메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Development of PD-1/PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small Cell Lung Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD274 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TUMOR MARKER;

EID: 84939456588     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13110     Document Type: Article
Times cited : (351)

References (70)
  • 2
    • 84875013121 scopus 로고    scopus 로고
    • Current adoptive immunotherapy in non-small cell lung cancer and potential influence of therapy outcome
    • Zheng, Y. W., Li, R. M., Zhang, X. W. & Ren, X. B. Current adoptive immunotherapy in non-small cell lung cancer and potential influence of therapy outcome. Cancer Invest. 31, 197-205 (2013).
    • (2013) Cancer Invest , vol.31 , pp. 197-205
    • Zheng, Y.W.1    Li, R.M.2    Zhang, X.W.3    Ren, X.B.4
  • 3
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjöblom, T. et al. The consensus coding sequences of human breast and colorectal cancers. J. Science. 314, 268-274 (2006).
    • (2006) J Science , vol.314 , pp. 268-274
    • Sjöblom, T.1
  • 4
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann, T. R. & Sad, S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today. 17, 138-46 (1996).
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 5
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. J. Nat Rev Cancer. 5, 263-274 (2005).
    • (2005) J Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 6
    • 49249089425 scopus 로고    scopus 로고
    • Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    • Fife, B. T. & Bluestone, J. A. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. J. Immunological reviews. 224, 166-182 (2008).
    • (2008) J Immunological Reviews , vol.224 , pp. 166-182
    • Fife, B.T.1    Bluestone, J.A.2
  • 7
    • 84886948036 scopus 로고    scopus 로고
    • B7 family checkpoint regulators in immune regulation and disease
    • Ceeraz, S., Nowak, E. C. & Noelle, R. J. B7 family checkpoint regulators in immune regulation and disease. J. Trends Immunol. 34, 556-563 (2013).
    • (2013) J Trends Immunol , vol.34 , pp. 556-563
    • Ceeraz, S.1    Nowak, E.C.2    Noelle, R.J.3
  • 8
    • 65349118810 scopus 로고    scopus 로고
    • PD-1 signaling in primary T cells
    • Riley, J. L. PD-1 signaling in primary T cells. J. Immunological reviews. 229, 114-125 (2009).
    • (2009) J Immunological Reviews , vol.229 , pp. 114-125
    • Riley . J, L.1
  • 10
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco, L. M. et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. J Exp Med. 206, 3015-3029 (2009).
    • (2009) J J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1
  • 11
    • 84891534246 scopus 로고    scopus 로고
    • Programmed death ligand-1 expression in non-small cell lung cancer
    • Velcheti, V. et al. Programmed death ligand-1 expression in non-small cell lung cancer. J. Laboratory Investigation. 94, 107-116 (2013).
    • (2013) J Laboratory Investigation , vol.94 , pp. 107-116
    • Velcheti, V.1
  • 12
    • 84875238628 scopus 로고    scopus 로고
    • Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung
    • Boland, J. M. et al. Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. J. Clin Lung Cancer. 14, 157-163 (2013).
    • (2013) J Clin Lung Cancer , vol.14 , pp. 157-163
    • Boland, J.M.1
  • 13
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. J. Sci Transl Med. 5 (200): 200ra116 (2013).
    • (2013) J Sci Transl Med , vol.5 , Issue.200 , pp. 200ra116
    • Spranger, S.1
  • 14
    • 27644562256 scopus 로고    scopus 로고
    • Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma
    • Thompson, R. H. et al. Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma. J. Cancer. 104, 2084-2091 (2005).
    • (2005) J Cancer , vol.104 , pp. 2084-2091
    • Thompson, R.H.1
  • 15
    • 84900499259 scopus 로고    scopus 로고
    • Radiation-induced modulation of costimulatory and coinhibitory T-Cell signaling molecules on human prostate carcinoma cells promotes productive antitumor immune interactions
    • Bernstein, M. B. et al. Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions. J. Cancer Biother Radio. 29, 153-161 (2014).
    • (2014) J Cancer Biother Radio , vol.29 , pp. 153-161
    • Bernstein, M.B.1
  • 16
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. J. Nature Medicine. 8, 793-800 (2002).
