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Volumn 69, Issue 1, 2017, Pages 213-224

Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN A; CALGRANULIN B; CALGRANULIN C; CD56 ANTIGEN; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR LIKE 1; FORMYLPEPTIDE RECEPTOR LIKE 2; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GRANZYME; GRANZYME B; GRANZYME K; INTERFERON GAMMA RECEPTOR 2; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR A3; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR A5; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR B3; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; NATURAL KILLER CELL LECTIN LIKE RECEPTOR G1; RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 85007406123     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39933     Document Type: Article
Times cited : (66)

References (50)
  • 1
    • 79959963298 scopus 로고    scopus 로고
    • Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions
    • Mellins ED, Macaubas C, Grom AA. Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nat Rev Rheumatol 2011;7:416–26.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 416-426
    • Mellins, E.D.1    Macaubas, C.2    Grom, A.A.3
  • 2
    • 84866862867 scopus 로고    scopus 로고
    • Systemic juvenile idiopathic arthritis
    • Martini A. Systemic juvenile idiopathic arthritis. Autoimmun Rev 2012;12:56–9.
    • (2012) Autoimmun Rev , vol.12 , pp. 56-59
    • Martini, A.1
  • 3
    • 84861685616 scopus 로고    scopus 로고
    • Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment
    • Ravelli A, Grom AA, Behrens EM, Cron RQ. Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment. Genes Immun 2012;13:289–98.
    • (2012) Genes Immun , vol.13 , pp. 289-298
    • Ravelli, A.1    Grom, A.A.2    Behrens, E.M.3    Cron, R.Q.4
  • 4
    • 34248666067 scopus 로고    scopus 로고
    • Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    • Behrens EM, Beukelman T, Paessler M, Cron RQ. Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis. J Rheumatol 2007;34:1133–8.
    • (2007) J Rheumatol , vol.34 , pp. 1133-1138
    • Behrens, E.M.1    Beukelman, T.2    Paessler, M.3    Cron, R.Q.4
  • 5
    • 84855932987 scopus 로고    scopus 로고
    • Familial and acquired hemophagocytic lymphohistiocytosis
    • Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med 2012;63:233–46.
    • (2012) Annu Rev Med , vol.63 , pp. 233-246
    • Janka, G.E.1
  • 7
    • 21744452702 scopus 로고    scopus 로고
    • Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • Villanueva J, Lee S, Giannini EH, Graham TB, Passo MH, Filipovich A, et al. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther 2005;7:R30–37.
    • (2005) Arthritis Res Ther , vol.7 , pp. R30-37
    • Villanueva, J.1    Lee, S.2    Giannini, E.H.3    Graham, T.B.4    Passo, M.H.5    Filipovich, A.6
  • 8
    • 84923065252 scopus 로고    scopus 로고
    • Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis. Cytokine
    • Avau A, Put K, Wouters CH, Matthys P. Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis. Cytokine Growth Factor Rev 2015;26:35–45.
    • (2015) Growth Factor Rev , vol.26 , pp. 35-45
    • Avau, A.1    Put, K.2    Wouters, C.H.3    Matthys, P.4
  • 9
    • 69449093422 scopus 로고    scopus 로고
    • Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis
    • De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, et al. Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2009;60:2782–93.
    • (2009) Arthritis Rheum , vol.60 , pp. 2782-2793
    • De Jager, W.1    Vastert, S.J.2    Beekman, J.M.3    Wulffraat, N.M.4    Kuis, W.5    Coffer, P.J.6
  • 10
    • 84885771863 scopus 로고    scopus 로고
    • Natural killer cell activity and frequency of killer cell immunoglobulin-like receptors in children with different forms of juvenile idiopathic arthritis
    • Zhou J, Tang X, Ding Y, An Y, Zhao X. Natural killer cell activity and frequency of killer cell immunoglobulin-like receptors in children with different forms of juvenile idiopathic arthritis. Pediatr Allergy Immunol 2013;24:691–6.
