Phytochemicals in Wound Healing

Advances in Wound Care

Volumn 5, Issue 5, 2016, Pages 230-241

  Thangapazham, Rajesh L ^a   Sharad, Shashwat ^a   Maheshwari, Radha K ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARNEBIN 1; COLLAGEN; CURCUMIN; DEXAMETHASONE; FIBRONECTIN; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KUTKIN; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BIOLOGICAL ACTIVITY; CHRONIC WOUND; DRUG MECHANISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; REGENERATION; TRADITIONAL MEDICINE; WOUND HEALING;

EID: 85007378068     PISSN: 21621918     EISSN: 21621934     Source Type: Journal    
DOI: 10.1089/wound.2013.0505     Document Type: Article

References (55)

1. Hsu S: Green tea and the skin. J Am Acad Dermatol 2005; 52: 1049
2. Farnsworth NR: Ethnopharmacology and drug discovery. Proceedings of Ciba foundation symposium. Chinchester: Wiley 1994, Vol. 185, pp. 42-59
3. Sharma RA, Gescher AJ, and Steward WP: Curcumin: The story so far. Eur J Cancer 2005; 41: 1955
4. Bhattacharjee S and Mandal DP: Angiogenesis modulation-the "spice effect. " J Environ Pathol Toxicol Oncol 2012; 31: 273
5. Vanden Berghe W and Haegeman G: Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality? Curr Drug Metab 2010; 11: 436
6. Mohanty C, Das M, and Sahoo SK: Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. Mol Pharm 2012; 9: 2801
7. Chandan KS, Gayle MG, Sashwati R, et al. : Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair Regen 2009; 17: 763
8. Aukhil I: Biology of wound healing. Periodontol 2000; 22: 44
9. Thangapazham RL, Sharad S, and Maheshwari RK: Skin regenerative potentials of curcumin. Biofactors 2013; 39: 141
10. Sidhu GS, Singh AK, Thaloor D, et al. : Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998; 6: 167
11. Mani H, Sidhu GS, Kumari R, Gaddipati JP, Seth P, and Maheshwari RK: Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors 2002; 16: 29
12. Robson MC, Steed DL, and Franz MG: Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg 2001; 38: 72
13. Majewska I and Gendaszewska-Darmach E: Proangiogenic activity of plant extracts in accelerating wound healing-a new face of old phytomedicines. Acta Biochim Pol 2011; 58: 449
14. Iocono JA, Ehrlich HP, Gottrup F, and Leaper DJ: The biology of healing. In: Wounds: Biology and Management, edited by Leaper DJ and KG Harding. Oxford, United Kingdom: Oxford University Press, 1998, pp. 4-15
15. Reszka E, Wasowicz W, and Gromadzinska J: Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility. Br J Nutr 2006; 96: 609
16. Cheppudira B, Fowler M, McGhee L, et al. : Curcumin: A novel therapeutic for burn pain and wound healing. Expert Opin Invest Drugs 2013; 22: 1295
17. Jagetia GC and Rajanikant GK: Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated c radiation. Int Wound J 2012; 9: 76
18. Lin YG, Kunnumakkara AB, Nair A, et al. : Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res 2007; 13: 3423
19. Cheng AL, Hsu CH, Lin JK, et al. : Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001; 21: 2895
20. Ohori H, Yamakoshi H, Tomizawa M, et al. : Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther 2006; 5: 2563
21. Cen L, Hutzen B, Ball S, et al. : New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC Cancer 2009; 9: 99
22. Mimeault M and Batra SK: Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin Med 2011; 6: 31
23. Thangapazham RL, Sharma A, and Maheshwari RK: Beneficial role of curcumin in skin diseases. Adv Exp Med Biol 2007; 595: 343
24. Thangapazham RL, Sharma A, and Maheshwari RK: Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J 2006; 8: 443
25. Maheshwari RK, Singh AK, Gaddipati J, and Srimal RC: Multiple biological activities of curcumin: A short review. Life Sci 2006; 78: 2081
26. Chun KS, Keum YS, Han SS, Song YS, Kim SH, and Surh YJ: Curcumin inhibits phorbol esterinduced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NFkappaB activation. Carcinogenesis 2003; 24: 1515
27. Grandjean-Laquerriere A, Gangloff SC, Le Naour R, Trentesaux C, Hornebeck W, and Guenounou M: Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 2002; 18: 168
