Mixed model of repeated measures versus slope models in alzheimer's disease clinical trials

Journal of Nutrition, Health and Aging

Volumn 16, Issue 4, 2012, Pages 360-364

  Donohue, M C ^a,b   Aisen, P S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Clinical trials efficiency; Missing data; Mixed effects models; Mixed model of repeated measures (MMRM); Quantitative review

Indexed keywords

ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; DONEPEZIL; PREDNISONE; SIMVASTATIN; VITAMIN B GROUP;

ALZHEIMER DISEASE; ANALYTIC METHOD; ARTICLE; CLINICAL TRIAL (TOPIC); HYBRID MODEL; INTERMETHOD COMPARISON; LINEAR TIME EFFECT MODEL; MIXED MODEL OF REPEATED MEASURE; PRIORITY JOURNAL; QUADRATIC TIME EFFECT MODEL; QUANTITATIVE ANALYSIS;

EID: 84863469055     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-012-0047-7     Document Type: Article

References (16)

1. Molenberghs, G and Kenward, MG. Missing data in clinical studies. Wiley, Chichester, 2007.
2. Mallinckrodt, Ch, Sanger, TM, Dubé, S, DeBrota, DJ, Molenberghs, G, and Carroll, RJ. Assessing and interpreting treatment effects in longitudinal clinical trials with missing data. Biological Psychiatry, 53(8), 754-60., 53, 8 (2003), 754-60.
3. Mallinckrodt, Ch, Clark, WS, and David, SR. Accounting for dropout bias using mixed-effects models. Journal of Biopharmaceutical Statistics, 11 (2001), 1-2.
4. Laird, N.M and Ware, J.H. Random-effects Models for Longitudinal Data. Biometrics, 38 (1982), 963-974. (Pubitemid 14272804)
5. Mallinckrodt, Ch, Clark, WS, and David, SR. Type i error rates from mixe d effects model repeated measures versus fixed effects AnoVA with missing values imputed via Last observation Carried Forward. Drug information J, 35 (2001), 1215-25. (Pubitemid 34563415)
6. Siddiqui, O., hung, M.J., and Oneill, R. MMRM vs. LoCF: A comprehensive comparison based on simulation study and 25 nDA datasets. Journal ofBiopharmaceutical Statistics, 19 (2009), 227-246.
7. Lin, h, Scharfstein, D.O., and Rosenheck, R.A. Analysis of longitudinal data with irregular, informative follow-up. Journal of the Royal Statistical Society, Series B, 66 (2004), 791-813. (Pubitemid 39015913)
8. Kittelson, JM, Sharples, K, and emerson, SS. Group sequential clinical trials for longitudinal data with analyses using summary statistics. Statistics in Medicine, 24, 16 (2005), 2457-75. (Pubitemid 41093925)
9. Jones, RH. Longitudinal data with serial correlation: A state-space approach. Chapman & hall, London; new York, 1993.
10. Pinheiro, JC and Bates, DM. Mixed-effects models in S and S-PLuS.. Springer, new York, 2000.
11. Akaike, Hirotugu. A new look at the statistical model identification. Ieee Transactions on Automatic Control, 19, 6 (1974), 716-723.
12. Aisen, PS, Stokes, KT, Thomas, RG, Thal, LJ, Jin, S, Schneider, LS, and al, et. Highdose B vitamin supplementation and cognitive decline in alzheimer disease: Arandomized controlled trial. Journal of the American Medical Association, 300, 15 (2008), 1774-83.
13. Petersen, R.C., Thomas, R.G., Grundman, M. et al. Vitamin e and donepezil for the treatment of mild cognitive impairment. The new england Journal of Medicine, 352, 23 (2005), 2379-88. (Pubitemid 40958434)
14. Aisen, PS, Davis, KL, Berg, JD et al. A randomized controlled trial of prednisone in Alzheimer's disease. neurology, 54, 3 (2000), 588-93. (Pubitemid 30082922)
15. Sano, M, Bell, KL, Galasko, D, Galvin, Je, Thomas, RG, van Dyck, Ch, and al, et. A randomized; double-blind; placebo-controlled trial of simvastatin to treat Alzheimer disease. neurology, 77, 6 (2011), 556-63.
16. Quinn, JF, Shinto, L, Raman, R, Thomas, RG, emond, J, Aisen, PS, and al, et. Docosahexaenoic acid supplementation and cognitive decline in alzheimer disease: A randomized trial. Journal of the American Medical Association, 304, 17 (2010), 1903-11.