Endothelial Microparticles from Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways

Circulation

Volumn 135, Issue 3, 2017, Pages 280-296

  Abbas, Malak ^a,b   Jesel, Laurence ^a   Auger, Cyril ^a   Amoura, Lamia ^a   Messas, Nathan ^c   Manin, Guillaume ^c   Rumig, Cordula ^d   León González, Antonio J ^a   Ribeiro, Thais P ^a   Silva, Grazielle C ^a   Abou Merhi, Raghida ^b   Hamade, Eva ^b   Hecker, Markus ^d   Georg, Yannick ^c   Chakfe, Nabil ^c   Ohlmann, Patrick ^c   Schini Kerth, Valérie B ^a   Toti, Florence ^a   Morel, Olivier ^a,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b LEBANESE UNIVERSITY   (Lebanon)

^c HÔPITAL CIVIL   (France)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

aging; cell derived microparticles; endothelium; myocardial infarction; thrombosis

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BETA GALACTOSIDASE; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROETHIDINE; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P16; PROTEIN P21; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THROMBOPLASTIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1;

ACUTE CORONARY SYNDROME; ADULT; AGED; AGGREGOMETER; ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ARTERY ENDOTHELIUM; ARTICLE; CELL AGING; CELL ISOLATION; CLINICAL ARTICLE; CONE AND PLATE VISCOMETER; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY CIRCUMFLEX BRANCH; DOWN REGULATION; ENDOTHELIAL MICROPARTICLE; ENDOTHELIUM CELL; ENZYMATIC ASSAY; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; MIDDLE AGED; NONHUMAN; OXIDATIVE STRESS; PIG; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; SHEAR STRESS; THROMBOCYTE AGGREGATION; THROMBOGENICITY; UPREGULATION; VENOUS BLOOD; VERY ELDERLY; VISCOMETER; VISCOMETRY; WESTERN BLOTTING; DRUG EFFECTS; METABOLISM; RISK FACTOR;

ACUTE CORONARY SYNDROME; ANGIOTENSIN II; CELL AGING; HUMANS; MAP KINASE KINASE 1; NADPH OXIDASE; PHOSPHATIDYLINOSITOL 3-KINASES; RISK FACTORS;

EID: 85007164252     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.017513     Document Type: Article

References (35)

