메뉴 건너뛰기




Volumn 46, Issue 2, 2017, Pages 120-128

The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review

Author keywords

Chronic obstructive pulmonary disease; Effect; Exacerbation; Meta analysis; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; SCAVENGER;

EID: 85009732651     PISSN: 01479563     EISSN: 15273288     Source Type: Journal    
DOI: 10.1016/j.hrtlng.2016.12.004     Document Type: Review
Times cited : (44)

References (31)
  • 1
    • 54149090275 scopus 로고    scopus 로고
    • The Global Burden of Disease
    • WHO update Geneva update
    • 1 World Health Organization (WHO). The Global Burden of Disease. 2004 update, WHO, Geneva.
    • (2004)
  • 2
    • 84873956600 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    • 2 Vestbo, J., Hurd, S.S., Agusti, A.G., et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187 (2013), 347–365, 10.1164/rccm.201204-0596PP.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 347-365
    • Vestbo, J.1    Hurd, S.S.2    Agusti, A.G.3
  • 4
    • 34548107307 scopus 로고    scopus 로고
    • Effect of oral N-acetylcysteine in COPD—a randomised controlled trial
    • 4 Bachh, Arshad Altaf, Bhargava, Rakesh, Shah, Naveed Nazir, et al. Effect of oral N-acetylcysteine in COPD—a randomised controlled trial. JK Pract 14 (2007), 12–16.
    • (2007) JK Pract , vol.14 , pp. 12-16
    • Bachh, A.A.1    Bhargava, R.2    Shah, N.N.3
  • 5
    • 0032759974 scopus 로고    scopus 로고
    • N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD
    • 5 Pela, R., Calcagni, A.M., Subiaco, S., et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 66 (1999), 495–500.
    • (1999) Respiration , vol.66 , pp. 495-500
    • Pela, R.1    Calcagni, A.M.2    Subiaco, S.3
  • 6
    • 84895803870 scopus 로고    scopus 로고
    • Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial
    • 6 Zheng, J.P., Wen, F.Q., Bai, C.X., et al. Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. Lancet Respir Med 2 (2014), 187–194, 10.1016/s2213-2600(13)70286-8.
    • (2014) Lancet Respir Med , vol.2 , pp. 187-194
    • Zheng, J.P.1    Wen, F.Q.2    Bai, C.X.3
  • 7
    • 0028040727 scopus 로고
    • Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis
    • 7 Hansen, N.C., Skriver, A., Brorsen-Riis, L., et al. Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis. Respir Med 88 (1994), 531–535.
    • (1994) Respir Med , vol.88 , pp. 531-535
    • Hansen, N.C.1    Skriver, A.2    Brorsen-Riis, L.3
  • 8
    • 84940663022 scopus 로고    scopus 로고
    • Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis
    • 8 Cazzola, M., Calzetta, L., Page, C., et al. Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis. Eur Respir Rev 24 (2015), 451–461, 10.1183/16000617.00002215.
    • (2015) Eur Respir Rev , vol.24 , pp. 451-461
    • Cazzola, M.1    Calzetta, L.2    Page, C.3
  • 9
    • 84900801448 scopus 로고    scopus 로고
    • Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis
    • 9 Shen, Y., Cai, W., Lei, S., et al. Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis. COPD 11 (2014), 351–358, 10.3109/15412555.2013.858315.
    • (2014) COPD , vol.11 , pp. 351-358
    • Shen, Y.1    Cai, W.2    Lei, S.3
  • 10
    • 84861558523 scopus 로고    scopus 로고
    • Nutritional support in chronic obstructive pulmonary disease: a systematic review and meta-analysis
    • 10 Collins, P.F., Stratton, R.J., Elia, M., Nutritional support in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Am J Clin Nutr 95 (2012), 1385–1395, 10.3945/ajcn.111.023499.
    • (2012) Am J Clin Nutr , vol.95 , pp. 1385-1395
    • Collins, P.F.1    Stratton, R.J.2    Elia, M.3
  • 11
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: is blinding necessary?