    • (2013) Pediatr Allergy Immunol , vol.24 , pp. 691-696
    • Zhou, J.1    Tang, X.2    Ding, Y.3    An, Y.4    Zhao, X.5
  • 11
    • 1542283765 scopus 로고    scopus 로고
    • Natural killer cell dysfunction: a common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? [review]
    • Grom AA. Natural killer cell dysfunction: a common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? [review]. Arthritis Rheum 2004;50:689–98.
    • (2004) Arthritis Rheum , vol.50 , pp. 689-698
    • Grom, A.A.1
  • 12
    • 0026014522 scopus 로고
    • Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis
    • De Benedetti F, Massa M, Robbioni P, Ravelli A, Burgio GR, Martini A. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum 1991;34:1158–63.
    • (1991) Arthritis Rheum , vol.34 , pp. 1158-1163
    • De Benedetti, F.1    Massa, M.2    Robbioni, P.3    Ravelli, A.4    Burgio, G.R.5    Martini, A.6
  • 15
    • 84939495316 scopus 로고    scopus 로고
    • Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis tipping the balance between interleukin-18 and interferon-γ
    • (Oxford)
    • Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, et al. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ. Rheumatology (Oxford) 2015;54:1507–17.
    • (2015) Rheumatology , vol.54 , pp. 1507-1517
    • Put, K.1    Avau, A.2    Brisse, E.3    Mitera, T.4    Put, S.5    Proost, P.6
  • 16
    • 77955751173 scopus 로고    scopus 로고
    • Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
    • Shimizu M, Yokoyama T, Yamada K, Kaneda H, Wada H, Wada T, et al. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Rheumatology (Oxford) 2010;49:1645–53.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1645-1653
    • Shimizu, M.1    Yokoyama, T.2    Yamada, K.3    Kaneda, H.4    Wada, H.5    Wada, T.6
  • 17
    • 18644385243 scopus 로고    scopus 로고
    • Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    • Pascual V, Allantaz F, Arce E, Punaro M, Banchereau J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005;201:1479–86.
    • (2005) J Exp Med , vol.201 , pp. 1479-1486
    • Pascual, V.1    Allantaz, F.2    Arce, E.3    Punaro, M.4    Banchereau, J.5
  • 19
    • 84899740594 scopus 로고    scopus 로고
    • Systemic juvenile idiopathic arthritis–like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ. Arthritis
    • Avau A, Mitera T, Put S, Put K, Brisse E, Filtjens J, et al. Systemic juvenile idiopathic arthritis–like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ. Arthritis Rheumatol 2014;66:1340–51.
    • (2014) Rheumatol , vol.66 , pp. 1340-1351
    • Avau, A.1    Mitera, T.2    Put, S.3    Put, K.4    Brisse, E.5    Filtjens, J.6
  • 20
    • 10744230484 scopus 로고    scopus 로고
    • International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001
    • Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004;31:390–2.
    • (2004) J Rheumatol , vol.31 , pp. 390-392
    • Petty, R.E.1    Southwood, T.R.2    Manners, P.3    Baum, J.4    Glass, D.N.5    Goldenberg, J.6
  • 21
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: a Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson MD, McCarthy DJ, Smyth GK. EdgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010;26:139–40.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 22
    • 84865743056 scopus 로고    scopus 로고
    • CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data
    • Shoemaker JE, Lopes TJ, Ghosh S, Matsuoka Y, Kawaoka Y, Kitano H. CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data. BMC Genomics 2012;13:460.
    • (2012) BMC Genomics , vol.13 , pp. 460
    • Shoemaker, J.E.1    Lopes, T.J.2    Ghosh, S.3    Matsuoka, Y.4    Kawaoka, Y.5    Kitano, H.6
  • 23
    • 36049020585 scopus 로고    scopus 로고
    • Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    • Fall N, Barnes M, Thornton S, Luyrink L, Olson J, Ilowite NT, et al. Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum 2007;56:3793–804.
