostic tool best direct patients with cancer to immunotherapy?

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED CANCER; CANCER IMMUNOTHERAPY; CANCER PATIENT; CLINICAL PRACTICE; DIAGNOSTIC TEST; DOWN REGULATION; EPIGENETIC REPRESSION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENOMIC INSTABILITY; HUMAN; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MICROSATELLITE MARKER; MISMATCH REPAIR; MUTATIONAL LOAD; NEXT GENERATION SEQUENCING; NOTE; PATIENT IDENTIFICATION; SOMATIC MUTATION; AGAR GEL ELECTROPHORESIS; GENE LOCUS; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; MUTATION; NEOPLASM;

EID: 85009999839     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-017-1119-6     Document Type: Note
Times cited : (42)

References (28)
  • 1
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189-99.
    • (2014) N Engl J Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 2
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-8.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 3
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509-20.
    • (2015) N Engl J Med , vol.372 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 4
    • 84943516465 scopus 로고    scopus 로고
    • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
    • Van Allen EM, Miao D, Schilling B, et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science. 2015;350:207-11.
    • (2015) Science , vol.350 , pp. 207-211
    • Allen, E.M.1    Miao, D.2    Schilling, B.3
  • 5
    • 84962301577 scopus 로고    scopus 로고
    • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
    • McGranahan N, Furness AJS, Rosenthal R, et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science. 2016;351:1463-9.
    • (2016) Science , vol.351 , pp. 1463-1469
    • McGranahan, N.1    Furness, A.J.S.2    Rosenthal, R.3
  • 6
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
    • Hugo W, Zaretsky JM, Sun L, et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell. 2016;165:35-44.
    • (2016) Cell , vol.165 , pp. 35-44
    • Hugo, W.1    Zaretsky, J.M.2    Sun, L.3
  • 7
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Zaretsky JM, Garcia-Diaz A, Shin DS, et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med. 2016;375:819-29.
    • (2016) N Engl J Med , vol.375 , pp. 819-829
    • Zaretsky, J.M.1    Garcia-Diaz, A.2    Shin, D.S.3
  • 8
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzier KW, Volgestein B. Genetic instabilities in human cancers. Nature. 1998;396:643-9.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzier, K.W.2    Volgestein, B.3
  • 9
    • 0034639682 scopus 로고    scopus 로고
    • Microsatellite instability in tumors as a model to study the process of microsatellite mutations
    • Sturzeneker R, Bevilacqua RA, Haddad LA, Simpson AJ, Pena SD. Microsatellite instability in tumors as a model to study the process of microsatellite mutations. Hum Mol Genet. 2000;9:347-52.
    • (2000) Hum Mol Genet , vol.9 , pp. 347-352
    • Sturzeneker, R.1    Bevilacqua, R.A.2    Haddad, L.A.3    Simpson, A.J.4    Pena, S.D.5
  • 10
    • 84941010087 scopus 로고    scopus 로고
    • Deficient mismatch repair: read all about it
    • Richman S. Deficient mismatch repair: read all about it. Int J Oncol. 2015;47:1189-202.
    • (2015) Int J Oncol , vol.47 , pp. 1189-1202
    • Richman, S.1
  • 11
    • 84991735355 scopus 로고    scopus 로고
    • Mismatch repair deficiency and response to immune checkpoint blockade
    • Lee V, Murphy A, Le DT, Diaz LA Jr. Mismatch repair deficiency and response to immune checkpoint blockade. Oncologist. 2016;21:1200-11.
    • (2016) Oncologist , vol.21 , pp. 1200-1211
    • Lee, V.1    Murphy, A.2    Le, D.T.3    Diaz, L.A.4
  • 12
    • 84982267373 scopus 로고    scopus 로고
    • Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer
    • Graff JN, Alumkal JJ, Drake CG, et al. Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer. Oncotarget. 2016;33:52810-7.
    • (2016) Oncotarget , vol.33 , pp. 52810-52817
    • Graff, J.N.1    Alumkal, J.J.2    Drake, C.G.3
  • 13
    • 85009976759 scopus 로고    scopus 로고
    • The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1
    • Jin Z, Yoon HH. The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1. J Gastrointest Oncol. 2016;7:771-88.
    • (2016) J Gastrointest Oncol. , vol.7 , pp. 771-788
    • Jin, Z.1    Yoon, H.H.2
  • 14
    • 84987603333 scopus 로고    scopus 로고
    • PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers
    • (abstr)
    • Le DT, Uram JN, Wang H, et al. PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers. J Clin Oncol. 2016;34 (abstr):195.
    • (2016) J Clin Oncol , vol.34 , pp. 195
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 15
    • 85007346453 scopus 로고    scopus 로고
    • Pathological complete response with anti-PD-1 therapy in a patient with microsatellite instable high, BRAF mutant metastatic colon cancer: a case report and review of literature
    • Sehdev A, Cramer HM, Ibrahim AA, Younger AE, O'Neil BH. Pathological complete response with anti-PD-1 therapy in a patient with microsatellite instable high, BRAF mutant metastatic colon cancer: a case report and review of literature. Discov Med. 2016;21:341-7.
