메뉴 건너뛰기




Volumn 39, Issue 5, 2017, Pages 1012-1025

Cardiovascular Effects of Glucose-lowering Therapies for Type 2 Diabetes: New Drugs in Perspective

Author keywords

cardiovascular outcomes; GLP agonists; glucose lowering drugs; SGLT 2 inhibitors; type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ALBIGLUTIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DULAGLUTIDE; EXENDIN 4; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; INSULIN; LINAGLIPTIN; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; MIGLITOL; PIOGLITAZONE; ROSIGLITAZONE; SAXAGLIPTIN; SEMAGLUTIDE; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA DERIVATIVE; VILDAGLIPTIN; VOGLIBOSE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85006753325     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2016.10.008     Document Type: Review
Times cited : (17)

References (79)
  • 1
    • 0033533596 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association
    • 1 Grundy, S.M., Benjamin, I.J., Burke, G.L., et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100 (1999), 1134–1146.
    • (1999) Circulation , vol.100 , pp. 1134-1146
    • Grundy, S.M.1    Benjamin, I.J.2    Burke, G.L.3
  • 2
    • 84886943101 scopus 로고    scopus 로고
    • Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation
    • 2 Waugh, N., Cummins, E., Royle, P., et al. Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation. Health Technol Assess 14 (2010), 1–248.
    • (2010) Health Technol Assess , vol.14 , pp. 1-248
    • Waugh, N.1    Cummins, E.2    Royle, P.3
  • 3
    • 84960521846 scopus 로고    scopus 로고
    • 5. Glycemic Targets
    • 3 American Diabetes Association (ADA). 5. Glycemic Targets. Diabetes Care 39 (2016), S39–S46.
    • (2016) Diabetes Care , vol.39 , pp. S39-S46
  • 4
    • 84885997413 scopus 로고    scopus 로고
    • ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
    • 4 Ryden, L., Grant, P.J., Anker, S.D., et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34 (2013), 3035–3087.
    • (2013) Eur Heart J , vol.34 , pp. 3035-3087
    • Ryden, L.1    Grant, P.J.2    Anker, S.D.3
  • 5
    • 0032511583 scopus 로고    scopus 로고
    • UK Prospective Diabetes Study (UKPDS) Group
    • 5 Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352 (1998), 837–853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 6
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • 6 Gerstein, H.C., Miller, M.E., Byington, R.P., et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358 (2008), 2545–2559.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 7
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • 7 Patel, A., MacMahon, S., Chalmers, J., et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358 (2008), 2560–2572.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 8
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • 8 Duckworth, W., Abraira, C., Moritz, T., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360 (2009), 129–139.
    • (2009) N Engl J Med , vol.360 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 9
    • 70349881450 scopus 로고    scopus 로고
    • Intensive glucose control and macrovascular outcomes in type 2 diabetes
    • 9 Turnbull, F.M., Abraira, C., Anderson, R.J., et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 52 (2009), 2288–2298.
    • (2009) Diabetologia , vol.52 , pp. 2288-2298
    • Turnbull, F.M.1    Abraira, C.2    Anderson, R.J.3
  • 10
    • 53749091595 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • 10 Holman, R.R., Paul, S.K., Bethel, M.A., et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359 (2008), 1577–1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 11
    • 84930532577 scopus 로고    scopus 로고
    • VADT Investigators. Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes
    • 11 Hayward, R.A., Reaven, P.D., Wiitala, W.L., et al. VADT Investigators. Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes. N Engl J Med 372 (2015), 2197–2206.
    • (2015) N Engl J Med , vol.372 , pp. 2197-2206
    • Hayward, R.A.1    Reaven, P.D.2    Wiitala, W.L.3
  • 12
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • 12 Nathan, D.M., Cleary, P.A., Backlund, J.Y., et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353:25 (2005), 2643–2653.
    • (2005) N Engl J Med , vol.353 , Issue.25 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 13
    • 84963669785 scopus 로고    scopus 로고
    • Metabolic memory and all-cause death in community-based patients with type 2 diabetes: the Fremantle Diabetes Study
    • 13 Davis, T.M., Chubb, S.A., Bruce, D.G., Davis, W.A., Metabolic memory and all-cause death in community-based patients with type 2 diabetes: the Fremantle Diabetes Study. Diabetes Obes Metab 18 (2016), 598–606.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 598-606
    • Davis, T.M.1    Chubb, S.A.2    Bruce, D.G.3    Davis, W.A.4
  • 14
    • 85020559451 scopus 로고    scopus 로고
    • Diabetes Mellitus — Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). December
    • 14 Guidance for Industry. Diabetes Mellitus — Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). December 2008.
