In vivo evaluation of a new magnetic resonance imaging contrast agent (P947) to target matrix metalloproteinases in expanding experimental abdominal aortic aneurysms

Investigative Radiology

Volumn 45, Issue 10, 2010, Pages 662-668

  Bazeli, Romain ^a   Coutard, Michèle ^b,c   Duport, Benjamin Daumas ^b,c   Lancelot, Eric ^d   Corot, Claire ^d   Laissy, Jean Pierre ^a,b,c   Letourneur, Didier ^b,c   Michel, Jean Baptiste ^b,c   Serfaty, Jean Michel ^a,b,c  

^a BICHAT HOSPITAL   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Laboratoire Guerbet   (France)

Author keywords

aneurysms; magnetic resonance imaging; matrix metalloproteinases; molecular probe

Indexed keywords

CONTRAST MEDIUM; ELASTASE; GADOTERIC ACID; MATRIX METALLOPROTEINASE; NEW DRUG; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; P 947; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME LOCALIZATION; FROZEN SECTION; HISTOLOGY; IN VIVO STUDY; MALE; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; ZYMOGRAPHY;

EID: 77957283443     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0b013e3181ee5bbf     Document Type: Article

References (33)

1. Sakalihasan N, Limet R, Defawe O. Abdominal aortic aneurysm. Lancet. 2005;365:1577-1589.
2. Vorp DA, Vande Geest JP. Biochemical determinants of abdominal aortic aneurysm rupture. Arterioscler Thromb Vasc Biol. 2005;25:1558-1566.
3. Limet R, Sakalihassan N, Albert A. Determination of the expansion rate and incidence of rupture of abdominal aortic aneurysms. J Vasc Surg. 1991;14: 540-548
4. Brown LC, Powell JT. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg. 1999;230:289-296.
5. Hanss SS, Jareunpoon O, Balasubramaniam M, et al. Size and location of thrombus in intact and ruptured abdominal aortic aneurysms. J Vasc Surg. 2005;41:584-588.
6. Powell JT, Brady AR. Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2004;24:241-245.
7. Ballard DJ, Fowkes FG, Powell JT. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev. 2000;2:CD001835.
8. Reed D, Reed C, Stemmermann G, et al. Are aortic aneurysms caused by atherosclerosis? Circulation. 1992;85:205-211.
9. Michel JB. Contrasting outcome of atheroma evolution. Intimal accumulation versus medial destruction Arterioscler Thromb Vasc Biol. 2001;21:1389-1392.
10. Tilson DM. Aortic aneurysms and atherosclerosis. Circulation. 1992;85:378-379.
11. Freestone T, Turner RJ, Coady A, et al. Inflammation and matrix metallo-proteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15:1145-1151.
12. MacSweeney ST, Powell JT, Greenhalgh RM. Pathogenesis of abdominal aortic aneurysm. Br J Surg. 1994;81:935-941.
13. Dobrin PB, Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc Surg. 1994;2:484-488.
14. Anidjar S, Salzmann JL, Gentric D, et al. Elastase-induced experimental aneurysms in rats. Circulation. 1990;82:973-981.
15. Halpern VJ, Nackman GB, Gandhi RH, et al. The elastase infusion model of experimental aortic aneurysms: synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response. J Vasc Surg. 1994;20:51-60.
16. Thompson RW, Parks WC. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci. 1996;800:157-174.
17. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol. 1995;7:728-735.
18. Sakalihasan N, Delvenne P, Nusgens BV, et al. Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. J Vasc Surg. 1996;24:127-133.
19. Pham W, Choi Y, Weissleder R, et al. Developing a peptide-based near-infrared molecular probe for protease sensing. Bioconjug Chem. 2004;15: 1403-1407.
20. Chen J, Tung CH, Allport JR, et al. Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation. 2005;111:1800-1805.
21. Deguchi J, Aikawa M, Tung C, et al. Inflammation in atherosclerosis. Visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006;114:55-62.
22. Lee S, Park K, Lee SY, et al. Dark quenched matrix metalloproteinase fluoregenic probe for imaging osteoarthritis development in vivo. Bioconjug Chem. 2008;19:1743-1747.
23. Faust A, Waschkau B, Waldeck J, et al. Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases. Bioconjug Chem. 2008;19:1001-1008.
24. Lancelot E, Amirbekian V, Brigger I, et al. Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach. Arterioscler Thromb Vasc Biol. 2008;28:425-432.
25. Amirbekian V, Aguinaldo JG, Amirbekian S, et al. Atherosclerosis and matrix metalloproteinases: experimental molecular MR imaging in vivo. Radiology. 2009;251:429-438.
26. Alsaid H, De Souza G, Bourdillon MC, et al. Biomimetic MRI contrast agent for imaging of inflammation in atherosclerotic plaque of ApoE\/\mice. Invest Radiol. 2009;44:151-158.
27. Coutard M, Osborne-Pellegrin M, Fontaine V, et al. High flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms. J Vasc Res. 2006;43:217-228.
28. Yu WH, Woessner JF. Heparin-enhanced zymographic detection of matrily-sin and collagenases. Anal Biochem. 2001;293:38-42.
29. Hyafil F, Cornily JC, Vucic E, et al. In vivo monitoring of matrix metallo-proteinase activity with P947-enhanced MRI in atherosclerotic plaques of hypercholesterolemic rabbits. Circulation. 2006;114:541-542.
30. Sarda-Mantel L, Coutard M, Rouzet F, et al. 99mTc-annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms. Arte-rioscler Thromb Vasc Biol. 2006;26:2153-2159.
31. Colonnello JS, Hance KA, Shames ML, et al. Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm. J Vasc Surg. 2003;38:138-146.
32. Wills A, Thompson MM, Crowther M, et al. Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of aneurysmal disease. J Vasc Surg. 1996;24:667-679.
33. Wilson WR, Schwalbe EC, Jones JL, et al. Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. Br J Surg. 2005;92:828-833.