Intracellular expression of a single-chain antibody directed against human papillomavirus type 16 E7 oncoprotein achieves targeted antineoplastic effects

Cancer Research

Volumn 58, Issue 9, 1998, Pages 1893-1900

  Wang Johanning, Feng ^a   Gillespie, G Yancey ^b   Grim, Jon ^a   Rancourt, Claudine ^a   Alvarez, Ronald D ^a   Siegal, Gene P ^c   Curiel, David T ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UTERINE CERVIX CANCER; WART VIRUS;

ANIMALS; ANTIBODIES, VIRAL; CELL DIVISION; DOWN-REGULATION; FEMALE; GENE TARGETING; GENE THERAPY; GENES, IMMUNOGLOBULIN; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PLASMIDS; TRANSFECTION; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0032080418     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. zur Hausen, H. Papillomaviruses in human cancer. Appl. Pathol., 5: 19-24, 1987.
2. Dürst, M., Gissmann, L., Ikenberg, H., and zur Hausen, H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA, 80: 3812-3815, 1983.
3. Steele, C., and Shillitoe, E. J. Viruses and oral cancer. Crit. Rev. Oral Biol. Med., 2: 153-175, 1991.
4. Bedell, M. A., Jones, K. H., Grossman, S. R., and Laimins, L. A. Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells. J. Virol., 63: 1247-1255, 1989.
5. Crook, T., Morgenstern, J. P., Crawford, L., and Banks, L. Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras. EMBO J., 8: 513-519, 1989.
6. Halbert, C. L., Demers, G. W., and Galloway, D. A. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J. Virol., 65: 473-478, 1991.
7. Marilu, M., Janicek, M. F., Bernd-Uwe, S., Perras, J., Estape, R., Penalver, M., and Averette, H. E. In vitro antigene therapy targeting HPV-16 E6 and E7 in cervical carcinoma. Gynecol. Oncol., 64: 18-25, 1997.
8. Seedorf, K., Krämmer, G., Dürst, M., Suhai, S., and Röwekamp, W. G. Human papillomavirus type 16 DNA sequence. Virology, 145: 181-185, 1985.
9. Shirasawa, H., Tomita, Y., Sekiya, S., Takamizawa, H., and Simizu, B. Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas. J. Gen. Virol., 68: 583-591, 1987.
10. Smotkin, D., and Wettstein, F. O. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA, 83: 4680-4684, 1986.
11. Hawley-Nelson, P., Vousden, K. H., Hubbert, N. L., Lowy, D. R., and Schiller, J. T. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J., 8: 3905-3910, 1989.
12. Kaur, P., McDougall, J. K., and Cone, R. Immortalization of primary human epithelial cells by cloned cervical DNA containing human papillomavirus type 16 E6/E7 open reading frames. J. Gen. Virol., 70: 1261-1266, 1989.
13. von Knebel Doeberitz, M., Oltersdorf, T., Schwarz, E., and Gissmann, L. Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res., 48: 3780-3786, 1988.
14. Shillitoe, E. J., Kamath, P., and Chen, Z. Papillomaviruses as targets for cancer gene therapy. Cancer Gene Ther., 1: 193-204, 1994.
15. Hamada, K., Sakaue, M., Alemany, R., Zhang, W. W., Horio, Y., Roth, J. A., and Mitchell, M. F. Adenovirus-mediated transfer of HPV16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol. Oncol., 63: 219-227, 1996.
16. Hu, G., Liu, W., Hanania, E. G., Fu, S., Wang, T., and Deisseroth, A. B. Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and the sense mRNA for the retinoblastoma gene in cervical carcinoma cells. Cancer Gene Ther., 2: 19-32, 1995.
17. Madrigal, M., Janicek, M. F., Sevin, B. U., Perras, J., Estape, R., Penalver, M., and Averette, H. E. In vitro antigene therapy targeting HPV-16 E6 and E7 in cervical carcinoma. Gynecol. Oncol., 64: 18-25, 1997.
18. Steele, C., Sacks, P. G., Adler-Storthz, K., and Shillitoe, E. J. Effect on cancer cells of plasmids that express antisense RNA of human papillomavirus type 18. Cancer Res., 52: 4706-4711, 1992.
19. Steele, C., Cowsert, L. M., and Shillitoe, E. J. Effects of human papillomavirus type 18-specific antisense oligonucleotides on the transformed phenotype of human carcinoma cell lines. Cancer Res., 53 (Suppl. 10): 2330-2337, 1993.