    • (2002) J Nature Medicine , vol.8 , pp. 793-800
    • Dong, H.1
  • 17
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube, J. M. et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. J. Sci Transl Med. 4, 127ra37 (2012).
    • (2012) J Sci Transl Med , vol.4 , pp. 127ra37
    • Taube, J.M.1
  • 18
    • 84874869077 scopus 로고    scopus 로고
    • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer
    • Sznol, M. & Chen, L. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. J. Clin Cancer Res. 19, 1021-1034 (2013).
    • (2013) J Clin Cancer Res , vol.19 , pp. 1021-1034
    • Sznol, M.1    Chen, L.2
  • 19
    • 77956527537 scopus 로고    scopus 로고
    • Interferon-γ and tumor necrosis factor-α induce an immunoinhibitory molecule, B7-H1, via nuclear factor-κ B activation in blasts in myelodysplastic syndromes
    • Kondo, A. et al. Interferon-γ and tumor necrosis factor-α induce an immunoinhibitory molecule, B7-H1, via nuclear factor-κ B activation in blasts in myelodysplastic syndromes. J. Blood. 116, 1124-1131 (2010).
    • (2010) J Blood , vol.116 , pp. 1124-1131
    • Kondo, A.1
  • 20
    • 58249112908 scopus 로고    scopus 로고
    • PI (3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
    • Crane, C. A. et al. PI (3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. J. Oncogene. 28, 306-312 (2008).
    • (2008) J Oncogene , vol.28 , pp. 306-312
    • Crane, C.A.1
  • 21
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa, A. T. et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. J. Nature Medicine. 13, 84-88 (2006).
    • (2006) J Nature Medicine , vol.13 , pp. 84-88
    • Parsa, A.T.1
  • 22
    • 63149085789 scopus 로고    scopus 로고
    • MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes
    • Gong, A. Y. et al. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes. J. J Immunol. 182, 1325-1333 (2009).
    • (2009) J J Immunol , vol.182 , pp. 1325-1333
    • Gong, A.Y.1
  • 23
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte, M. J., Keir, M. E., Phamduy, T. B., Sharpe, A. H. & Freeman, G. J. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. J. Immunity. 27, 111-122 (2007).
    • (2007) J Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 24
    • 78651107871 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and hepatocellular carcinoma: Molecular biology
    • Hiraoka, N. Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology. Int J Clin Oncol. 15, 544-551 (2010).
    • (2010) Int J Clin Oncol , vol.15 , pp. 544-551
    • Hiraoka, N.1
  • 25
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immuno-therapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immuno-therapy. Nat Rev Cancer. 12, 252-264 (2012).
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 26
    • 84880305809 scopus 로고    scopus 로고
    • Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity
    • Ramsay, A. G. Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity. Br J Haematol. 162, 313-325 (2013).
    • (2013) Br J Haematol , vol.162 , pp. 313-325
    • Ramsay, A.G.1
  • 27
    • 84961289417 scopus 로고    scopus 로고
    • PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment
    • Li, J. PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment. Cancer Res. 75(3), 508-518 (2015).
    • (2015) Cancer Res , vol.75 , Issue.3 , pp. 508-518
    • Li, J.1
  • 28
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel, T. J. et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. J. Nature Medicine. 9, 562-567 (2003).
    • (2003) J Nature Medicine , vol.9 , pp. 562-567
    • Curiel, T.J.1
  • 29
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin, D. M. The global health burden of infection-associated cancers in the year 2002. J. Int J Clin Oncol. 118, 3030-3044 (2006).
    • (2006) J Int J Clin Oncol , vol.118 , pp. 3030-3044
    • Parkin, D.M.1
  • 30
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infectionv
    • Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infectionv. J. Nature. 439, 682-687 (2005).
    • (2005) J Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 31
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • Duraiswamy, J., Freeman, G. J. & Coukos, G. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. J. Cancer Research. 73, 6900-6912 (2013).
    • (2013) J Cancer Research , vol.73 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 32
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco, L. M. et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. J Exp Med. 206, 3015-3029 (2009).
    • (2009) J J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1
  • 33
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3 signalosome and downstream signaling to PKCθ
    • Sheppard, K. A. et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3 signalosome and downstream signaling to PKCθ . J. FEBS Letters. 574, 37-41 (2004).
