메뉴 건너뛰기




Volumn 186, Issue , 2017, Pages 55-62

Treatment of negative symptoms: Where do we stand, and where do we go?

Author keywords

Antipsychotics; Cognitive behavioral therapy; Negative symptoms; Schizophrenia; Transcranial magnetic stimulation; Treatment

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; BITOPERTIN; CARBAMAZEPINE; CLOZAPINE; CYCLOSERINE; DEXTRO SERINE; FLUOXETINE; GLYCINE; HALOPERIDOL; LAMOTRIGINE; MEMANTINE; MIANSERIN; MINOCYCLINE; MIRTAZAPINE; NEUROLEPTIC AGENT; OLANZAPINE; OXYTOCIN; PERPHENAZINE; QUETIAPINE; REBOXETINE; RISPERIDONE; RITANSERIN; SARCOSINE; SEROTONIN UPTAKE INHIBITOR; TOPIRAMATE; TRAZODONE; UNINDEXED DRUG; VALPROIC ACID; ZIPRASIDONE;

EID: 85006741596     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2016.05.015     Document Type: Review
Times cited : (139)

References (102)
  • 1
    • 84907976568 scopus 로고    scopus 로고
    • Pomaglumetad methionil (LY2140023 monohydrate) and aripiprazole in patients with schizophrenia: a phase 3, multicenter, double-blind comparison
    • 758212
    • Adams, D.H., Zhang, L., Millen, B.A., Kinon, B.J., Gomez, J.C., Pomaglumetad methionil (LY2140023 monohydrate) and aripiprazole in patients with schizophrenia: a phase 3, multicenter, double-blind comparison. Schizophr. Res. Treat., 758212, 2014.
    • (2014) Schizophr. Res. Treat.
    • Adams, D.H.1    Zhang, L.2    Millen, B.A.3    Kinon, B.J.4    Gomez, J.C.5
  • 2
    • 84883607647 scopus 로고    scopus 로고
    • Use of repetitive transcranial magnetic stimulation for treatment in psychiatry
    • (Aug)
    • Aleman, A., Use of repetitive transcranial magnetic stimulation for treatment in psychiatry. Clin. Psychopharmacol. Neurosci. 11:2 (2013), 53–59 (Aug).
    • (2013) Clin. Psychopharmacol. Neurosci. , vol.11 , Issue.2 , pp. 53-59
    • Aleman, A.1
  • 3
    • 0032832346 scopus 로고    scopus 로고
    • Memory impairment in schizophrenia: a meta-analysis
    • (Sep)
    • Aleman, A., Hijman, R., de Haan, E.H., Kahn, R.S., Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry 156:9 (1999), 1358–1366 (Sep).
    • (1999) Am. J. Psychiatry , vol.156 , Issue.9 , pp. 1358-1366
    • Aleman, A.1    Hijman, R.2    de Haan, E.H.3    Kahn, R.S.4
  • 4
    • 0034054949 scopus 로고    scopus 로고
    • Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists
    • Anand, A., Charney, D.S., Oren, D.A., Berman, R.M., Hu, X.S., Cappiello, A., Krystal, J.H., Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Arch. Gen. Psychiatry 57 (2000), 270–276.
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 270-276
    • Anand, A.1    Charney, D.S.2    Oren, D.A.3    Berman, R.M.4    Hu, X.S.5    Cappiello, A.6    Krystal, J.H.7
  • 5
    • 0033958273 scopus 로고    scopus 로고
    • Fluoxetine as an adjunct to conventional antipsychotic treatment of schizophrenia patients with residual symptoms
    • (Jan)
    • Arango, C., Kirkpatrick, B., Buchanan, R.W., Fluoxetine as an adjunct to conventional antipsychotic treatment of schizophrenia patients with residual symptoms. J. Nerv. Ment. Dis. 188:1 (2000), 50–53 (Jan).
    • (2000) J. Nerv. Ment. Dis. , vol.188 , Issue.1 , pp. 50-53
    • Arango, C.1    Kirkpatrick, B.2    Buchanan, R.W.3
  • 6
    • 1142285269 scopus 로고    scopus 로고
    • The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms
    • (Feb)
    • Arango, C., Buchanan, R.W., Kirkpatrick, B., Carpenter, W.T., The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms. Eur. Psychiatry 19:1 (2004), 21–26 (Feb).
    • (2004) Eur. Psychiatry , vol.19 , Issue.1 , pp. 21-26
    • Arango, C.1    Buchanan, R.W.2    Kirkpatrick, B.3    Carpenter, W.T.4
  • 7
    • 84886297495 scopus 로고    scopus 로고
    • Pharmacological approaches to treating negative symptoms: a review of clinical trials
    • (Nov)
    • Arango, C., Garibaldi, G., Marder, S.R., Pharmacological approaches to treating negative symptoms: a review of clinical trials. Schizophr. Res. 150:2–3 (2013), 346–352 (Nov).
    • (2013) Schizophr. Res. , vol.150 , Issue.2-3 , pp. 346-352
    • Arango, C.1    Garibaldi, G.2    Marder, S.R.3
  • 8
    • 33645925691 scopus 로고    scopus 로고
    • Negative signs and symptoms secondary to antipsychotics: a double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers
    • (Mar)
    • Artaloytia, J.F., Arango, C., Lahti, A., Sanz, J., Pascual, A., Cubero, P., Prieto, D., Palomo, T., Negative signs and symptoms secondary to antipsychotics: a double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers. Am. J. Psychiatry 163:3 (2006), 488–493 (Mar).
    • (2006) Am. J. Psychiatry , vol.163 , Issue.3 , pp. 488-493
    • Artaloytia, J.F.1    Arango, C.2    Lahti, A.3    Sanz, J.4    Pascual, A.5    Cubero, P.6    Prieto, D.7    Palomo, T.8
  • 9
    • 77950891328 scopus 로고    scopus 로고
    • Subjective tolerability of antipsychotic medications and the emerging science of subjective tolerability disorders
    • Awad, A.G., Subjective tolerability of antipsychotic medications and the emerging science of subjective tolerability disorders. Expert Rev. Pharmacoecon. Outcomes Res. 10 (2010), 1–4.