20. Storey, A., Oates, D., Banks, L., Crawford, L., and Crook, T. Antisense phosphorothioate oligonucleotides have both specific and nonspecific effects on cells containing human papillomavirus type 16. Nucleic Acids Res., 19: 4109-4114, 1991.
21. Tan, T. M., Gloss, B., Bernard, H. U., and Ting, R. C. Mechanism of translation of the bicistronic mRNA encoding human papillomavirus type 16 E6-E7 genes. J. Gen. Virol., 75: 2663-2670, 1994.
22. Tan, T. M., and Ting, R. C. In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes. Cancer Res., 55: 4599-4605, 1995.
23. von Knebel Doeberitz, M. Papillomaviruses in human disease: Part I. Pathogenesis and epidemiology of human papillomavirus infections. Eur. J. Med., 1: 415-423, 1992.
24. Wong, Y. F., Chung, T. K., Cheung, T. H., Lam, S. K., and Chang, A. M. Effects of human papillomavirus type-specific antisense oligonucleotides on cervical cancer cells containing papillomavirus type 16. Med. Sci. Res., 22: 511-513, 1994.
25. Chen, Z., Kamath, P., Zhang, S., Weil, M. M., and Shillitoe, E. J. Effectiveness of three ribozymes for cleavage of an RNA transcript from human papillomavirus type 18. Cancer Gene Ther., 2: 263-271, 1995.
26. Chen, Z., Kamath, P., Zhang, S., St. John, L., Adler-Storthz, K., and Shillitoe, E. J. Effects on tumor cells of ribozymes that cleave the RNA transcripts of human papillomavirus type 18. Cancer Gene Ther., 3: 18-23, 1996.
27. Lu, D., Chatterjee, S., Brar, D., and Wong, K. K., Jr. Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16. Cancer Gene Ther., 1: 267-277, 1994.
28. Cambridge, M. Antisense aims for a renaissance. Science (Washington DC), 276: 1192-1193, 1997.
29. Matteucci, M. D., and Wagner, R. W. In pursuit of antisense. Nature (Lond.), 384: 20-22, 1996.
30. Grim, J., Deshane, J., Feng, M., Lieber, A., Kay, M., and Curiel, D. T. erbB-2 knockout employing an intracellular single-chain antibody (scFv) accomplishes specific toxicity in erbB-2 expressing lung cancer cells. Am. J. Respir. Cell Mol Biol., 15: 348-354, 1996.
31. Gillespie, G. Y., Vanwyk, J. J., Underwood, L. E., Svoboda, M., and Russell, W. E. Derivation of monoclonal antibodies to human somatomedin-C/IGF-1. Methods Enzymol., 146: 207-216, 1987.
32. Kalderon, D., Roberts, B. L., Richardson, W. D., and Smith, A. E. A short amino acid sequence able to specify nuclear location. Cell, 39: 499-509, 1984.
33. Munro, S., and Pelham, H. R. A C-terminal signal prevents secretion of luminal ER proteins. Cell, 48: 899-907, 1987.
34. Curiel, D. T., Wagner, E., Cotten, M., Birnstiel, M. L., Agarwal, S., Li, C. M., Loechel, S., and Hu, P. C. High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Hum. Gene Ther., 3: 147-154, 1992.
35. Seedorf, K., Oltersdorf, T., Krämmer, G., and Röwekamp, W. Identification of early proteins of human papilloma viruses type 16 (HPV16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J., 6: 139-144, 1987.
36. Deshane, J., Loechel, F., Conry, R. M., Siegal, G. P., King, C. R., and Curiel, D. T. Intracellular single-chain antibody directed against erbB2 overexpressing cancer cell lines. Gene Ther., 1: 332-337, 1994.
37. Deshane, J., Siegal, G. P., Alvarez, R. D., Wang, M. H., Feng, M., Cabrera, G., Liu, T., Kay, M., and Curiel, D. T. Targeted tumor killing via an intracellular antibody against erbB2. J. Clin. Invest., 96: 2980-2989, 1995.
38. Smotkin, D., and Wettstein, F. O. The major human papillomavirus protein in cervical cancer is a cytoplasmic phosphoprotein. J. Virol., 65: 1686-1689, 1987.
39. Sato, H., Watanase, S., Furuno, A., and Yoshike, K. Human papillomavirus type 16 E7 protein expressed in E. coli and monkey COS-1 cells: immunofluorescence detection of the nuclear E7 protein. Virology, 17: 311-315, 1989.
40. Mizutani, Y., Bonavida, B., Fukumoto, M., and Yoshida, O. Enhanced susceptibility of c-myc antisense oliogonucleotide-treated human renal cell carcinoma cells to lysis by peripheral blood lymphocytes. J. Immunother. Emphasis Tumor Immunol., 17: 78-87, 1995.