MiRNA-30e mediated cardioprotection of ACE2 in rats with Doxorubicin-induced heart failure through inhibiting cardiomyocytes autophagy

Life Sciences

Volumn 169, Issue , 2017, Pages 69-75

  Lai, Lei ^a   Chen, Junzhu ^a   Wang, Ningfu ^a   Zhu, Gangjie ^a   Duan, Xu ^a   Ling, Feng ^a  

^a HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Autophagy; Beclin 1; Caspase 3; LC3 II I; rhACE2

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; BECLIN 1; CASPASE 3; DOXORUBICIN; LC3 I PROTEIN; LC3 II PROTEIN; MICRORNA; MICRORNA 30A; MICRORNA 30C; MICRORNA 30E; PROTEIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CARDIOTONIC AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; MIRN30 MICRORNA, RAT; RECOMBINANT PROTEIN;

3' UNTRANSLATED REGION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; CONTROLLED STUDY; DOWN REGULATION; DOXORUBICIN INDUCED HEART FAILURE; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HEART FAILURE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; MALE; NONHUMAN; PLASMID; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VECTOR CONTROL; WESTERN BLOTTING; ANIMAL; CARDIOMYOPATHIES; CELL CULTURE; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; AUTOPHAGY; BECLIN-1; CARDIOMYOPATHIES; CARDIOTONIC AGENTS; CELL LINE; CELLS, CULTURED; DOXORUBICIN; GENE EXPRESSION REGULATION; HUMANS; MALE; MICRORNAS; MYOCYTES, CARDIAC; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 85008893170     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2016.09.006     Document Type: Article

References (26)

