Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro

Phytomedicine

Volumn 19, Issue 1, 2011, Pages 32-37

  Keller, Amy C ^a   Ma, Jun ^b   Kavalier, Adam ^a   He, Kan ^c   Brillantes, Anne Marie B ^d   Kennelly, Edward J ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Naturex Inc   (United States)

^d ARMGO Pharma Inc   (United States)

Author keywords

Alternative medicine; Bitter melon; Diabetes; Hypoglycemia; Insulin secretion; Momordica charantia

Indexed keywords

3 HYDROXYCUCURBITA 5,24 DIEN 19 AL 7,23 DI O BETA GLUCOPYRANOSIDE; 3BETA,7BETA,25 TRIHYDROXYCUCURBITA 5,23 DIEN 19 AL; ALCOHOL; ANTIDIABETIC AGENT; DIMETHYL SULFOXIDE; GLIPIZIDE; GLUCOSE; KUGUAGLYCOSIDE G; MOMORDICA CHARANTIA EXTRACT; MOMORDICINE I; MOMORDICINE II; SAPONIN; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA; LIQUID CHROMATOGRAPHY; MOMORDICA CHARANTIA; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; BLOOD GLUCOSE; CELL LINE; FRUIT; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MICE; MOMORDICA CHARANTIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; SAPONINS; SEEDS;

CUCUMIS; CUCURBITACEAE; MOMORDICA CHARANTIA;

EID: 82755189591     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.06.019     Document Type: Article

References (29)