    • (2010) Expert Rev. Pharmacoecon. Outcomes Res. , vol.10 , pp. 1-4
    • Awad, A.G.1
  • 10
    • 65349153837 scopus 로고    scopus 로고
    • Schizophrenia. Cognitive Theory, Research and Therapy
    • Guilford Press New York
    • Beck, A.T., Rector, N.A., Stolar, N., Grant, P.M., Schizophrenia. Cognitive Theory, Research and Therapy. 2009, Guilford Press, New York.
    • (2009)
    • Beck, A.T.1    Rector, N.A.2    Stolar, N.3    Grant, P.M.4
  • 12
    • 84979787055 scopus 로고    scopus 로고
    • Motivation and avolition in schizophrenia patients: the role of self-efficacy
    • Bentall, R.P., Simpson, P.W., Lee, D.A., Williams, S., Elves, S., Brabbins, C., et al. Motivation and avolition in schizophrenia patients: the role of self-efficacy. Psychosis 2 (2010), 12–22.
    • (2010) Psychosis , vol.2 , pp. 12-22
    • Bentall, R.P.1    Simpson, P.W.2    Lee, D.A.3    Williams, S.4    Elves, S.5    Brabbins, C.6
  • 13
    • 77950307734 scopus 로고    scopus 로고
    • Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study
    • (Mar)
    • Bobes, J., Arango, C., Garcia-Garcia, M., Rejas, J., CLAMORS Study Collaborative Group. Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study. J. Clin. Psychiatry 71:3 (2010), 280–286 (Mar).
    • (2010) J. Clin. Psychiatry , vol.71 , Issue.3 , pp. 280-286
    • Bobes, J.1    Arango, C.2    Garcia-Garcia, M.3    Rejas, J.4
  • 15
    • 0031746826 scopus 로고    scopus 로고
    • Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome
    • (Jun)
    • Buchanan, R.W., Breier, A., Kirkpatrick, B., Ball, P., Carpenter, W.T. Jr., Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome. Am. J. Psychiatry 155:6 (1998), 751–760 (Jun).
    • (1998) Am. J. Psychiatry , vol.155 , Issue.6 , pp. 751-760
    • Buchanan, R.W.1    Breier, A.2    Kirkpatrick, B.3    Ball, P.4    Carpenter, W.T.5
  • 16
    • 35748969317 scopus 로고    scopus 로고
    • The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan, R.W., Javitt, D.C., Marder, S.R., Schooler, N.R., Gold, J.M., McMahon, R.P., Heresco-Levy, U., Carpenter, W.T., The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am. J. Psychiatry 164:10 (2007), 1593–1602.
    • (2007) Am. J. Psychiatry , vol.164 , Issue.10 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3    Schooler, N.R.4    Gold, J.M.5    McMahon, R.P.6    Heresco-Levy, U.7    Carpenter, W.T.8
  • 19
    • 84902305515 scopus 로고    scopus 로고
    • A phase II/III trial of bitopertin monotherapy compared with placebo in patients with an acute exacerbation of schizophrenia - results from the CandleLyte study
    • Bugarski-Kirola, D., Wang, A., Abi-Saab, D., Blättler, T., A phase II/III trial of bitopertin monotherapy compared with placebo in patients with an acute exacerbation of schizophrenia - results from the CandleLyte study. Eur. Neuropsychopharmacol. 24:7 (2014), 1024–1036.
    • (2014) Eur. Neuropsychopharmacol. , vol.24 , Issue.7 , pp. 1024-1036
    • Bugarski-Kirola, D.1    Wang, A.2    Abi-Saab, D.3    Blättler, T.4
  • 22
    • 84923571778 scopus 로고    scopus 로고
    • Theta-burst stimulation: a new form of TMS treatment for depression?
    • (Mar)
    • Chung, S.W., Hoy, K.E., Fitzgerald, P.B., Theta-burst stimulation: a new form of TMS treatment for depression?. Depress. Anxiety 32:3 (2015), 182–192 (Mar).
    • (2015) Depress. Anxiety , vol.32 , Issue.3 , pp. 182-192
    • Chung, S.W.1    Hoy, K.E.2    Fitzgerald, P.B.3
  • 25
    • 72849132183 scopus 로고    scopus 로고
    • Improvement of negative and positive symptoms in treatment-refractory schizophrenia: a double-blind, randomized, placebo-controlled trial with memantine add-on therapy to clozapine
    • (2009 Oct, Erratum in: J Clin Psychiatry. 2011 Aug;72(8):1157)
    • De Lucena, D., Fernandes, B.S., Berk, M., Dodd, S., Medeiros, D.W., Pedrini, M., Kunz, M., Gomes, F.A., Giglio, L.F., Lobato, M.I., Belmonte-de-Abreu, P.S., Gama, C.S., Improvement of negative and positive symptoms in treatment-refractory schizophrenia: a double-blind, randomized, placebo-controlled trial with memantine add-on therapy to clozapine. J. Clin. Psychiatry 70:10 (2009), 1416–1423, 10.4088/JCP.08m04935gry (2009 Oct, Erratum in: J Clin Psychiatry. 2011 Aug;72(8):1157).
    • (2009) J. Clin. Psychiatry , vol.70 , Issue.10 , pp. 1416-1423
    • De Lucena, D.1    Fernandes, B.S.2    Berk, M.3    Dodd, S.4    Medeiros, D.W.5    Pedrini, M.6    Kunz, M.7    Gomes, F.A.8    Giglio, L.F.9    Lobato, M.I.10    Belmonte-de-Abreu, P.S.11    Gama, C.S.12
  • 27
    • 84881027906 scopus 로고    scopus 로고
    • Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy
    • (August)
    • Deutsch, S.I., Schwartz, B.L., Schooler, N.R., Brown, C.H., Rosse, R.B., Rosse, S.M., Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy. Schizophr. Res. 148:0 (2013), 138–144 (August).
    • (2013) Schizophr. Res. , vol.148 , pp. 138-144
    • Deutsch, S.I.1    Schwartz, B.L.2    Schooler, N.R.3    Brown, C.H.4    Rosse, R.B.5    Rosse, S.M.6
  • 28
    • 0028874976 scopus 로고
    • Family interventions for schizophrenia
    • Dixon, L., Lehman, A.F., Family interventions for schizophrenia. Schizophr. Bull. 21 (1995), 631–643.