1. [1] Mitry, M.A., Edwards, J.G., Doxorubicin induced heart failure: phenotype and molecular mechanisms. Int. J. Cardiol. Heart Vasc. 10 (2016), 17–24.
2. [2] Song, B., Zhang, Z.Z., Zhong, J.C., Yu, X.Y., Oudit, G.Y., Jin, H.Y., Lu, L., Xu, Y.L., Kassiri, Z., Shen, W.F., et al. Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway. Circ. J. 77:12 (2013), 2997–3006.
3. [3] Johnson, J.A., West, J., Maynard, K.B., Hemnes, A.R., ACE2 improves right ventricular function in a pressure overload model. PLoS One, 6(6), 2011, e20828.
4. [4] Zhong, J., Basu, R., Guo, D., Chow, F.L., Byrns, S., Schuster, M., Loibner, H., Wang, X.H., Penninger, J.M., Kassiri, Z., et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation 122:7 (2010), 717–728 (718 p following 728).
5. [5] Keidar, S., Kaplan, M., Gamliel-Lazarovich, A., ACE2 of the heart: from angiotensin I to angiotensin (1–7). Cardiovasc. Res. 73:3 (2007), 463–469.
6. [6] Lu, L., Wu, W., Yan, J., Li, X., Yu, H., Yu, X., Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. Int. J. Cardiol. 134:1 (2009), 82–90.
7. [7] Li, Z., Wang, J., Yang, X., Functions of autophagy in pathological cardiac hypertrophy. Int. J. Biol. Sci. 11:6 (2015), 672–678.
8. [8] Schneider, M., Ackermann, K., Stuart, M., Wex, C., Protzer, U., Schatzl, H.M., Gilch, S., Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. J. Virol. 86:18 (2012), 10112–10122.
9. [9] Nandi, S.S., Duryee, M.J., Shahshahan, H.R., Thiele, G.M., Anderson, D.R., Mishra, P.K., Induction of autophagy markers is associated with attenuation of miR-133a in diabetic heart failure patients undergoing mechanical unloading. Am. J. Transl. Res. 7:4 (2015), 683–696.
10. [10] Duygu, B., de Windt, L.J., da Costa Martins, P.A., Targeting microRNAs in heart failure. Trends Cardiovasc. Med., 2015.
11. [11] Chen, M., Ma, G., Yue, Y., Wei, Y., Li, Q., Tong, Z., Zhang, L., Miao, G., Zhang, J., Downregulation of the miR-30 family microRNAs contributes to endoplasmic reticulum stress in cardiac muscle and vascular smooth muscle cells. Int. J. Cardiol. 173:1 (2014), 65–73.
12. [12] Duisters, R.F., Tijsen, A.J., Schroen, B., Leenders, J.J., Lentink, V., van der Made, I., Herias, V., van Leeuwen, R.E., Schellings, M.W., Barenbrug, P., et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ. Res. 104:2 (2009), 170–178 (176p following 178).
13. [13] Pan, W., Zhong, Y., Cheng, C., Liu, B., Wang, L., Li, A., Xiong, L., Liu, S., MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One, 8(1), 2013, e53950.
14. [14] Louch, W.E., Sheehan, K.A., Wolska, B.M., Methods in cardiomyocyte isolation, culture, and gene transfer. J. Mol. Cell. Cardiol. 51:3 (2011), 288–298.
15. [15] Dong, B., Zhang, C., Feng, J.B., Zhao, Y.X., Li, S.Y., Yang, Y.P., Dong, Q.L., Deng, B.P., Zhu, L., Yu, Q.T., et al. Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 28:7 (2008), 1270–1276.
16. [16] Barth, S., Glick, D., Macleod, K.F., Autophagy: assays and artifacts. J. Pathol. 221:2 (2010), 117–124.
17. [17] Yang, C., Pan, Y., Fluorouracil induces autophagy-related gastric carcinoma cell death through Beclin-1 upregulation by miR-30 suppression. Tumour Biol., 2015.
18. [18] Jia, N., Dong, P., Huang, Q., Jin, W., Zhang, J., Dai, Q., Liu, S., Cardioprotective effects of granulocyte colony-stimulating factor in angiotensin II-induced cardiac remodelling. Clin. Exp. Pharmacol. Physiol. 36:3 (2009), 262–266.
19. [19] Parajuli, N., Ramprasath, T., Patel, V.B., Wang, W., Putko, B., Mori, J., Oudit, G.Y., Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases. Can. J. Physiol. Pharmacol. 92:7 (2014), 558–565.
20. [20] Liang, B., Li, Y., Han, Z., Xue, J., Zhang, Y., Jia, S., Wang, C., ACE2-Ang (1–7) axis is induced in pressure overloaded rat model. Int. J. Clin. Exp. Pathol. 8:2 (2015), 1443–1450.
21. [21] Zhao, Y.X., Yin, H.Q., Yu, Q.T., Qiao, Y., Dai, H.Y., Zhang, M.X., Zhang, L., Liu, Y.F., Wang, L.C., Liu de, S., et al. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Hum. Gene Ther. 21:11 (2010), 1545–1554.
22. [22] Zhou, T., Wang, Z., Fan, J., Chen, S., Tan, Z., Yang, H., Yin, Y., Angiotensin-converting enzyme-2 overexpression improves atrial remodeling and function in a canine model of atrial fibrillation. J. Am. Heart Assoc., 4(3), 2015, e001530.
23. [23] Govender, J., Loos, B., Marais, E., Engelbrecht, A.M., Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J. Pineal Res. 57:4 (2014), 367–380.
24. [24] Kawaguchi, T., Takemura, G., Kanamori, H., Takeyama, T., Watanabe, T., Morishita, K., Ogino, A., Tsujimoto, A., Goto, K., Maruyama, R., et al. Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes. Cardiovasc. Res. 96:3 (2012), 456–465.
25. [25] Smuder, A.J., Kavazis, A.N., Min, K., Powers, S.K., Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals. J. Appl. Physiol. 115:2 (2013), 176–185.
26. [26] Lin, H., Li, H.F., Chen, H.H., Lai, P.F., Juan, S.H., Chen, J.J., Cheng, C.F., Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway. Mol. Pharmacol. 85:5 (2014), 682–691.