Expression of Hippo signaling molecules in gastric carcinogenesis

World Chinese Journal of Digestology

Volumn 20, Issue 31, 2012, Pages 3027-3032

  Wei, Wen Chao ^a   Zhang, Cui Ping ^a   Zhang, Qi ^a   Wang, Xiao Wei ^a   Zhang, Hong Zhu ^a   Zhao, Kun ^a   Tian, Zi Bin ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Gastric cancer; Gastric carcinogenesis; Hippo pathway; Oncogene; Tumor suppressor gene

Indexed keywords

LATS1 PROTEIN; MST1 PROTEIN; PEPTIDES AND PROTEINS; TRANSCRIPTION FACTOR YAP1; UNCLASSIFIED DRUG;

ARTICLE; ATROPHIC GASTRITIS; CONTROLLED STUDY; DYSPLASIA; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CARCINOGENESIS; STOMACH MUCOSA; TUMOR DIFFERENTIATION;

EID: 85008420267     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Chinese Source.
2. Chinese Source.
3. Chinese Source.
4. Jarosz M, Sekula W, Rychlik E, Figurska K. Impact of diet on long-term decline in gastric cancer incidence in Poland. World J Gastroenterol 2011; 17: 89-97
5. Chinese Source.
6. Michael Stock, Florian Otto. Gene deregulation in gastric cancer. Gene 2005; 360: 1-19.
7. Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ. size and cancer. Curr Opin Cell Biol 2008; 20: 638-646
8. Guo AT, Song X, Wei LX, Zhao P. Histological origin of pseudomyxoma peritonei in Chinese women: clinicopathology and immunohistochemistry. World J Gastroenterol 2011; 17: 3531-3537
9. Zeng Q, Hong W.The emerging role of the hippo pathway in cell contact inhibition,organ size control,and cancer development in mammals. Cancer Cell 2008; 13: 188-192
10. Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol 2009; 21: 837-843
11. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21: 2747-2761
12. Morinaka A, Funato Y, Uesugi K, Miki H. Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis. Oncogene 2011; 30: 4208-4218
13. Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J 2004; 381: 453-462
14. Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A 2012; 109: 13632-13637
15. Lin Y, Khokhlatchev A, Figeys D, Avruch J. Death associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem 2002; 277: 47991-48001
16. Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003; 114: 457-467
17. Avruch J, Zhou D, Fitamant J, Bardeesy N. Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer 2011; 104: 24-32
18. Cinar B, Collak FK, Lopez D, Akgul S, Mukhopadhyay NK, Kilicarslan M, Gioeli DG, Freeman MR. MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling. Cancer Res 2011; 71: 4303-4313
19. Callus BA, Verhagen AM, Vaux DL. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J 2006; 273: 4264-4276
20. Visser-Grieve S, Zhou Z, She YM, Huang H, Cyr TD, Xu T, Yang X. LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization. Cell Res 2011; 21: 1513-1516
21. Xu ZP, Zhu JS, Zhang Q, Wang XY. A breakdown of the Hippo pathway in gastric cancer. Hepatogastroenterology 2011; 58: 1611-1617.
22. Chinese Source.
23. Lam-Himlin DM, Daniels JA, Gayyed MF, Dong J, Maitra A, Pan D, Montqomery EA, Anders RA. The hippo pathway in human upper gastrointestinal dysplasia and carcinoma:a novel oncogenic pathway. Int J Gastrointest Cancer 2006; 37: 103-109