Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders

Molecular Cell

Volumn 64, Issue 6, 2016, Pages 1023-1034

  Quesnel Vallières, Mathieu ^a,b   Dargaei, Zahra ^c   Irimia, Manuel ^d,e   Gonatopoulos Pournatzis, Thomas ^a   Ip, Joanna Y ^f   Wu, Mingkun ^a   Sterne Weiler, Timothy ^a   Nakagawa, Shinichi ^f   Woodin, Melanie A ^c   Blencowe, Benjamin J ^a   Cordes, Sabine P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d BARCELONA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Spain)

^e UNIVERSITAT POMPEU FABRA   (Spain)

^f RIKEN   (Japan)

Author keywords

alternative splicing; autism spectrum disorder; microexons; neuronal activity; nSR100 SRRM4

Indexed keywords

BRAIN PROTEIN; NSR100 PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN; NSR100 PROTEIN, MOUSE; SRRM4 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTISM; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE REGULATORY NETWORK; HAPLOINSUFFICIENCY; HETEROZYGOSITY; MOLECULAR PATHOLOGY; MOUSE; MUTANT MOUSE STRAIN; NERVE CELL DIFFERENTIATION; NERVE CELL EXCITABILITY; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; SYNAPSE; SYNAPTIC TRANSMISSION; ANIMAL; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; EXON; GENE EXPRESSION; GENETICS; HUMAN; MALE; MAMMALIAN EMBRYO; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; STARTLE REFLEX;

ALTERNATIVE SPLICING; ANIMALS; AUTISM SPECTRUM DISORDER; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EXONS; FEMALE; GENE EXPRESSION; HAPLOINSUFFICIENCY; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONS; REFLEX, STARTLE; SYNAPTIC TRANSMISSION;

EID: 85008190858     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.11.033     Document Type: Article

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