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Angewandte Chemie - International Edition

Volumn 56, Issue 8, 2017, Pages 2187-2191

In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation

(9) Kloss, Florian a,e Krchnak, Viktor b,c Krchnakova, Anna b Schieferdecker, Sebastian a,e Dreisbach, Julia d,f Krone, Volker f Möllmann, Ute a Hoelscher, Michael d,f Miller, Marvin J b

a HANS KNÖLL INSTITUTE (Germany)

b UNIVERSITY OF NOTRE DAME (United States)

c PALACKÝ UNIVERSITY (Czech Republic)

d LUDWIG MAXIMILIANS UNIVERSITY (Germany)

e InfectControl 2020 ^* (Germany)

f Partner Site Munich (Germany)

Author keywords

benzothiazinones; DprE1 inhibitors; metabolite identification; prodrugs; transient metabolites

Indexed keywords

MAMMALS;

ANTITUBERCULOSIS AGENTS; BENZOTHIAZINONES; COMPLEX FORMATIONS; DESIGN AND IMPLEMENTATIONS; MAMMALIAN SPECIES; METABOLITE IDENTIFICATION; PRODRUGS; REDUCTION PROCESS;

METABOLITES;

2-(2-METHYL-1,4-DIOXA-8-AZASPIRO(4.5)DEC-8-YL)-8-NITRO-6-(TRIFLUOROMETHYL)-4H-1,3-BENZOTHIAZIN-4-ONE; MACOZINONE; PIPERAZINE DERIVATIVE; SPIRO COMPOUND; THIAZINE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTITUBERCULAR AGENTS; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; HUMANS; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PIPERAZINES; SPIRO COMPOUNDS; TANDEM MASS SPECTROMETRY; THIAZINES;

EID: 85009747701 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201609737 Document Type: Article

Times cited : (52)

References (19)

1
- 65649096556
- V. Makarov, G. Manina, K. Mikusova, U. Möllmann, O. Ryabova, B. Saint-Joanis, N. Dhar, M. R. Pasca, S. Buroni, A. P. Lucarelli, A. Milano, E. De Rossi, M. Belanova, A. Bobovska, P. Dianiskova, J. Kordulakova, C. Sala, E. Fullam, P. Schneider, J. D. McKinney, P. Brodin, T. Christophe, S. Waddell, P. Butcher, J. Albrethsen, I. Rosenkrands, R. Brosch, V. Nandi, S. Bharath, S. Gaonkar, R. K. Shandil, V. Balasubramanian, T. Balganesh, S. Tyagi, J. Grosset, G. Riccardi, S. T. Cole, Science 2009, 324, 801–804.
- (2009) Science , vol.324 , pp. 801-804
- Makarov, V.¹ Manina, G.² Mikusova, K.³ Möllmann, U.⁴ Ryabova, O.⁵ Saint-Joanis, B.⁶ Dhar, N.⁷ Pasca, M.R.⁸ Buroni, S.⁹ Lucarelli, A.P.¹⁰ Milano, A.¹¹ De Rossi, E.¹² Belanova, M.¹³ Bobovska, A.¹⁴ Dianiskova, P.¹⁵ Kordulakova, J.¹⁶ Sala, C.¹⁷ Fullam, E.¹⁸ Schneider, P.¹⁹ McKinney, J.D.²⁰ more..

2
- 84896716778
- V. Makarov, B. Lechartier, M. Zhang, J. Neres, A. M. van der Sar, S. A. Raadsen, R. C. Hartkoorn, O. B. Ryabova, A. Vocat, L. A. Decosterd, N. Widmer, T. Buclin, W. Bitter, K. Andries, F. Pojer, P. J. Dyson, S. T. Cole, EMBO Mol. Med. 2014, 6, 372–383.
- (2014) EMBO Mol. Med. , vol.6 , pp. 372-383
- Makarov, V.¹ Lechartier, B.² Zhang, M.³ Neres, J.⁴ van der Sar, A.M.⁵ Raadsen, S.A.⁶ Hartkoorn, R.C.⁷ Ryabova, O.B.⁸ Vocat, A.⁹ Decosterd, L.A.¹⁰ Widmer, N.¹¹ Buclin, T.¹² Bitter, W.¹³ Andries, K.¹⁴ Pojer, F.¹⁵ Dyson, P.J.¹⁶ Cole, S.T.¹⁷

3
- 0038224377
- 20 ed
- WHO, Global Tuberculosis Report 2015, 20 ed., WHO Press, Geneva, Switzerland, 2015.
- (2015) Global Tuberculosis Report , vol.20

4
- 84886094308
- WHO, Multidrug-Resistant Tuberculosis (MDR-TB) 2015 Update, 2015.
- (2015) Multidrug-Resistant Tuberculosis (MDR-TB)

5
- 84900449838
- R. Tiwari, U. Möllmann, S. Cho, S. G. Franzblau, P. A. Miller, M. J. Miller, ACS Med. Chem. Lett. 2014, 5, 587–591;
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 587-591
- Tiwari, R.¹ Möllmann, U.² Cho, S.³ Franzblau, S.G.⁴ Miller, P.A.⁵ Miller, M.J.⁶

6
- 84863919677
- S. M. Batt, T. Jabeen, V. Bhowruth, L. Quill, P. A. Lund, L. Eggeling, L. J. Alderwick, K. Fütterer, G. S. Besra, Proc. Natl. Acad. Sci. USA 2012, 109, 11354–11359.
- (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 11354-11359
- Batt, S.M.¹ Jabeen, T.² Bhowruth, V.³ Quill, L.⁴ Lund, P.A.⁵ Eggeling, L.⁶ Alderwick, L.J.⁷ Fütterer, K.⁸ Besra, G.S.⁹

