Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells

Oncotarget

Volumn 7, Issue 51, 2016, Pages 84093-84117

  Zhou, Fuling ^a,b   Li, Ming ^a   Wei, Yongchang ^a,b   Lin, Kevin ^c   Lu, Yue ^c   Shen, Jianjun ^c   Johanning, Gary L ^a   Wang Johanning, Feng ^a  

^a SRI INTERNATIONAL   (United States)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Breast cancer; HERV K; Ras signaling; ShRNA; Tumorigenesis and metastasis

Indexed keywords

CYCLIN DEPENDENT KINASE 5; HUMAN ENDOGENOUS RETROVIRUS TYPE K VIRUS ENVELOPE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MYC PROTEIN; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIRAL PROTEIN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; NP9 PROTEIN, HERV-K, HUMAN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER CELL LINE; BREAST CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA SEQUENCE; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; ANIMAL; BREAST TUMOR; CARCINOGENESIS; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MCF-7 CELL LINE; METASTASIS; NONOBESE DIABETIC MOUSE; PATHOLOGY; RNA INTERFERENCE; RNAI THERAPEUTICS; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARCINOGENESIS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE PRODUCTS, ENV; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MCF-7 CELLS; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NEOPLASM METASTASIS; RNA INTERFERENCE; RNAI THERAPEUTICS; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85007490443     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11455     Document Type: Article

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