Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Brain, Behavior, and Immunity

Volumn 61, Issue , 2017, Pages 306-316

  Dempsey, C ^a   Rubio Araiz, A ^a   Bryson, K J ^a   Finucane, O ^a   Larkin, C ^a   Mills, E L ^a   Robertson, A A B ^b   Cooper, M A ^b   O'Neill, L A J ^a   Lynch, M A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alzheimer's disease; APP PS1 mice; Caspase 1; Inflammasome; Interleukin 1 ; Microglia; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MCC 950; MESSENGER RNA; PRESENILIN 1; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; MCC-950; SULFONE;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COGNITION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PYROPTOSIS; ANIMAL; DRUG EFFECT; GENETICS; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; COGNITION; DISEASE MODELS, ANIMAL; HETEROCYCLIC COMPOUNDS, 4 OR MORE RINGS; INFLAMMASOMES; MICE; MICROGLIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PRESENILIN-1; SULFONES;

EID: 85008181949     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2016.12.014     Document Type: Article

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