    • (1995) Schizophr. Bull. , vol.21 , pp. 631-643
    • Dixon, L.1    Lehman, A.F.2
  • 29
    • 77951029973 scopus 로고    scopus 로고
    • Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: review and meta-analysis
    • Dlabac-de Lange, J.J., Knegtering, R., Aleman, A., Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: review and meta-analysis. J. Clin. Psychiatry 71 (2010), 411–418.
    • (2010) J. Clin. Psychiatry , vol.71 , pp. 411-418
    • Dlabac-de Lange, J.J.1    Knegtering, R.2    Aleman, A.3
  • 30
    • 84925250295 scopus 로고    scopus 로고
    • Efficacy of bilateral repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: results of a multicenter double-blind randomized controlled trial
    • (Apr)
    • Dlabac-de Lange, J.J., Bais, L., van Es, F.D., Visser, B.G., Reinink, E., Bakker, B., van den Heuvel, E.R., Aleman, A., Knegtering, H., Efficacy of bilateral repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: results of a multicenter double-blind randomized controlled trial. Psychol. Med. 45:6 (2015), 1263–1275 (Apr).
    • (2015) Psychol. Med. , vol.45 , Issue.6 , pp. 1263-1275
    • Dlabac-de Lange, J.J.1    Bais, L.2    van Es, F.D.3    Visser, B.G.4    Reinink, E.5    Bakker, B.6    van den Heuvel, E.R.7    Aleman, A.8    Knegtering, H.9
  • 31
    • 84966344919 scopus 로고    scopus 로고
    • Self-evaluation of negative symptoms: a novel tool to assess negative symptoms
    • Dollfus, S., Mach, C., Morello, R., Self-evaluation of negative symptoms: a novel tool to assess negative symptoms. Schizophr. Bull. 42 (2016), 571–578.
    • (2016) Schizophr. Bull. , vol.42 , pp. 571-578
    • Dollfus, S.1    Mach, C.2    Morello, R.3
  • 32
    • 58249083788 scopus 로고    scopus 로고
    • Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations
    • Dominguez Mde, G., Viechtbauer, W., Simons, C.J., van Os, J., Krabbendam, L., Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations. Psychol. Bull. 135:1 (2009), 157–171.
    • (2009) Psychol. Bull. , vol.135 , Issue.1 , pp. 157-171
    • Dominguez Mde, G.1    Viechtbauer, W.2    Simons, C.J.3    van Os, J.4    Krabbendam, L.5
  • 34
    • 0034036184 scopus 로고    scopus 로고
    • Management of negative symptoms among patients with schizophrenia attending multiple-family groups
    • Dyck, D.G., Short, R.A., Hendryx, M.S., Norell, D., Myers, M., Patterson, T., et al. Management of negative symptoms among patients with schizophrenia attending multiple-family groups. Psychiatr. Serv. 51 (2000), 513–519.
    • (2000) Psychiatr. Serv. , vol.51 , pp. 513-519
    • Dyck, D.G.1    Short, R.A.2    Hendryx, M.S.3    Norell, D.4    Myers, M.5    Patterson, T.6
  • 35
    • 84881543290 scopus 로고    scopus 로고
    • Negative symptom improvement during cognitive rehabilitation. Results from a two-year trial of cognitive enhancement therapy
    • Eak, S.M., Mesholam-Gateley, R.I., Greenwald, D.P., Hogarty, S.S., Keshavan, M.S., Negative symptom improvement during cognitive rehabilitation. Results from a two-year trial of cognitive enhancement therapy. Psychiatry Res. 209 (2013), 21–26.
    • (2013) Psychiatry Res. , vol.209 , pp. 21-26
    • Eak, S.M.1    Mesholam-Gateley, R.I.2    Greenwald, D.P.3    Hogarty, S.S.4    Keshavan, M.S.5
  • 36
    • 84883023444 scopus 로고    scopus 로고
    • Psychosocial treatments for negative symptoms in schizophrenia: current practices and future directions
    • Elis, O., Caponigro, J.M., Kring, A.M., Psychosocial treatments for negative symptoms in schizophrenia: current practices and future directions. Clin. Psychol. Rev. 33 (2013), 914–928.
    • (2013) Clin. Psychol. Rev. , vol.33 , pp. 914-928
    • Elis, O.1    Caponigro, J.M.2    Kring, A.M.3
  • 37
    • 0034058017 scopus 로고    scopus 로고
    • Placebo-controlled trial of glycine added to clozapine in schizophrenia
    • (e.a.)
    • Evins, A.E., Fitzgerald, S.M., Wine, L., Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am. J. Psychiatry 157 (2000), 826–828 (e.a.).
    • (2000) Am. J. Psychiatry , vol.157 , pp. 826-828
    • Evins, A.E.1    Fitzgerald, S.M.2    Wine, L.3
  • 38
    • 77955061273 scopus 로고    scopus 로고
    • Anticipatory pleasure skills training: a new intervention to reduce anhedonia in schizophrenia
    • Favrod, J., Giuliani, F., Ernst, F., Bonsack, C., Anticipatory pleasure skills training: a new intervention to reduce anhedonia in schizophrenia. Perspect. Psychiatr. Care 46 (2010), 171–181.
    • (2010) Perspect. Psychiatr. Care , vol.46 , pp. 171-181
    • Favrod, J.1    Giuliani, F.2    Ernst, F.3    Bonsack, C.4
  • 39
    • 84955581741 scopus 로고    scopus 로고
    • A review of oxytocin's effects on the positive, negative, and cognitive domains of schizophrenia
    • (Feb 1)
    • Feifel, D., Shilling, P.D., MacDonald, K., A review of oxytocin's effects on the positive, negative, and cognitive domains of schizophrenia. Biol. Psychiatry 79:3 (2016), 222–233 (Feb 1).
    • (2016) Biol. Psychiatry , vol.79 , Issue.3 , pp. 222-233
    • Feifel, D.1    Shilling, P.D.2    MacDonald, K.3
  • 41
    • 84919472460 scopus 로고    scopus 로고
    • A negative pilot study of daily bimodal transcranial direct current stimulation in schizophrenia
    • (Nov-Dec)
    • Fitzgerald, P.B., McQueen, S., Daskalakis, Z.J., Hoy, K.E., A negative pilot study of daily bimodal transcranial direct current stimulation in schizophrenia. Brain Stimul. 7:6 (2014), 813–816 (Nov-Dec).
