Transient receptor potential A1 channels: Insights into cough and airway inflammatory disease

Chest

Volumn 140, Issue 4, 2011, Pages 1040-1047

  Belvisi, Maria G ^a,b   Dubuis, Eric ^a   Birrell, Mark A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 CHLOROPHYNYL] 3 METHYLBUT 3 EN 2 OXIME; ACROLEIN; ALLYL ISOTHIOCYANATE; AP 18; CAPSAZEPINE; CIGARETTE SMOKE; CYCLOPENTENONE; DICLOFENAC; FLUFENAMIC ACID; FLURBIPROFEN; HC 030031; INDOMETACIN; ION TRANSPORT AFFECTING AGENT; ISOFLURANE; MEFENAMIC ACID; NIFLUMIC ACID; PARACETAMOL; PROSTAGLANDIN DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

AIR POLLUTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BREATHING PATTERN; CHANNEL GATING; CHRONIC OBSTRUCTIVE LUNG DISEASE; COUGHING; DRUG PROTEIN BINDING; DRUG TARGETING; DYSPNEA; EXHAUST GAS; GENE ACTIVATION; GENETIC VARIABILITY; HUMAN; HYPERALGESIA; INFLAMMATION; INFLAMMATORY DISEASE; MARKER GENE; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESPIRATORY TRACT DISEASE; SENSORY NERVE; SENSORY STIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STIMULUS RESPONSE; TRPA1 GENE; VAGUS NERVE STIMULATION;

EID: 80053536430     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-3327     Document Type: Article

References (65)

