Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients

Clinical Nutrition ESPEN

Volumn 17, Issue , 2017, Pages 100-104

  Kawai, Keisuke ^a,b   Nakashima, Megumi ^b   Kojima, Masayasu ^c   Yamashita, Sakino ^b   Takakura, Shu ^b   Shimizu, Miki ^b   Kubo, Chiharu ^d   Sudo, Nobuyuki ^b  

^a 1 7 1 Kohnodai   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KURUME UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Activation; Anorexia nervosa; Ghrelin; Medium chain triglycerides; Neuropeptide Y

Indexed keywords

ELECTROLYTE; GHRELIN; GROWTH HORMONE; LEPTIN; MEDIUM CHAIN TRIACYLGLYCEROL; NEUROPEPTIDE Y; SOMATOMEDIN; BIOLOGICAL MARKER; GHRL PROTEIN, HUMAN; TRIACYLGLYCEROL;

ADULT; ANOREXIA NERVOSA; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY TEMPERATURE; BODY WEIGHT; BONE DENSITY; CACHEXIA; CALORIE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; DUAL ENERGY X RAY ABSORPTIOMETRY; EDEMA; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART RATE; HORMONE ACTION; HOSPITALIZATION; HUMAN; IMMUNORADIOMETRIC ASSAY; LENGTH OF STAY; ADOLESCENT; BLOOD; BODY WEIGHT GAIN; COMPARATIVE STUDY; ENTERIC FEEDING; FEMALE; JAPAN; NUTRITIONAL ASSESSMENT; PATHOPHYSIOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR; TREATMENT OUTCOME; UPREGULATION; YOUNG ADULT;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; BIOMARKERS; BODY COMPOSITION; ENTERAL NUTRITION; FEMALE; GHRELIN; HUMANS; JAPAN; NEUROPEPTIDE Y; NUTRITION ASSESSMENT; TIME FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES; UP-REGULATION; WEIGHT GAIN; YOUNG ADULT;

EID: 85008660995     PISSN: 24054577     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnesp.2016.10.001     Document Type: Article

References (19)

1. [1] Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999), 656–660.
2. [2] Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., et al. A role for ghrelin in the central regulation of feeding. Nature 409 (2001), 194–198.
3. [3] Tesauro, M., Schinzari, F., Caramanti, M., Lauro, R., Cardillo, C., Metabolic and cardiovascular effects of ghrelin. Int J Pept 2010 (2010), 1–7.
4. [4] Strassburg, S., Anker, S.D., Castaneda, T.R., Burget, L., Perez-Tilve, D., Pfluger, P.T., et al. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab 295 (2008), E78–E84.
5. [5] Kohno, D., Gao, H.Z., Muroya, S., Kikuyama, S., Yada, T., Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52 (2003), 948–956.
6. [6] Nedvídková, J., Krykorková, I., Barták, V., Papezová, H., Gold, P.W., Alesci, S., et al. Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. J Clin Endocrinol Metab 88 (2003), 1678–1682.
7. [7] Kawai, K., Yamanaka, T., Yamashita, S., Gondo, M., Morita, C., Arimura, C., et al. Somatic and psychological factors related to the body mass index of patients with anorexia nervosa. Eat Weight Disord 13 (2008), 198–204.
8. [8] Hotta, M., Ohwada, R., Akamizu, T., Shibasaki, T., Takano, K., Kangawa, K., Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. Endocr J 56 (2009), 1119–1128.
9. [9] Fukumori, R., Sugino, T., Shingu, H., Moriya, N., Kobayashi, H., Hasegawa, Y., et al. Ingestion of medium chain fatty acids by lactating dairy cows increases concentrations of plasma ghrelin. Domest Anim Endocrinol 45 (2013), 216–223.
10. [10] Nishi, Y., Hiejima, H., Hosoda, H., Kaiya, H., Mori, K., Fukue, Y., et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 146 (2005), 2255–2264.
11. [11] First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W., Structured clinical interview for axis I disorder DSM-VI patient edition (SCID-I/P). 1995, NYSPI, Biometric Research Department, New York.
12. [12] Amemiya, N., Takii, M., Hata, T., Morita, C., Takakura, S., Urabe, H., et al. The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit. Eat Weight Disord 17 (2012), e1–8.
13. [13] Goulet, O., Postaire, M., De Potter, S., Boya, I., Jouniaux, A.M., Bereziat, G., et al. Medium-chain triglycerides and long-term parenteral nutrition in children. Nutrition 8 (1992), 333–337.
14. [14] Fujitsuka, N., Asakawa, A., Uezono, Y., Minami, K., Yamaguchi, T., Niijima, A., et al. Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. Transl Psychiatry, 1, 2011, e23.
15. [15] Nagaya, N., Kojima, M., Uematsu, M., Yamagishi, M., Hosoda, H., Oya, H., et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol 280 (2001), R1483–R1487.
16. [16] Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., et al. Ghrelin directly regulates bone formation. J Bone Min Res 20 (2005), 790–798.
17. [17] Miljic, D., Pekic, S., Djurovic, M., Doknic, M., Milic, N., Casanueva, F.F., et al. Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa. J Clin Endocrinol Metab 91 (2006), 1491–1495.
18. [18] Matsumura, T., Arai, M., Yonemitsu, Y., Maruoka, D., Tanaka, T., Suzuki, T., et al. The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice. J Gastroenterol 45 (2010), 300–307.
19. [19] Takeda, H., Sadakane, C., Hattori, T., Katsurada, T., Ohkawara, T., Nagai, K., et al. Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 134 (2008), 2004–2013.