    • (2016) Discov Med , vol.21 , pp. 341-347
    • Sehdev, A.1    Cramer, H.M.2    Ibrahim, A.A.3    Younger, A.E.4    O'Neil, B.H.5
  • 17
    • 0033846517 scopus 로고    scopus 로고
    • Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype
    • Chaves P, Cruz C, Lage P, et al. Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype. J Pathol. 2000;191:355-60.
    • (2000) J Pathol. , vol.191 , pp. 355-360
    • Chaves, P.1    Cruz, C.2    Lage, P.3
  • 18
    • 84902078459 scopus 로고    scopus 로고
    • Mismatch repair pathway: molecules, functions, and role in colorectal carcinogenesis
    • Sameer AS, Nissar S, Fatima K. Mismatch repair pathway: molecules, functions, and role in colorectal carcinogenesis. Eur J Cancer Prev. 2014;23:246-57.
    • (2014) Eur J Cancer Prev , vol.23 , pp. 246-257
    • Sameer, A.S.1    Nissar, S.2    Fatima, K.3
  • 19
    • 84957553878 scopus 로고    scopus 로고
    • Combined microsatellite instability, MLH1 methylation analysis, and immunohistochemistry for Lynch Syndrome screening in endometrial cancers from GOG210: an NRG Oncology and Gynecologic Oncology Group Study
    • Goodfellow PJ, Billingsley CC, Lankes HA, et al. Combined microsatellite instability, MLH1 methylation analysis, and immunohistochemistry for Lynch Syndrome screening in endometrial cancers from GOG210: an NRG Oncology and Gynecologic Oncology Group Study. J Clin Oncol. 2015;33:4301-8.
    • (2015) J Clin Oncol , vol.33 , pp. 4301-4308
    • Goodfellow, P.J.1    Billingsley, C.C.2    Lankes, H.A.3
  • 20
    • 0037096949 scopus 로고    scopus 로고
    • Microsatellite instability and mutation analysis of candidate genes in unselected Sardinian patients with endometrial cancer
    • Baldinu P, Cossu A, Manca A, et al. Microsatellite instability and mutation analysis of candidate genes in unselected Sardinian patients with endometrial cancer. Cancer. 2002;94:3157-68.
    • (2002) Cancer , vol.94 , pp. 3157-3168
    • Baldinu, P.1    Cossu, A.2    Manca, A.3
  • 21
    • 0036739002 scopus 로고    scopus 로고
    • Prevalence and prognostic role of microsatellite instability in patients with rectal carcinoma
    • Colombino M, Cossu A, Manca A, et al. Prevalence and prognostic role of microsatellite instability in patients with rectal carcinoma. Ann Oncol. 2002;13:1447-53.
    • (2002) Ann Oncol , vol.13 , pp. 1447-1453
    • Colombino, M.1    Cossu, A.2    Manca, A.3
  • 22
    • 10744222045 scopus 로고    scopus 로고
    • Microsatellite instability and mutation analysis among Southern Italian patients with colorectal carcinoma: detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases
    • Colombino M, Cossu A, Arba A, et al. Microsatellite instability and mutation analysis among Southern Italian patients with colorectal carcinoma: detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases. Ann Oncol. 2003;14:1530-6.
    • (2003) Ann Oncol , vol.14 , pp. 1530-1536
    • Colombino, M.1    Cossu, A.2    Arba, A.3
  • 23
    • 0141563684 scopus 로고    scopus 로고
    • High-resolution methylation analysis of hMLH1 promoter in sporadic endometrial and colorectal carcinomas
    • Strazzullo M, Cossu A, Baldinu P, et al. High-resolution methylation analysis of hMLH1 promoter in sporadic endometrial and colorectal carcinomas. Cancer. 2003;98:1540-6.
    • (2003) Cancer , vol.98 , pp. 1540-1546
    • Strazzullo, M.1    Cossu, A.2    Baldinu, P.3
  • 24
    • 20944446585 scopus 로고    scopus 로고
    • Identification of predictive factors for the occurrence of predisposing MLH1 and MSH2 germline mutations among Sardinian patients with colorectal carcinoma
    • Colombino M, Cossu A, Budroni M, et al. Identification of predictive factors for the occurrence of predisposing MLH1 and MSH2 germline mutations among Sardinian patients with colorectal carcinoma. Eur J Cancer. 2005;41:1058-64.
    • (2005) Eur J Cancer , vol.41 , pp. 1058-1064
    • Colombino, M.1    Cossu, A.2    Budroni, M.3
  • 25
    • 79551478326 scopus 로고    scopus 로고
    • MSI phenotype and MMR alterations in familial and sporadic gastric cancer
    • Leite M, Corso G, Sousa S, et al. MSI phenotype and MMR alterations in familial and sporadic gastric cancer. Int J Cancer. 2011;128:1606-13.
    • (2011) Int J Cancer , vol.128 , pp. 1606-1613
    • Leite, M.1    Corso, G.2    Sousa, S.3
  • 26
    • 84940004205 scopus 로고    scopus 로고
    • Microsatellite instability: an update
    • Yamamoto H, Imai K. Microsatellite instability: an update. Arch Toxicol. 2015;89:899-921.
    • (2015) Arch Toxicol , vol.89 , pp. 899-921
    • Yamamoto, H.1    Imai, K.2
  • 27
    • 47649123223 scopus 로고    scopus 로고
    • Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry
    • Shia J. Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J Mol Diagn. 2008;10:293-300.
    • (2008) J Mol Diagn , vol.10 , pp. 293-300
    • Shia, J.1
  • 28
    • 10744233937 scopus 로고    scopus 로고
    • Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    • Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004;96:261-8.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 261-268
    • Umar, A.1    Boland, C.R.2    Terdiman, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.