Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: A pilot study

Endocrine Journal

Volumn 56, Issue 9, 2009, Pages 1119-1128

  Hotta, Mari ^a,b   Ohwada, Rina ^b   Akamizu, Takashi ^c   Shibasaki, Tamotsu ^d   Takano, Kazue ^b   Kangawa, Kenji ^e  

^a NATIONAL GRADUATE INSTITUTE FOR POLICY STUDIES   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NIPPON MEDICAL SCHOOL   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Anorexia nervosa; Food intake; Ghrelin; Hunger

Indexed keywords

GHRELIN; PROTEIN; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; APPETITE; ARTICLE; BODY MASS; CALORIC INTAKE; CLINICAL ARTICLE; CONSTIPATION; DRUG DOSE REDUCTION; DRUG EFFICACY; EPIGASTRIC DISCOMFORT; FEMALE; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; HUMAN; HUNGER; JAPANESE; LOOSE FECES; NUTRITIONAL PARAMETERS; PILOT STUDY; PROTEIN BLOOD LEVEL; SIDE EFFECT; SOMNOLENCE; SWEATING; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; UNPLEASANT SENSATION; VISUAL ANALOG SCALE; WARM SENSATION;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANOREXIA NERVOSA; APPETITE STIMULANTS; BODY MASS INDEX; CONSTIPATION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIET; ENERGY INTAKE; FEMALE; GHRELIN; HUMANS; HUNGER; INFUSIONS, INTRAVENOUS; JAPAN; NUTRITIONAL STATUS; PILOT PROJECTS; WEIGHT GAIN; YOUNG ADULT;

EID: 74749100265     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K09E-168     Document Type: Article

References (34)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
2. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M (2000) Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 275: 477-480.
3. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K (2001) Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86: 4753-4758.
4. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I (2002) Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest. 109: 1429-1436.
5. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992-5995.
6. Akamizu T, Takaya K, Irako T, Hosoda H, Teramukai S, Matsuyama A, Tada H, Miura K, Shimizu A, Fukushima M, Yokode M, Tanaka K, Kangawa K (2004) Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol 150: 447-455.
7. Druce MR, Wren AM, Park AJ, Milton JE, Patterson M, Frost G, Ghatei MA, Small C, Bloom SR (2005) Ghrelin increases food intake in obese as well as lean subjects. Int J Obes (Lond) 29: 1130-1136.
8. Nagaya N, Moriya J, Yasumura Y, Uematsu M, Ono F, Shimizu W, Ueno K, Kitakaze M, Miyatake K, Kangawa K (2004) Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 110: 3674-3679.
9. Nagaya N, Itoh T, Murakami S, Oya H, Uematsu M, Miyatake K, Kangawa K. (2005) Treatment of cachexia with ghrelin in patients with COPD. Chest 128: 1187-1193.
10. Neary NM, Small CJ, Wren AM, Lee JL, Druce MR, Palmieri C, Frost GS, Ghatei MA, Coombes RC, Bloom SR (2004) Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 89: 2832-2836.
11. Akamizu T, Iwakura H, Ariyasu H, Hosoda H, Murayama T, Yokode M, Teramukai S, Seno H, Chiba T, Noma S, Nakai Y, Fukunaga M, Nakai Y, Kangawa K, FD Clinical Study Team (2008) Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite. Eur J Endocrinol 158: 481-498.
12. Haller E (1992) Eating disorders. A review and update. West J Med 157: 658-662.
13. Crisp AH (1985) Gastrointestinal disturbance in anorexia nervosa. Postgrad Med J 61: 3-5.
14. Abell TL, Malagelada JR, Lucas AR, Brown ML, Camilleri M, Go VL, Azpiroz F, Callaway CW, Kao PC, Zinsmeister AR (1987) Gastric electromechanical and neurohormonal function in anorexia nervosa. Gastroenterology 93: 958-965.
15. Domstad PA, Shih WJ , Humphries L, Deland FH, Digenis GA (1987) Radionuclide gastric emptying studies in patients with anorexia nervosa. J Nucl Med 28: 816-819.
16. th ed. Washington D.C. American Psychiatric Association 1992.
17. Hotta M, Fukuda I, Sato K, Hizuka N, Shibasaki T, Takano K (2000) The relationship between bone turn-over and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa. J Clin Endocrinol Metab 85: 200-206.
18. Parker BA, Sturm K, MacIntosh CG, Feinle C, Horowitz M, Chapman IM (2004) Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur J Clin Nutr 58: 212-218.
19. Zung W W (1965) A self-rating depression scale. Arch Gen Psychiatry 12: 63-70.
20. Iwata N, Mishima N, Shimizu T, Mizoue T, Fukuhara M, Hidano T, Spielberger C (1998) The Japanese adaptation of the STAI Form Y in Japanese working adults - the presence or absence of anxiety. Indust Heal 36: 8-13.
21. Garner DM, Garfinkel PE (1979) The eating attitude test: an index of symptoms of anorexia nervosa. Psychol Med 9: 273-279.
22. Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N, Takano K (2004) Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa J Clin Endocrinol Metab 89: 5707-5712.
23. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K (2000) Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276: 905-908.
24. Edholm T, Levin F, Hellstrom PM & Schmidt PT (2004) Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 121: 25-30.
25. Levin F, Edholm T, Ehrström M, Wallin B, Schmidt PT, Kirchgessner AM, Hilsted LM, Hellström PM, Näslund E (2005) Effect of peripherally administrated ghrelin on gastric emptying and acid secretion in the rat. Regul Pept 131: 59-65.
26. Levin F, Edholm T, Schmidt PT, Grybäck P, Jacobsson H, Degerblad M, Höybye C, Holst JJ, Rehfeld JF, Hellström PM, Näslund E (2006) Ghrelin stimulates gastric emptying and hunger in normal-weight humans. J Clin Endocrinol Metab 91: 3296-3302.
27. Murray CD, Martin NM, Patterson M, Taylor SA, Ghatei MA, Kamm MA, Johnston C, Bloom SR, Emmanuel AV (2005) Ghrelin enhances gastric emptying in diabetic gastroparesis: a double-blind, placebo-controlled, cross-over study. Gut 54: 1693-1698.
28. Binn M, Albert C, Gougeon A, Maerki H, Coulie B, Lemoyne M, Rabasa Lhoret R, Tomasetto C, Poitras P (2006) Ghrelin gastrokinetic action in patients with neurogenic gastroparesis. Peptides 27: 1603-1606.
29. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T (2005) Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. Gut 55: 327-333.
30. Strasser F, Lutz TA , Maeder MT, Thuerlimann B, Bueche D, Tschöp M, Kaufmann K, Holst B, Brändle M, von Moos R, Demmer R, Cerny T (2008) Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study. Br J Cancer 98: 300-308.
31. Sepple CP, Read NW (1989) Gastrointestinal correlates of the development of hunger in man. Appetite 13: 183-191.
32. Yücel B, Ozbey N, Polat A, Yager J (2005) Weight fluctuations during early refeeding period in anorexia nervosa: case reports. Int J Eat Disord 37: 175-177.
33. Miljic D, Pekic S, Djurovic M, Doknic M, Milic N, Casanueva FF, Ghatei M, Popovic V (2006) Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa. J Clin Endocrinol Metab 91: 1491-1495.
34. Broglio F, Gianotti L, Destefanis S, Fassino S, Abbate Daga G, Mondelli V, Lanfranco F, Gottero C, Gauna C, Hofland L, Van der Lely AJ, Ghigo E (2004) The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol (Oxf) 60: 592-599.