Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells

Oncotarget

Volumn 7, Issue 22, 2016, Pages 33004-33015

  Li, Xiaodong ^a   Chen, Fang ^a   Zhu, Qiuhua ^a   Ding, Bingjie ^a   Zhong, Qingxiu ^a,b   Huang, Kaikai ^a   Jiang, Xuejie ^a   Wang, Zhixiang ^a   Yin, Changxin ^a   Zhu, Yufeng ^a   Li, Zhen ^a   Meng, Fanyi ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Department of Inspection   (China)

Author keywords

Gli 1 PI3K AKT NF kB; LDE225; Radioresistance; Refractory AML

Indexed keywords

HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAK; PROTEIN KINASE B; SONIDEGIB; TRANSCRIPTION FACTOR GLI1; GLI1 PROTEIN, HUMAN;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHEMORADIOTHERAPY; CONTROLLED STUDY; FEMALE; HEDGEHOG SIGNALING PATHWAY; HL 60 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING; ACUTE MYELOID LEUKEMIA; ANIMAL; BAGG ALBINO MOUSE; DRUG SCREENING; GENETICS; HL-60 CELL LINE; METABOLISM; NUDE MOUSE; RADIATION TOLERANCE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FEMALE; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED BALB C; MICE, NUDE; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZINC FINGER PROTEIN GLI1;

EID: 84973574858     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8844     Document Type: Article

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