메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Reprogramming the immunological microenvironment through radiation and targeting Axl

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 6; PIMONIDAZOLE; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN KINASE AXL; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN; AXL RECEPTOR TYROSINE KINASE; CYTOKINE; HLA ANTIGEN CLASS 1; ONCOPROTEIN;

EID: 85007079696     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13898     Document Type: Article
Times cited : (145)

References (45)
  • 1
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • Postow, M. A., Callahan, M. K. & Wolchok, J. D. Immune checkpoint blockade in cancer therapy. J. Clin. Oncol. 33, 1974-1982 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1974-1982
    • Postow, M.A.1    Callahan, M.K.2    Wolchok, J.D.3
  • 2
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 3
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 4
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 5
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1
  • 6
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow, M. A. et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N. Engl. J. Med. 366, 925-931 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 925-931
    • Postow, M.A.1
  • 7
    • 84871694504 scopus 로고    scopus 로고
    • A systemic complete response of metastatic melanoma to local radiation and immunotherapy
    • Hiniker, S. M. et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl. Oncol. 5, 404-407 (2012).
    • (2012) Transl. Oncol. , vol.5 , pp. 404-407
    • Hiniker, S.M.1
  • 8
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
    • Slovin, S. F. et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann. Oncol. 24, 1813-1821 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 1813-1821
    • Slovin, S.F.1
  • 9
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • Twyman-Saint Victor, C. et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520, 373-377 (2015).
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1
  • 10
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden, E. B., Demaria, S., Schiff, P. B., Chachoua, A. & Formenti, S. C. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol. Res. 1, 365-372 (2013).
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 11
    • 84904061705 scopus 로고    scopus 로고
    • Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
    • Grimaldi, A. M. et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 3, e28780 (2014).
    • (2014) Oncoimmunology , vol.3 , pp. e28780
    • Grimaldi, A.M.1
  • 12
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng, L. et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J. Clin. Invest. 124, 687-695 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 687-695
    • Deng, L.1
  • 13
    • 84983353116 scopus 로고    scopus 로고
    • Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen
    • Sharabi, A. B. et al. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol. Res. 3, 345-355 (2015).
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 345-355
    • Sharabi, A.B.1
  • 14
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class i expression, and induces successful antitumor immunotherapy
    • Reits, E. A. et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J. Exp. Med. 203, 1259-1271 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1259-1271
    • Reits, E.A.1
  • 15
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
    • Dovedi, S. J. et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 74, 5458-5468 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 5458-5468
    • Dovedi, S.J.1
  • 16
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • Spranger, S., Bao, R. & Gajewski, T. F. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523, 231-235 (2015).
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 17
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim, K. et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc. Natl Acad. Sci. USA 111, 11774-11779 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 11774-11779
    • Kim, K.1
  • 18
    • 84934973340 scopus 로고    scopus 로고
    • MET is required for the recruitment of anti-tumoural neutrophils
    • Finisguerra, V. et al. MET is required for the recruitment of anti-tumoural neutrophils. Nature 522, 349-353 (2015).
    • (2015) Nature , vol.522 , pp. 349-353
    • Finisguerra, V.1
  • 19
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang, Z. et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat. Genet. 44, 852-860 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 852-860
    • Zhang, Z.1
  • 20
    • 84907192193 scopus 로고    scopus 로고
    • Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
    • Rankin, E. B. et al. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc. Natl Acad. Sci. USA 111, 13373-13378 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13373-13378
    • Rankin, E.B.1
  • 21
    • 84922481128 scopus 로고    scopus 로고
    • The TAM family: Phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer
    • Graham, D. K., DeRyckere, D., Davies, K. D. & Earp, H. S. The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nat. Rev. Cancer 14, 769-785 (2014).
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 769-785
    • Graham, D.K.1    DeRyckere, D.2    Davies, K.D.3    Earp, H.S.4
  • 22
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
    • Hugo, W. et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165, 35-44 (2016).
    • (2016) Cell , vol.165 , pp. 35-44
    • Hugo, W.1
  • 23
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloidderived suppressor cells in tumor-bearing mice
