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Volumn 10, Issue 2, 2013, Pages 164-171

High-dose N-acetylcysteine in the prevention of COPD exacerbations: Rationale and design of the PANTHEON study

Author keywords

Anti inflammation; Anti oxidant; COPD; Exacerbation; ICS; Mucolytics; N Acetylcysteine; Quality of Life

Indexed keywords

ACETYLCYSTEINE; PLACEBO;

EID: 84875866752     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2012.732628     Document Type: Article
Times cited : (17)

References (37)
  • 2
    • 0242363130 scopus 로고    scopus 로고
    • Preventing exacerbations of chronic bronchitis and COPD: Therapeutic potential of mucolytic agents
    • Poole PJ, Black PN. Preventing exacerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents. Am J Respir Med 2003; 2(5):367-370.
    • (2003) Am J Respir Med , vol.2 , Issue.5 , pp. 367-370
    • Poole, P.J.1    Black, P.N.2
  • 3
    • 0029947193 scopus 로고    scopus 로고
    • Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity
    • Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Respir Crit Care Med 1996; 153(5):1530-1535.
    • (1996) Copenhagen City Heart Study Group. Am J Respir Crit Care Med , vol.153 , Issue.5 , pp. 1530-1535
    • Vestbo, J.1    Prescott, E.2    Lange, P.3
  • 4
    • 2342596597 scopus 로고    scopus 로고
    • Exacerbations of chronic obstructive pulmonary disease
    • Wedzicha JA, Donaldson GC. Exacerbations of chronic obstructive pulmonary disease. Respir Care 2003; 48(12):1204-1213.
    • (2003) Respir Care , vol.48 , Issue.12 , pp. 1204-1213
    • Wedzicha, J.A.1    Donaldson, G.C.2
  • 5
    • 44849100529 scopus 로고    scopus 로고
    • Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): A randomized placebocontrolled study
    • Zheng J-P, Kang J, Huang S-G, Chen P, et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): A randomized placebocontrolled study. Lancet 2008; 371:2013-2018.
    • (2008) Lancet , vol.371 , pp. 2013-2018
    • Zheng, J.-P.1    Kang, J.2    Huang, S.-G.3    Chen, P.4
  • 6
    • 0030586689 scopus 로고    scopus 로고
    • In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation
    • Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol1996; 157(4):1630-1637.
    • (1996) J Immunol , vol.157 , Issue.4 , pp. 1630-1637
    • Blackwell, T.S.1    Blackwell, T.R.2    Holden, E.P.3    Christman, B.W.4    Christman, J.W.5
  • 7
    • 0038697896 scopus 로고    scopus 로고
    • N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro
    • Lappas M, Permezel M, Rice GE. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J Clin Endocrinol Metab 2003; 88(4):1723-1729.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.4 , pp. 1723-1729
    • Lappas, M.1    Permezel, M.2    Rice, G.E.3
  • 8
    • 31344465272 scopus 로고    scopus 로고
    • New developments in the treatment of COPD: Comparing the effects of inhaled corticosteroids and N-acetylcysteine
    • van Overveld FJ, Demkow U, Górecka D, de Backer WA, Zielinski J. New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine. J Physiol Pharmacol 2005; 56 Suppl 4:135-142.
    • (2005) J Physiol Pharmacol , vol.56 , Issue.SUPPL. 4 , pp. 135-142
    • Van Overveld, F.J.1    Demkow, U.2    Górecka, D.3    De Backer, W.A.4    Zielinski, J.5
  • 9
    • 0032962228 scopus 로고    scopus 로고
    • N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis
    • Ekberg-Jansson A, Larson M, MacNee W, Tunek A, Wahlgren L, Wouters EF, Larsson S. N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis. Eur Respir J 1999; 13:829-834.