    • (2004) J FEBS Letters , vol.574 , pp. 37-41
    • Sheppard, K.A.1
  • 34
    • 84870945643 scopus 로고    scopus 로고
    • PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A
    • Patsoukis, N., Sari, D. & Boussiotis, V. A. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. J. Cell Cycle. 11, 4305-4309 (2012).
    • (2012) J Cell Cycle , vol.11 , pp. 4305-4309
    • Patsoukis, N.1    Sari, D.2    Boussiotis, V.A.3
  • 35
    • 84879125380 scopus 로고    scopus 로고
    • Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner
    • Charlton, J. J. et al. Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner. J. J Immunol. 190, 6104-6114 (2013).
    • (2013) J J Immunol , vol.190 , pp. 6104-6114
    • Charlton, J.J.1
  • 36
    • 80051619906 scopus 로고    scopus 로고
    • The programmed death-1 ligand 1: B7-1 pathway restrains diabetogenic effector T cells in vivo
    • Paterson, A. M. et al. The programmed death-1 ligand 1: B7-1 pathway restrains diabetogenic effector T cells in vivo. J. J Immunol. 187, 1097-1105 (2011).
    • (2011) J J Immunol , vol.187 , pp. 1097-1105
    • Paterson, A.M.1
  • 37
    • 84875936184 scopus 로고    scopus 로고
    • Harnessing the immune system for the treatment of non-small-cell lung cancer
    • Brahmer, J. R. Harnessing the immune system for the treatment of non-small-cell lung cancer. J. J Clin Oncol. 31, 1021-1028 (2013).
    • (2013) J J Clin Oncol , vol.31 , pp. 1021-1028
    • Brahmer, J.R.1
  • 38
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu, C. Y., Huang, J. A., Chen, Y., Chen, C. & Zhang, X. G. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. J. Med Oncol. 28, 682-688 (2011).
    • (2011) J Med Oncol , vol.28 , pp. 682-688
    • Mu, C.Y.1    Huang, J.A.2    Chen, Y.3    Chen, C.4    Zhang, X.G.5
  • 39
    • 84939446640 scopus 로고    scopus 로고
    • Abstract 8066. Presented at:2014 Annual Meeting of ASCO; May 30-June 30; Chicago IL USA
    • Sun J.-M. et al. Abstract 8066. Presented at:2014 Annual Meeting of ASCO; May 30-June 30; Chicago, IL, USA
    • Sun, J.-M.1
  • 40
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao, Q. et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. J. Clin Cancer Res. 15, 971-979 (2009).
    • (2009) J Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1
  • 41
    • 84897404380 scopus 로고    scopus 로고
    • Programmed cell death-ligand 1 expression in surgically resected stage i pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
    • Yang, C. Y., Lin, M. W., Chang, Y. L., Wu, C. T. & Yang, P. C. et al. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. J. Eur J Cancer. 50, 1361-1369 (2014).
    • (2014) J Eur J Cancer , vol.50 , pp. 1361-1369
    • Yang, C.Y.1    Lin, M.W.2    Chang, Y.L.3    Wu, C.T.4    Yang, P.C.5
  • 42
    • 84939429347 scopus 로고    scopus 로고
    • PD-1 gene promoter polymorphisms correlate with a poor prognosis in non-small cell lung cancer
    • Sasaki, H., Tatemaysu, T. & Okuda, K. et al. PD-1 gene promoter polymorphisms correlate with a poor prognosis in non-small cell lung cancer. J. J Cancer Res Clin. 2 (6), 1035-1042 (2014).
    • (2014) J. J Cancer Res Clin , vol.2 , Issue.6 , pp. 1035-1042
    • Sasaki, H.1    Tatemaysu, T.2    Okuda, K.3
  • 43
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer
    • Azuma, K. et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer. J. Ann Oncol, mdu242 (2014).
    • (2014) J Ann Oncol, Mdu , vol.242
    • Azuma, K.1
  • 44
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer
    • Garon, E. B. et al. Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer. J. N Engl J Med. 372, 2018-2028 (2015).
    • (2015) J. N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1
  • 45
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. J. N Engl J Med. 366, 2443-2454 (2012).