28. Gopinath D, Ahmed MR, Gomathi K, Chitra K, Sehgal PK, and Jayakumar R: Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 2004; 25: 1911
29. Shehzad A, Rehman G, and Lee YS: Curcumin in inflammatory diseases. Biofactors 2013; 39: 69
30. Kulac M, Aktas C, Tulubas F, et al. : The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Histol 2013; 44: 83
31. Sidhu GS, Mani H, Gaddipati JP, et al. : Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999; 7: 362
32. Panchatcharam M, Miriyala S, Gayathri VS, and Suguna L: Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 2006; 290: 87
33. Sharma AV, Ganguly K, Paul S, Maulik N, and Swarnakar S: Curcumin heals indomethacininduced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling. Antioxid Redox Signal 2012; 16: 351
34. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, and Sharma AV: Curcumin regulates expression and activity of matrix metalloproteinases-9 and-2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005; 280: 9409
35. Phan TT, See PS, Lee T, and Chan SY: Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing. J Trauma 2001; 51: 927
36. Khachigian LM, Lindner V, Williams AJ, and Collins T: Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science 1997; 271: 1427
37. Pendurthi UR and Rao LV: Suppression of transcription factor Egr-1 by curcumin. Thromb Res 2000; 97: 179
38. Gu Q, Wang D, Cui C, Gao Y, Xia G, and Cui X: Effects of radiation on wound healing. J Environ Pathol Toxicol Oncol 1998; 17: 117
39. Jagetia GC and Rajanikant GK: Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gammairradiation. Plast Reconstr Surg 2005; 115: 515
40. Jagetia GC and Rajanikant GK: Effect of curcumin on radiation-impaired healing of excisional wounds in mice. J Wound Care 2004; 13: 107
41. Jagetia GC and Rajanikant GK: Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excisionwound, in mice whole-body exposed to various doses of gamma-radiation. J Surg Res 2004; 120: 127
42. Anand P, Kunnumakkara AB, Newman RA, and Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharmaceutics 2007; 4: 807
43. Gadekar R, Saurabh MK, Thakur GS, and Saurabh A: Study of formulation, characterization and wound healing potential of transdermal patches of curcumin. Asian J Pharm Clin Res 2012; 5 (Suppl 4): 225
44. Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, and Aggarwal BB. Modification of cysteine residue in p65 subunit of nuclear factorkappaB (NF-kappaB) by picroliv suppresses NFkappaB-regulated gene products and potentiates apoptosis. Cancer Res 2008; 68: 8861
45. Chereddy KK, Coco R, Memvanga PB, et al. : Combined effect of PLGA and curcumin on wound healing activity. J Control Release 2013; 171: 208
46. Gong C, Wu Q, Wang Y, et al. : A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 2013; 34: 6377
47. Heng MC: Wound healing in adult skin: Aiming for perfect regeneration. Int J Dermatol 2011; 50: 1058
48. Basnet P and Skalko-Basnet N: Curcumin: An antiinflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011; 16: 4567
49. Kui Zhang, Jian-Jie Yu, Yu-Min Li, et al. : A Picrorhiza kurroa derivative, picroliv, attenuates the development of dextran-sulfate-sodium-induced colitis in mice. Mediators Inflamm 2012; 2012: 751629
50. Sampath KHM, Singh PP, Pal P, et al. : Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice. Vaccine 2010; 28: 8327
51. Singh AK, Sharma A, Warren J, et al. : Picroliv accelerates epithelialization and angiogenesis in rat wounds. Planta Med 2007; 73: 251
52. Sidhu GS, Singh AK, Banaudha KK, Gaddipati JP, Patnaik GK, and Maheshwari RK: Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol 1999; 113: 773
53. Shukla YN, Tandon JS, Bhakun DS, and Dhar MM: Naphthaquinones of Arnebin nobilis. Phytochemistry 1971; 10B: 109
54. Katti SB, Shukla YN, and Tandon JS: Arnebin derivatives for anti-cancer activity. Indian J Chem 1979; 18B: 440
55. Painuly P, Katt SB, Bajpai SK, and Tandon JS: Studies of metal (II and III) complexes of Arnebin-1. Indain J Chem 1984; 23A: 166