Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR-375

Oncology Reports

Volumn 37, Issue 1, 2017, Pages 305-312

  Jia, Lingfei ^a   Zhang, Shan ^a   Huang, Yiping ^a   Zheng, Yunfei ^a   Gan, Yehua ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

MiR 375; Radiosensitization; Tongue squamous cell carcinoma; Trichostatin A

Indexed keywords

CASPASE 3; CASPASE 7; MICRORNA 375; TRICHOSTATIN A; HISTONE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; MICRORNA; MIRN375 MICRORNA, HUMAN; PROTEIN KINASE B; RADIOSENSITIZING AGENT;

ANALYSIS OF VARIANCE; ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RADIOSENSITIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TONGUE CARCINOMA; TRANSCRIPTION INITIATION SITE; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; RADIATION RESPONSE; TONGUE NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; HYDROXAMIC ACIDS; MICRORNAS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-SENSITIZING AGENTS; TONGUE NEOPLASMS;

EID: 85006482108     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.5261     Document Type: Article

References (37)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 57: 43-66, 2007.
2. Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P and Bertrand P: Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91: 2081-2086, 1999.
3. Bussink J, van der Kogel AJ and Kaanders JH: Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 9: 288-296, 2008.
4. Zhu L, Wu K, Ma S and Zhang S: HDAC inhibitors: A new radiosensitizer for non-small-cell lung cancer. Tumori 101: 257-262, 2015.
5. Kim IA, Kim IH, Kim HJ, Chie EK and Kim JS: HDAC inhibitormediated radiosensitization in human carcinoma cells: A general phenomenon? J Radiat Res (Tokyo) 51: 257-263, 2010.
6. Zhang Y, Jung M, Dritschilo A and Jung M: Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161: 667-674, 2004.
7. Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB and Mei QB: Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther 8: 823-831, 2009.
8. Yu J, Mi J, Wang Y, Wang A and Tian X: Regulation of radiosensitivity by HDAC inhibitor trichostatin A in the human cervical carcinoma cell line Hela. Eur J Gynaecol Oncol 33: 285-290, 2012.
9. He G, Wang Y, Pang X and Zhang B: Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. Tumour Biol 35: 1003-1011, 2014.
10. Karagiannis TC, Smith AJ and El' Osta A: Radio- and chemosensitization of human erythroleukemic K562 cells by the histone deacetylase inhibitor Trichostatin A. Hell J Nucl Med 7: 184-191, 2004.
11. Zhang Y, Carr T, Dimtchev A, Zaer N, Dritschilo A and Jung M: Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. Radiat Res 168: 115-124, 2007.
12. Kim IA, Shin JH, Kim IH, Kim JH, Kim JS, Wu HG, Chie EK, Ha SW, Park CI and Kao GD: Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: Class differences and the potential influence of p53. Clin Cancer Res 12: 940-949, 2006.
13. Dong Q, Sharma S, Liu H, Chen L, Gu B, Sun X and Wang G: HDAC inhibitors reverse acquired radio resistance of KYSE-150R esophageal carcinoma cells by modulating Bmi-1 expression. Toxicol Lett 224: 121-129, 2014.
14. Q u JQ, Yi HM, Ye X, Li LN, Zhu JF, Xiao T, Yuan L, Li JY, Wang YY, Feng J, et al: MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway. Oncotarget 6: 28341-28356, 2015.
15. Balça-Silva J, Sousa Neves S, Gonçalves AC, Abrantes AM, Casalta-Lopes J, Botelho MF, Sarmento-Ribeiro AB and Silva HC: Effect of miR-34b overexpression on the radiosensitivity of non-small cell lung cancer cell lines. Anticancer Res 32: 1603-1609, 2012.
16. Yang W, Shen Y, Wei J and Liu F: MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species. Oncotarget 6: 22006-22027, 2015.
17. Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y and Wu G: MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGFVEGFR2 pathway. PLoS One 8: e78344, 2013.
18. Zhao L, Bode AM, Cao Y and Dong Z: Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity. Carcinogenesis 33: 2220-2227, 2012.
19. Isozaki Y, Hoshino I, Nohata N, Kinoshita T, Akutsu Y, Hanari N, Mori M, Yoneyama Y, Akanuma N, Takeshita N, et al: Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma. Int J Oncol 41: 985-994, 2012.
20. Yin LH, Zheng XQ, Li HY, Bi LX, Shi YF, Ye AF, Wu JB and Gao SM: Epigenetic deregulated miR-375 contributes to the constitutive activation of JAK2/STAT signaling in myeloproliferative neoplasm. Leuk Res 39: 471-478, 2015.
21. Jia L, Huang Y, Zheng Y, Lyu M, Zhang C, Meng Z, Gan Y and Yu G: miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma. Oncol Rep 33: 2061-2071, 2015.
22. Manning BD and Cantley LC: AKT/PKB signaling: Navigating downstream. Cell 129: 1261-1274, 2007.
23. Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S and Schmidt-Ullrich R: Stress and radiationinduced activation of multiple intracellular signaling pathways. Radiat Res 159: 283-300, 2003.
24. Meng Z and Gan YH: Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization. Biochem Biophys Res Commun 460: 198-204, 2015.
25. Hu S, Zhang M, Sun F, Ren L, He X, Hua J and Peng S: miR-375 controls porcine pancreatic stem cell fate by targeting 3-phosphoinositide- dependent protein kinase-1 (Pdk1). Cell Prolif 49: 395-406, 2016.
26. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, et al: MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 70: 2339-2349, 2010.
27. Zhou J, Song S, He S, Zhu X, Zhang Y, Yi B, Zhang B, Qin G and Li D: MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. Int J Mol Med 33: 950-956, 2014.
28. Jia LF, Wei SB, Gong K, Gan YH and Yu GY: Prognostic implications of micoRNA miR-195 expression in human tongue squamous cell carcinoma. PLoS One 8: e56634, 2013.
29. Harris T, Jimenez L, Kawachi N, Fan JB, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R, et al: Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas. Am J Pathol 180: 917-928, 2012.
30. Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H, et al: Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet 56: 595-601, 2011.
31. Jamali Z, Asl Aminabadi N, Attaran R, Pournagiazar F, Ghertasi Oskouei S and Ahmadpour F: MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: A systematic review and meta-analysis. Oral Oncol 51: 321-331, 2015.
32. Song L, Liu S, Zeng S, Zhang L and Li X: miR-375 modulates radiosensitivity of HR-HPV-positive cervical cancer cells by targeting UBE3A through the p53 pathway. Med Sci Monit 21: 2210-2217, 2015.
33. Cortez MA, Valdecanas D, Niknam S, Peltier HJ, Diao L, Giri U, Komaki R, Calin GA, Gomez DR, Chang JY, et al: In vivo delivery of miR-34a sensitizes lung tumors to radiation through RAD51 regulation. Mol Ther Nucleic Acids 4: e270, 2015.
34. Kraus AC, Ferber I, Bachmann SO, Specht H, Wimmel A, Gross MW, Schlegel J, Suske G and Schuermann M: In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 21: 8683-8695, 2002.
35. Li X, Chen F, Zhu Q, Ding B, Zhong Q, Huang K, Jiang X, Wang Z, Yin C, Zhu Y, et al: Gli-1/PI3K/AKT/NF-?B pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells. Oncotarget 7: 33004- 33015, 2016.
36. Luo XM, Xu B, Zhou ML, Bao YY, Zhou SH, Fan J and Lu ZJ: Co-inhibition of GLUT-1 expression and the PI3K/Akt signaling pathway to enhance the radiosensitivity of laryngeal carcinoma xenografts in vivo. PLoS One 10: e0143306, 2015.
37. Wang L, Song G, Liu M, Chen B, Chen Y, Shen Y, Zhu J and Zhou X: MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway. Int J Mol Med 37: 47-55, 2016.