    • (2008)
    • Guidance for Industry1
  • 15
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • 15 DeFronzo, R.A., Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131 (1999), 281–303.
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • DeFronzo, R.A.1
  • 16
    • 0000559926 scopus 로고
    • A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes
    • 16 The University Group Diabetes Program. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. Diabetes 19:suppl 2 (1970), 747–830.
    • (1970) Diabetes , vol.19 , pp. 747-830
  • 17
    • 0015401059 scopus 로고
    • A summary of criticisms of the findings and conclusions of the University Group Diabetes Program
    • 17 Seltzer, H.S., A summary of criticisms of the findings and conclusions of the University Group Diabetes Program. Diabetes 21 (1972), 976–979.
    • (1972) Diabetes , vol.21 , pp. 976-979
    • Seltzer, H.S.1
  • 18
    • 33846690465 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin
    • 18 Gangji, A.S., Cukierman, T., Gerstein, H.C., et al. A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin. Diabetes Care 30 (2007), 389–394.
    • (2007) Diabetes Care , vol.30 , pp. 389-394
    • Gangji, A.S.1    Cukierman, T.2    Gerstein, H.C.3
  • 19
    • 0037326224 scopus 로고    scopus 로고
    • Editorial: sulfonylureas differ in effects on ischemic preconditioning–is it time to retire glyburide?
    • 19 Riddle, M.C., Editorial: sulfonylureas differ in effects on ischemic preconditioning–is it time to retire glyburide?. J Clin Endocrinol Metab 88 (2003), 528–530.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 528-530
    • Riddle, M.C.1
  • 20
    • 84964769831 scopus 로고    scopus 로고
    • The association between sulfonylurea use and all-cause and cardiovascular mortality: a meta-analysis with trial sequential analysis of randomized clinical trials
    • 20 Varvaki Rados, D., Catani Pinto, L., Reck Remonti, L., et al. The association between sulfonylurea use and all-cause and cardiovascular mortality: a meta-analysis with trial sequential analysis of randomized clinical trials. PloS Med, 13, 2016, e1001992.
    • (2016) PloS Med , vol.13 , pp. e1001992
    • Varvaki Rados, D.1    Catani Pinto, L.2    Reck Remonti, L.3
  • 22
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: a review of its metabolic effects
    • 22 Cusi, K., DeFronzo, R.A., Metformin: a review of its metabolic effects. Diabetes Rev 6 (1998), 89–131.
    • (1998) Diabetes Rev , vol.6 , pp. 89-131
    • Cusi, K.1    DeFronzo, R.A.2
  • 23
    • 84957440490 scopus 로고    scopus 로고
    • Metformin and the gastrointestinal tract
    • 23 McCreight, L.J., Bailey, C.J., Pearson, E.R., Metformin and the gastrointestinal tract. Diabetologia 59 (2016), 426–435.
    • (2016) Diabetologia , vol.59 , pp. 426-435
    • McCreight, L.J.1    Bailey, C.J.2    Pearson, E.R.3
  • 24
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • 24 UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352 (1998), 854–865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 26
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials
    • 26 Lamanna, C., Monami, M., Marchionni, N., Mannucci, E., Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 13 (2011), 221–228.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 27
    • 84860167144 scopus 로고    scopus 로고
    • Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials
    • 27 Boussageon, R., Supper, I., Bejan-Angoulvant, T., et al. Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials. PloS Med, 9, 2012, e1001204.
    • (2012) PloS Med , vol.9 , pp. e1001204
    • Boussageon, R.1    Supper, I.2    Bejan-Angoulvant, T.3
  • 28
    • 84878753448 scopus 로고    scopus 로고
    • Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes
    • 28 Scheen, A.J., Paquot, N., Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes. Diabetes Metab 39 (2013), 179–190.
    • (2013) Diabetes Metab , vol.39 , pp. 179-190
    • Scheen, A.J.1    Paquot, N.2
  • 29
    • 84973472686 scopus 로고    scopus 로고
    • Diabetes medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis
    • 29 Maruthur, N.M., Tseng, E., Hutfless, S., et al. Diabetes medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 164 (2016), 740–751.