1. Brodsky SV, Gealekman O, Chen J, Zhang F, Togashi N, Crabtree M, Gross SS, Nasjletti A, Goligorsky MS. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res. 2004;94:377-384. doi: 10.1161/01.RES.0000111802.09964.E.F.
2. Amabile N, Cheng S, Renard JM, Larson MG, Ghorbani A, Mc-Cabe E, Griffin G, Guerin C, Ho JE, Shaw SY, Cohen KS, Vasan RS, Tedgui A, Boulanger CM, Wang TJ. Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study. Eur Heart J. 2014;35:2972-2979. doi: 10.1093/eurheartj/ehu153.
3. Rautou PE, Vion AC, Amabile N, Chironi G, Simon A, Tedgui A, Boulanger CM. Microparticles, vascular function, and atherothrombosis. Circ Res. 2011;109:593-606. doi: 10.1161/CIRCRESAHA.110.233163.
4. Morel O, Pereira B, Averous G, Faure A, Jesel L, Germain P, Grunebaum L, Ohlmann P, Freyssinet JM, Bareiss P, Toti F. Increased levels of procoagulant tissue factor-bearing microparticles within the occluded coronary artery of patients with ST-segment elevation myocardial infarction: role of endothelial damage and leukocyte activation. Atherosclerosis. 2009;204:636-641. doi: 10.1016/j. atherosclerosis.2008.10.039.
5. Empana JP, Boulanger CM, Tafflet M, Renard JM, Leroyer AS, Varenne O, Prugger C, Silvain J, Tedgui A, Cariou A, Montalescot G, Jouven X, Spaulding C. Microparticles and sudden cardiac death due to coronary occlusion. The TIDE (Thrombus and Inflammation in sudden DEath) study. Eur Heart J Acute Cardiovasc Care. 2015;4:28-36. doi: 10.1177/2048872614538404.
6. Porto I, Biasucci LM, De Maria GL, Leone AM, Niccoli G, Burzotta F, Trani C, Tritarelli A, Vergallo R, Liuzzo G, Crea F. Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention. Eur Heart J. 2012;33:2928-2938. doi: 10.1093/eurheartj/ehs065.
7. Bonderman D, Teml A, Jakowitsch J, Adlbrecht C, Gyöngyösi M, Sperker W, Lass H, Mosgoeller W, Glogar DH, Probst P, Maurer G, Nemerson Y, Lang IM. Coronary no-reflow is caused by shedding of active tissue factor from dissected atherosclerotic plaque. Blood. 2002;99:2794-2800.
8. Leroyer AS, Isobe H, Lesèche G, Castier Y, Wassef M, Mallat Z, Binder BR, Tedgui A, Boulanger CM. Cellular origins and thrombogenic activity of microparticles isolated from human atherosclerotic plaques. J Am Coll Cardiol. 2007;49:772-777. doi: 10.1016/j.jacc.2006.10.053.
9. Boulanger CM, Scoazec A, Ebrahimian T, Henry P, Mathieu E, Tedgui A, Mallat Z. Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation. 2001;104:2649-2652.
10. Burger D, Kwart DG, Montezano AC, Read NC, Kennedy CR, Thompson CS, Touyz RM. Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. J Am Heart Assoc. 2012;1:e001842. doi: 10.1161/JAHA.112.001842.
11. Han X, Ling S, Gan W, Sun L, Duan J, Xu J-W. 2,3,5,4?-tetrahydroxystilbene-2-O-?-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis. 2012;225:76-82. doi: http://dx.doi.org/10.1016/j.atherosclerosis.2012.08.011.
12. Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK, Cheung WM, Sherwin SJ, Bennett MR, Gil J, Mason JC, Haskard DO, Evans PC. Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arterioscler Thromb Vasc Biol. 2014;34:985-995. doi: 10.1161/ATVBAHA.114.303415.
13. Burger D, Montezano AC, Nishigaki N, He Y, Carter A, Touyz RM. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/Rho kinase pathways targeted to lipid rafts. Arterioscler Thromb Vasc Biol. 2011;31:1898-1907. doi: 10.1161/ATVBAHA.110.222703.
14. Lacroix R, Judicone C, Poncelet P, Robert S, Arnaud L, Sampol J, Dignat-George F. Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol. J Thromb Haemost. 2012;10:437-446. doi: 10.1111/j.1538-7836.2011.04610.x.
15. Hugel B, Zobairi F, Freyssinet JM, Nomura S, Shet AS, Key NS, Hebbel RP. Measuring circulating cell-derived microparticles. J Thromb Haemost. 2004;2:1846-1847. doi: 10.1111/j.1538-7836.2004.00936.x.
16. Khemais-Benkhiat S, Idris-Khodja N, Ribeiro TP, Silva GC, Abbas M, Kheloufi M, Lee JO, Toti F, Auger C, Schini-Kerth VB. The redoxsensitive induction of the local angiotensin system promotes both premature and replicative endothelial senescence: preventive effect of a standardized crataegus extract. J Gerontol A Biol Sci Med Sci. 2016;71:1581-1590. doi: 10.1093/gerona/glv213.
17. R: A Language and Environment for Statistical Computing [computer program]. Version. Vienna, Austria: R Foundation for Statistical Computing; 2016.
18. Pohlert T. PMCMR: Calculate Pairwise Multiple Comparisons of Mean Rank Sums. 2014. http://CRAN.R-project.org/package=PMCMR. Accessed September 5, 2016.
19. Morel O, Toti F, Hugel B, Bakouboula B, Camoin-Jau L, Dignat-George F, Freyssinet JM. Procoagulant microparticles: disrupting the vascular homeostasis equation? Arterioscler Thromb Vasc Biol. 2006;26:2594-2604. doi: 10.1161/01.ATV.0000246775. 14471.26.
20. Oeseburg H, Iusuf D, van der Harst P, van Gilst WH, Henning RH, Roks AJ. Bradykinin protects against oxidative stress-induced endothelial cell senescence. Hypertension. 2009;53:417-422. doi: 10.1161/HYPERTENSIONAHA.108.123729.
21. Galimov ER. The role of p66shc in oxidative stress and apoptosis. Acta Naturae. 2010;2:44-51.
22. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002;105:1541-1544.
23. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ Res. 2001;89:793-798.
24. Wu Z, Yu Y, Liu C, Xiong Y, Montani JP, Yang Z, Ming XF. Role of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathway. Aging (Albany NY). 2015;7:70-81. doi: 10.18632/aging.100722.
25. Curtis AM, Wilkinson PF, Gui M, Gales TL, Hu E, Edelberg JM. p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles. J Thromb Haemost. 2009;7:701-709. doi: 10.1111/j.1538-7836.2009.03304.x.
26. Donato AJ, Morgan RG, Walker AE, Lesniewski LA. Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol. 2015;89(Pt B):122-135. doi: 10.1016/j.yjmcc.2015.01.021.
27. Vasile E, Tomita Y, Brown LF, Kocher O, Dvorak HF. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001;15:458-466. doi: 10.1096/fj.00-0051com.
28. Karbach S, Wenzel P, Waisman A, Munzel T, Daiber A. eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation. Curr Pharm Des. 2014;20:3579-3594.
29. Gustafson CM, Shepherd AJ, Miller VM, Jayachandran M. Age-and sex-specific differences in blood-borne microvesicles from apparently healthy humans. Biol Sex Differ. 2015;6:10. doi: 10.1186/s13293-015-0028-8.
30. Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985). 2009;106:326-332. doi: 10.1152/japplphysiol.91353.2008.
31. Wu SJ, Soulez M, Yang YH, Chu CS, Shih SC, Hébert MJ, Kuo MC, Hsieh YJ. Local augmented angiotensinogen secreted from apoptotic vascular endothelial cells is a vital mediator of vascular remodelling. PLoS One. 2015;10:e0132583. doi: 10.1371/journal. pone.0132583.
32. Li D, Saldeen T, Romeo F, Mehta JL. Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB. Circulation. 2000;102:1970-1976.
33. Mu X, He K, Sun H, Zhou X, Chang L, Li X, Chu W, Qiao G, Lu Y. Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human umbilical vein endothelial cells. Free Radic Res. 2013;47:116-122. doi: 10.3109/10715762.2012.749987.
34. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379-2393. doi: 10.1016/j.jacc.2007.02.059.
35. Vion AC, Ramkhelawon B, Loyer X, Chironi G, Devue C, Loirand G, Tedgui A, Lehoux S, Boulanger CM. Shear stress regulates endothelial microparticle release. Circ Res. 2013;112:1323-1333. doi: 10.1161/CIRCRESAHA.112.300818.