7
- 84855948516
- C. Trefzer, H. Skovierova, S. Buroni, A. Bobovska, S. Nenci, E. Molteni, F. Pojer, M. R. Pasca, V. Makarov, S. T. Cole, G. Riccardi, K. Mikusova, K. Johnsson, J. Am. Chem. Soc. 2012, 134, 912–915.
- (2012) J. Am. Chem. Soc. , vol.134 , pp. 912-915
- Trefzer, C.¹ Skovierova, H.² Buroni, S.³ Bobovska, A.⁴ Nenci, S.⁵ Molteni, E.⁶ Pojer, F.⁷ Pasca, M.R.⁸ Makarov, V.⁹ Cole, S.T.¹⁰ Riccardi, G.¹¹ Mikusova, K.¹² Johnsson, K.¹³

8
- 43549101762
- B. A. Wolucka, FEBS J. 2008, 275, 2691–2711.
- (2008) FEBS J. , vol.275 , pp. 2691-2711
- Wolucka, B.A.¹

9
- 0035945974
- J. Suwiński, K. Świerczek, Tetrahedron 2001, 57, 1639–1662;
- (2001) Tetrahedron , vol.57 , pp. 1639-1662
- Suwiński, J.¹ Świerczek, K.²

10
- 34848923102
- V. N. Charushin, O. N. Chupakhin, Mendeleev Commun. 2007, 17, 249–254.
- (2007) Mendeleev Commun. , vol.17 , pp. 249-254
- Charushin, V.N.¹ Chupakhin, O.N.²

11
- 84910405189
- V. v. Richter, Chem. Ber. 1871, 4, 21–22.
- (1871) Chem. Ber. , vol.4 , pp. 21-22
- Richter, V.V.¹

12
- 84874851496
- R. Tiwari, G. C. Moraski, V. Krchnak, P. A. Miller, M. Colon-Martinez, E. Herrero, A. G. Oliver, M. J. Miller, J. Am. Chem. Soc. 2013, 135, 3539–3549.
- (2013) J. Am. Chem. Soc. , vol.135 , pp. 3539-3549
- Tiwari, R.¹ Moraski, G.C.² Krchnak, V.³ Miller, P.A.⁴ Colon-Martinez, M.⁵ Herrero, E.⁶ Oliver, A.G.⁷ Miller, M.J.⁸

13
- 84878798474
- J. C. Anderson, P. J. Koovits, Chem. Sci. 2013, 4, 2897–2901.
- (2013) Chem. Sci. , vol.4 , pp. 2897-2901
- Anderson, J.C.¹ Koovits, P.J.²

14
- 84970928513
- J. Meisenheimer, Liebigs Ann. Chem. 1902, 323, 205–246;
- (1902) Liebigs Ann. Chem. , vol.323 , pp. 205-246
- Meisenheimer, J.¹

15
- 0002630982
- F. Terrier, Chem. Rev. 1982, 82, 77–152;
- (1982) Chem. Rev. , vol.82 , pp. 77-152
- Terrier, F.¹

16
- 46749152256
- R. O. Al-Kaysi, I. Gallardo, G. Guirado, Molecules 2008, 13, 1282–1302.
- (2008) Molecules , vol.13 , pp. 1282-1302
- Al-Kaysi, R.O.¹ Gallardo, I.² Guirado, G.³

17
- 84880933909
- I. V. Khilyas, A. M. Ziganshin, A. J. Pannier, R. Gerlach, Biodegradation 2013, 24, 631–644.
- (2013) Biodegradation , vol.24 , pp. 631-644
- Khilyas, I.V.¹ Ziganshin, A.M.² Pannier, A.J.³ Gerlach, R.⁴

18
- 0033064437
- P.-G. Rieger, V. Sinnwell, A. Preuß, W. Francke, H.-J. Knackmuss, J. Bacteriol. 1999, 181, 1189–1195.
- (1999) J. Bacteriol. , vol.181 , pp. 1189-1195
- Rieger, P.-G.¹ Sinnwell, V.² Preuß, A.³ Francke, W.⁴ Knackmuss, H.-J.⁵

19
- 84865960733
- 121
- J. Neres, F. Pojer, E. Molteni, L. R. Chiarelli, N. Dhar, S. Boy-Röttger, S. Buroni, E. Fullam, G. Degiacomi, A. P. Lucarelli, R. J. Read, G. Zanoni, D. E. Edmondson, E. De Rossi, M. R. Pasca, J. D. McKinney, P. J. Dyson, G. Riccardi, A. Mattevi, S. T. Cole, C. Binda, Sci. Trans. Med. 2012, 4, 150ra121.
- (2012) Sci. Trans. Med. , vol.4 , pp. 150
- Neres, J.¹ Pojer, F.² Molteni, E.³ Chiarelli, L.R.⁴ Dhar, N.⁵ Boy-Röttger, S.⁶ Buroni, S.⁷ Fullam, E.⁸ Degiacomi, G.⁹ Lucarelli, A.P.¹⁰ Read, R.J.¹¹ Zanoni, G.¹² Edmondson, D.E.¹³ De Rossi, E.¹⁴ Pasca, M.R.¹⁵ McKinney, J.D.¹⁶ Dyson, P.J.¹⁷ Riccardi, G.¹⁸ Mattevi, A.¹⁹ Cole, S.T.²⁰ Binda, C.²¹ more..

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