A breakdown of the hippo pathway in gastric cancer

Hepato-Gastroenterology

Volumn 58, Issue 110-111, 2011, Pages 1611-1617

  Xu, Zhi Peng ^a   Zhu, Jin Shui ^a   Zhang, Qiang ^a   Wang, Xiao Ying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Gastric cancer; Hippo pathway

Indexed keywords

LARGE TUMOR SUPPRESSOR 1 PROTEIN; LARGE TUMOR SUPPRESSOR 2 PROTEIN; SALVADOR HOMOLOGY 1 PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADENOMA; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH EPITHELIUM; STOMACH MUCOSA;

EID: 83355163502     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge10669     Document Type: Article

References (37)

1. Croce CM: Oncogenes and cancer. N Engl J Med 2008; 358:502-511.
2. Harvey KF, Pfleger CM, Hariharan IK: The drosophila mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003; 114:457-467. (Pubitemid 37100994)
3. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD: Delineation of a fat tumor suppressor pathway. Nat Genet 2006; 38:1142-1150. (Pubitemid 44470359)
4. Huang J, Wu S, Barrera J, Matthews K, Pan D: The hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating yorkie, the drosophila homolog of yap. Cell 2005; 122:421-434. (Pubitemid 41127143)
5. Udan RS, Kango-Singh M, Nolo R, Tao C, Haider G: Hippo promotes proliferation arrest and apoptosis in the salvador/warts pathway. Nat Cell Biol 2003; 5:914-920. (Pubitemid 37220698)
6. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Haider G, Lai ZC, Guan KL: Inactivation of yap oncoprotein by the hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21:2747-2761. (Pubitemid 350070721)
7. Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y: A ww domain-containing yes-associated protein (yap) is a novel transcriptional co-activator. Embo J 1999; 18:2551-2562. (Pubitemid 29213286)
8. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA: Transforming properties of yap, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006; 103:12405-12410. (Pubitemid 44267272)
9. Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML: Tead/tef transcription factors utilize the activation domain of yap65, a src/yes-associated protein localized in the cytoplasm. Genes Dev 2001; 15:1229-1241. (Pubitemid 32472752)
10. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J: The tead/tef family of transcription factor scalloped mediates hippo signaling in organ size control. Dev Cell 2008; 14:377-387.
11. Basu S, Totty NF, Irwin MS, Sudol M, Downward J: Akt phosphorylates the yes-associated protein, yap, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 2003; 11:11-23. (Pubitemid 36126587)
12. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL: A coordinated phosphorylation by lats and ck1 regulates yap stability through scf (beta-trcp). Genes Dev 2010; 24:72-85.
13. Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell GW, Jaenisch R, Brummelkamp TR: Yap1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007; 17:2054-2060. (Pubitemid 350180465)
14. Zhao B, Kim J, Ye X, Lai ZC, Guan KL: Both tead-binding and ww domains are required for the growth stimulation and oncogenic transformation activity of yesassociated protein. Cancer Res 2009; 69:1089-1098.
15. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 2010; 107:1437-1442.
16. Harvey K, Tapon N: The salvador-warts-hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer 2007; 7:182-191.
17. Dan I, Watanabe NM, Kusumi A: The ste20 group kinases as regulators of map kinase cascades. Trends Cell Biol 2001; 11:220-230. (Pubitemid 32367879)
18. Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS: Crucial role for mst1 and mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 2009; 29:6309-6320.
19. Kim D, Shu S, Coppola MD, Kaneko S, Yuan ZQ, Cheng JQ: Regulation of proapoptotic mammalian ste20-like kinase mst2 by the igf1-akt pathway. PLoS One 2010; 5:e9616.
20. Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y: Mammalian mst1 and mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 2010; 107:1431-1436.
21. Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N: Mst1 and mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the yap1 oncogene. Cancer Cell 2009; 16:425-438.
22. Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S: Mst, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem 2001; 276:19276-19285.
23. Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J: Regulation of the mstl kinase by autophosphorylation, by the growth inhibitory proteins, rassf1 and nore1, and by ras. Biochem J 2004; 381:453-462. (Pubitemid 38969690)
24. Densham RM, O'Neill E, Munro J, Konig I, Anderson K, Kolch W, Olson MF: Mst kinases monitor actin cytoskeletal integrity and signal via c-jun n-terminal kinase stress-activated kinase to regulate p21waf1/cip1 stability. Mol Cell Biol 2009; 29:6380-6390.
25. Kilili GK, Kyriakis JM: Mammalian ste20-like kinase (mst2) indirectly supports raf-1/erk pathway activity via maintenance of protein phosphatase-2a catalytic subunit levels and consequent suppression of inhibitory raf-1 phosphorylation. J Biol Chem 2010; 285:15076-15087.
26. Callus BA, Verhagen AM, Vaux DL: Association of mammalian sterile twenty kinases, mst1 and mst2, with hsalvador via c-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J 2006; 273:4264-4276. (Pubitemid 44326506)
27. Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, Leng Y, Gardner K, Judge SI, Li QQ, Hu J, Gong J: The human ww45 protein enhances mst1-mediated apoptosis in vivo. Int J Mol Med 2009; 23:357-362.
28. Lee KP, Lee JH, Kim TS, Kim TH, Park HD, Byun JS, Kim MC, Jeong WI, Calvisi DF, Kim JM, Lim DS: The hippo-salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci USA 2010; 107:8248-8253.
29. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK: Salvador promotes both cell cycle exit and apoptosis in drosophila and is mutated in human cancer cell lines. Cell 2002; 110:467-478.
30. Yoo NJ, Soung YH, Lee JW, Park WS, Kim SY, Nam SW, Han JH, Kim SH, Lee JY, Lee SH: Mutational analysis of Salvador gene in human carcinomas. Apmis 2003; 111:595-598. (Pubitemid 37130029)
31. Yang X, Li DM, Chen W, Xu T: Human homologue of drosophila lats, lats1, negatively regulate growth by inducing g(2)/m arrest or apoptosis. Oncogene 2001; 20:6516-6523. (Pubitemid 32980276)
32. Li Y, Pei J, Xia H, Ke H, Wang H, Tao W: Lats2, a putative tumor suppressor, inhibits g1/s transition. Oncogene 2003; 22:4398-4405. (Pubitemid 36897970)
33. Visser S, Yang X: Identification of lats transcriptional targets in hela cells using whole human genome oligonucleotide microarray. Gene 2010; 449:22-29.
34. St JM, Tao W, Fei X, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu T: Mice deficient of lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet 1999; 21:182-186. (Pubitemid 29070363)
35. Tao W, Zhang S, Turenchalk GS, Stewart RA, St JM, Chen W, Xu T: Human homologue of the drosophila melanogaster lats tumour suppressor modulates cdc2 activity. Nat Genet 1999; 21:177-181. (Pubitemid 29070362)
36. McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R: Lats2/kpm is required for embryonic development, proliferation control and genomic integrity. Embo J 2004; 23:3677-3688. (Pubitemid 39336289)
37. Oka T, Mazack V, Sudol M: Mst2 and lats kinases regulate apoptotic function of yes kinase-associated protein (yap). J Biol Chem 2008; 283:27534-27546.