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ChemMedChem

Volumn 9, Issue 2, 2014, Pages 277-281

Design and synthesis of tricyclic jak3 inhibitors with picomolar affinities as novel molecular probes

(4) Gehringer, Matthias a Pfaffenrot, Ellen a Bauer, Silke a Laufer, Stefan A a

a UNIVERSITY OF TÜBINGEN (Germany)

Author keywords

Inflammation; Isoform Selectivity; Janus Kinase 3; Medicinal Chemistry; Tricyclic Kinase Inhibitors

Indexed keywords

EXOCYCLIC DOUBLE BOND; IMIDAZOLE; JANUS KINASE 3 INHIBITOR; STAT PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; TOFACITINIB;

AFFINITY LABELING; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HECK REACTION; HUMAN; HUMAN CELL; IC 50; ISOMERIZATION; MICHAEL ADDITION; MOLECULAR PROBE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

INFLAMMATION; ISOFORM SELECTIVITY; JANUS KINASE 3; MEDICINAL CHEMISTRY; TRICYCLIC KINASE INHIBITORS;

DRUG DESIGN; HELA CELLS; HUMANS; JANUS KINASE 3; MODELS, MOLECULAR; MOLECULAR PROBES; PHOSPHORYLATION; PIPERIDINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84897024546 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300520 Document Type: Article

Times cited : (31)

References (21)

1
- 70350337910
- M. G. Cornejo, T. J. Boggon, T. Mercher, Int. J. Biochem. Cell Biol. 2009, 41, 2376-2379.
- (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 2376-2379
- Cornejo, M.G.¹ Boggon, T.J.² Mercher, T.³

2
- 77954385114
- J. E. Chrencik, A. Patny, I. K. Leung, B. Korniski, T. L. Emmons, T. Hall, R. A. Weinberg, J. A. Gormley, J. M. Williams, J. E. Day, J. L. Hirsch, J. R. Kiefer, J. W. Leone, H. D. Fischer, C. D. Sommers, H.-C. Huang, E. J. Jacobsen, R. E. Tenbrink, A. G. Tomasselli, T. E. Benson, J. Mol. Biol. 2010, 400, 413-433.
- (2010) J. Mol. Biol. , vol.400 , pp. 413-433
- Chrencik, J.E.¹ Patny, A.² Leung, I.K.³ Korniski, B.⁴ Emmons, T.L.⁵ Hall, T.⁶ Weinberg, R.A.⁷ Gormley, J.A.⁸ Williams, J.M.⁹ Day, J.E.¹⁰ Hirsch, J.L.¹¹ Kiefer, J.R.¹² Leone, J.W.¹³ Fischer, H.D.¹⁴ Sommers, C.D.¹⁵ Huang, H.-C.¹⁶ Jacobsen, E.J.¹⁷ Tenbrink, R.E.¹⁸ Tomasselli, A.G.¹⁹ Benson, T.E.²⁰ more..

3
- 7044272247
- J. J. O'Shea, Ann. Rheum. Dis. 2004, 63 (Suppl. 2), ii67-ii71.
- (2004) Ann. Rheum. Dis. , vol.63 , Issue.SUPPL. 2
- O'Shea, J.J.¹

4
- 78650362917
- M. E. Flanagan, T. A. Blumenkopf, W. H. Brissette, M. F. Brown, J. M. Casavant, C. Shang-Poa, J. L. Doty, E. A. Elliott, M. B. Fisher, M. Hines, C. Kent, E. M. Kudlacz, B. M. Lillie, K. S. Magnuson, S. P. McCurdy, M. J. Munchhof, B. D. Perry, P. S. Sawyer, T. J. Strelevitz, C. Subramanyam, J. M. Sun, D. A. Whipple, P. S. Changelian, J. Med. Chem. 2010, 53, 8468-8484.
- (2010) J. Med. Chem. , vol.53 , pp. 8468-8484
- Flanagan, M.E.¹ Blumenkopf, T.A.² Brissette, W.H.³ Brown, M.F.⁴ Casavant, J.M.⁵ Shang-Poa, C.⁶ Doty, J.L.⁷ Elliott, E.A.⁸ Fisher, M.B.⁹ Hines, M.¹⁰ Kent, C.¹¹ Kudlacz, E.M.¹² Lillie, B.M.¹³ Magnuson, K.S.¹⁴ McCurdy, S.P.¹⁵ Munchhof, M.J.¹⁶ Perry, B.D.¹⁷ Sawyer, P.S.¹⁸ Strelevitz, T.J.¹⁹ Subramanyam, C.²⁰ more..

