Human endogenous retroviral K element encodes fusogenic activity in melanoma cells

Journal of Carcinogenesis

Volumn 12, Issue , 2013, Pages

  Huang, Gengming ^a   Li, Zhongwu ^b,c   Wan, Xiaohua ^b,c   Wang, Yue ^d   Dong, Jianli ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c PEKING UNIVERSITY   (China)

^d Center for Medical Genetics   (United States)

Author keywords

Cell fusion; K type human endogenous retroviral deoxyribonucleic acid; melanoma

Indexed keywords

HUMAN ENDOGENOUS RETROVIRAL K ELEMENT; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CANCER GENETICS; CELL CLONE; CELL FUSION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EVOLUTION; GENE EXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MELANOMA CELL; MULTINUCLEAR CELL; RNA INTERFERENCE;

EID: 84888047460     PISSN: 09746773     EISSN: 14773163     Source Type: Journal    
DOI: 10.4103/1477-3163.109032     Document Type: Article

References (43)

1. Eggermont AM, Robert C. New drugs in melanoma: It′s a whole new world. Eur J Cancer 2011;47:2150-7.
2. Flaherty KT. Next generation therapies change the landscape in melanoma. F1000 Med Rep 2011;3:8.
3. Li J, Xu M, Yang Z, Li A, Dong J. Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. Cancer Invest 2010;28:350-6.
4. Zhao Y, Zhang Y, Yang Z, Li A, Dong J. Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis. Biochem Biophys Res Commun 2008;370:509-13.
5. Li Z, Sheng T, Wan X, Liu T, Wu H, Dong J. Expression of HERV-K correlates with status of MEK-ERK and p16INK4A-CDK4 pathways in melanoma cells. Cancer Invest 2010;28:1031-7.
6. de Parseval N, Heidmann T. Human endogenous retroviruses: From infectious elements to human genes. Cytogenet Genome Res 2005;110:318-32. (Pubitemid 41159909)
7. Kurth R, Bannert N. Beneficial and detrimental effects of human endogenous retroviruses. Int J Cancer 2010;126:306-14.
8. Blomberg J, Benachenhou F, Blikstad V, Sperber G, Mayer J. Classification and nomenclature of endogenous retroviral sequences (ERVs): Problems and recommendations. Gene 2009;448:115-23.
9. Ahn K, Kim HS. Structural and quantitative expression analyses of HERV gene family in human tissues. Mol Cells 2009;28:99-103.
10. Büscher K, Trefzer U, Hofmann M, Sterry W, Kurth R, Denner J. Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res 2005;65:4172-80. (Pubitemid 40775655)
11. Muster T, Waltenberger A, Grassauer A, Hirschl S, Caucig P, Romirer I, et al. An endogenous retrovirus derived from human melanoma cells. Cancer Res 2003;63:8735-41. (Pubitemid 38064051)
12. Mangeney M, Pothlichet J, Renard M, Ducos B, Heidmann T. Endogenous retrovirus expression is required for murine melanoma tumor growth in vivo. Cancer Res 2005;65:2588-91. (Pubitemid 40490056)
13. Oricchio E, Sciamanna I, Beraldi R, Tolstonog GV, Schumann GG, Spadafora C. Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression. Oncogene 2007;26:4226-33. (Pubitemid 46975802)
14. Pothlichet J, Mangeney M, Heidmann T. Mobility and integration sites of a murine C57BL/6 melanoma endogenous retrovirus involved in tumor progression in vivo. Int J Cancer 2006;119:1869-77. (Pubitemid 44356845)
15. Serafino A, Balestrieri E, Pierimarchi P, Matteucci C, Moroni G, Oricchio E, et al. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Exp Cell Res 2009;315:849-62.
16. Carter A. Cell fusion theory: Can it explain what triggers metastasis? J Natl Cancer Inst 2008;100:1279-81.
17. Pawelek JM, Chakraborty AK. Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis. Nat Rev Cancer 2008;8:377-86. (Pubitemid 351589699)
18. Tchenio T, Heidmann T. Defective retroviruses can disperse in the human genome by intracellular transposition. J Virol 1991;65:2113-8.
19. Ancrile B, Lim KH, Counter CM. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev 2007;21:1714-9. (Pubitemid 47076470)