    • (2014) Brain Stimul. , vol.7 , Issue.6 , pp. 813-816
    • Fitzgerald, P.B.1    McQueen, S.2    Daskalakis, Z.J.3    Hoy, K.E.4
  • 42
    • 84922253021 scopus 로고    scopus 로고
    • Dissecting negative symptoms in schizophrenia: opportunities for translation into new treatments
    • (Feb)
    • Foussias, G., Siddiqui, I., Fervaha, G., Agid, O., Remington, G., Dissecting negative symptoms in schizophrenia: opportunities for translation into new treatments. J. Psychopharmacol. 29:2 (2015), 116–126 (Feb).
    • (2015) J. Psychopharmacol. , vol.29 , Issue.2 , pp. 116-126
    • Foussias, G.1    Siddiqui, I.2    Fervaha, G.3    Agid, O.4    Remington, G.5
  • 43
    • 60249097465 scopus 로고    scopus 로고
    • Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia
    • Freitas, C., Fregni, F., Pascual-Leone, A., Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia. Schizophr. Res. 108 (2009), 11–24.
    • (2009) Schizophr. Res. , vol.108 , pp. 11-24
    • Freitas, C.1    Fregni, F.2    Pascual-Leone, A.3
  • 44
    • 84936753582 scopus 로고    scopus 로고
    • Treatments of negative symptoms in schizophrenia: meta-analysis of 168 randomized placebo-controlled trials
    • (Jul)
    • Fusar-Poli, P., Papanastasiou, E., Stahl, D., Rocchetti, M., Carpenter, W., Shergill, S., McGuire, P., Treatments of negative symptoms in schizophrenia: meta-analysis of 168 randomized placebo-controlled trials. Schizophr. Bull. 41:4 (2015), 892–899 (Jul).
    • (2015) Schizophr. Bull. , vol.41 , Issue.4 , pp. 892-899
    • Fusar-Poli, P.1    Papanastasiou, E.2    Stahl, D.3    Rocchetti, M.4    Carpenter, W.5    Shergill, S.6    McGuire, P.7
  • 45
    • 76649135819 scopus 로고    scopus 로고
    • Efficacy and effectiveness of individual family intervention on social and clinical functioning and family burden in severe schizophrenia: a 2-year randomized controlled study
    • Giron, M., Fernandez-Yanez, A., Mana-Alvarenga, S., Molina-Habas, A., Nolasco, A., Gomez-Beneyto, M., Efficacy and effectiveness of individual family intervention on social and clinical functioning and family burden in severe schizophrenia: a 2-year randomized controlled study. Psychol. Med. 40 (2010), 73–84.
    • (2010) Psychol. Med. , vol.40 , pp. 73-84
    • Giron, M.1    Fernandez-Yanez, A.2    Mana-Alvarenga, S.3    Molina-Habas, A.4    Nolasco, A.5    Gomez-Beneyto, M.6
  • 46
    • 84902180976 scopus 로고    scopus 로고
    • Bitopertin: the good news and bad news
    • Goff, D.C., Bitopertin: the good news and bad news. JAMA Psychiatry 71 (2014), 621–622.
    • (2014) JAMA Psychiatry , vol.71 , pp. 621-622
    • Goff, D.C.1
  • 47
    • 77952099237 scopus 로고    scopus 로고
    • Asocial beliefs as predictors of asocial behavior in schizophrenia
    • Grant, P.M., Beck, A.T., Asocial beliefs as predictors of asocial behavior in schizophrenia. Psychiatry Res. 177 (2010), 65–70.
    • (2010) Psychiatry Res. , vol.177 , pp. 65-70
    • Grant, P.M.1    Beck, A.T.2
  • 48
    • 84856740864 scopus 로고    scopus 로고
    • Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia
    • Grant, P., Huh, G.A., Perivoliotis, D., Stolar, N.M., Beck, A.T., Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia. Arch. Gen. Psychiatry 69 (2012), 121–127.
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 121-127
    • Grant, P.1    Huh, G.A.2    Perivoliotis, D.3    Stolar, N.M.4    Beck, A.T.5
  • 49
    • 84946480162 scopus 로고    scopus 로고
    • Sex hormones and oxytocin augmentation strategies in schizophrenia: a quantitative review
    • (doi:S0920-9964(15)00174-7)
    • Heringa, S.M., Begemann, M.J., Goverde, A.J., Sommer, I.E., Sex hormones and oxytocin augmentation strategies in schizophrenia: a quantitative review. Schizophr. Res., 2015 (doi:S0920-9964(15)00174-7).
    • (2015) Schizophr. Res.
    • Heringa, S.M.1    Begemann, M.J.2    Goverde, A.J.3    Sommer, I.E.4
  • 50
    • 0022622270 scopus 로고
    • Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia: I. one-year effects of a controlled study on relapse and expressed emotion
    • Hogarty, G.E., Anderson, C.M., Reiss, D.J., et al. Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia: I. one-year effects of a controlled study on relapse and expressed emotion. Arch. Gen. Psychiatry 43 (1986), 633–642.
    • (1986) Arch. Gen. Psychiatry , vol.43 , pp. 633-642
    • Hogarty, G.E.1    Anderson, C.M.2    Reiss, D.J.3
  • 51
    • 77956653559 scopus 로고    scopus 로고
    • Pharmacological treatment of negative symptoms in schizophrenia; research and practice. [Medicamenteuze interventie bij negatieve symptomen bij patienten met schizofrenie]
    • Jiawan, V.C., Arends, J., Slooff, C.J., Knegtering, H., Pharmacological treatment of negative symptoms in schizophrenia; research and practice. [Medicamenteuze interventie bij negatieve symptomen bij patienten met schizofrenie]. Tijdschr. Psychiatrie 52:9 (2010), 627–637.
    • (2010) Tijdschr. Psychiatrie , vol.52 , Issue.9 , pp. 627-637
    • Jiawan, V.C.1    Arends, J.2    Slooff, C.J.3    Knegtering, H.4
  • 52
    • 84906775841 scopus 로고    scopus 로고
    • Off-label use of memantine as adjunctive treatment in schizophrenia: a retrospective case series study
    • John, J.P., Lukose, A., Manjunath, S., Off-label use of memantine as adjunctive treatment in schizophrenia: a retrospective case series study. Pharmacopsychiatry 47:6 (2014), 202–209.
