TRPA1 gene polymorphisms and childhood asthma

Pediatric Allergy and Immunology

Volumn 28, Issue 2, 2017, Pages 191-198

  Gallo, Valentina ^a   Dijk, F Nicole ^b   Holloway, John W ^c   Ring, Susan M ^d   Koppelman, Gerard H ^b   Postma, Dirkje S ^e   Strachan, David P ^f   Granell, Raquel ^d   de Jongste, Johan C ^g   Jaddoe, Vincent W V ^g   den Dekker, Herman T ^g   Duijts, Liesbeth ^g   Henderson, A John ^d   Shaheen, Seif O ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f ST GEORGE S HOSPITAL   (United Kingdom)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

asthma; Avon Longitudinal Study of Parents and Children; birth cohort; Generation R; gene environment interaction; genotype; paracetamol; prenatal exposure; Prevention and Incidence of Asthma and Mite Allergy; transient receptor potential ankyrin 1

Indexed keywords

IMMUNOGLOBULIN E; PARACETAMOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRPA1 PROTEIN, HUMAN;

ALLELE; ARTICLE; ASTHMA; CHILD; COHORT ANALYSIS; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC VARIABILITY; HUMAN; INCIDENCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; CLINICAL TRIAL; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MATERNAL EXPOSURE; MULTICENTER STUDY; NETHERLANDS; PREGNANCY; PRESCHOOL CHILD;

ACETAMINOPHEN; ASTHMA; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; MATERNAL EXPOSURE; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TRPA1 CATION CHANNEL;

EID: 85006482447     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12673     Document Type: Article

References (36)

1. Kang K, Pulver SR, Panzano VC, et al. Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 2010: 464: 597–600.
2. Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Investig 2008: 118: 1899–910.
3. Facchinetti FP, Patacchini R. The rising role of TRPA1 in asthma. Open Drug Discov J. 2010: 2: 71–80.
4. Belvisi MG, Dubuis E, Birrell MA. Transient receptor potential A1 channels: insights into cough and airway inflammatory disease. Chest 2011: 140: 1040–7.
5. Bautista DM, Pellegrino M, Tsunozaki M. TRPA1: a gatekeeper for inflammation. Annu Rev Physiol 2013: 75: 181–200.
6. Caceres AI, Brackmann M, Elia MD, et al. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci USA 2009: 106: 9099–104.
7. Hox V, Vanoirbeek JA, Alpizar YA, et al. Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice. Am J Respir Crit Care Med 2013: 187: 486–93.
8. Shaheen SO, Sterne JA, Songhurst CE, Burney PG. Frequent paracetamol use and asthma in adults. Thorax 2000: 55: 266–70.
9. Henderson AJ, Shaheen SO. Acetaminophen and asthma. Paediatr Respir Rev 2013: 14: 9–15; quiz 6.
10. Nassini R, Materazzi S, Andre E, et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010: 24: 4904–16.
11. Boyd A, Golding J, Macleod J, et al. Cohort Profile: the ‘children of the 90s’–the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 2013: 42: 111–27.
12. Fraser A, Macdonald-Wallis C, Tilling K, et al. Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol 2013: 42: 97–110.
13. Smit LA, Kogevinas M, Anto JM, et al. Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respir Res 2012: 13: 26.
14. Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010: 363: 1211–21.
15. Binder A, May D, Baron R, et al. Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS One 2011: 6: e17387.
16. Kim H, Mittal DP, Iadarola MJ, Dionne RA. Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet 2006: 43: e40.
17. Doehring A, Kusener N, Fluhr K, Neddermeyer TJ, Schneider G, Lotsch J. Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures. PLoS One 2011: 6: e17724.
18. Uhl GR, Walther D, Behm FM, Rose JE. Menthol preference among smokers: association with TRPA1 variants. Nicotine Tob Res 2011: 13: 1311–5.
19. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005: 21: 263–5.
20. Newson RB. Attributable and unattributable risks and fractions and other scenario comparisons. STATA J 2013: 13: 672–98.
21. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004: 74: 765–9.
22. Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 2005: 95: 221–7.
23. Brunekreef B, Smit J, de Jongste J, et al. The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results. Pediatr Allergy Immunol 2002: 13 (Suppl 15): 55–60.
24. Wijga AH, Kerkhof M, Gehring U, et al. Cohort profile: the prevention and incidence of asthma and mite allergy (PIAMA) birth cohort. Int J Epidemiol 2014: 43: 527–35.
25. Jaddoe VW, van Duijn CM, van der Heijden AJ, et al. The Generation R Study: design and cohort update 2010. Eur J Epidemiol 2010: 25: 823–41.
26. Kruithof CJ, Kooijman MN, van Duijn CM, et al. The Generation R Study: biobank update 2015. Eur J Epidemiol 2014: 29: 911–27.
27. Deering-Rice CE, Shapiro D, Romero EG, et al. Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma. Am J Respir Cell Mol Biol 2015: 53: 893–901.
28. Bonnelykke K, Sleiman P, Nielsen K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 2014: 46: 51–5.
29. Siroux V, Gonzalez JR, Bouzigon E, et al. Genetic heterogeneity of asthma phenotypes identified by a clustering approach. Eur Respir J 2014: 43: 439–52.
30. Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011: 127: 355–60.
31. Meyers DA, Bleecker ER, Holloway JW, Holgate ST. Asthma genetics and personalised medicine. Lancet Respir Med 2014: 2: 405–15.
32. Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med 1990: 9: 235–43.
33. Andre E, Campi B, Materazzi S, et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Investig 2008: 118: 2574–82.
34. Nassini R, Pedretti P, Moretto N, et al. Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS One 2012: 7: e42454.
35. Mukhopadhyay I, Gomes P, Aranake S, et al. Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. J Recept Signal Transduct Res 2011: 31: 350–8.
36. Raemdonck K, de Alba J, Birrell MA, et al. A role for sensory nerves in the late asthmatic response. Thorax 2012: 67: 19–25.