5
- 84863109520
- J. J. Kulagowski, W. Bair, R. J. Bull, C. Chang, G. Deshmukh, H. J. Dyke, C. Eigenbrot, N. Ghilardi, P. Gibbons, T. K. Harrison, P. R. Hewitt, M. Liimatta, C. A. Hurley, A. Johnson, T. Johnson, J. R. Kenny, P. B. Kohli, R. J. Maxey, R. Mendonca, K. Mortara, J. Murray, R. Narukulla, S. Shia, M. Steffek, S. Ubhayakar, M. Ultsch, A. van Abbema, S. I. Ward, B. Waszkowycz, M. Zak, J. Med. Chem. 2012, 55, 5901-5921.
- (2012) J. Med. Chem. , vol.55 , pp. 5901-5921
- Kulagowski, J.J.¹ Bair, W.² Bull, R.J.³ Chang, C.⁴ Deshmukh, G.⁵ Dyke, H.J.⁶ Eigenbrot, C.⁷ Ghilardi, N.⁸ Gibbons, P.⁹ Harrison, T.K.¹⁰ Hewitt, P.R.¹¹ Liimatta, M.¹² Hurley, C.A.¹³ Johnson, A.¹⁴ Johnson, T.¹⁵ Kenny, J.R.¹⁶ Kohli, P.B.¹⁷ Maxey, R.J.¹⁸ Mendonca, R.¹⁹ Mortara, K.²⁰ more..

6
- 84861390265
- C. A. Zerbini, A. B. Lomonte, Expert Rev. Clin. Immunol. 2012, 8, 319-331.
- (2012) Expert Rev. Clin. Immunol. , vol.8 , pp. 319-331
- Zerbini, C.A.¹ Lomonte, A.B.²

7
- 84875182662
- B. W. Dymock, C. S. See, Expert Opin. Ther. Pat. 2013, 23, 449-501.
- (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 449-501
- Dymock, B.W.¹ See, C.S.²

8
- 84871312669
- S. Knapp, P. Arruda, J. Blagg, S. Burley, D. H. Drewry, A. Edwards, D. Fabbro, P. Gillespie, N. S. Gray, B. Kuster, K E. Lackey, P. Mazzafera, N. C. O. Tomkinson, T. M. Willson, P. Workman, W. J. Zuercher, Nat. Chem. Biol. 2013, 9, 3-6.
- (2013) Nat. Chem. Biol. , vol.9 , pp. 3-6
- Knapp, S.¹ Arruda, P.² Blagg, J.³ Burley, S.⁴ Drewry, D.H.⁵ Edwards, A.⁶ Fabbro, D.⁷ Gillespie, P.⁸ Gray, N.S.⁹ Kuster, B.¹⁰ Lackey K, E.¹¹ Mazzafera, P.¹² Tomkinson, N.C.O.¹³ Willson, T.M.¹⁴ Workman, P.¹⁵ Zuercher, W.J.¹⁶