1. McCormick A, Fleming DM, Charlton J. Office of Population Censuses and Surveys. Morbidity Statistics from General Practice, Fourth National Study 1991-1992. Series MB5 no 3. London, England: HMSO; 1995.
2. Irwin RS, Corrao WM, Pratter MR. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis. 1981;123(4 pt 1):413-417. (Pubitemid 11105709)
3. Ford AC, Forman D, Moayyedi P, Morice AH. Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. Thorax. 2006;61(11):975-979. (Pubitemid 44787168)
4. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ. 2002;324(7333):329-331. (Pubitemid 34142752)
5. Smith SM, Henman M, Schroeder K, Fahey T. Over-thecounter cough medicines in children: neither safe or efficacious? Br J Gen Pract. 2008;58(556):757-758.
6. World Health Organization. Asthma. Fact Sheet No. 307. World Health Organization Web site. http://www.who.int/mediacentre/factsheets/fs307/en/index. html. Accessed May 2011.
7. World Health Organization. Chronic Obstructive Pulmonary Disease (COPD). Fact Sheet No. 315. World Health Organization Web site. http://www.who.int/ mediacentre/factsheets/fs315/en/index.html. Accessed February 2011.
8. Clapham DE. TRP channels as cellular sensors. Nature. 2003;426(6966):517-524. (Pubitemid 37522633)
9. Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov. 2009;8(1):55-68.
10. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999;398(6726):436-441. (Pubitemid 29180377)
11. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002;416(6876):52-58. (Pubitemid 34215395)
12. Anand U, Otto WR, Facer P, et al. TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosci Lett. 2008;438(2):221-227.
13. Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112(6):819-829. (Pubitemid 36378884)
14. Nassenstein C, Kwong K, Taylor-Clark T, et al. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol. 2008;586(6):1595-1604. (Pubitemid 351404963)
15. Rech JC, Eckert WA, Maher MP, Banke T, Bhattacharya A, Wickenden AD. Recent advances in the biology and medicinal chemistry of TRPA1. Future Med Chem. 2010;2(5):843-858.
16. Jaquemar D, Schenker T, Trueb B. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem. 1999;274(11):7325-7333.
17. Jordt SE, Bautista DM, Chuang HH, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427(6971):260-265. (Pubitemid 38112043)
18. Bandell M, Story GM, Hwang SW, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004;41(6):849-857. (Pubitemid 38429729)
19. Macpherson LJ, Geierstanger BH, Viswanath V, et al. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol. 2005;15(10):929-934. (Pubitemid 40772062)
20. Bautista DM, Jordt SE, Nikai T, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124(6):1269-1282.
21. Facchinetti F, Amadei F, Geppetti P, et al. Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages. Am J Respir Cell Mol Biol. 2007;37(5):617-623. (Pubitemid 350058193)
22. Macpherson LJ, Dubin AE, Evans MJ, et al. Noxious compounds activate TRPA1 ion channels through covalent modifi cation of cysteines. Nature. 2007;445(7127):541-545. (Pubitemid 46197634)
23. McNamara CR, Mandel-Brehm J, Bautista DM, et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007;104(33):13525-13530. (Pubitemid 47293978)
24. Trevisani M, Siemens J, Materazzi S, et al. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007;104(33):13519- 13524. (Pubitemid 47293977)
25. Andrè E, Campi B, Materazzi S, et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008;118(7):2574-2582. (Pubitemid 351949784)
26. Brône B, Peeters PJ, Marrannes R, et al. Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008;231(2):150-156.
27. Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008;28(10):2485-2494. (Pubitemid 351348185)
28. Talavera K, Gees M, Karashima Y, et al. Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci. 2009;12(10):1293-1299.
29. Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA. Transient receptor potential ankyrin 1 mediates toluene diisocyanateevoked respiratory irritation. Am J Respir Cell Mol Biol. 2009;40(6):756-762.
30. Taylor-Clark TE, Undem BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol. 2010;588(pt 3):423-433.
31. Hu H, Tian J, Zhu Y, et al. Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 2010;459(4):579-592.
32. Doerner JF, Gisselmann G, Hatt H, Wetzel CH. Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem. 2007;282(18):13180- 13189. (Pubitemid 47100541)
33. Zurborg S, Yurgionas B, Jira JA, Caspani O, Heppenstall PA. Direct activation of the ion channel TRPA1 by Ca2+. Nat Neurosci. 2007;10(3):277-279.
34. Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER. The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J. Biol Chem. 2008;283(47):32691-32703.
35. Vyklický L, Nováková-Tousová K, Benedikt J, Samad A, Touska F, Vlachová V. Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin. Physiol Res. 2008;57(suppl 3):S59-S68.
36. Viana F, Ferrer-Montiel A. TRPA1 modulators in preclinical development. Expert Opin Ther Pat. 2009;19(12):1787-1799.
37. Bessac BF, Jordt SE. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 2008;23:360-370.
38. Petrus M, Peier AM, Bandell M, et al. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain. 2007;3:40.
39. Eid SR, Crown ED, Moore EL, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008;4:48.
40. Laude EA, Higgins KS, Morice AH. A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man. Pulm Pharmacol. 1993;6(3):171-175. (Pubitemid 23270144)
41. Lalloo UG, Fox AJ, Belvisi MG, Chung KF, Barnes PJ. Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol. 1995;79(4):1082-1087.
42. Trevisani M, Milan A, Gatti R, et al. Antitussive activity of iodo-resiniferatoxin in guinea pigs. Thorax. 2004;59(9):769-772. (Pubitemid 39215373)
43. Groneberg DA, Niimi A, Dinh QT, et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med. 2004;170(12):1276-1280. (Pubitemid 39657190)
44. Taylor-Clark TE, McAlexander MA, Nassenstein C, et al. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol. 2008;586(14):3447-3459. (Pubitemid 352003876)
45. Birrell MA, Belvisi MG, Grace M, et al. TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med. 2009;180(11):1042- 1047.
46. Andrè E, Gatti R, Trevisani M, et al. Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol. 2009;158(6):1621-1628.
47. Lee LY, Burki NK, Gerhardstein DC, Gu Q, Kou YR, Xu J. Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors. Pulm Pharmacol Ther. 2007;20(4):355-364. (Pubitemid 46518192)
48. Thurston GD, Bates DV. Air pollution as an underappreciated cause of asthma symptoms. JAMA. 2003;290(14):1915-1917. (Pubitemid 37430609)
49. Leikauf GD. Hazardous air pollutants and asthma. Environ Health Perspect. 2002;110(suppl 4):505-526.
50. Zhang G, Lin RL, Wiggers M, Snow DM, Lee LY. Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol. 2008;586(pt 23):5771-5786.
51. Mitchell JE, Campbell AP, New NE, et al. Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp Lung Res. 2005;31(3):295-306. (Pubitemid 40463471)
52. Cantero-Recasens G, Gonzalez JR, Fandos C, et al. Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J Biol Chem. 2010;285(36):27532- 27535.
53. Brooks SM, Weiss MA, Bernstein IL. Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures. Chest. 1985;88(3):376-384. (Pubitemid 15248096)
54. Prezant DJ, Levin S, Kelly KJ, Aldrich TK. Upper and lower respiratory diseases after occupational and environmental disasters. Mt Sinai J Med. 2008;75(2):89-100.
55. Shakeri MS, Dick FD, Ayres JG. Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic review. Occup Med (Lond). 2008;58(3):205-211.
56. Dai Y, Wang S, Tominaga M, et al. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest. 2007;117(7):1979-1987. (Pubitemid 47036332)
57. Coffey MJ, Wheeler CS, Gross KB, Eschenbacher WL, Sporn PH, Peters-Golden M. Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology. 1996;114(3):187-197. (Pubitemid 26421932)
58. Moller DR, McKay RT, Bernstein IL, Brooks SM. Persistent airways disease caused by toluene diisocyanate. Am Rev Respir Dis. 1986;134(1):175-176. (Pubitemid 16057481)
59. Birrell MA, Hardaker E, Wong S, et al. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med. 2005;172(8):962-971. (Pubitemid 41476532)
60. Caceres AI, Brackmann M, Elia MD, et al. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A. 2009;106(22):9099-9104.
61. Raemdonck K, De Alba J, Birrell MA, Belvisi MG. A role for airway sensory nerves in the allergen induced late asthmatic response in a rat model of allergic asthma. Am J Respir Crit Care Med. 2010;181:A5542.
62. Nassini R, Materazzi S, Andrè E, et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J. 2010;24(12):4904-4916.
63. Cavanaugh EJ, Simkin D, Kim D. Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2 1 reveals different functional channel states. Neuroscience. 2008;154(4):1467-1476.
64. Maher SA, Grace MS, Birrell MA, Belvisi MG. Prostaglandin E2-induced sensory nerve activation is mediated by TRPA1 and TRPV1. Am J Respir Crit Care Med. 2010;181:A5541.
65. 1H-inden-4-yl)-3-(2-(piperidin-1-yl)- 4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008;326(1):218-229.