Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 3, 2017, Pages 580-585

  Chen, Peiwen ^a   Zuo, Hao ^a   Xiong, Hu ^a,b   Kolar, Matthew J ^c   Chu, Qian ^c   Saghatelian, Alan ^c   Siegwart, Daniel J ^a,b   Wan, Yihong ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Breast cancer; Gpr132; Lactate; Macrophage; Metastasis

Indexed keywords

ANTIGEN; CD163 ANTIGEN; CD200 RECEPTOR; CD206 ANTIGEN; CHEMOKINE RECEPTOR CCR2; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 132; LACTIC ACID; MACROPHAGE DERIVED CHEMOKINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; G2A RECEPTOR;

ANIMAL EXPERIMENT; BREAST CANCER; CELL ADHESION; CELL MIGRATION; CONFERENCE PAPER; HUMAN; HUMAN TISSUE; LUNG METASTASIS; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BREAST TUMOR; C57BL MOUSE; CELL MOTION; DEFICIENCY; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; PATHOLOGY; PROGNOSIS; SECONDARY; TUMOR CELL LINE; TUMOR INVASION; TUMOR MICROENVIRONMENT;

ANIMALS; BREAST NEOPLASMS; CELL ADHESION; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; LACTIC ACID; LUNG NEOPLASMS; MACROPHAGE ACTIVATION; MACROPHAGES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM INVASIVENESS; PROGNOSIS; RECEPTORS, G-PROTEIN-COUPLED; TUMOR MICROENVIRONMENT;

EID: 85009819036     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1614035114     Document Type: Article

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