    • (2014) Pharmacopsychiatry , vol.47 , Issue.6 , pp. 202-209
    • John, J.P.1    Lukose, A.2    Manjunath, S.3
  • 53
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay, S.R., Fiszbein, A., Opler, L.A., The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13:2 (1987), 261–276.
    • (1987) Schizophr. Bull. , vol.13 , Issue.2 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 54
    • 84860743254 scopus 로고    scopus 로고
    • Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy
    • (May)
    • Kegeles, L.S., Mao, X., Stanford, A.D., Girgis, R., Ojeil, N., Xu, X., Gil, R., Slifstein, M., Abi-Dargham, A., Lisanby, S.H., Shungu, D.C., Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy. Arch. Gen. Psychiatry 69:5 (2012), 449–459 (May).
    • (2012) Arch. Gen. Psychiatry , vol.69 , Issue.5 , pp. 449-459
    • Kegeles, L.S.1    Mao, X.2    Stanford, A.D.3    Girgis, R.4    Ojeil, N.5    Xu, X.6    Gil, R.7    Slifstein, M.8    Abi-Dargham, A.9    Lisanby, S.H.10    Shungu, D.C.11
  • 55
    • 81955168013 scopus 로고    scopus 로고
    • Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms
    • (Dec)
    • Kelly, D.L., Vyas, G., Richardson, C.M., Koola, M., McMahon, R.P., Buchanan, R.W., Wehring, H.J., Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms. Schizophr. Res. 133:1–3 (2011), 257–258 (Dec).
    • (2011) Schizophr. Res. , vol.133 , Issue.1-3 , pp. 257-258
    • Kelly, D.L.1    Vyas, G.2    Richardson, C.M.3    Koola, M.4    McMahon, R.P.5    Buchanan, R.W.6    Wehring, H.J.7
  • 58
    • 84942109073 scopus 로고    scopus 로고
    • Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionil in schizophrenia
    • (Mar 19. pii:S0006-3223(15)00254-1)
    • Kinon, B.J., Millen, B.A., Zhang, L., McKinzie, D.L., Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionil in schizophrenia. Biol. Psychiatry, 2015, 10.1016/j.biopsych.2015.03.016 (Mar 19. pii:S0006-3223(15)00254-1).
    • (2015) Biol. Psychiatry
    • Kinon, B.J.1    Millen, B.A.2    Zhang, L.3    McKinzie, D.L.4
  • 60
    • 84971663781 scopus 로고    scopus 로고
    • Secondary negative symptoms – a review of mechanisms, assessment and treatment
    • Kirschner, M., Aleman, A., Kaiser, S., Secondary negative symptoms – a review of mechanisms, assessment and treatment. Schizophr. Res. 186 (2017), 29–38.
    • (2017) Schizophr. Res. , vol.186 , pp. 29-38
    • Kirschner, M.1    Aleman, A.2    Kaiser, S.3
  • 61
    • 80052250357 scopus 로고    scopus 로고
    • Negative symptoms of schizophrenia as primary target of cognitive behavioral therapy: results of the randomized clinical TONES study
    • Klingberg, S., Wölwer, W., Engel, C., Wittorf, A., Herrlich, J., Meisner, C., et al. Negative symptoms of schizophrenia as primary target of cognitive behavioral therapy: results of the randomized clinical TONES study. Schizophr. Bull. 37 (2011), S98–S110.
    • (2011) Schizophr. Bull. , vol.37 , pp. S98-S110
    • Klingberg, S.1    Wölwer, W.2    Engel, C.3    Wittorf, A.4    Herrlich, J.5    Meisner, C.6
  • 62
    • 84873396022 scopus 로고    scopus 로고
    • The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation
    • (Feb)
    • Kring, A.M., Gur, R.E., Blanchard, J.J., Horan, W.P., Reise, S.P., The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation. Am. J. Psychiatry 170:2 (2013), 165–172 (Feb).
    • (2013) Am. J. Psychiatry , vol.170 , Issue.2 , pp. 165-172
    • Kring, A.M.1    Gur, R.E.2    Blanchard, J.J.3    Horan, W.P.4    Reise, S.P.5
  • 63
    • 84960908805 scopus 로고    scopus 로고
    • Toward illness phase-specific pharmacotherapy for schizophrenia
    • (Dec 1)
    • Krystal, J.H., Anticevic, A., Toward illness phase-specific pharmacotherapy for schizophrenia. Biol. Psychiatry 78:11 (2015), 738–740 (Dec 1).
    • (2015) Biol. Psychiatry , vol.78 , Issue.11 , pp. 738-740
    • Krystal, J.H.1    Anticevic, A.2
  • 64
    • 27744529018 scopus 로고    scopus 로고
    • Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study
    • (Nov)
    • Lane, H.Y., Chang, Y.C., Liu, Y.C., Chiu, C.C., Tsai, G.E., Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. Arch. Gen. Psychiatry 62:11 (2005), 1196–1204 (Nov).
    • (2005) Arch. Gen. Psychiatry , vol.62 , Issue.11 , pp. 1196-1204
    • Lane, H.Y.1    Chang, Y.C.2    Liu, Y.C.3    Chiu, C.C.4    Tsai, G.E.5
  • 65
    • 33749496746 scopus 로고    scopus 로고
    • The treatment of negative symptoms and deficit states of chronic schizophrenia: olanzapine compared to amisulpride and placebo in a 6-month double-blind controlled clinical trial
    • (Nov)
    • Lecrubier, Y., Quintin, P., Bouhassira, M., Perrin, E., Lancrenon, S., The treatment of negative symptoms and deficit states of chronic schizophrenia: olanzapine compared to amisulpride and placebo in a 6-month double-blind controlled clinical trial. Acta Psychiatr. Scand. 114:5 (2006), 319–327 (Nov).
    • (2006) Acta Psychiatr. Scand. , vol.114 , Issue.5 , pp. 319-327
    • Lecrubier, Y.1    Quintin, P.2    Bouhassira, M.3    Perrin, E.4    Lancrenon, S.5
  • 66
    • 58049157203 scopus 로고    scopus 로고
    • Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    • (Jan 3)
    • Leucht, S., Corves, C., Arbter, D., Engel, R.R., Li, C., Davis, J.M., Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373:9657 (2009), 31–41 (Jan 3).