    • (2012) J. N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 46
    • 84937544139 scopus 로고    scopus 로고
    • Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients with nonsmall cell lung cancer (NSCLC) treated with nivolumab (Anti-PD-1; BMS-936558; ONO-4538
    • Antonia, S. J. et al. Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients with nonsmall cell lung cancer (NSCLC) treated with nivolumab (Anti-PD-1; BMS-936558; ONO-4538). J Thorac Oncol. 8, S907-S908 (2013).
    • (2013) J Thorac Oncol , vol.8 , pp. S907-S908
    • Antonia, S.J.1
  • 47
    • 84920655625 scopus 로고    scopus 로고
    • PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
    • D'Incecco, A. et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. J. Br J Cancer. 112, 95-102 (2015).
    • (2015) J Br J Cancer , vol.112 , pp. 95-102
    • D'Incecco, A.1
  • 48
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumorinfiltrating CD8± T lymphocytes in human non-small cell lung cancer
    • Zhang, Y., Huang, S., Gong, D., Qin, Y. & Shen, Q. Programmed death-1 upregulation is correlated with dysfunction of tumorinfiltrating CD8± T lymphocytes in human non-small cell lung cancer. J. Cellular & Molecular Immunology. 7, 389-395 (2010).
    • (2010) J Cellular & Molecular Immunology , vol.7 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3    Qin, Y.4    Shen, Q.5
  • 49
    • 84904654996 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with non-small cell lung cancer (NSCLC): Overall survival and long-term safety in a phase 1 trial
    • Brahmer, J. R. et al. Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with non-small cell lung cancer (NSCLC): overall survival and long-term safety in a phase 1 trial. J. J Thorac Oncol. 8, S365-S366 (2013).
    • (2013) J J Thorac Oncol , vol.8 , pp. S365-S366
    • Brahmer, J.R.1
  • 50
    • 84904659431 scopus 로고    scopus 로고
    • Preliminary clinical safety and activity of MK-3475 monotherapy for the treatment of previously treated patients with non-small cell lung cancer (NSCLC)
    • Garon, E. et al. Preliminary clinical safety and activity of MK-3475 monotherapy for the treatment of previously treated patients with non-small cell lung cancer (NSCLC). J. J Thorac Oncol. 8, S364-S365 (2013).
    • (2013) J J Thorac Oncol , vol.8 , pp. S364-S365
    • Garon, E.1
  • 51
    • 84922471654 scopus 로고    scopus 로고
    • Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies
    • Philips, G. K. & Atkins, M. Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies. J. Int Immunol. 27, 39-46 (2014).
    • (2014) J Int Immunol , vol.27 , pp. 39-46
    • Philips, G.K.1    Atkins, M.2
  • 52
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. J. N Engl J Med. 366, 2455-2465 (2012).
    • (2012) J N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 53
    • 84887262315 scopus 로고    scopus 로고
    • A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • Herbst, R. S. et al. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J. J Clin Oncol. 31(No 15suppl):3000 (2013).
    • (2013) J J Clin Oncol , vol.31 , Issue.15 , pp. 3000
    • Herbst, R.S.1
  • 54
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • Spigel, D. R. et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). J. J Clin Oncol. 31, 3622 (2013).
    • (2013) J J Clin Oncol , vol.31 , pp. 3622
    • Spigel, D.R.1
  • 55
    • 84880746773 scopus 로고    scopus 로고
    • Biomarkers and associations with the clinical activity of PD-L1 blockade in a MPDL3280A study
    • Powderly, J. D. et al. Biomarkers and associations with the clinical activity of PD-L1 blockade in a MPDL3280A study. J. J Clin Oncol. 31, 3001 (2013).
    • (2013) J J Clin Oncol , vol.31 , pp. 3001
    • Powderly, J.D.1
  • 56
    • 84890893426 scopus 로고    scopus 로고
    • MEDI4736, an anti-PD-L1 antibody with modified Fc domain: Preclinical evaluation and early clinical results from a phase i study in patients with advanced solid tumors
    • Khleif, S. et al. MEDI4736, an anti-PD-L1 antibody with modified Fc domain: preclinical evaluation and early clinical results from a phase I study in patients with advanced solid tumors. J. Eur J Cancer. 49, S161 (2013).