20. Rotolo S, Diotti R, Gordon RE, Qiao RF, Yao Z, Phelps RG, et al. Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells. Int J Cancer 2005;115:164-9. (Pubitemid 40559683)
21. Dewannieux M, Blaise S, Heidmann T. Identification of a functional envelope protein from the HERV-K family of human endogenous retroviruses. J Virol 2005;79:15573-7. (Pubitemid 43032339)
22. Gao P, Zheng J. Oncogenic virus-mediated cell fusion: New insights into initiation and progression of oncogenic viruses-Related cancers. Cancer Lett 2011;303:1-8.
23. Parris GE. The role of viruses in cell fusion and its importance to evolution, invasion and metastasis of cancer clones. Med Hypotheses 2005;64:1011-4. (Pubitemid 40385961)
24. Büscher K, Hahn S, Hofmann M, Trefzer U, Ozel M, Sterry W, et al. Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines. Melanoma Res 2006;16:223-34. (Pubitemid 44085096)
25. Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: A mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011;12:385-92.
26. Hufton AL, Panopoulou G. Polyploidy and genome restructuring: A variety of outcomes. Curr Opin Genet Dev 2009;19:600-6.
27. Davoli T, de Lange T. The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol 2011;27:585-610.
28. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 2007;17:157-62. (Pubitemid 46551722)
29. Neville PJ, Conti DV, Krumroy LM, Catalona WJ, Suarez BK, Witte JS, et al. Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies. Genes Chromosomes Cancer 2003;36:332-9. (Pubitemid 36314516)
30. Nakayama K, Takebayashi Y, Hata K, Fujiwaki R, Iida K, Fukumoto M, et al. Allelic loss at 19q12 and Xq11-12 predict an adverse clinical outcome in patients with mucinous ovarian tumours of low malignant potential. Br J Cancer 2004;90:1204-10. (Pubitemid 38496814)
31. Barlogie B, Drewinko B, Schumann J, Göhde W, Dosik G, Latreille J, et al. Cellular DNA content as a marker of neoplasia in man. Am J Med 1980;69:195-203. (Pubitemid 10036816)
32. Søndergaard K, Larsen JK, Møller U, Christensen IJ, Hou-Jensen K. DNA ploidy-characteristics of human malignant melanoma analysed by flow cytometry and compared with histology and clinical course. Virchows Arch B Cell Pathol Incl Mol Pathol 1983;42:43-52. (Pubitemid 13179448)
33. Whang-Peng J, Chretien P, Knutsen T. Polyploidy in malignant melanoma. Cancer 1970;25:1216-23.
34. Larsson LI, Bjerregaard B, Talts JF. Cell fusions in mammals. Histochem Cell Biol 2008;129:551-61.
35. Witze E, Rothman JH. Cell fusion: An EFFicient sculptor. Curr Biol 2002;12:R467-9. (Pubitemid 34766925)
36. Lin EH, Salon C, Brambilla E, Lavillette D, Szecsi J, Cosset FL, et al. Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: A potential therapy agent for lung cancer. Cancer Gene Ther 2010;17:256-65.
37. Cui Y, Borysova MK, Johnson JO, Guadagno TM. Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. Cancer Res 2010;70:675-84.
38. Kamata T, Hussain J, Giblett S, Hayward R, Marais R, Pritchard C. BRAF inactivation drives aneuploidy by deregulating CRAF. Cancer Res 2010;70:8475-86.
39. Saavedra HI, Fukasawa K, Conn CW, Stambrook PJ. MAPK mediates RAS-induced chromosome instability. J Biol Chem 1999;274:38083-90. (Pubitemid 30026878)
40. Fuchs NV, Kraft M, Tondera C, Hanschmann KM, Löwer J, Löwer R. Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3. J Virol 2011;85:3436-48.
41. Reiche J, Pauli G, Ellerbrok H. Differential expression of human endogenous retrovirus K transcripts in primary human melanocytes and melanoma cell lines after UV irradiation. Melanoma Res 2010;20:435-40.
42. Schanab O, Humer J, Gleiss A, Mikula M, Sturlan S, Grunt S, et al. Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma. Pigment Cell Melanoma Res 2011;24:656-65.
43. Stengel S, Fiebig U, Kurth R, Denner J. Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation. Genes Chromosomes Cancer 2010;49:401-11.