    • (2009) Lancet , vol.373 , Issue.9657 , pp. 31-41
    • Leucht, S.1    Corves, C.2    Arbter, D.3    Engel, R.R.4    Li, C.5    Davis, J.M.6
  • 67
    • 84973169092 scopus 로고    scopus 로고
    • Delayed effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia: findings from a randomized controlled trial
    • (Apr 22)
    • Li, Z., Yin, M., Lyu, X.L., Zhang, L.L., Du, X.D., Hung, G.C., Delayed effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia: findings from a randomized controlled trial. Psychiatry Res. 240 (2016), 333–335 (Apr 22).
    • (2016) Psychiatry Res. , vol.240 , pp. 333-335
    • Li, Z.1    Yin, M.2    Lyu, X.L.3    Zhang, L.L.4    Du, X.D.5    Hung, G.C.6
  • 68
    • 84875908782 scopus 로고    scopus 로고
    • Two subdomains of negative symptoms in psychotic disorders: established and confirmed in two large cohorts
    • Liemburg, E., Castelein, S., Stewart, R., van der Gaag, M., Aleman, A., Knegtering, H., et al. Two subdomains of negative symptoms in psychotic disorders: established and confirmed in two large cohorts. J. Psychiatr. Res. 47 (2013), 718–725.
    • (2013) J. Psychiatr. Res. , vol.47 , pp. 718-725
    • Liemburg, E.1    Castelein, S.2    Stewart, R.3    van der Gaag, M.4    Aleman, A.5    Knegtering, H.6
  • 69
    • 80052216057 scopus 로고    scopus 로고
    • Negative symptoms and social cognition. Detecting suitable targets for psychological interventions
    • Lincoln, T.M., Mehl, S., Kesting, M.-L., Rief, W., Negative symptoms and social cognition. Detecting suitable targets for psychological interventions. Schizophr. Bull. 37 (2011), S23–S32.
    • (2011) Schizophr. Bull. , vol.37 , pp. S23-S32
    • Lincoln, T.M.1    Mehl, S.2    Kesting, M.-L.3    Rief, W.4
  • 70
    • 84878967787 scopus 로고    scopus 로고
    • A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: challenges and therapeutic opportunities
    • Lindenmayer, J.P., Nasrallah, H., Pucci, M., James, S., Citrome, L., A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: challenges and therapeutic opportunities. Schizophr. Res. 147:2–3 (2013), 241–252.
    • (2013) Schizophr. Res. , vol.147 , Issue.2-3 , pp. 241-252
    • Lindenmayer, J.P.1    Nasrallah, H.2    Pucci, M.3    James, S.4    Citrome, L.5
  • 71
    • 84895818899 scopus 로고    scopus 로고
    • Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial
    • Liu, F., Guo, X., Wu, R., Ou, J., Zheng, Y., Zhang, B., Zhao, J., Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. Schizophr. Res. 153:1–3 (2014), 169–176.
    • (2014) Schizophr. Res. , vol.153 , Issue.1-3 , pp. 169-176
    • Liu, F.1    Guo, X.2    Wu, R.3    Ou, J.4    Zheng, Y.5    Zhang, B.6    Zhao, J.7
  • 72
    • 4243110486 scopus 로고    scopus 로고
    • Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition
    • (z'Ω`, Mar;153(1-3):177-83)
    • Lysaker, P.H., Davis, L.W., Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition. Health Qual. Life Outcomes, 2, 2004, 15 (z'Ω`, Mar;153(1-3):177-83).
    • (2004) Health Qual. Life Outcomes , vol.2 , pp. 15
    • Lysaker, P.H.1    Davis, L.W.2
  • 73
    • 84941937744 scopus 로고    scopus 로고
    • Pharmacological treatment of negative symptoms in schizophrenia
    • (Oct)
    • Möller, H.J., Czobor, P., Pharmacological treatment of negative symptoms in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 265:7 (2015), 567–578 (Oct).
    • (2015) Eur. Arch. Psychiatry Clin. Neurosci. , vol.265 , Issue.7 , pp. 567-578
    • Möller, H.J.1    Czobor, P.2
  • 74
    • 0028946201 scopus 로고
    • A path-analytical approach to differentiate between direct and indirect drug effects on negative symptoms in schizophrenic patients. A re-evaluation of the North American risperidone study
    • Möller, H.J., Müller, H., Borison, R.L., Schooler, N.R., Chouinard, G., A path-analytical approach to differentiate between direct and indirect drug effects on negative symptoms in schizophrenic patients. A re-evaluation of the North American risperidone study. Eur. Arch. Psychiatry Clin. Neurosci. 245:1 (1995), 45–49.
    • (1995) Eur. Arch. Psychiatry Clin. Neurosci. , vol.245 , Issue.1 , pp. 45-49
    • Möller, H.J.1    Müller, H.2    Borison, R.L.3    Schooler, N.R.4    Chouinard, G.5
  • 75
    • 84969920340 scopus 로고    scopus 로고
    • Primary and persistent negative symptoms: concepts, assessments and neurobiological bases
    • Mucci, A., Merlotti, E., Üçok, A., Aleman, A., Galderisi, S., Primary and persistent negative symptoms: concepts, assessments and neurobiological bases. Schizophr. Res. 186 (2017), 19–28.
    • (2017) Schizophr. Res. , vol.186 , pp. 19-28
    • Mucci, A.1    Merlotti, E.2    Üçok, A.3    Aleman, A.4    Galderisi, S.5
  • 76
    • 67649946057 scopus 로고    scopus 로고
    • Schizophrenia: core interventions in the treatment and management of schizophrenia in adults in primary and secondary care. NICE clinical guideline 82
    • Available at
    • NICE, Schizophrenia: core interventions in the treatment and management of schizophrenia in adults in primary and secondary care. NICE clinical guideline 82. Available at www.nice.org.uk/CG82, 2009.
    • (2009)
    • NICE1
  • 77
    • 84922705265 scopus 로고    scopus 로고
    • Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta- analysis of randomized controlled trials
    • (Sep)
    • Oya, K., Kishi, T., Iwata, N., Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta- analysis of randomized controlled trials. Hum. Psychopharmacol. 29:5 (2014), 483–491 (Sep).