1. R. Allen, L.F. Cushman, S. Morris, J. Feldman, C. Wade, D. McMahon, M. Moses, and F. Kronenberg Use of complementary and alternative medicine among Dominican emergency department patients Am. J. Emerg. Med. 18 2000 51 54 (Pubitemid 30073196)
2. P.M. Barnes, B. Bloom, and R.L. Nahin Complementary and alternative medicine use among adults and children: United States 2007. N. C. f. C. a. A. Medicine 2008 National Institutes of Health Washington, DC
3. P.M. Barnes, E. Powell-Griner, K. McFann, and R.L. Nahin Complementary and alternative medicine use among adults: United States, 2002 Semin. Int. Med. 2 2002 54 71
4. E. Basch, S. Gabardi, and C. Ulbricht Bitter melon (Momordica charantia): a review of efficacy and safety Am. J. Health. Syst. Pharm. 60 2003 356 359 (Pubitemid 36749034)
5. Centers for Disease Control and Prevention, 2010. National Diabetes Fact Sheet, 2007. Available from: http://www.cdc.gov/diabetes/pubs/pdf/ndfs-2007.pdf (retrieved April, 2010).
6. L. Egede, X. Ye, D. Zheng, and M.D. Silverstein The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes Diabetes Care 25 2002 324 329 (Pubitemid 41079630)
7. G. Francis, Z. Kerem, H.P.S. Makker, and K. Becker The biological action of saponins in animal systems: a review Br. J. Nutr. 88 2002 587 605 (Pubitemid 36082888)
8. C. Gauthier, J. Legault, K. Girard-Lalancette, V. Mshvildadze, and A. Pichette Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane- type saponins Bioorg. Med. Chem. 17 2009 2002 2008
9. L. Harinantenaina, M. Tanaka, S. Takaoka, M. Oda, O. Mogami, M. Uchida, and Y. Asakawa Momordica charantia constituents and antidiabetic screening of the isolated major compounds Chem. Pharm. Bull. 54 2006 1017 1021
10. K. Hostettmann, and A. Marston Chemistry and Pharmacology of Natural Products: Saponins 1995 Cambridge University Press Cambridge 233-283
11. H. Ishihara, T. Asano, K. Tsukuda, H. Katagiri, K. Inukai, M. Anai, M. Kikuchi, Y. Yazaki, J.-I. Miyazaki, and Y. Oka Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets Diabetologia 36 1993 1139 1145 (Pubitemid 23314564)
12. J. Ma, P. Whittaker, A.C. Keller, E.P. Mazzola, R.S. Pawar, K.D. White, J.H. Callahan, E.J. Kennelly, A.J. Krynitsky, and J.I. Rader Cucurbitane-type triterpenoids from Momordica charantia Planta Med. 76 2010 1758 1761
13. R.J. Marles, and N.R. Farnsworth Antidiabetic plants and their active constituents Phytomedicine 2 1995 137 189
14. M. Miro Cucurbitacins and their pharmacological effects Phyto. Res. 9 1995 159 168
15. T. Miura, C. Itoh, N. Iwamoto, M. Kato, M. Kawai, S.R. Park, and I. Suzuki Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice J. Nutr. Sci. Vitaminol. 47 2001 340 344 (Pubitemid 33139560)
16. T. Miura, Y. Itoh, N. Iwamoto, M. Kato, and T. Ishida Suppressive activity of the fruit of Momordica charantia with exercise on blood glucose in type 2 diabetic mice Biol. Pharm. Bull. 27 2004 248 250 (Pubitemid 41694711)
17. P.V. Nerurkar, Y.K. Lee, M. Motosue, K. Adeli, and V.R. Nerurkar Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions Br. J. Nutr. 100 2008 751 759
18. Y. Oishi, T. Sakamoto, H. Udagawa, H. Taniguchi, K. Kobayashi-Hattori, Y. Ozawa, and T. Takita Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction Biosci. Biotechnol. Biochem. 71 2007 735 740 (Pubitemid 46481449)
19. W. Oleszek, M. Junkuszew, and A. Stochmal Determination and toxicity of saponins from Amaranthus cruentus seeds J. Agric. Food Chem. 47 1999 3685 3687 (Pubitemid 29449489)
20. S.J. Persaud, H. Al-Majed, A. Raman, and P.M. Jones Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability J. Endocrinol. 163 1999 207 212
21. I. Podolak, A. Galanty, and D. Sobolewska Saponins as cytotoxic agents: a review Phytochem. Rev. 9 2010 425 474
22. C.C. Shih, C.H. Lin, and W.L. Lin Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet Diabetes Res. Clin. Pract. 81 2008 134 143
23. C. Talchai, H.V. Lin, T. Kitamura, and D. Accili Genetic and biochemical pathways of β-cell failure in type 2 diabetes Diabetes Obes. Metab. 11 2009 38 45
24. M.J. Tan, J.M. Ye, N. Turner, C. Hohnen-Behrens, C.-Q. Ke, C.-P. Tang, T. Chen, H.-C. Weiss, E.-R. Gesing, A. Rowland, and D.E.Y.Y. James Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway Chem. Biol. 15 2008 263 273 (Pubitemid 351381992)
25. W. Wang, Y. Zhao, E.R. Rayburn, D.L. Hill, H. Wang, and R. Zhang In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng Cancer Chemother. Pharmacol. 59 2007 589 601 (Pubitemid 46295123)
26. World Health Organization, 2010. Diabetes Programme. Available from: http://www.who.int/diabetes/en/ (retrieved April, 2010).
27. L. Xiang, X. Huang, L. Chen, P. Rao, and L. Ke The reparative effects of Momordica charantia Linn. extract on HIT-T15 pancreatic β-cells Asia Pac. J. Clin. Nutr. 16 2007 249 252 (Pubitemid 46524609)
28. Q.F. Xu, X.L. Fang, and D.F. Chen Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats J. Ethnopharmacol. 84 2003 187 192 (Pubitemid 36324258)
29. C.-S. Yang, S.-R. Ko, B.-G. Cho, D.-M. Shin, J.-M. Yuk, S. Li, J.-M. Kim, R.M. Evans, J.-S. Jung, D.-K. Song, and E.-K. Jo The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock J. Cell. Mol. Mech. 12 2008 1739 1753