Molecular Imaging of Abdominal Aortic Aneurysms

Trends in Molecular Medicine

Volumn 23, Issue 2, 2017, Pages 150-164

  Brangsch, Julia ^a   Reimann, Carolin ^a   Collettini, Federico ^a   Buchert, Ralf ^a   Botnar, René M ^a,b,c,d,e   Makowski, Marcus R ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e The National Institute for Health Research Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London in partnership with UK Health Security Agency   (United Kingdom)

Author keywords

abdominal aortic aneurysm; magnetic resonance imaging; molecular imaging; positron emission tomography; single photon emission computed tomography

Indexed keywords

COLLAGEN; ELASTIN; FLUORODEOXYGLUCOSE F 18; MATRIX METALLOPROTEINASE; PADGEM PROTEIN; VITRONECTIN RECEPTOR;

ABDOMINAL AORTA ANEURYSM; HUMAN; MACROPHAGE; MOLECULAR IMAGING; MOLECULAR PATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; ABDOMINAL AORTA; ABDOMINAL AORTIC ANEURYSM; ANIMAL; DIAGNOSTIC IMAGING; PROCEDURES;

ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; HUMANS; MAGNETIC RESONANCE IMAGING; MOLECULAR IMAGING; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 85009476476     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2016.12.002     Document Type: Review

References (79)

