NOX2-ROS-HIF-1α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation

Biomedicine and Pharmacotherapy

Volumn 85, Issue , 2017, Pages 733-739

  Guo, Yongfeng ^a   Han, Bing ^a   Luo, Kongliang ^a   Ren, Zhijian ^a   Cai, Lei ^b   Sun, Li ^b  

^a The Ninth Hospital of Xi'an City   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HIF 1 ; NOX2; Oleanolic acid; Proliferation; Rectal cancer

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OLEANOLIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; CYBB PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HEMATOCRIT; HT-29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RECTUM CANCER; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RECTAL NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OLEANOLIC ACID; REACTIVE OXYGEN SPECIES; RECTAL NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 85007536657     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.11.091     Document Type: Article

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