    • (2013) J Eur J Cancer , vol.49 , pp. S161
    • Khleif, S.1
  • 57
    • 84907532904 scopus 로고    scopus 로고
    • A phase 1 study of MEDI4736 an anti-PD-L1 antibody in patients with advanced solid tumors
    • Lutzky, J., Antonia, S. J. & Blake-Haskins, A. et al. A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors. J. J Clin Oncol. 32, 3001 (2014).
    • (2014) J J Clin Oncol , vol.32 , pp. 3001
    • Lutzky, J.1    Antonia, S.J.2    Blake-Haskins, A.3
  • 58
    • 84907651084 scopus 로고    scopus 로고
    • Clinical activity and biomarkers of MEDI4736 an anti-PD-L1 antibody in patients with NSCLC
    • Brahmer, J. R., Rizvi, N. A. & Lutzky. J. et al. Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. J Clin Oncol. 32, 8021 (2014).
    • (2014) J Clin Oncol , vol.32 , pp. 8021
    • Brahmer, J.R.1    Rizvi, N.A.2    Lutzky, J.3
  • 59
    • 84865416551 scopus 로고    scopus 로고
    • B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets
    • Mkrtichyan, M. et al. B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets. J. The Journal of Immunology. 189, 2338-2347 (2012).
    • (2012) J the Journal of Immunology , vol.189 , pp. 2338-2347
    • Mkrtichyan, M.1
  • 60
    • 84887262780 scopus 로고    scopus 로고
    • AMP-224, a fusion protein that targets PD-1
    • Smothers, F. J. AMP-224, a fusion protein that targets PD-1. J. Ann Oncol. 24, i7 (2013).
    • (2013) J Ann Oncol , vol.24 , pp. i7
    • Smothers, F.J.1
  • 61
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng, L. F. et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J. J Clin Invest. 124, 687-695 (2014).
    • (2014) J J Clin Invest , vol.124 , pp. 687-695
    • Deng, L.F.1
  • 62
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman, M. & Dranoff, G. Combining immunotherapy and targeted therapies in cancer treatment. J. Nature Reviews Cancer. 12, 237-251 (2012).
    • (2012) J Nature Reviews Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 63
    • 84904055758 scopus 로고    scopus 로고
    • Immune cell-poor melanomas benefit from PD-1 Blockade after Targeted Type i IFN Activation
    • Bald, T. et al. Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation. J. Cancer Discovery. 4, 674-687 (2014).
    • (2014) J Cancer Discovery , vol.4 , pp. 674-687
    • Bald, T.1
  • 64
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558 ONO-4538) and ipilimumab in first-line NSCLC: Interim phase i results
    • Antonia, S. J., Gettinger, S. N. & Chow, L. Q. M. et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. J. J Clin Oncol. 32, 5s (2014).
    • (2014) J J Clin Oncol , vol.32 , pp. 5s
    • Antonia, S.J.1    Gettinger, S.N.2    Chow, L.Q.M.3
  • 65
    • 84937630627 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
    • Antonia, S. J. et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J. International Journal of Radiation Oncology Biology Physics. 90, S2 (2014).
    • (2014) J International Journal of Radiation Oncology Biology Physics , vol.90 , pp. S2
    • Antonia, S.J.1
  • 66
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
    • Duraiswamy, J., Kaluza, K. M., Freeman, G. J. & Coukos, G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. J. Cancer Research. 73, 3591-3603 (2013).
    • (2013) J Cancer Research , vol.73 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3    Coukos, G.4
  • 67
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice with Intracranial Gliomas
    • Zeng, J. Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas. Int J Radiat Oncol Biol Phys 86 (2), 343-349 (2013).
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , Issue.2 , pp. 343-349
    • Zeng, J.1
  • 69
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by Concurrent PD-L1 Blockade
    • Simon, J. D. et al. Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade. Cancer Research Oct 74, 5458 (2014).
    • (2014) Cancer Research Oct , vol.74 , pp. 5458
    • Simon, J.D.1
  • 70
    • 84984919880 scopus 로고    scopus 로고
    • PD-L1 expression in nonclear-cell renal cell carcinoma
    • Choueiri, T. K. et al. PD-L1 expression in nonclear-cell renal cell carcinoma. J. Ann Oncol. 25, 2178-2184 (2014).
    • (2014) J Ann Oncol , vol.25 , pp. 2178-2184
    • Choueiri, T.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.