Blood-Based Analysis of Circulating Cell-Free DNA and Tumor Cells for Early Cancer Detection

PLoS Medicine

Volumn 13, Issue 12, 2016, Pages

  Pantel, Klaus ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CHLOROPLAST DNA; CIRCULATING CELL FREE DNA; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; K RAS PROTEIN; MERLIN; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; UNCLASSIFIED DRUG; TUMOR MARKER;

ARTICLE; BLOOD ANALYSIS; CANCER DIAGNOSIS; CANCER RISK; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIRCULATING TUMOR CELL; EPITHELIUM CELL; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; INFLAMMATORY BOWEL DISEASE; LEUKEMIA; LUNG CANCER; RNA DEGRADATION; RNA SEQUENCE; SMOKING; TUMOR CELL; BLOOD; CELL FREE SYSTEM; EARLY CANCER DIAGNOSIS; MUTATION; NEOPLASMS; PROCEDURES;

BIOMARKERS, TUMOR; CELL-FREE SYSTEM; DNA, NEOPLASM; EARLY DETECTION OF CANCER; HUMANS; MUTATION; NEOPLASMS;

EID: 85007574101     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002205     Document Type: Article

References (30)

1. Alix-Panabieres C, Pantel K, Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy. Cancer Discov. 2016;6(5):479–91. doi: 10.1158/2159-8290.CD-15-148326969689
2. Schwarzenbach H, Hoon DS, Pantel K, Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011;11(6):426–37. Epub 2011/05/13. doi: 10.1038/nrc306621562580
3. Diehl F, Schmidt K, Choti MA, Romans K, Goodman S, Li M, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008;14(9):985–90. doi: 10.1038/nm.178918670422
4. Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014;6(224):224ra24. Epub 2014/02/21. doi: 10.1126/scitranslmed.300709424553385
5. Newman AM, Bratman SV, To J, Wynne JF, Eclov NC, Modlin LA, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20(5):548–54. doi: 10.1038/nm.351924705333
6. Newman AM, Lovejoy AF, Klass DM, Kurtz DM, Chabon JJ, Scherer F, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nat Biotechnol. 2016;34(5):547–55. doi: 10.1038/nbt.352027018799
7. Babayan A, Alawi M, Gormley M, Muller V, Wikman H, McMullin RP, et al. Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells. Oncotarget. 2016.
8. Schwarzenbach H, Nishida N, Calin GA, Pantel K, Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. 2014;11(3):145–56. doi: 10.1038/nrclinonc.2014.524492836
9. Best MG, Sol N, Kooi I, Tannous J, Westerman BA, Rustenburg F, et al. RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell. 2015;28(5):666–76. doi: 10.1016/j.ccell.2015.09.01826525104
10. Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015;523(7559):177–82. doi: 10.1038/nature1458126106858
11. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527(7578):329–35. doi: 10.1038/nature1575626524530
12. Fernandez-Cuesta L, Perdomo S, Avogbe PH, Leblay N, Delhomme TM, Gaborieau V, et al. Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer. EBioMedicine. 2016;10:117–23. doi: 10.1016/j.ebiom.2016.06.03227377626
13. George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, et al. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015;524(7563):47–53. doi: 10.1038/nature1466426168399
14. Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, et al. Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues. Proc Natl Acad Sci U S A. 2016;113(21):6005–10. doi: 10.1073/pnas.160131111327152024
15. Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371(26):2477–87. doi: 10.1056/NEJMoa140940525426838
16. Kato S, Lippman SM, Flaherty KT, Kurzrock R, The Conundrum of Genetic "Drivers" in Benign Conditions. J Natl Cancer Inst. 2016;108(8).
17. Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33(1):19–20. doi: 10.1038/ng105412447372
18. Hafner C, van Oers JM, Hartmann A, Landthaler M, Stoehr R, Blaszyk H, et al. High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol. 2006;126(11):2404–7. doi: 10.1038/sj.jid.570042216778799
19. Alix-Panabieres C, Pantel K, Challenges in circulating tumour cell research. Nat Rev Cancer. 2014;14(9):623–31. doi: 10.1038/nrc382025154812
20. Rack B, Schindlbeck C, Juckstock J, Andergassen U, Hepp P, Zwingers T, et al. Circulating tumor cells predict survival in early average-to-high risk breast cancer patients. J Natl Cancer Inst. 2014;106(5).
21. Ilie M, Hofman V, Long-Mira E, Selva E, Vignaud JM, Padovani B, et al. "Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease. PLoS ONE. 2014;9(10):e111597. doi: 10.1371/journal.pone.011159725360587
22. Tie J, Wang Y, Tomasetti C, Li L, Springer S, Kinde I, et al. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci Transl Med. 2016;8(346):346ra92. doi: 10.1126/scitranslmed.aaf621927384348
23. Jordan NV, Bardia A, Wittner BS, Benes C, Ligorio M, Zheng Y, et al. HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature. 2016;537(7618):102–6. doi: 10.1038/nature1932827556950
24. Pantel K, Deneve E, Nocca D, Coffy A, Vendrell JP, Maudelonde T, et al. Circulating epithelial cells in patients with benign colon diseases. Clin Chem. 2012;58(5):936–40. Epub 2011/12/30. doi: 10.1373/clinchem.2011.17557022205690
25. Baccelli I, Schneeweiss A, Riethdorf S, Stenzinger A, Schillert A, Vogel V, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol. 2013;31(6):539–44. doi: 10.1038/nbt.257623609047
26. Hodgkinson CL, Morrow CJ, Li Y, Metcalf RL, Rothwell DG, Trapani F, et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nat Med. 2014;20(8):897–903. doi: 10.1038/nm.360024880617
27. Cayrefourcq L, Mazard T, Joosse S, Solassol J, Ramos J, Assenat E, et al. Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res. 2015;75(5):892–901. doi: 10.1158/0008-5472.CAN-14-261325592149
28. Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat Med. 2015;21(7):827.
29. Bidard FC, Fehm T, Ignatiadis M, Smerage JB, Alix-Panabieres C, Janni W, et al. Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials. Cancer Metastasis Rev. 2013;32(1–2):179–88. doi: 10.1007/s10555-012-9398-023129208
30. Gorges TM, Kuske A, Rock K, Mauermann O, Muller V, Peine S, et al. Accession of Tumor Heterogeneity by Multiplex Transcriptome Profiling of Single Circulating Tumor Cells. Clin Chem. 2016; 62(11):1504–15. doi: 10.1373/clinchem.2016.26029927630154