Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma

Cancer

Volumn 94, Issue 12, 2002, Pages 3157-3168

  Baldinu, Paola ^a   Cossu, Antonio ^b   Manca, Antonella ^a   Satta, Maria P ^a   Pisano, Marina ^a   Casula, Milena ^a   Dessole, Salvatore ^b   Pintus, Adriana ^b   Tanda, Francesco ^b   Palmieri, Giuseppe ^a  

^a CNR   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

Endometrial carcinoma; hMLH1; hMSH2; Immunohistochemistry; Microsatellite instability; Mutational analysis; Polymerase chain reaction; Prognosis; PTEN

Indexed keywords

GENE PRODUCT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM CARCINOMA; GENE EXPRESSION; GENE INACTIVATION; GENETIC CODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MISSENSE MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TISSUE SECTION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CARRIER PROTEINS; DNA-BINDING PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0037096949     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10606     Document Type: Article

References (50)

1. Endometrial carcinoma
2. Involvement of p53 gene mutations in human endometrial carcinomas
3. Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas
4. HER-2/neu expression: A major prognostic factor in endometrial carcinoma
5. Identification of a candidate tumor suppressor gene MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
6. PTEN, a putative protein tyrosinase phosphatase gene mutated in human brain, breast and prostate cancer
7. PTEN1 is frequently mutated in primary endometrial carcinomas
8. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
9. Molecular identification of latent precancers in histologically normal endometrium
10. PTEN/MMAC1 mutations in endometrial cancers
11. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
12. Identification of a 790-kilobase region of common allelic loss in chromosome 10q25-q26 in human endometrial cancer
13. Mapping an endometrial cancer tumor suppressor gene at 10q25 and development of a bacterial colne contig for the consensus interval
14. Microsatellite analysis at 10q25-q26 in Sardinian patients with sporadic endometrial carcinoma: Identification of specific patterns of genetic alteration
15. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
16. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
17. Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma
18. Microsatellite instability in cervical and endometrial carcinomas
19. Microsatellite instability in endometrial carcinoma: Clinicopathologic correlations in a series of 42 cases
20. Causes and consequences of microsatellite instability in endometrial carcinoma
21. Mutations predisposing to hereditary nonpolyposis colorectal cancer
22. Standardized approach for microsatellite instability detection in colorectal carcinomas
23. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
24. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis
25. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
26. Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype
27. Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: Associations with family history and histopathology
28. Altered expression of hMLH1 and hMSH2 protein in endometrial carcinomas with microsatellite instability
29. Clinical significance of microsatellite instability in endometrial carcinoma
30. Tumor registry of Sassari
31. Changes in gynecological cancer staging by the International Federation of Gynecology and Obstetrics
32. Identification of a founder BRCA2 mutation in Sardinia
33. Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases
34. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
35. Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)
36. Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradientgel electrophoresis
37. High-accuracy DNA sequence variation screening by DHPLC
38. Familial endometrial cancer in female carriers of MSH6 germline mutations
39. Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer
40. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
41. Genetic instabilities in human cancers
42. Microsatellite instability in tumors as a model to study the process of microsatellite mutations
43. The DNA repair gene MB4 (MED1) is mutated in human carcinomas with microsatellite instability
44. Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability
45. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
46. Better survival rates in patients with Mlh1-associated hereditary colon cancer
47. Microsatellite instability is an independent indicator of recurrence in sporadic Stage I-II endometrial adenocarcinoma
48. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy
49. Microsatellite instability as a molecular marker for very good survival in colorectal cancer patients receiving adjuvant chemotherapy