9
- 58149092616
- J. K. Jiang, K. Ghoreschi, F. Deflorian, Z. Chen, M. Perreira, M. Pesu, J. Smith, D. T. Nguyen, E. H. Liu, W. Leister, S. Costanzi, J. J. O'Shea, C. J. Thomas, J. Med. Chem. 2008, 51, 8012-8018.
- (2008) J. Med. Chem. , vol.51 , pp. 8012-8018
- Jiang, J.K.¹ Ghoreschi, K.² Deflorian, F.³ Chen, Z.⁴ Perreira, M.⁵ Pesu, M.⁶ Smith, J.⁷ Nguyen, D.T.⁸ Liu, E.H.⁹ Leister, W.¹⁰ Costanzi, S.¹¹ O'Shea, J.J.¹² Thomas, C.J.¹³

10
- 84867368167
- R. Selig, M. Goettert, V. Schattel, D. Schollmeyer, W. Albrech, S. Laufer, J. Med. Chem. 2012, 55, 8429-8439.
- (2012) J. Med. Chem. , vol.55 , pp. 8429-8439
- Selig, R.¹ Goettert, M.² Schattel, V.³ Schollmeyer, D.⁴ Albrech, W.⁵ Laufer, S.⁶

11
- 33845951667
- S. A. Laufer, G. M. Ahrens, S. C. Karcher, J. S. Hering, R. Niess, J. Med. Chem. 2006, 49, 7912-7915.
- (2006) J. Med. Chem. , vol.49 , pp. 7912-7915
- Laufer, S.A.¹ Ahrens, G.M.² Karcher, S.C.³ Hering, J.S.⁴ Niess, R.⁵

12
- 79953213695
- K. W. Rickert, S. B. Patel, T. J. Allison, N. J. Byrne, P. L. Darke, R. E. Ford, D. J. Guerin, D. L. Hall, M. Kornienko, J. Lu, S. K. Munshi, J. C. Reid, J. M. Shipman, E. F. Stanton, K. J. Wilson, J. R. Young, S. M. Soisson, K. J. Lumb, J. Biol. Chem. 2011, 286, 11218-11225.
- (2011) J. Biol. Chem. , vol.286 , pp. 11218-11225
- Rickert, K.W.¹ Patel, S.B.² Allison, T.J.³ Byrne, N.J.⁴ Darke, P.L.⁵ Ford, R.E.⁶ Guerin, D.J.⁷ Hall, D.L.⁸ Kornienko, M.⁹ Lu, J.¹⁰ Munshi, S.K.¹¹ Reid, J.C.¹² Shipman, J.M.¹³ Stanton, E.F.¹⁴ Wilson, K.J.¹⁵ Young, J.R.¹⁶ Soisson, S.M.¹⁷ Lumb, K.J.¹⁸

13
- 84867224583
- E. Pfaffenrot, D. Schollmeyer, S. Laufer, Acta Crystallogr. Sect. E 2012, 68, o3052.
- (2012) Acta Crystallogr. Sect. E , vol.68
- Pfaffenrot, E.¹ Schollmeyer, D.² Laufer, S.³

14
- 84863822923
- M. Zak, R. Mendonca, M. Balazs, K. Barrett, P. Bergeron, W. S. Blair, C. Chang, G. Deshmukh, J. DeVoss, P. S. Dragovich, C. Eigenbrot, N. Ghilardi, P. Gibbons, S. Gradl, C. Hamman, E. J. Hanan, E. Harstad, P. R. Hewitt, C. A. Hurley, T. Jin, A. Johnson, T. Johnson, J. R. Kenny, M. F. T. Koehler, P. B. Kohli, J. J. Kulagowski, S. Labadie, J. P. Liao, M. Liimatta, Z. H. Lin, P. J. Lupardus, R. J. Maxey, J. M. Murray, R. Pulk, M. Rodriguez, S. Savage, S. Shia, M. Steffek, S. Ubhayakar, M. Ultsch, A. van Abbema, S. I. Ward, L. Xiao, Y. S. Xiao, J. Med. Chem. 2012, 55, 6176-6193.
- (2012) J. Med. Chem. , vol.55 , pp. 6176-6193
- Zak, M.¹ Mendonca, R.² Balazs, M.³ Barrett, K.⁴ Bergeron, P.⁵ Blair, W.S.⁶ Chang, C.⁷ Deshmukh, G.⁸ DeVoss, J.⁹ Dragovich, P.S.¹⁰ Eigenbrot, C.¹¹ Ghilardi, N.¹² Gibbons, P.¹³ Gradl, S.¹⁴ Hamman, C.¹⁵ Hanan, E.J.¹⁶ Harstad, E.¹⁷ Hewitt, P.R.¹⁸ Hurley, C.A.¹⁹ Jin, T.²⁰ more..