    • (2016) Ann Intern Med , vol.164 , pp. 740-751
    • Maruthur, N.M.1    Tseng, E.2    Hutfless, S.3
  • 30
    • 78651338445 scopus 로고    scopus 로고
    • Standards of medical care in diabetes—2011
    • 30 American Diabetes Association. Standards of medical care in diabetes—2011. Diabetes Care 34:Suppl 1 (2011), S11–S61.
    • (2011) Diabetes Care , vol.34 , pp. S11-S61
  • 31
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • 31 Inzucchi, S.E., Bergenstal, R.M., Buse, J.B., et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 38 (2015), 140–149.
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 32
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • 32 Nissen, S.E., Wolski, K., Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356 (2007), 2457–2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 33
    • 34548306407 scopus 로고    scopus 로고
    • Rosiglitazone and cardiovascular risk
    • 33 Diamond, G.A., Kaul, S., Rosiglitazone and cardiovascular risk. N Engl J Med 357 (2007), 938–939.
    • (2007) N Engl J Med , vol.357 , pp. 938-939
    • Diamond, G.A.1    Kaul, S.2
  • 34
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • 34 Dormandy, J.A., Charbonnel, B., Eckland, D.J., et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366 (2005), 1279–1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 35
    • 84957848154 scopus 로고    scopus 로고
    • Ten-year observational follow-up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes
    • 35 Erdmann, E., Harding, S., Lam, H., Perez, A., Ten-year observational follow-up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes. Diabetes Obes Metab 18 (2016), 266–273.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 266-273
    • Erdmann, E.1    Harding, S.2    Lam, H.3    Perez, A.4
  • 36
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
    • 36 Lincoff, A.M., Wolski, K., Nicholls, S.J., Nissen, S.E., Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 298 (2007), 1180–1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 37
    • 84962114446 scopus 로고    scopus 로고
    • IRIS Trial Investigators. Pioglitazone after ischemic stroke or transient ischemic attack
    • 37 Kernan, W.N., Viscoli, C.M., Furie, K.L., et al. IRIS Trial Investigators. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med 374 (2016), 1321–1331.
    • (2016) N Engl J Med , vol.374 , pp. 1321-1331
    • Kernan, W.N.1    Viscoli, C.M.2    Furie, K.L.3
  • 38
    • 79953236112 scopus 로고    scopus 로고
    • Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials
    • 38 Hernandez, A.V., Usmani, A., Rajamanickam, A., Moheet, A., Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials. Am J Cardiovasc Drugs 11 (2011), 115–128.
    • (2011) Am J Cardiovasc Drugs , vol.11 , pp. 115-128
    • Hernandez, A.V.1    Usmani, A.2    Rajamanickam, A.3    Moheet, A.4
  • 39
    • 84862684037 scopus 로고    scopus 로고
    • The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study
    • 39 Azoulay, L., Yin, H., Filion, K.B., et al. The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ, 344, 2012, e3645.
    • (2012) BMJ , vol.344 , pp. e3645
    • Azoulay, L.1    Yin, H.2    Filion, K.B.3
  • 40
    • 84938364689 scopus 로고    scopus 로고
    • Pioglitazone use and risk of bladder cancer and other common cancers in persons with diabetes
    • 40 Lewis, J.D., Habel, L.A., Quesenberry, C.P., et al. Pioglitazone use and risk of bladder cancer and other common cancers in persons with diabetes. JAMA 314 (2015), 265–277.
    • (2015) JAMA , vol.314 , pp. 265-277
    • Lewis, J.D.1    Habel, L.A.2    Quesenberry, C.P.3
  • 41
    • 0037097039 scopus 로고    scopus 로고
    • Acarbose for the prevention of diabetes mellitus: the STOP-NIDDM randomised trial. STOP-NIDDM Trial Research Group
    • 41 Chiasson, J.L., Josse, R.G., Gomis, R., et al. Acarbose for the prevention of diabetes mellitus: the STOP-NIDDM randomised trial. STOP-NIDDM Trial Research Group. Lancet 359 (2002), 2072–2077.
    • (2002) Lancet , vol.359 , pp. 2072-2077
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3
  • 42
    • 84902959136 scopus 로고    scopus 로고
    • Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial
    • 42 Holman, R.R., Bethel, M.A., Chan, J.C., et al., ACE Study Group. Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial. Am Heart J 168 (2014), 23–29.