    • Youn, J. I., Nagaraj, S., Collazo, M. & Gabrilovich, D. I. Subsets of myeloidderived suppressor cells in tumor-bearing mice. J. Immunol. 181, 5791-5802 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 24
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K. S., Quezada, S. A., Chambers, C. A., Korman, A. J. & Allison, J. P. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 206, 1717-1725 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 25
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan, M. Z. et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin. Cancer Res. 15, 5379-5388 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1
  • 26
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007).
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 27
    • 33846193992 scopus 로고    scopus 로고
    • Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells
    • Sen, P. et al. Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood 109, 653-660 (2007).
    • (2007) Blood , vol.109 , pp. 653-660
    • Sen, P.1
  • 28
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock
    • Camenisch, T. D., Koller, B. H., Earp, H. S. & Matsushima, G. K. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162, 3498-3503 (1999).
    • (1999) J. Immunol , vol.162 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 29
    • 79960328662 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition augments the expression of MHC class i and II genes
    • Pollack, B. P., Sapkota, B. & Cartee, T. V. Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes. Clin. Cancer Res. 17, 4400-4413 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4400-4413
    • Pollack, B.P.1    Sapkota, B.2    Cartee, T.V.3
  • 30
    • 84885137302 scopus 로고    scopus 로고
    • Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser
    • Cline, M. S. et al. Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser. Sci. Rep. 3, 2652 (2013).
    • (2013) Sci. Rep. , vol.3 , pp. 2652
    • Cline, M.S.1
  • 31
    • 84871998076 scopus 로고    scopus 로고
    • An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers, L. A. et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin. Cancer Res. 19, 279-290 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 279-290
    • Byers, L.A.1
  • 32
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad, M., Sathe, P., Helft, J., Miller, J. & Mortha, A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563-604 (2013).
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 33
    • 37649015079 scopus 로고    scopus 로고
    • CD4CD25Foxp3 regulatory T cells induce alternative activation of human monocytes/macrophages
    • Tiemessen, M. M. et al. CD4CD25Foxp3 regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl Acad. Sci. USA 104, 19446-19451 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 19446-19451
    • Tiemessen, M.M.1
  • 34
    • 78651062856 scopus 로고    scopus 로고
    • Phenotypic and functional switch of macrophages induced by regulatory CD4CD25 T cells in mice
    • Liu, G. et al. Phenotypic and functional switch of macrophages induced by regulatory CD4CD25 T cells in mice. Immunol. Cell Biol. 89, 130-142 (2011).
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 130-142
    • Liu, G.1
  • 35
    • 84924425611 scopus 로고    scopus 로고
    • An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
    • Kariolis, M. S. et al. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat. Chem. Biol. 10, 977-983 (2014).
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 977-983
    • Kariolis, M.S.1
  • 36
    • 77957109253 scopus 로고    scopus 로고
    • An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye, X. et al. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29, 5254-5264 (2010).
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1
  • 37
    • 84892438921 scopus 로고    scopus 로고
    • First Axl inhibitor enters clinical trials
    • Sheridan, C. First Axl inhibitor enters clinical trials. Nat. Biotechnol. 31, 775-776 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 775-776
    • Sheridan, C.1
  • 38
    • 70149109569 scopus 로고    scopus 로고
    • Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: Activation of AXL
    • Liu, L. et al. Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: Activation of AXL. Cancer Res. 69, 6871-6878 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 6871-6878
    • Liu, L.1
  • 40
    • 84897954522 scopus 로고    scopus 로고
    • The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
    • Paolino, M. et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 507, 508-512 (2014).
    • (2014) Nature , vol.507 , pp. 508-512
    • Paolino, M.1
  • 41
    • 77952490280 scopus 로고    scopus 로고
    • TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    • Alciato, F., Sainaghi, P. P., Sola, D., Castello, L. & Avanzi, G. C. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J. Leukoc. Biol. 87, 869-875 (2010).
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 869-875
    • Alciato, F.1    Sainaghi, P.P.2    Sola, D.3    Castello, L.4    Avanzi, G.C.5
  • 42
    • 84873736003 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target
    • Paccez, J. D. et al. The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Oncogene 32, 689-698 (2013).
    • (2013) Oncogene , vol.32 , pp. 689-698
    • Paccez, J.D.1
  • 43
    • 33947321266 scopus 로고    scopus 로고
    • Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice
    • Davie, S. A. et al. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res. 16, 193-201 (2007).
    • (2007) Transgenic Res. , vol.16 , pp. 193-201
    • Davie, S.A.1
  • 45
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman, A. M. et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat. Med. 20, 548-554 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 548-554
    • Newman, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.