1. 1 Nevitt, M.P., et al. Prognosis of abdominal aortic aneurysms. A population-based study. N. Engl. J. Med. 321 (1989), 1009–1014.
2. 2 Thompson, R.W., et al. Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr. Probl. Surg. 39 (2002), 110–230.
3. 3 Hallett, J.W. Jr., Management of abdominal aortic aneurysms. Mayo Clin. Proc. 75 (2000), 395–399.
4. 4 Sakalihasan, N., et al. Abdominal aortic aneurysm. Lancet 365 (2005), 1577–1589.
5. 5 Matsumura, K., et al. Incidence of aneurysms in Takayasu's arteritis. Angiology 42 (1991), 308–315.
6. 6 Towbin, J.A., et al. The molecular basis of vascular disorders. Am. J. Hum. Genet. 64 (1999), 678–684.
7. 7 Alcorn, H.G., et al. Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study. Arterioscler. Thromb. Vasc. Biol. 16 (1996), 963–970.
8. 8 Johansen, K., Koepsell, T., Familial tendency for abdominal aortic aneurysms. JAMA 256 (1986), 1934–1936.
9. 9 Hong, H., et al. Imaging of abdominal aortic aneurysm: the present and the future. Curr. Vasc. Pharmacol. 8 (2010), 808–819.
10. 10 Golledge, J., et al. Circulating markers of abdominal aortic aneurysm presence and progression. Circulation 118 (2008), 2382–2392.
11. 11 Lin, J.B., et al. Imaging of small animal peripheral artery disease models: recent advancements and translational potential. Int. J. Mol. Sci. 16 (2015), 11131–11177.
12. 12 Botnar, R.M., et al. Molecular imaging in cardiovascular diseases. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 36 (2015), 92–101.
13. 13 Johnson, G.A., et al. Histology by magnetic resonance microscopy. Mag. Reson. Q. 9 (1993), 1–30.
14. 14 Ammirati, E., et al. Non-invasive imaging of vascular inflammation. Front. Immunol., 5, 2014, 399.
15. 15 Brockmann, M.A., et al. Current issues and perspectives in small rodent magnetic resonance imaging using clinical MRI scanners. Methods 43 (2007), 79–87.
16. 16 Krettek, A., et al. Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis. Arterioscler. Thromb. Vasc. Biol. 23 (2003), 582–587.
17. 17 Halm, M., et al. Visualizing tropoelastin in a long-term human elastic fibre cell culture model. Sci. Rep., 6, 2016, 20378.
18. 18 Sakalihasan, N., et al. Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. J. Vasc. Surg. 24 (1996), 127–133.
19. 19 Daugherty, A., Cassis, L.A., Mechanisms of abdominal aortic aneurysm formation. Curr. Atheroscler. Rep. 4 (2002), 222–227.
20. 20 Hellenthal, F.A., et al. Biomarkers of AAA progression. Part 1: extracellular matrix degeneration. Nat. Rev. Cardiol. 6 (2009), 464–474.
21. 21 Makowski, M.R., et al. Three-dimensional imaging of the aortic vessel wall using an elastin-specific magnetic resonance contrast agent. Invest. Radiol. 47 (2012), 438–444.
22. 22 von Bary, C., et al. MRI of coronary wall remodeling in a swine model of coronary injury using an elastin-binding contrast agent. Circ. Cardiovasc. Imaging 4 (2011), 147–155.
23. 23 Botnar, R.M., et al. In vivo assessment of aortic aneurysm wall integrity using elastin-specific molecular magnetic resonance imaging. Circ. Cardiovasc. Imaging 7 (2014), 679–689.
24. 24 Okamura, H., et al. Assessment of elastin deficit in a Marfan mouse aneurysm model using an elastin-specific magnetic resonance imaging contrast agent. Circ. Cardiovasc. Imaging 7 (2014), 690–696.
25. 25 Menashi, S., et al. Collagen in abdominal aortic aneurysm: typing, content, and degradation. J. Vasc. Surg. 6 (1987), 578–582.
26. 26 Burton, A.C., Relation of structure to function of the tissues of the wall of blood vessels. Physiol. Rev. 34 (1954), 619–642.
27. 27 Murphy, G., Reynolds, J.J., Current views of collagen degeradation. Progress towards understanding the resorption of connective tissues. Bioessays 2 (1985), 55–60.
28. 28 Shimizu, K., et al. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 26 (2006), 987–994.
29. 29 Abdul-Hussien, H., et al. Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases. Am. J. Pathol. 170 (2007), 809–817.
30. 30 Klink, A., et al. In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging. J. Am. Coll. Cardiol. 58 (2011), 2522–2530.
31. 31 Birkedal-Hansen, H., Proteolytic remodeling of extracellular matrix. Curr. Opin. Cell Biol. 7 (1995), 728–735.
32. 32 Bazeli, R., et al. In vivo evaluation of a new magnetic resonance imaging contrast agent (P947) to target matrix metalloproteinases in expanding experimental abdominal aortic aneurysms. Invest. Radiol. 45 (2010), 662–668.
33. 33 Irizarry, E., et al. Demonstration of interstitial collagenase in abdominal aortic aneurysm disease. J. Surg. Res. 54 (1993), 571–574.
34. 34 Newman, K.M., et al. Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arterioscler. Thromb. 14 (1994), 1315–1320.
35. 35 Curci, J.A., et al. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102 (1998), 1900–1910.
36. 36 Mao, D., et al. Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. Biochem. Biophys. Res. Commun. 261 (1999), 904–910.
37. 37 Thompson, R.W., Parks, W.C., Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann. N. Y. Acad. Sci. 800 (1996), 157–174.
38. 38 Freestone, T., et al. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 15 (1995), 1145–1151.
39. 39 Knox, J.B., et al. Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases. Circulation 95 (1997), 205–212.
40. 40 Mills, C.D., M1 and M2 Macrophages: oracles of health and disease. Crit. Rev. Immunol. 32 (2012), 463–488.