    • (2014) Am Heart J , vol.168 , pp. 23-29
    • Holman, R.R.1    Bethel, M.A.2    Chan, J.C.3
  • 43
    • 84978976076 scopus 로고    scopus 로고
    • Comparison of clinical outcomes and adverse events associated with glucose-lowering drugs in patients with type 2 diabetes: a meta-analysis
    • 43 Palmer, S.C., Mavridis, D., Nicolucci, A., et al. Comparison of clinical outcomes and adverse events associated with glucose-lowering drugs in patients with type 2 diabetes: a meta-analysis. JAMA 316 (2016), 313–324.
    • (2016) JAMA , vol.316 , pp. 313-324
    • Palmer, S.C.1    Mavridis, D.2    Nicolucci, A.3
  • 44
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • 44 ORIGIN Trial Investigators, Gerstein, H.C., Bosch, J., Dagenais, G.R., Díaz, R., et al. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367 (2012), 319–328.
    • (2012) N Engl J Med , vol.367 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3    Díaz, R.4
  • 45
    • 85020603827 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01959529?term=DEVOTE&rank=1, A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE). Accessed September 12
    • 45 ClinicalTrials.gov. A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE). https://clinicaltrials.gov/ct2/show/NCT01959529?term=DEVOTE&rank=1. Accessed September 12, 2016.
    • (2016)
  • 46
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • 46 Drucker, D.J., Nauck, M.A., The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368 (2006), 1696–1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 47
    • 84957878858 scopus 로고    scopus 로고
    • Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
    • 47 Nauck, M., Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes Obes Metab 18 (2016), 203–216.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 203-216
    • Nauck, M.1
  • 48
    • 84924961701 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes
    • 48 Scheen, A.J., Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opin Drug Saf 14 (2015), 505–524.
    • (2015) Expert Opin Drug Saf , vol.14 , pp. 505-524
    • Scheen, A.J.1
  • 49
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • 49 White, W.B., Cannon, C.P., Heller, S.R., et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 369 (2013), 1327–1335.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 50
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • 50 Scirica, B.M., Bhatt, D.L., Braunwald, E., et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369 (2013), 1317–1326.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 51
    • 84937053742 scopus 로고    scopus 로고
    • Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
    • 51 Green, J.B., Bethel, M.A., Armstrong, P.W., et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 373 (2015), 232–242.
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 52
    • 84930085787 scopus 로고    scopus 로고
    • Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
    • 52 Zannad, F., Cannon, C.P., Cushman, W.C., et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 385 (2015), 2067–2076.
    • (2015) Lancet , vol.385 , pp. 2067-2076
    • Zannad, F.1    Cannon, C.P.2    Cushman, W.C.3
  • 53
    • 85021438535 scopus 로고    scopus 로고
    • Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: Secondary analysis of a randomized clinical trial
    • 53 McGuire, D.K., Van de Werf, F., Armstrong, P.W., et al. Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: Secondary analysis of a randomized clinical trial. JAMA Cardiol 1 (2016), 126–135.
    • (2016) JAMA Cardiol , vol.1 , pp. 126-135
    • McGuire, D.K.1    Van de Werf, F.2    Armstrong, P.W.3
  • 54
    • 85020568049 scopus 로고    scopus 로고
    • Drug Safety Communication: FDA adds warnings about heart failure risk to labels of type 2 diabetes medicines containing saxagliptin and alogliptin. Accessed September 2, 2016.
    • 54 FDA. Drug Safety Communication: FDA adds warnings about heart failure risk to labels of type 2 diabetes medicines containing saxagliptin and alogliptin. http://www.fda.gov/Drugs/DrugSafety/ucm486096.htm. Accessed September 2, 2016.
    • FDA1
  • 55
    • 85020558613 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01243424?term=CAROLINA+Linagliptin&rank=1, CAROLINA: Cardiovascular outcome study of linagliptin vs glimepiride in patients with type 2 diabetes. Accessed September 2
    • 55 ClinicalTrials.gov. CAROLINA: Cardiovascular outcome study of linagliptin vs glimepiride in patients with type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT01243424?term=CAROLINA+Linagliptin&rank=1. Accessed September 2, 2016.
    • (2016)
  • 56
    • 85020570755 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01897532, CARMELINA: Cardiovascular and renal microvascular outcome study with linagliptin in patients with type 2 diabetes mellitus. ? Accessed September 2
    • 56 ClinicalTrials.gov. CARMELINA: Cardiovascular and renal microvascular outcome study with linagliptin in patients with type 2 diabetes mellitus. https://clinicaltrials.gov/ct2/show/NCT01897532? Accessed September 2, 2016.