    • (2014) Hum. Psychopharmacol. , vol.29 , Issue.5 , pp. 483-491
    • Oya, K.1    Kishi, T.2    Iwata, N.3
  • 78
    • 84983071561 scopus 로고    scopus 로고
    • Tackling negative symptoms of schizophrenia with memantine
    • Paraschakis, A., Tackling negative symptoms of schizophrenia with memantine. Case Reports in Psychiatry, 2014, 2014, 384783.
    • (2014) Case Reports in Psychiatry, 2014 , pp. 384783
    • Paraschakis, A.1
  • 80
    • 81255210685 scopus 로고    scopus 로고
    • Transcranial electrical stimulation (tES - tDCS; tRNS, tACS) methods
    • (Oct)
    • Paulus, W., Transcranial electrical stimulation (tES - tDCS; tRNS, tACS) methods. Neuropsychol. Rehabil. 21:5 (2011), 602–617 (Oct).
    • (2011) Neuropsychol. Rehabil. , vol.21 , Issue.5 , pp. 602-617
    • Paulus, W.1
  • 81
    • 70349987512 scopus 로고    scopus 로고
    • Repetitive transcranial magnetic stimulation or transcranial direct current stimulation?
    • (Oct)
    • Priori, A., Hallett, M., Rothwell, J.C., Repetitive transcranial magnetic stimulation or transcranial direct current stimulation?. Brain Stimul. 2:4 (2009), 241–245 (Oct).
    • (2009) Brain Stimul. , vol.2 , Issue.4 , pp. 241-245
    • Priori, A.1    Hallett, M.2    Rothwell, J.C.3
  • 82
    • 84948973607 scopus 로고    scopus 로고
    • Ventral striatal activation during reward processing in psychosis: a neurofunctional meta-analysis
    • (Dec)
    • Radua, J., Schmidt, A., Borgwardt, S., Heinz, A., Schlagenhauf, F., McGuire, P., Fusar-Poli, P., Ventral striatal activation during reward processing in psychosis: a neurofunctional meta-analysis. JAMA Psychiatry 72:12 (2015), 1243–1251 (Dec).
    • (2015) JAMA Psychiatry , vol.72 , Issue.12 , pp. 1243-1251
    • Radua, J.1    Schmidt, A.2    Borgwardt, S.3    Heinz, A.4    Schlagenhauf, F.5    McGuire, P.6    Fusar-Poli, P.7
  • 83
    • 33846222251 scopus 로고    scopus 로고
    • Integrated psychological therapy (IPT) for schizophrenia: is it effective?
    • Roder, V., Mueller, D., Mueser, K.T., Brenner, H.D., Integrated psychological therapy (IPT) for schizophrenia: is it effective?. Schizophr. Bull. 32 (2006), 81–93.
    • (2006) Schizophr. Bull. , vol.32 , pp. 81-93
    • Roder, V.1    Mueller, D.2    Mueser, K.T.3    Brenner, H.D.4
  • 84
    • 84900283431 scopus 로고    scopus 로고
    • Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: a meta-analysis
    • Shi, C., Yu, X., Cheung, E.F., Shum, D.H., Chan, R.C., Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: a meta-analysis. Psychiatry Res. 215 (2014), 505–513.
    • (2014) Psychiatry Res. , vol.215 , pp. 505-513
    • Shi, C.1    Yu, X.2    Cheung, E.F.3    Shum, D.H.4    Chan, R.C.5
  • 85
    • 80052996482 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia
    • (Oct 1)
    • Singh, S.P., Singh, V., Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs 25:10 (2011), 859–885 (Oct 1).
    • (2011) CNS Drugs , vol.25 , Issue.10 , pp. 859-885
    • Singh, S.P.1    Singh, V.2
  • 86
    • 77956864079 scopus 로고    scopus 로고
    • Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis
    • Singh, S.P., Singh, V., Kar, N., Chan, K., Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis. Br. J. Psychiatry 197:3 (2010), 174–179.
    • (2010) Br. J. Psychiatry , vol.197 , Issue.3 , pp. 174-179
    • Singh, S.P.1    Singh, V.2    Kar, N.3    Chan, K.4
  • 87
    • 84942374483 scopus 로고    scopus 로고
    • Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: a randomized controlled study
    • (Jul)
    • Smith, R.C., Boules, S., Mattiuz, S., Youssef, M., Tobe, R.H., Sershen, H., Lajtha, A., Nolan, K., Amiaz, R., Davis, J.M., Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: a randomized controlled study. Schizophr. Res., 16, 2015 (Jul).
    • (2015) Schizophr. Res. , vol.16
    • Smith, R.C.1    Boules, S.2    Mattiuz, S.3    Youssef, M.4    Tobe, R.H.5    Sershen, H.6    Lajtha, A.7    Nolan, K.8    Amiaz, R.9    Davis, J.M.10
  • 88
    • 84874714618 scopus 로고    scopus 로고
    • Cognitive Behavioral Therapy for negative symptoms (CBT-n) in psychotic disorders: a pilot study
    • Staring, A.B., Ter Huurne, M.A., van der Gaag, M., Cognitive Behavioral Therapy for negative symptoms (CBT-n) in psychotic disorders: a pilot study. J. Behav. Ther. Exp. Psychiatry 44 (2013), 300–306.
    • (2013) J. Behav. Ther. Exp. Psychiatry , vol.44 , pp. 300-306
    • Staring, A.B.1    Ter Huurne, M.A.2    van der Gaag, M.3
  • 89
    • 84886304673 scopus 로고    scopus 로고
    • Pomaglumetad methionil: no significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
    • (Nov)
    • Stauffer, V.L., Millen, B.A., Andersen, S., Kinon, B.J., Lagrandeur, L., Lindenmayer, J.P., Gomez, J.C., Pomaglumetad methionil: no significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo. Schizophr. Res. 150:2–3 (2013), 434–441 (Nov).
    • (2013) Schizophr. Res. , vol.150 , Issue.2-3 , pp. 434-441
    • Stauffer, V.L.1    Millen, B.A.2    Andersen, S.3    Kinon, B.J.4    Lagrandeur, L.5    Lindenmayer, J.P.6    Gomez, J.C.7
  • 91
    • 84945241306 scopus 로고    scopus 로고
    • Randomized controlled trials of add-on antidepressants in schizophrenia
    • (doi:pyv049 [pii])
    • Terevnikov, V., Joffe, G., Stenberg, J.H., Randomized controlled trials of add-on antidepressants in schizophrenia. Int. J. Neuropsychopharmacol., 2015 (doi:pyv049 [pii]).
