Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 2, 2017, Pages 621-632

  Robledo O'Ryan, Natalia ^a   Moncada Basualto, Mauricio ^a,c   Mura, Francisco ^a   Olea Azar, Claudio ^a   Matos, Maria João ^b   Vazquez Rodriguez, Saleta ^b   Santana, Lourdes ^b   Uriarte, Eugenio ^b   Lapier, Michel ^d   Maya, Juan Diego ^d  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

Author keywords

Antioxidant activity; Chagas disease; Hydroxy 3 arylcoumarins; Trypanosome

Indexed keywords

5,7 DIHYDROXY 3 (3' HYDROXYPHENYL)COUMARIN; 6 HYDROXY 3 (2' HYDROXYPHENYL)COUMARIN; 7,8 DIHYDROXY 3 (2' HYDROXYPHENYL)COUMARIN; 7,8 DIHYDROXY 3 (3' HYDROXYPHENYL)COUMARIN; 8 HYDROXY 3 (3' HYDROXYPHENYL)COUMARIN; ANTIOXIDANT; ANTITRYPANOSOMAL AGENT; COUMARIN DERIVATIVE; HYDROXY 3 ARYLCOUMARIN DERIVATIVE; NIFURTIMOX; PEROXY RADICAL; REACTIVE OXYGEN METABOLITE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL VIABILITY; CHAGAS DISEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMICAL ANALYSIS; ELECTRON SPIN RESONANCE; EPIMASTIGOTE; HYDROGEN PEROXIDE SCAVENGING ASSAY; IC50; IN VITRO STUDY; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PARASITE VIABILITY; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; MOUSE; PARASITOLOGY; RAW 264.7 CELL LINE; SYNTHESIS; VERO CELL LINE;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; RAW 264.7 CELLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 85007270642     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.11.033     Document Type: Article

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