    • (2016)
  • 57
    • 84929947880 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: nonglycemic clinical effects in weight loss and beyond
    • 57 Ryan, D., Acosta, A., GLP-1 receptor agonists: nonglycemic clinical effects in weight loss and beyond. Obesity (Silver Spring) 23 (2015), 1119–1129.
    • (2015) Obesity (Silver Spring) , vol.23 , pp. 1119-1129
    • Ryan, D.1    Acosta, A.2
  • 58
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • 58 Pfeffer, M.A., Claggett, B., Diaz, R., et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257.
    • (2015) N Engl J Med , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 59
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • 59 Marso, S.P., Daniels, G.H., Brown-Frandsen, K., et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375 (2016), 311–322.
    • (2016) N Engl J Med , vol.375 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 60
    • 84982082404 scopus 로고    scopus 로고
    • NHLBI Heart Failure Clinical Research Network. Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial
    • 60 Margulies, K.B., Hernandez, A.F., Redfield, M.M., NHLBI Heart Failure Clinical Research Network. Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial. JAMA 316 (2016), 500–508.
    • (2016) JAMA , vol.316 , pp. 500-508
    • Margulies, K.B.1    Hernandez, A.F.2    Redfield, M.M.3
  • 61
    • 85020593956 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01720446?term=SUSTAIN+6+Semaglutide&rank=1, SUSTAIN 6: Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes. Accessed September 2
    • 61 ClinicalTrials.gov. SUSTAIN 6: Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes. https://clinicaltrials.gov/ct2/show/NCT01720446?term=SUSTAIN+6+Semaglutide&rank=1. Accessed September 2, 2016.
    • (2016)
  • 62
    • 84994813253 scopus 로고    scopus 로고
    • for the SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes [published online September 16, 2016]. N Engl J Med.
    • 62 Marso SP, Bain SC, Consoli A, et al, for the SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes [published online September 16, 2016]. N Engl J Med.
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 63
    • 85020599162 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01144338?term=EXSCEL+Exenatide&rank=1, EXSCEL: A Trial to Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus. Accessed September 2
    • 63 ClinicalTrials.gov. EXSCEL: A Trial to Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus. https://clinicaltrials.gov/ct2/show/NCT01144338?term=EXSCEL+Exenatide&rank=1. Accessed September 2, 2016.
    • (2016)
  • 64
    • 85020573508 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01394952?term=REWIND+Dulaglutide&rank=1, REWIND: Researching cardiovascular events with a weekly incretin in diabetes. Accessed September 2
    • 64 ClinicalTrials.gov. REWIND: Researching cardiovascular events with a weekly incretin in diabetes. https://clinicaltrials.gov/ct2/show/NCT01394952?term=REWIND+Dulaglutide&rank=1. Accessed September 2, 2016.
    • (2016)
  • 65
    • 85020570788 scopus 로고    scopus 로고
    • https://clinicaltrials.gov.ct2/show/NCT02465515?term=HARMONY+7&rank=6, HARMONY: Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus. Accessed October 15
    • 65 ClinicalTrials.gov. HARMONY: Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus. https://clinicaltrials.gov.ct2/show/NCT02465515?term=HARMONY+7&rank=6. Accessed October 15, 2016.
    • (2016)
  • 66
    • 84980320178 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes: cardiovascular and kidney effects, potential mechanisms and clinical applications [published online July 28, 2016]. Circulation.
    • 66 Heerspink HJ, Perkins BA, Fitchett DH, et al. Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes: cardiovascular and kidney effects, potential mechanisms and clinical applications [published online July 28, 2016]. Circulation.
    • Heerspink, H.J.1    Perkins, B.A.2    Fitchett, D.H.3
  • 67
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • 67 Scheen, A.J., Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs 75 (2015), 33–59.
    • (2015) Drugs , vol.75 , pp. 33-59
    • Scheen, A.J.1
  • 68
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
    • 68 Zinman, B., Wanner, C., Lachin, J.M., Fitchett, D., et al., EMPA-REG OUTCOME Investigators. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 373 (2015), 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3    Fitchett, D.4
  • 69
    • 84963814140 scopus 로고    scopus 로고
    • Diabetes medications with cardiovascular protection in the wake of EMPA-REG OUTCOME: the optimal combination may be metformin, pioglitazone and empagliflozin
    • 69 Ryder, R.E.J., Defronzo, R.A., Diabetes medications with cardiovascular protection in the wake of EMPA-REG OUTCOME: the optimal combination may be metformin, pioglitazone and empagliflozin. Br J Diabetes Vasc Dis 15 (2015), 151–154.