    • (1999) Eur Respir J , vol.13 , pp. 829-834
    • Ekberg-Jansson, A.1    Larson, M.2    Macnee, W.3    Tunek, A.4    Wahlgren, L.5    Wouters, E.F.6    Larsson, S.7
  • 10
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo doseeffects: A review
    • Sadowska AM, Manuel-Y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo doseeffects: A review. Pulm Pharmacol Ther 2007; 20:9-22.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 9-22
    • Sadowska, A.M.1    Manuel-Y-Keenoy, B.2    De Backer, W.A.3
  • 12
    • 0030699339 scopus 로고    scopus 로고
    • Neutrophil function and glutathione-peroxidase (GSH-px) activity in healthy individuals after treatment with N-acetyl-L-cysteine
    • Urban T, Akerlund B, Jarstrand C, Lindeke B. Neutrophil function and glutathione-peroxidase (GSH-px) activity in healthy individuals after treatment with N-acetyl-L-cysteine. Biomed Pharmacother 1997; 51(9):388-390.
    • (1997) Biomed Pharmacother , vol.51 , Issue.9 , pp. 388-390
    • Urban, T.1    Akerlund, B.2    Jarstrand, C.3    Lindeke, B.4
  • 13
    • 0033768954 scopus 로고    scopus 로고
    • Inhibitory eff ect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro
    • Riise GC, Qvarfordt I, Larsson S, Eliasson V, Andersson BA. Inhibitory eff ect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration 2000; 67(5):552-558.
    • (2000) Respiration , vol.67 , Issue.5 , pp. 552-558
    • Riise, G.C.1    Qvarfordt, I.2    Larsson, S.3    Eliasson, V.4    Andersson, B.A.5
  • 14
    • 79960928566 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)
    • Mata M, Morcillo E, Gimeno C, Cortijo J. N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV). Biochem Pharmacol 2011; 82(5):548-555.
    • (2011) Biochem Pharmacol , vol.82 , Issue.5 , pp. 548-555
    • Mata, M.1    Morcillo, E.2    Gimeno, C.3    Cortijo, J.4
  • 16
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): A randomised placebo-controlled trial
    • Decramer M, Rutten-van Molken M, Dekhuijzen PNR, et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): A randomised placebo-controlled trial. Lancet 2005; 365:1552-1560.
    • (2005) Lancet , vol.365 , pp. 1552-1560
    • Decramer, M.1    Rutten-Van Molken, M.2    Dekhuijzen, P.N.R.3
  • 17
    • 1842481121 scopus 로고    scopus 로고
    • Antioxidant properties of N-acetylcysteine: Their relevance in relation to chronic obstructive pulmonary disease
    • Dekhuijzen PNR. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 2004; 23:629-636.
    • (2004) Eur Respir J , vol.23 , pp. 629-636
    • Dekhuijzen, P.N.R.1
  • 19
    • 0037718518 scopus 로고    scopus 로고
    • N-Acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease
    • Gerrits CMJM, Herings RMC, Laufkens HGM, et al. N-Acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. Eur Respir J 2003; 21:795-798.
    • (2003) Eur Respir J , vol.21 , pp. 795-798
    • Gerrits, C.M.J.M.1    Herings, R.M.C.2    Laufkens, H.G.M.3
  • 20
    • 22544436397 scopus 로고    scopus 로고
    • High dose N-Acetylcysteine in Patients with Exacerbations of Chronic Obstructive Pulmonary Diseases
    • Zuin R, Palamidese A, Negrin R, et al. High dose N-Acetylcysteine in Patients with Exacerbations of Chronic Obstructive Pulmonary Diseases. Clin Drug Invest 2005; 25(6):401-408.
    • (2005) Clin Drug Invest , vol.25 , Issue.6 , pp. 401-408
    • Zuin, R.1    Palamidese, A.2    Negrin, R.3
  • 21
    • 0035857966 scopus 로고    scopus 로고
    • The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials
    • Moher D, Schulz KF, Altman DG, et al. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001; 357:1191-1194.
    • (2001) Lancet , vol.357 , pp. 1191-1194
    • Moher, D.1    Schulz, K.F.2    Altman, D.G.3
  • 25
    • 0034777617 scopus 로고    scopus 로고
    • Health status measurement in chronic obstructive pulmonary disease
    • Jones PW. Health status measurement in chronic obstructive pulmonary disease. Thorax 2001; 56:880-887.
    • (2001) Thorax , vol.56 , pp. 880-887
    • Jones, P.W.1
  • 26
    • 0029090616 scopus 로고
    • American Thoracic Society. Standardization of spirometry-1994 update
    • Crapo RO, Hankinson JL, Irvin C, et al. American Thoracic Society. Standardization of spirometry-1994 update. Am J Respir Crit Care Med 1995; 152: 1107-1136.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1107-1136
    • Crapo, R.O.1    Hankinson, J.L.2    Irvin, C.3
  • 27
    • 0027564322 scopus 로고
    • Standardized lung function testing. Official Statement of the European Respiratory Society
    • Quanjer PH. Standardized lung function testing. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16:5-40.
    • (1993) Eur Respir J Suppl , vol.16 , pp. 5-40
    • Quanjer, P.H.1
  • 28
    • 0036163834 scopus 로고    scopus 로고
    • Normative values for pulmonary function testing in Chinese adults
    • Zheng JP, Zhong NS. Normative values for pulmonary function testing in Chinese adults. Chin Med J 2002; 115:50-54.
    • (2002) Chin Med J , vol.115 , pp. 50-54
    • Zheng, J.P.1    Zhong, N.S.2
  • 30
    • 0034643610 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial
    • Burge PS, Calverley PMA, Jones PW, Spencer S, Anderson JA, Maslem TK. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ 2000; 320:1297-1303.
    • (2000) BMJ , vol.320 , pp. 1297-1303
    • Burge, P.S.1    Calverley, P.M.A.2    Jones, P.W.3    Spencer, S.4    Anderson, J.A.5    Maslem, T.K.6
  • 31
    • 53749102775 scopus 로고    scopus 로고
    • A 4-year trial of tiotropium in Chronic Obstructive Pulmonary Disease
    • for the UPLIFT Study Investigators
    • Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, Decramer M, for the UPLIFT Study Investigators. A 4-year trial of tiotropium in Chronic Obstructive Pulmonary Disease. N Engl J Med 2008; 359:1543-1554
    • (2008) N Engl J Med , vol.359 , pp. 1543-1554
    • Tashkin, D.P.1    Celli, B.2    Senn, S.3    Burkhart, D.4    Kesten, S.5    Menjoge, S.6    Decramer, M.7
  • 32
    • 55149105278 scopus 로고    scopus 로고
    • Carbocisteine for acute exacerbations of COPD - Authors' reply
    • Zheng JP, Zhong NS, Jiang M, et al. Carbocisteine for acute exacerbations of COPD - Authors' reply. Lancet 2008; 372:1631-1632.
    • (2008) Lancet , vol.372 , pp. 1631-1632
    • Zheng, J.P.1    Zhong, N.S.2    Jiang, M.3
  • 33
    • 42949146028 scopus 로고    scopus 로고
    • Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)
    • Vestbo J, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). ERJ 2008; 31:869-873.
    • (2008) ERJ , vol.31 , pp. 869-873
    • Vestbo, J.1
  • 35
    • 35348974996 scopus 로고    scopus 로고
    • Biomass fuels are the probable risk factor for chronic obstructive pulmonary disease in rural South China
    • Liu S, Zhou Y, Wang X, Wang D, Zheng J, Zhong N, Ran P, et al. Biomass fuels are the probable risk factor for chronic obstructive pulmonary disease in rural South China. Thorax 2007; 62:889-897.
    • (2007) Thorax , vol.62 , pp. 889-897
    • Liu, S.1    Zhou, Y.2    Wang, X.3    Wang, D.4    Zheng, J.5    Zhong, N.6    Ran, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.