    • 11 Jadad, A.R., Moore, R.A., Carroll, D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 17 (1996), 1–12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 12
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    • 12 Celli, B.R., MacNee, W., Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 23 (2004), 932–946.
    • (2004) Eur Respir J , vol.23 , pp. 932-946
    • Celli, B.R.1    MacNee, W.2
  • 13
    • 0037764092 scopus 로고    scopus 로고
    • COPD exacerbations: definitions and classifications
    • 13 Burge, S., Wedzicha, J.A., COPD exacerbations: definitions and classifications. Eur Respir J Suppl 41 (2003), 46s–53s.
    • (2003) Eur Respir J Suppl , vol.41 , pp. 46s-53s
    • Burge, S.1    Wedzicha, J.A.2
  • 14
    • 84880047842 scopus 로고    scopus 로고
    • High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study
    • 14 Tse, H.N., Raiteri, L., Wong, K.Y., et al. High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest 144 (2013), 106–118, 10.1378/chest.12-2357.
    • (2013) Chest , vol.144 , pp. 106-118
    • Tse, H.N.1    Raiteri, L.2    Wong, K.Y.3
  • 15
    • 0022414065 scopus 로고
    • Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee
    • 15 McGavin, C.R., Macfarlane, J.T., Prescott, R.J., et al. Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee. Thorax 40 (1985), 832–835.
    • (1985) Thorax , vol.40 , pp. 832-835
    • McGavin, C.R.1    Macfarlane, J.T.2    Prescott, R.J.3
  • 16
    • 0017111053 scopus 로고
    • A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis
    • 16 Grassi, C., Morandini, G.C., A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis. Eur J Clin Pharmacol 09 (1976), 393–396.
    • (1976) Eur J Clin Pharmacol , vol.9 , pp. 393-396
    • Grassi, C.1    Morandini, G.C.2
  • 17
    • 0023912569 scopus 로고
    • Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis
    • 17 Rasmussen, J.B., Glennow, C., Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Eur Respir J 1 (1988), 351–355.
    • (1988) Eur Respir J , vol.1 , pp. 351-355
    • Rasmussen, J.B.1    Glennow, C.2
  • 18
    • 60649103762 scopus 로고    scopus 로고
    • Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis
    • 18 Schermer, T., Chavannes, N., Dekhuijzen, R., et al. Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis. Respir Med 103 (2009), 542–551, 10.1016/j.rmed.2008.11.003.
    • (2009) Respir Med , vol.103 , pp. 542-551
    • Schermer, T.1    Chavannes, N.2    Dekhuijzen, R.3
  • 19
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial
    • 19 Decramer, M., Rutten-van Molken, M., Dekhuijzen, P.N., et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 365 (2005), 1552–1560, 10.1016/s0140-6736(05)66456-2.
    • (2005) Lancet , vol.365 , pp. 1552-1560
    • Decramer, M.1    Rutten-van Molken, M.2    Dekhuijzen, P.N.3
  • 20
    • 68849103501 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study
    • 20 Stav, D., Raz, M., Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study. Chest 136 (2009), 381–386, 10.1378/chest.09-0421.
    • (2009) Chest , vol.136 , pp. 381-386
    • Stav, D.1    Raz, M.2
  • 21
    • 84888172067 scopus 로고    scopus 로고
    • Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients
    • 21 De Backer, J., Vos, W., Van Holsbeke, C., et al. Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. Int J Chron Obstruct Pulmon Dis 8 (2013), 569–579, 10.2147/copd.s49307.
    • (2013) Int J Chron Obstruct Pulmon Dis , vol.8 , pp. 569-579
    • De Backer, J.1    Vos, W.2    Van Holsbeke, C.3
  • 22
    • 84875866752 scopus 로고    scopus 로고
    • High-dose N-acetylcysteine in the prevention of COPD exacerbations: rationale and design of the PANTHEON Study