15
- 84879045959
- M. Zak, C. A. Hurley, S. I. Ward, P. Bergeron, K. Barrett, M. Balazs, W. S. Blair, R. Bull, P. Chakravarty, C. Chang, P. Crackett, G. Deshmukh, J. DeVoss, P. S. Dragovich, C. Eigenbrot, C. Ellwood, S. Gaines, N. Ghilardi, P. Gibbons, S. Gradl et al., J. Med. Chem. 2013, 56, 4764-4785.
- (2013) J. Med. Chem. , vol.56 , pp. 4764-4785
- Zak, M.¹ Hurley, C.A.² Ward, S.I.³ Bergeron, P.⁴ Barrett, K.⁵ Balazs, M.⁶ Blair, W.S.⁷ Bull, R.⁸ Chakravarty, P.⁹ Chang, C.¹⁰ Crackett, P.¹¹ Deshmukh, G.¹² DeVoss, J.¹³ Dragovich, P.S.¹⁴ Eigenbrot, C.¹⁵ Ellwood, C.¹⁶ Gaines, S.¹⁷ Ghilardi, N.¹⁸ Gibbons, P.¹⁹ Gradl, S.²⁰ more..

16
- 13844320566
- G. Wolber, T. Langer, J. Chem. Inf. Model. 2005, 45, 160-169.
- (2005) J. Chem. Inf. Model. , vol.45 , pp. 160-169
- Wolber, G.¹ Langer, T.²

17
- 0344361923
- J. E. Baldwin, J. Chem. Soc. Chem. Commun. 1976, 734-736.
- (1976) J. Chem. Soc. Chem. Commun. , pp. 734-736
- Baldwin, J.E.¹

18
- 61349149899
- N. K. Williams, R. S. Bamert, O. Patel, C. Wang, P. M. Walden, A. F. Wilks, E. Fantino, J. Rossjohn, I. S. Lucet, J. Mol. Biol. 2009, 387, 219-232.
- (2009) J. Mol. Biol. , vol.387 , pp. 219-232
- Williams, N.K.¹ Bamert, R.S.² Patel, O.³ Wang, C.⁴ Walden, P.M.⁵ Wilks, A.F.⁶ Fantino, E.⁷ Rossjohn, J.⁸ Lucet, I.S.⁹

19
- 77951095524
- G. Wuitschik, E. M. Carreira, B. Wagner, H. Fischer, I. Parrilla, F. Schuler, M. Rogers-Evans, K. Muller, J. Med. Chem. 2010, 53, 3227-3246.
- (2010) J. Med. Chem. , vol.53 , pp. 3227-3246
- Wuitschik, G.¹ Carreira, E.M.² Wagner, B.³ Fischer, H.⁴ Parrilla, I.⁵ Schuler, F.⁶ Rogers-Evans, M.⁷ Muller, K.⁸

20
- 84897027282
- Kinase HotSpot assay, Reaction Biology Corp. (Malvern, PA, USA)
- Kinase HotSpot assay, Reaction Biology Corp. (Malvern, PA, USA); http://www.reactionbiology.com.

21
- 84897021059
- Milliplex MAP STAT luminex-based multiplex immunoassay, EMD Millipore Corp. (Billerica, MA, USA)
- Milliplex MAP STAT luminex-based multiplex immunoassay, EMD Millipore Corp. (Billerica, MA, USA); http://www.millipore.com/LeadDiscovery.

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