An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Clinical Gastroenterology and Hepatology

Volumn 15, Issue 4, 2017, Pages 555-562.e3

  Roberts, Dean W ^a,b,c   Lee, William M ^d   Hinson, Jack A ^a,b   Bai, Shasha ^a,c   Swearingen, Christopher J ^a,c   Stravitz, R Todd ^e   Reuben, Adrian ^f   Letzig, Lynda ^a,c   Simpson, Pippa M ^g   Rule, Jody ^d   Fontana, Robert J ^h   Ganger, Daniel ⁱ   Reddy, K Rajender ^j   Liou, Iris ^k   Fix, Oren ^l   James, Laura P ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Acetaminophen Toxicity Diagnostics LLC   (United States)

^c ARKANSAS CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^g Children's Hospital of Wisconsin   (United States)

^h UNIVERSITY OF MICHIGAN   (United States)

ⁱ NORTHWESTERN UNIVERSITY   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k UNIVERSITY OF WASHINGTON   (United States)

^l UNIVERSITY OF CALIFORNIA   (United States)

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Author keywords

AcetaSTAT; Hepatitis; Hepatotoxicity; Metabolism

Indexed keywords

ACETAMINOPHEN PROTEIN ADDUCT; PARACETAMOL; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; PROTEIN;

ACUTE LIVER FAILURE; ADULT; AGED; ANALYTICAL EQUIPMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE REGISTRY; DRUG BLOOD LEVEL; EARLY DIAGNOSIS; ELECTROCHEMICAL DETECTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; INTERMETHOD COMPARISON; LATERAL FLOW IMMUNOCHROMATOGRAPHIC ASSAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; POINT OF CARE TESTING; PREDICTIVE VALUE; PROTEIN ANALYSIS; SENSITIVITY AND SPECIFICITY; TOXIC HEPATITIS; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; ELECTROCHEMICAL ANALYSIS; EVALUATION STUDY; LIVER; MIDDLE AGED; PATHOPHYSIOLOGY; POINT OF CARE SYSTEM; PROCEDURES; SERUM; YOUNG ADULT;

ACETAMINOPHEN; ADULT; AGED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMICAL TECHNIQUES; FEMALE; HUMANS; IMMUNOASSAY; LIVER; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; POINT-OF-CARE SYSTEMS; PREDICTIVE VALUE OF TESTS; PROTEINS; SENSITIVITY AND SPECIFICITY; SERUM; YOUNG ADULT;

EID: 85008625538     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2016.09.007     Document Type: Article

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