41. 41 Dale, M.A., et al. Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization. J. Immunol. 196 (2016), 4536–4543.
42. 42 Hellenthal, F.A., et al. Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation. Nat. Rev. Cardiol. 6 (2009), 543–552.
43. 43 Thompson, R.W., et al. Production and localization of 92-kilodalton gelatinase in abdominal aortic-aneurysms – an elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J. Clin. Invest. 96 (1995), 318–326.
44. 44 Turner, G.H., et al. Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm. J. Magn. Reson. Imaging 30 (2009), 455–460.
45. 45 Richards, J.M., et al. Abdominal aortic aneurysm growth predicted by uptake of ultrasmall superparamagnetic particles of iron oxide: a pilot study. Circ. Cardiovasc. Imaging 4 (2011), 274–281.
46. 46 Sadat, U., et al. Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms – a feasibility study. Eur. J. Vasc. Endovasc. Surg. 41 (2011), 167–174.
47. 47 Nchimi, A., et al. MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans. Radiology 254 (2010), 973–981.
48. 48 McBride, O.M.B., et al. MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery – the MA(3)RS study. Open Heart, 2, 2015, e000190.
49. 49 Phelps, M.E., PET: the merging of biology and imaging into molecular imaging. J. Nucl. Med. 41 (2000), 661–681.
50. 50 Sakalihasan, N., et al. Contribution of PET scanning to the evaluation of abdominal aortic aneurysm. Semin. Vasc. Surg. 17 (2004), 144–153.
51. 51 Gambhir, S.S., Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer 2 (2002), 683–693.
52. 52 Amsallem, M., et al. Magnetic resonance imaging and positron emission tomography approaches to imaging vascular and cardiac inflammation. Circulation J. 80 (2016), 1269–1277.
53. 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model. Ann. Surg. 261 (2015), 395–404.
54. 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms. J. Vasc. Surg. 56 (2012), 765–773.
55. 55 Fu, Y., et al. Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation. Blood Cells Mol. Dis. 32 (2004), 182–190.
56. 56 Nahrendorf, M., et al. Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arterioscler. Thromb. Vasc. Biol. 31 (2011), 750–757.
57. 57 Brooks, P.C., et al. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264 (1994), 569–571.
58. 58 Tedesco, M.M., et al. Analysis of in situ and ex vivo vascular endothelial growth factor receptor expression during experimental aortic aneurysm progression. Arterioscler. Thromb. Vasc. Biol. 29 (2009), 1452–1457.
59. 59 Saraff, K., et al. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23 (2003), 1621–1626.
60. 60 Choke, E., et al. Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines. Arterioscler. Thromb. Vasc. Biol. 26 (2006), 2077–2082.
61. 61 Paik, D.C., et al. Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Exp. Mol. Med. 36 (2004), 524–533.
62. 62 Antonov, A.S., et al. Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. Am. J. Pathol. 165 (2004), 247–258.
63. 18F-labeled Arg-Gly-Asp positron-emission tomography. Circ. Cardiovasc. Imaging 6 (2013), 950–956.
64. 64 Golestani, R., Sadeghi, M.M., Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management. J. Nucl. Cardiol. 21 (2014), 251–267.
65. 65 Sakalihasan, N., et al. Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA). Eur. J. Vasc. Endovasc. Surg. 23 (2002), 431–436.
66. 18F-FDG aortic aneurysm uptake on PET/CT and future growth rate?. Eur. J. Nucl. Med. Mol. Imaging 38 (2011), 1493–1499.
67. 67 Palombo, D., et al. A positron emission tomography/computed tomography (PET/CT) evaluation of asymptomatic abdominal aortic aneurysms: another point of view. Ann. Vasc. Surg. 26 (2012), 491–499.
68. 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J. Vasc. Surg. 48 (2008), 417–423.
69. 18F-FDG uptake assessed by PET/CT in abdominal aortic aneurysms is associated with cellular and molecular alterations prefacing wall deterioration and rupture. J. Nucl. Med. 54 (2013), 1740–1747.
70. 70 Truijers, M., et al. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J. Endovasc. Ther. 15 (2008), 462–467.
71. 71 Kokje, V.B., et al. Pharmaceutical management of small abdominal aortic aneurysms: a systematic review of the clinical evidence. Eur. J. Vasc. Endovasc. Surg. 50 (2015), 702–713.
72. 72 Madsen, M.T., Recent advances in SPECT imaging. J. Nucl. Med. 48 (2007), 661–673.
73. 73 Peremans, K., et al. A review of small animal imaging planar and pinhole spect gamma camera imaging. Vet. Radiol. Ultrasound 46 (2005), 162–170.
74. 74 Ramaswamy, A.K., et al. Molecular imaging of experimental abdominal aortic aneurysms. ScientificWorldJournal, 2013, 2013, 973150.
75. 75 Golestani, R., et al. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circ. Cardiovasc. Imaging, 8, 2015, e002471.
76. 76 Razavian, M., et al. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J. Nucl. Med. 51 (2010), 1107–1115.
77. 77 Furie, B., Furie, B.C., Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol. Med. 10 (2004), 171–178.
78. 78 Hannawa, K.K., et al. Attenuation of experimental aortic aneurysm formation in P-selectin knockout mice. Ann. N. Y. Acad. Sci. 1085 (2006), 353–359.
79. 79 Bonnard, T., et al. Abdominal aortic aneurysms targeted by functionalized polysaccharide microparticles: a new tool for SPECT imaging. Theranostics 4 (2014), 592–603.