    • (2007) Arthritis Rheum , vol.56 , pp. 3793-3804
    • Fall, N.1    Barnes, M.2    Thornton, S.3    Luyrink, L.4    Olson, J.5    Ilowite, N.T.6
  • 24
    • 34548436508 scopus 로고    scopus 로고
    • Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    • Allantaz F, Chaussabel D, Stichweh D, Bennett L, Allman W, Mejias A, et al. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med 2007;204:2131–44.
    • (2007) J Exp Med , vol.204 , pp. 2131-2144
    • Allantaz, F.1    Chaussabel, D.2    Stichweh, D.3    Bennett, L.4    Allman, W.5    Mejias, A.6
  • 25
    • 67650066800 scopus 로고    scopus 로고
    • Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    • Barnes MG, Grom AA, Thompson SD, Griffin TA, Pavlidis P, Itert L, et al. Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis. Arthritis Rheum 2009;60:2102–12.
    • (2009) Arthritis Rheum , vol.60 , pp. 2102-2112
    • Barnes, M.G.1    Grom, A.A.2    Thompson, S.D.3    Griffin, T.A.4    Pavlidis, P.5    Itert, L.6
  • 26
    • 79958276203 scopus 로고    scopus 로고
    • Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    • Hinze CH, Fall N, Thornton S, Mo JQ, Aronow BJ, Layh-Schmitt G, et al. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res Ther 2010;12:R123.
    • (2010) Arthritis Res Ther , vol.12 , pp. R123
    • Hinze, C.H.1    Fall, N.2    Thornton, S.3    Mo, J.Q.4    Aronow, B.J.5    Layh-Schmitt, G.6
  • 28
    • 79960547202 scopus 로고    scopus 로고
    • bright NK cell-mediated immunoregulation of multiple sclerosis
    • bright NK cell-mediated immunoregulation of multiple sclerosis. J Immunol 2011;187:781–90.
    • (2011) J Immunol , vol.187 , pp. 781-790
    • Jiang, W.1    Chai, N.R.2    Maric, D.3    Bielekova, B.4
  • 29
    • 11144244014 scopus 로고    scopus 로고
    • Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells
    • Mavropoulos A, Sully G, Cope AP, Clark AR. Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood 2005;105:282–8.
    • (2005) Blood , vol.105 , pp. 282-288
    • Mavropoulos, A.1    Sully, G.2    Cope, A.P.3    Clark, A.R.4
  • 30
    • 0037338925 scopus 로고    scopus 로고
    • Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • Grom AA, Villanueva J, Lee S, Goldmuntz EA, Passo MH, Filipovich A. Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr 2003;142:292–6.
    • (2003) J Pediatr , vol.142 , pp. 292-296
    • Grom, A.A.1    Villanueva, J.2    Lee, S.3    Goldmuntz, E.A.4    Passo, M.H.5    Filipovich, A.6
  • 31
    • 84903318634 scopus 로고    scopus 로고
    • Update on research and clinical translation on specific clinical areas: from bench to bedside: how insight in immune pathogenesis can lead to precision medicine of severe juvenile idiopathic arthritis
    • Vastert S, Prakken B. Update on research and clinical translation on specific clinical areas: from bench to bedside: how insight in immune pathogenesis can lead to precision medicine of severe juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol 2014;28:229–46.
    • (2014) Best Pract Res Clin Rheumatol , vol.28 , pp. 229-246
    • Vastert, S.1    Prakken, B.2
  • 32
    • 34447523762 scopus 로고    scopus 로고
    • Specific gene expression profiles in systemic juvenile idiopathic arthritis
    • Ogilvie EM, Khan A, Hubank M, Kellam P, Woo P. Specific gene expression profiles in systemic juvenile idiopathic arthritis. Arthritis Rheum 2007;56:1954–65.