    • 22 Zheng, J.P., Wen, F.Q., Bai, C.X., et al. High-dose N-acetylcysteine in the prevention of COPD exacerbations: rationale and design of the PANTHEON Study. COPD 10 (2013), 164–171, 10.3109/15412555.2012.732628.
    • (2013) COPD , vol.10 , pp. 164-171
    • Zheng, J.P.1    Wen, F.Q.2    Bai, C.X.3
  • 23
    • 1842481121 scopus 로고    scopus 로고
    • Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease
    • 23 Dekhuijzen, P.N., Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 23 (2004), 629–636.
    • (2004) Eur Respir J , vol.23 , pp. 629-636
    • Dekhuijzen, P.N.1
  • 24
    • 58149335378 scopus 로고    scopus 로고
    • The effect of different treatment modalities on oxidative stress in COPD
    • 24 Kuleci, S., Hanta, I., Kocabas, A., et al. The effect of different treatment modalities on oxidative stress in COPD. Adv Ther 25 (2008), 710–717, 10.1007/s12325-008-0064-4.
    • (2008) Adv Ther , vol.25 , pp. 710-717
    • Kuleci, S.1    Hanta, I.2    Kocabas, A.3
  • 25
    • 85014060421 scopus 로고    scopus 로고
    • The effect of N-Acetylcysteine on oxidative stress and pulmonary function in elderly patients with COPD
    • 25 Li, J.H., He, H., Yu, W., et al. The effect of N-Acetylcysteine on oxidative stress and pulmonary function in elderly patients with COPD. J Yunyang Med Coll, 2008, 247–249.
    • (2008) J Yunyang Med Coll , pp. 247-249
    • Li, J.H.1    He, H.2    Yu, W.3
  • 26
    • 0034942666 scopus 로고    scopus 로고
    • Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease
    • 26 Kasielski, M., Nowak, D., Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease. Respir Med 95 (2001), 448–456, 10.1053/rmed.2001.1066.
    • (2001) Respir Med , vol.95 , pp. 448-456
    • Kasielski, M.1    Nowak, D.2
  • 27
    • 10644250916 scopus 로고    scopus 로고
    • Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD
    • 27 De Benedetto, F., Aceto, A., Dragani, B., et al. Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD. Pulm Pharmacol Ther 18 (2005), 41–47, 10.1016/j.pupt.2004.09.030.
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 41-47
    • De Benedetto, F.1    Aceto, A.2    Dragani, B.3
  • 28
    • 22544436397 scopus 로고    scopus 로고
    • High-dose N-acetylcysteine in patients with exacerbations of chronic obstructive pulmonary disease
    • 28 Zuin, R., Palamidese, A., Negrin, R., et al. High-dose N-acetylcysteine in patients with exacerbations of chronic obstructive pulmonary disease. Clin Drug Investig 25 (2005), 401–408.
    • (2005) Clin Drug Investig , vol.25 , pp. 401-408
    • Zuin, R.1    Palamidese, A.2    Negrin, R.3
  • 29
    • 31344465272 scopus 로고    scopus 로고
    • New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine
    • 29 van Overveld, F.J., Demkow, U., Gorecka, D., et al. New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine. J Physiol Pharmacol 56:suppl 4 (2005), 135–142.
    • (2005) J Physiol Pharmacol , vol.56 , pp. 135-142
    • van Overveld, F.J.1    Demkow, U.2    Gorecka, D.3
  • 30
    • 0028266997 scopus 로고
    • The intrabronchial microbial flora in chronic bronchitis patients: a target for N-acetylcysteine therapy?
    • 30 Riise, G.C., Larsson, S., Larsson, P., et al. The intrabronchial microbial flora in chronic bronchitis patients: a target for N-acetylcysteine therapy?. Eur Respir J 7 (1994), 94–101.
    • (1994) Eur Respir J , vol.7 , pp. 94-101
    • Riise, G.C.1    Larsson, S.2    Larsson, P.3
  • 31
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review
    • 31 Sadowska, A.M., Manuel, Y.K.B., De Backer, W.A., Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther 20 (2007), 9–22, 10.1016/j.pupt.2005.12.007.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 9-22
    • Sadowska, A.M.1    Manuel, Y.K.B.2    De Backer, W.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.