    • (2015) Br J Diabetes Vasc Dis , vol.15 , pp. 151-154
    • Ryder, R.E.J.1    Defronzo, R.A.2
  • 70
    • 84948432337 scopus 로고    scopus 로고
    • Cardiovascular risk and sodium–glucose cotransporter 2 inhibition in type 2 diabetes
    • 70 Ingelfinger, J.R., Rosen, C.J., Cardiovascular risk and sodium–glucose cotransporter 2 inhibition in type 2 diabetes. N Engl J Med 373 (2015), 2178–2179.
    • (2015) N Engl J Med , vol.373 , pp. 2178-2179
    • Ingelfinger, J.R.1    Rosen, C.J.2
  • 71
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial
    • e211
    • 71 Neal, B., Perkovic, V., de Zeeuw, D., et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial. Am Heart J 166 (2013), 217–223 e211.
    • (2013) Am Heart J , vol.166 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    de Zeeuw, D.3
  • 72
    • 85020592503 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01032629, CANVAS – CANagliflozin cardioVascular Assessment Study (CANVAS). Identifier: NCT01032629. Accessed September 2
    • 72 CANVAS – CANagliflozin cardioVascular Assessment Study (CANVAS). ClinicalTrials.gov Identifier: NCT01032629. https://clinicaltrials.gov/ct2/show/NCT01032629. Accessed September 2, 2016.
    • (2016)
  • 73
    • 85020589682 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT02065791?term=CREDENCE+Canagliflozin&rank=1, CREDENCE: Evaluation of the effects of canagliflozin on renal and cardiovascular outcomes in participants with diabetic nephropathy. Accessed September 2
    • 73 ClinicalTrials.gov. CREDENCE: Evaluation of the effects of canagliflozin on renal and cardiovascular outcomes in participants with diabetic nephropathy. https://clinicaltrials.gov/ct2/show/NCT02065791?term=CREDENCE+Canagliflozin&rank=1. Accessed September 2, 2016.
    • (2016)
  • 75
    • 85020593771 scopus 로고    scopus 로고
    • https://clinicaltrials.gov/ct2/show/NCT01986881?term=Ertugliflozin&rank=12, Cardiovascular outcomes following ertugliflozin treatment in type 2 diabetes mellitus participants With vascular disease. Accessed September 2
    • 75 ClinicalTrials.gov. VERTIS CV: Cardiovascular outcomes following ertugliflozin treatment in type 2 diabetes mellitus participants With vascular disease. https://clinicaltrials.gov/ct2/show/NCT01986881?term=Ertugliflozin&rank=12. Accessed September 2, 2016.
    • (2016)
    • VERTIS, C.V.1
  • 76
    • 84960094179 scopus 로고    scopus 로고
    • Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
    • 76 Ettehad, D., Emdin, C.A., Kiran, A., et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387 (2016), 957–967.
    • (2016) Lancet , vol.387 , pp. 957-967
    • Ettehad, D.1    Emdin, C.A.2    Kiran, A.3
  • 77
    • 84975698839 scopus 로고    scopus 로고
    • EMPA-REG OUTCOME® trial investigators. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
    • 77 Fitchett, D., Zinman, B., Wanner, C., et al. EMPA-REG OUTCOME® trial investigators. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 37 (2016), 1526–1534.
    • (2016) Eur Heart J , vol.37 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3
  • 78
    • 84964507777 scopus 로고    scopus 로고
    • SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
    • 78 Satttar, N., McLaren, J., Kristensen, S.L., et al. SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?. Diabetologia 59 (2016), 1333–1339.
    • (2016) Diabetologia , vol.59 , pp. 1333-1339
    • Satttar, N.1    McLaren, J.2    Kristensen, S.L.3
  • 79
    • 84991018034 scopus 로고    scopus 로고
    • Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: comparison with classic diuretics
    • 79 Scheen, A.J., Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: comparison with classic diuretics. Diabetes Meta 42 (2016), 224–233.
    • (2016) Diabetes Meta , vol.42 , pp. 224-233
    • Scheen, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.