    • (2015) Int. J. Neuropsychopharmacol.
    • Terevnikov, V.1    Joffe, G.2    Stenberg, J.H.3
  • 92
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis
    • Tiihonen, J., Wahlbeck, K., Kiviniemi, V., The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis. Schizophr. Res. 109 (2009), 10–14.
    • (2009) Schizophr. Res. , vol.109 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 93
    • 9244243064 scopus 로고    scopus 로고
    • Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis
    • Tuominen, H.J., Tiihonen, J., Wahlbeck, K., Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr. Res. 72:2–3 (2005), 225–234.
    • (2005) Schizophr. Res. , vol.72 , Issue.2-3 , pp. 225-234
    • Tuominen, H.J.1    Tiihonen, J.2    Wahlbeck, K.3
  • 94
    • 84897478043 scopus 로고    scopus 로고
    • Psychological interventions for psychosis: a meta-analysis of comparative outcome studies
    • Turner, D.T., van der Gaag, M., Karyotaki, E., Cuijpers, P., Psychological interventions for psychosis: a meta-analysis of comparative outcome studies. Am. J. Psychiatr. 171 (2014), 523–538.
    • (2014) Am. J. Psychiatr. , vol.171 , pp. 523-538
    • Turner, D.T.1    van der Gaag, M.2    Karyotaki, E.3    Cuijpers, P.4
  • 95
    • 85027951368 scopus 로고    scopus 로고
    • Clozapine augmented with glutamate modulators in refractory schizophrenia: a review and metaanalysis
    • Veerman, S.R., Schulte, P.F., Begemann, M.J., Engelsbel, F., de Haan, L., Clozapine augmented with glutamate modulators in refractory schizophrenia: a review and metaanalysis. Pharmacopsychiatry 47:6 (2014), 185–194.
    • (2014) Pharmacopsychiatry , vol.47 , Issue.6 , pp. 185-194
    • Veerman, S.R.1    Schulte, P.F.2    Begemann, M.J.3    Engelsbel, F.4    de Haan, L.5
  • 96
    • 85030422231 scopus 로고    scopus 로고
    • Memantine augmentation in clozapine-refractory schizophrenia: a randomized, double-blind, placebo-controlled crossover study
    • (Apr). (2014, [Epub ahead of print])
    • Veerman, S.R., Schulte, P.F., Smidt, J.D., de Haan, L., Memantine augmentation in clozapine-refractory schizophrenia: a randomized, double-blind, placebo-controlled crossover study. Psychol. Med. 6 (2016), 1–13 (Apr). (2014, [Epub ahead of print]).
    • (2016) Psychol. Med. , vol.6 , pp. 1-13
    • Veerman, S.R.1    Schulte, P.F.2    Smidt, J.D.3    de Haan, L.4
  • 97
    • 84930045977 scopus 로고    scopus 로고
    • A randomized pilot study of MOtiVation and Enhancement (MOVE) Training for negative symptoms in schizophrenia
    • Velligan, D., Roberts, D., Mintz, J., Maples, N., Li, X., Medellin, E., et al. A randomized pilot study of MOtiVation and Enhancement (MOVE) Training for negative symptoms in schizophrenia. Schizophr. Res. 165 (2015), 175–180.
    • (2015) Schizophr. Res. , vol.165 , pp. 175-180
    • Velligan, D.1    Roberts, D.2    Mintz, J.3    Maples, N.4    Li, X.5    Medellin, E.6
  • 98
    • 84927697164 scopus 로고    scopus 로고
    • Adapted cognitive–behavioural therapy required for targeting negative symptoms in schizophrenia: meta-analysis and meta-regression
    • Velthorst, E., Koeter, M., van der Gaag, M., et al. Adapted cognitive–behavioural therapy required for targeting negative symptoms in schizophrenia: meta-analysis and meta-regression. Psychol. Med. 45 (2015), 453–465.
    • (2015) Psychol. Med. , vol.45 , pp. 453-465
    • Velthorst, E.1    Koeter, M.2    van der Gaag, M.3
  • 99
    • 84884507145 scopus 로고    scopus 로고
    • Meta-analysis of efficacy of mirtazapine as an adjunctive treatment of negative symptoms in schizophrenia
    • (doi:H63X60J285V6X45K)
    • Vidal, C., Reese, C., Fischer, B.A., Chiapelli, J., Himelhoch, S., Meta-analysis of efficacy of mirtazapine as an adjunctive treatment of negative symptoms in schizophrenia. Clin. Schizophr. Relat. Psychoses, 2013, 1–24 (doi:H63X60J285V6X45K).
    • (2013) Clin. Schizophr. Relat. Psychoses , pp. 1-24
    • Vidal, C.1    Reese, C.2    Fischer, B.A.3    Chiapelli, J.4    Himelhoch, S.5
  • 101
    • 84929297589 scopus 로고    scopus 로고
    • Left prefrontal high-frequency repetitive transcranial magnetic stimulation for the treatment of schizophrenia with predominant negative symptoms: a sham-controlled, randomized multicenter trial
    • (Jun 1)
    • Wobrock, T., Guse, B., Cordes, J., Wölwer, W., Winterer, G., Gaebel, W., et al. Left prefrontal high-frequency repetitive transcranial magnetic stimulation for the treatment of schizophrenia with predominant negative symptoms: a sham-controlled, randomized multicenter trial. Biol. Psychiatry 77:11 (2015), 979–988 (Jun 1).
    • (2015) Biol. Psychiatry , vol.77 , Issue.11 , pp. 979-988
    • Wobrock, T.1    Guse, B.2    Cordes, J.3    Wölwer, W.4    Winterer, G.5    Gaebel, W.6
  • 102
    • 44949167544 scopus 로고    scopus 로고
    • Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor
    • Wykes, T., Steel, C., Everitt, B., Tarrier, N., Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor. Schizophr. Bull. 34 (2008), 523–537.
    • (2008) Schizophr. Bull. , vol.34 , pp. 523-537
    • Wykes, T.1    Steel, C.2    Everitt, B.3    Tarrier, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.