    • (2007) Arthritis Rheum , vol.56 , pp. 1954-1965
    • Ogilvie, E.M.1    Khan, A.2    Hubank, M.3    Kellam, P.4    Woo, P.5
  • 33
    • 0346340916 scopus 로고    scopus 로고
    • Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis
    • Muller K, Herner EB, Stagg A, Bendtzen K, Woo P. Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis. Br J Rheumatol 1998;37:562–9.
    • (1998) Br J Rheumatol , vol.37 , pp. 562-569
    • Muller, K.1    Herner, E.B.2    Stagg, A.3    Bendtzen, K.4    Woo, P.5
  • 34
    • 73449117152 scopus 로고    scopus 로고
    • Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states
    • Macaubas C, Nguyen K, Deshpande C, Phillips C, Peck A, Lee T, et al. Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states. Clin Immunol 2010;134:206–16.
    • (2010) Clin Immunol , vol.134 , pp. 206-216
    • Macaubas, C.1    Nguyen, K.2    Deshpande, C.3    Phillips, C.4    Peck, A.5    Lee, T.6
  • 35
    • 0035990194 scopus 로고    scopus 로고
    • Different circulating lymphocyte profiles in patients with different subtypes of juvenile idiopathic arthritis
    • Wouters CH, Ceuppens JL, Stevens EA. Different circulating lymphocyte profiles in patients with different subtypes of juvenile idiopathic arthritis. Clin Exp Rheumatol 2002;20:239–48.
    • (2002) Clin Exp Rheumatol , vol.20 , pp. 239-248
    • Wouters, C.H.1    Ceuppens, J.L.2    Stevens, E.A.3
  • 36
    • 49749127387 scopus 로고    scopus 로고
    • Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    • Zhang K, Biroschak J, Glass DN, Thompson SD, Finkel T, Passo MH, et al. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Arthritis Rheum 2008;58:2892–6.
    • (2008) Arthritis Rheum , vol.58 , pp. 2892-2896
    • Zhang, K.1    Biroschak, J.2    Glass, D.N.3    Thompson, S.D.4    Finkel, T.5    Passo, M.H.6
  • 38
    • 39749185953 scopus 로고    scopus 로고
    • Mutations of the hemophagocytic lymphohistiocytosis–associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis
    • Hazen MM, Woodward AL, Hofmann I, Degar BA, Grom A, Filipovich AH, et al. Mutations of the hemophagocytic lymphohistiocytosis–associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. Arthritis Rheum 2008;58:567–70.
    • (2008) Arthritis Rheum , vol.58 , pp. 567-570
    • Hazen, M.M.1    Woodward, A.L.2    Hofmann, I.3    Degar, B.A.4    Grom, A.5    Filipovich, A.H.6
  • 39
    • 77950531755 scopus 로고    scopus 로고
    • Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
    • Vastert SJ, van Wijk R, D'Urbano LE, de Vooght KM, de Jager W, Ravelli A, et al. Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 2010;49:441–9.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 441-449
    • Vastert, S.J.1    van Wijk, R.2    D'Urbano, L.E.3    de Vooght, K.M.4    de Jager, W.5    Ravelli, A.6
  • 40
    • 84912047373 scopus 로고    scopus 로고
    • Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis. Arthritis
    • Kaufman KM, Linghu B, Szustakowski JD, Husami A, Yang F, Zhang K, et al. Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis. Arthritis Rheumatol 2014;66:3486–95.
    • (2014) Rheumatol , vol.66 , pp. 3486-3495
    • Kaufman, K.M.1    Linghu, B.2    Szustakowski, J.D.3    Husami, A.4    Yang, F.5    Zhang, K.6
  • 41
    • 40549125931 scopus 로고    scopus 로고
    • Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis
    • Donn R, Ellison S, Lamb R, Day T, Baildam E, Ramanan AV. Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2008;58:869–74.
    • (2008) Arthritis Rheum , vol.58 , pp. 869-874
    • Donn, R.1    Ellison, S.2    Lamb, R.3    Day, T.4    Baildam, E.5    Ramanan, A.V.6
  • 42
    • 0037293064 scopus 로고    scopus 로고
    • Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
    • Wulffraat NM, Rijkers GT, Elst E, Brooimans R, Kuis W. Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford) 2003;42:375–9.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 375-379
    • Wulffraat, N.M.1    Rijkers, G.T.2    Elst, E.3    Brooimans, R.4    Kuis, W.5
  • 44
    • 84948743698 scopus 로고    scopus 로고
    • Therapeutic potential of interferon-γ and its antagonists in autoinflammation: lessons from murine models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
    • Avau A, Matthys P. Therapeutic potential of interferon-γ and its antagonists in autoinflammation: lessons from murine models of systemic juvenile idiopathic arthritis and macrophage activation syndrome. Pharmaceuticals (Basel) 2015;8:793–815.
    • (2015) Pharmaceuticals (Basel) , vol.8 , pp. 793-815
    • Avau, A.1    Matthys, P.2
  • 45
    • 84929612515 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis (HLH): a heterogeneous spectrum of cytokine-driven immune disorders
    • Brisse E, Wouters CH, Matthys P. Hemophagocytic lymphohistiocytosis (HLH): a heterogeneous spectrum of cytokine-driven immune disorders. Cytokine Growth Factor Rev 2015;26:263–80.
    • (2015) Cytokine Growth Factor Rev , vol.26 , pp. 263-280
    • Brisse, E.1    Wouters, C.H.2    Matthys, P.3
  • 46
    • 84978134924 scopus 로고    scopus 로고
    • A novel targeted approach to the treatment of hemophagocytic lymphohistiocytosis (HLH) with an anti-interferon γ (IFNγ) monoclonal antibody (mAb), NI-0501: first results from a pilot phase 2 study in children with primary HLH [abstract]
    • Jordan MB, Locatelli F, Allen CE, de Benedetti F, Grom AA, Ballabio M, et al. A novel targeted approach to the treatment of hemophagocytic lymphohistiocytosis (HLH) with an anti-interferon γ (IFNγ) monoclonal antibody (mAb), NI-0501: first results from a pilot phase 2 study in children with primary HLH [abstract]. Blood 2015;126:LBA–3.
    • (2015) Blood , vol.126 , pp. LBA-3
    • Jordan, M.B.1    Locatelli, F.2    Allen, C.E.3    de Benedetti, F.4    Grom, A.A.5    Ballabio, M.6
  • 47
    • 84946022428 scopus 로고    scopus 로고
    • Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome
    • Cifaldi L, Prencipe G, Caiello I, Bracaglia C, Locatelli F, de Benedetti F, et al. Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome. Arthritis Rheumatol 2015;67:3037–46.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 3037-3046
    • Cifaldi, L.1    Prencipe, G.2    Caiello, I.3    Bracaglia, C.4    Locatelli, F.5    de Benedetti, F.6
  • 48
    • 84920828341 scopus 로고    scopus 로고
    • Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer
    • Romee R, Leong JW, Fehniger TA. Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer. Scientifica (Cairo) 2014;2014:205796.
    • (2014) Scientifica (Cairo) , vol.2014 , pp. 205796
    • Romee, R.1    Leong, J.W.2    Fehniger, T.A.3
  • 50
    • 84861229062 scopus 로고    scopus 로고
    • Transient impairment of NK cell function in an infant born to a mother with adult-onset Still's disease: perinatal effect of maternal IL-18
    • Shimizu M, Sakakibara Y, Kawano M, Yachie A. Transient impairment of NK cell function in an infant born to a mother with adult-onset Still's disease: perinatal effect of maternal IL-18. Clin Immunol 2012;143:273–4.
    • (2012) Clin Immunol , vol.143 , pp. 273-274
    • Shimizu, M.1    Sakakibara, Y.2    Kawano, M.3    Yachie, A.4


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